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Q12864 (CAD17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-17
Alternative name(s):
Intestinal peptide-associated transporter HPT-1
Liver-intestine cadherin
Short name=LI-cadherin
Gene names
Name:CDH17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length832 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. Ref.1

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin. Ref.1

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 7 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 832810Cadherin-17
PRO_0000003812

Regions

Topological domain23 – 787765Extracellular Potential
Transmembrane788 – 80821Helical; Potential
Topological domain809 – 83224Cytoplasmic Potential
Domain30 – 12899Cadherin 1
Domain129 – 244116Cadherin 2
Domain245 – 34096Cadherin 3
Domain341 – 449109Cadherin 4
Domain450 – 566117Cadherin 5
Domain567 – 667101Cadherin 6
Domain668 – 777110Cadherin 7

Amino acid modifications

Glycosylation1491N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation4191N-linked (GlcNAc...) Potential
Glycosylation4561N-linked (GlcNAc...) Potential
Glycosylation5461N-linked (GlcNAc...) Potential
Glycosylation5871N-linked (GlcNAc...) Potential
Glycosylation7221N-linked (GlcNAc...) Potential

Natural variations

Natural variant1151K → E. Ref.1 Ref.4
Corresponds to variant rs2243518 [ dbSNP | Ensembl ].
VAR_055567
Natural variant4461I → T. Ref.2
Corresponds to variant rs1131829 [ dbSNP | Ensembl ].
VAR_031694
Natural variant7341E → D. Ref.1 Ref.4
Corresponds to variant rs1051623 [ dbSNP | Ensembl ].
VAR_031695
Natural variant7391E → A.
Corresponds to variant rs1051624 [ dbSNP | Ensembl ].
VAR_031696

Sequences

Sequence LengthMass (Da)Tools
Q12864 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 2707547DD2DB4202

FASTA83292,219
        10         20         30         40         50         60 
MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ FKANPPAVTF 

        70         80         90        100        110        120 
ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD ANGIIVEGPV PITIKVKDIN 

       130        140        150        160        170        180 
DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA TDLDDPATPN GQLYYQIVIQ LPMINNVMYF 

       190        200        210        220        230        240 
QINNKTGAIS LTREGSQELN PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK 

       250        260        270        280        290        300 
APKPVEMVEN STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR 

       310        320        330        340        350        360 
EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ ENERLGNSIG 

       370        380        390        400        410        420 
TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA GMLQLAKQSL KKQDTPQYNL 

       430        440        450        460        470        480 
TIEVSDKDFK TLCFVQINVI DINDQIPIFE KSDYGNLTLA EDTNIGSTIL TIQATDADEP 

       490        500        510        520        530        540 
FTGSSKILYH IIKGDSEGRL GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV 

       550        560        570        580        590        600 
FGVKYNASSF AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY 

       610        620        630        640        650        660 
SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV SEFHLILMDV 

       670        680        690        700        710        720 
NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG PHFTFSLGSG SLQNDWEVSK 

       730        740        750        760        770        780 
INGTHARLST RHTEFEEREY VVLIRINDGG RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT 

       790        800        810        820        830 
GIPTVGMAVG ILLTTLLVIG IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS 

« Hide

References

« Hide 'large scale' references
[1]"Association of intestinal peptide transport with a protein related to the cadherin superfamily."
Dantzig A.H., Hoskins J., Tabas L.B., Bright S., Shepard R.L., Jenkins I.L., Duckworth D.C., Sportsman J.R., MacKensen D., Rosteck P.R. Jr., Skatrud P.L.
Science 264:430-433(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS GLU-115 AND ASP-734.
Tissue: Colon adenocarcinoma.
[2]"Molecular cloning of human LI-cadherin: evidence for a novel type of cadherin within the cadherin superfamily."
Boettinger A., Kreft B., Fieger C., Dlouhy B., Berndorff D., Goessner R., Tauber R.
Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-446.
[3]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-115 AND ASP-734.
Tissue: Cerebellum.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U07969 mRNA. Translation: AAA19021.1.
X83228 mRNA. Translation: CAA58231.1.
AP003351 Genomic DNA. No translation available.
AP003478 Genomic DNA. No translation available.
BC112013 mRNA. Translation: AAI12014.1.
BC113464 mRNA. Translation: AAI13465.1.
CCDSCCDS6260.1.
PIRS55396.
RefSeqNP_001138135.1. NM_001144663.1.
NP_004054.3. NM_004063.3.
UniGeneHs.591853.

3D structure databases

ProteinModelPortalQ12864.
SMRQ12864. Positions 40-765.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107450. 1 interaction.
MINTMINT-5000411.
STRING9606.ENSP00000027335.

PTM databases

PhosphoSiteQ12864.

Polymorphism databases

DMDM308153624.

Proteomic databases

MaxQBQ12864.
PaxDbQ12864.
PRIDEQ12864.

Protocols and materials databases

DNASU1015.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000027335; ENSP00000027335; ENSG00000079112.
ENST00000450165; ENSP00000401468; ENSG00000079112.
GeneID1015.
KEGGhsa:1015.
UCSCuc003ygh.2. human.

Organism-specific databases

CTD1015.
GeneCardsGC08M095208.
H-InvDBHIX0025563.
HGNCHGNC:1756. CDH17.
HPACAB025143.
HPA023614.
HPA023616.
HPA026556.
MIM603017. gene.
neXtProtNX_Q12864.
PharmGKBPA26290.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313822.
HOGENOMHOG000231613.
HOVERGENHBG050767.
InParanoidQ12864.
KOK06811.
OMAGKPFMYV.
OrthoDBEOG7KWSH1.
PhylomeDBQ12864.
TreeFamTF316817.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressQ12864.
BgeeQ12864.
CleanExHS_CDH17.
GenevestigatorQ12864.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 7 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDH17. human.
GeneWikiCDH17.
GenomeRNAi1015.
NextBio4265.
PROQ12864.
SOURCESearch...

Entry information

Entry nameCAD17_HUMAN
AccessionPrimary (citable) accession number: Q12864
Secondary accession number(s): Q15336, Q2M2E0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM