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Q12864

- CAD17_HUMAN

UniProt

Q12864 - CAD17_HUMAN

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Protein
Cadherin-17
Gene
CDH17
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: UniProt
  3. transporter activity Source: ProtInc

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: UniProt
  2. cell adhesion Source: ProtInc
  3. homophilic cell adhesion Source: UniProt
  4. oligopeptide transmembrane transport Source: UniProt
  5. oligopeptide transport Source: UniProt
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-17
Alternative name(s):
Intestinal peptide-associated transporter HPT-1
Liver-intestine cadherin
Short name:
LI-cadherin
Gene namesi
Name:CDH17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:1756. CDH17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 787765Extracellular Reviewed prediction
Add
BLAST
Transmembranei788 – 80821Helical; Reviewed prediction
Add
BLAST
Topological domaini809 – 83224Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 832810Cadherin-17
PRO_0000003812Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi419 – 4191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi546 – 5461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi587 – 5871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi722 – 7221N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ12864.
PaxDbiQ12864.
PRIDEiQ12864.

PTM databases

PhosphoSiteiQ12864.

Expressioni

Tissue specificityi

Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.1 Publication

Gene expression databases

ArrayExpressiQ12864.
BgeeiQ12864.
CleanExiHS_CDH17.
GenevestigatoriQ12864.

Organism-specific databases

HPAiCAB025143.
HPA023614.
HPA023616.
HPA026556.

Interactioni

Protein-protein interaction databases

BioGridi107450. 1 interaction.
MINTiMINT-5000411.
STRINGi9606.ENSP00000027335.

Structurei

3D structure databases

ProteinModelPortaliQ12864.
SMRiQ12864. Positions 40-765.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 12899Cadherin 1
Add
BLAST
Domaini129 – 244116Cadherin 2
Add
BLAST
Domaini245 – 34096Cadherin 3
Add
BLAST
Domaini341 – 449109Cadherin 4
Add
BLAST
Domaini450 – 566117Cadherin 5
Add
BLAST
Domaini567 – 667101Cadherin 6
Add
BLAST
Domaini668 – 777110Cadherin 7
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 7 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313822.
HOGENOMiHOG000231613.
HOVERGENiHBG050767.
InParanoidiQ12864.
KOiK06811.
OMAiGKPFMYV.
OrthoDBiEOG7KWSH1.
PhylomeDBiQ12864.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12864-1 [UniParc]FASTAAdd to Basket

« Hide

MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ    50
FKANPPAVTF ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD 100
ANGIIVEGPV PITIKVKDIN DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA 150
TDLDDPATPN GQLYYQIVIQ LPMINNVMYF QINNKTGAIS LTREGSQELN 200
PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK APKPVEMVEN 250
STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR 300
EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ 350
ENERLGNSIG TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA 400
GMLQLAKQSL KKQDTPQYNL TIEVSDKDFK TLCFVQINVI DINDQIPIFE 450
KSDYGNLTLA EDTNIGSTIL TIQATDADEP FTGSSKILYH IIKGDSEGRL 500
GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV FGVKYNASSF 550
AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY 600
SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV 650
SEFHLILMDV NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG 700
PHFTFSLGSG SLQNDWEVSK INGTHARLST RHTEFEEREY VVLIRINDGG 750
RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT GIPTVGMAVG ILLTTLLVIG 800
IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS 832
Length:832
Mass (Da):92,219
Last modified:October 5, 2010 - v3
Checksum:i2707547DD2DB4202
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151K → E.2 Publications
Corresponds to variant rs2243518 [ dbSNP | Ensembl ].
VAR_055567
Natural varianti446 – 4461I → T.1 Publication
Corresponds to variant rs1131829 [ dbSNP | Ensembl ].
VAR_031694
Natural varianti734 – 7341E → D.2 Publications
Corresponds to variant rs1051623 [ dbSNP | Ensembl ].
VAR_031695
Natural varianti739 – 7391E → A.
Corresponds to variant rs1051624 [ dbSNP | Ensembl ].
VAR_031696

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07969 mRNA. Translation: AAA19021.1.
X83228 mRNA. Translation: CAA58231.1.
AP003351 Genomic DNA. No translation available.
AP003478 Genomic DNA. No translation available.
BC112013 mRNA. Translation: AAI12014.1.
BC113464 mRNA. Translation: AAI13465.1.
CCDSiCCDS6260.1.
PIRiS55396.
RefSeqiNP_001138135.1. NM_001144663.1.
NP_004054.3. NM_004063.3.
UniGeneiHs.591853.

Genome annotation databases

EnsembliENST00000027335; ENSP00000027335; ENSG00000079112.
ENST00000450165; ENSP00000401468; ENSG00000079112.
GeneIDi1015.
KEGGihsa:1015.
UCSCiuc003ygh.2. human.

Polymorphism databases

DMDMi308153624.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07969 mRNA. Translation: AAA19021.1 .
X83228 mRNA. Translation: CAA58231.1 .
AP003351 Genomic DNA. No translation available.
AP003478 Genomic DNA. No translation available.
BC112013 mRNA. Translation: AAI12014.1 .
BC113464 mRNA. Translation: AAI13465.1 .
CCDSi CCDS6260.1.
PIRi S55396.
RefSeqi NP_001138135.1. NM_001144663.1.
NP_004054.3. NM_004063.3.
UniGenei Hs.591853.

3D structure databases

ProteinModelPortali Q12864.
SMRi Q12864. Positions 40-765.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107450. 1 interaction.
MINTi MINT-5000411.
STRINGi 9606.ENSP00000027335.

PTM databases

PhosphoSitei Q12864.

Polymorphism databases

DMDMi 308153624.

Proteomic databases

MaxQBi Q12864.
PaxDbi Q12864.
PRIDEi Q12864.

Protocols and materials databases

DNASUi 1015.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000027335 ; ENSP00000027335 ; ENSG00000079112 .
ENST00000450165 ; ENSP00000401468 ; ENSG00000079112 .
GeneIDi 1015.
KEGGi hsa:1015.
UCSCi uc003ygh.2. human.

Organism-specific databases

CTDi 1015.
GeneCardsi GC08M095208.
H-InvDB HIX0025563.
HGNCi HGNC:1756. CDH17.
HPAi CAB025143.
HPA023614.
HPA023616.
HPA026556.
MIMi 603017. gene.
neXtProti NX_Q12864.
PharmGKBi PA26290.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313822.
HOGENOMi HOG000231613.
HOVERGENi HBG050767.
InParanoidi Q12864.
KOi K06811.
OMAi GKPFMYV.
OrthoDBi EOG7KWSH1.
PhylomeDBi Q12864.
TreeFami TF316817.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.

Miscellaneous databases

ChiTaRSi CDH17. human.
GeneWikii CDH17.
GenomeRNAii 1015.
NextBioi 4265.
PROi Q12864.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q12864.
Bgeei Q12864.
CleanExi HS_CDH17.
Genevestigatori Q12864.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 7 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Association of intestinal peptide transport with a protein related to the cadherin superfamily."
    Dantzig A.H., Hoskins J., Tabas L.B., Bright S., Shepard R.L., Jenkins I.L., Duckworth D.C., Sportsman J.R., MacKensen D., Rosteck P.R. Jr., Skatrud P.L.
    Science 264:430-433(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS GLU-115 AND ASP-734.
    Tissue: Colon adenocarcinoma.
  2. "Molecular cloning of human LI-cadherin: evidence for a novel type of cadherin within the cadherin superfamily."
    Boettinger A., Kreft B., Fieger C., Dlouhy B., Berndorff D., Goessner R., Tauber R.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-446.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-115 AND ASP-734.
    Tissue: Cerebellum.

Entry informationi

Entry nameiCAD17_HUMAN
AccessioniPrimary (citable) accession number: Q12864
Secondary accession number(s): Q15336, Q2M2E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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