Q12864 (CAD17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin-17

Alternative name(s):
Intestinal peptide-associated transporter HPT-1
Liver-intestine cadherin
Short name=LI-cadherin

Gene names

Name:

CDH17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	832 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. Ref.1
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin. Ref.1
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 7 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-dependent cell-cell adhesion Inferred from electronic annotation. Source: Compara cell adhesion Traceable author statement Ref.1. Source: ProtInc homophilic cell adhesion Inferred from electronic annotation. Source: Compara
Cellular_component	basolateral plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro proton-dependent oligopeptide secondary active transmembrane transporter activity Inferred from electronic annotation. Source: Compara transporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 832	810	Cadherin-17		PRO_0000003812
Regions
	Topological domain	23 – 787	765	Extracellular Potential
	Transmembrane	788 – 808	21	Helical; Potential
	Topological domain	809 – 832	24	Cytoplasmic Potential
	Domain	30 – 128	99	Cadherin 1
	Domain	129 – 244	116	Cadherin 2
	Domain	245 – 340	96	Cadherin 3
	Domain	341 – 449	109	Cadherin 4
	Domain	450 – 566	117	Cadherin 5
	Domain	567 – 667	101	Cadherin 6
	Domain	668 – 777	110	Cadherin 7
Amino acid modifications
	Glycosylation	149	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
	Glycosylation	250	1	N-linked (GlcNAc...) Potential
	Glycosylation	419	1	N-linked (GlcNAc...) Potential
	Glycosylation	456	1	N-linked (GlcNAc...) Potential
	Glycosylation	546	1	N-linked (GlcNAc...) Potential
	Glycosylation	587	1	N-linked (GlcNAc...) Potential
	Glycosylation	722	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	115	1	K → E. Ref.1 Ref.4 Corresponds to variant rs2243518 [ dbSNP | Ensembl ].		VAR_055567
	Natural variant	446	1	I → T. Ref.2 Corresponds to variant rs1131829 [ dbSNP | Ensembl ].		VAR_031694
	Natural variant	734	1	E → D. Ref.1 Ref.4 Corresponds to variant rs1051623 [ dbSNP | Ensembl ].		VAR_031695
	Natural variant	739	1	E → A. Corresponds to variant rs1051624 [ dbSNP | Ensembl ].		VAR_031696

Sequences

	Sequence		Length	Mass (Da)
	Q12864 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 2707547DD2DB4202	FASTA	832	92,219
	10 20 30 40 50 60 MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ FKANPPAVTF 70 80 90 100 110 120 ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD ANGIIVEGPV PITIKVKDIN 130 140 150 160 170 180 DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA TDLDDPATPN GQLYYQIVIQ LPMINNVMYF 190 200 210 220 230 240 QINNKTGAIS LTREGSQELN PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK 250 260 270 280 290 300 APKPVEMVEN STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR 310 320 330 340 350 360 EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ ENERLGNSIG 370 380 390 400 410 420 TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA GMLQLAKQSL KKQDTPQYNL 430 440 450 460 470 480 TIEVSDKDFK TLCFVQINVI DINDQIPIFE KSDYGNLTLA EDTNIGSTIL TIQATDADEP 490 500 510 520 530 540 FTGSSKILYH IIKGDSEGRL GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV 550 560 570 580 590 600 FGVKYNASSF AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY 610 620 630 640 650 660 SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV SEFHLILMDV 670 680 690 700 710 720 NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG PHFTFSLGSG SLQNDWEVSK 730 740 750 760 770 780 INGTHARLST RHTEFEEREY VVLIRINDGG RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT 790 800 810 820 830 GIPTVGMAVG ILLTTLLVIG IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Association of intestinal peptide transport with a protein related to the cadherin superfamily." Dantzig A.H., Hoskins J., Tabas L.B., Bright S., Shepard R.L., Jenkins I.L., Duckworth D.C., Sportsman J.R., MacKensen D., Rosteck P.R. Jr., Skatrud P.L. Science 264:430-433(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS GLU-115 AND ASP-734. Tissue: Colon adenocarcinoma.
[2]	"Molecular cloning of human LI-cadherin: evidence for a novel type of cadherin within the cadherin superfamily." Boettinger A., Kreft B., Fieger C., Dlouhy B., Berndorff D., Goessner R., Tauber R. Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-446.
[3]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-115 AND ASP-734. Tissue: Cerebellum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U07969 mRNA. Translation: AAA19021.1. X83228 mRNA. Translation: CAA58231.1. AP003351 Genomic DNA. No translation available. AP003478 Genomic DNA. No translation available. BC112013 mRNA. Translation: AAI12014.1. BC113464 mRNA. Translation: AAI13465.1.
IPI	IPI00290089.
PIR	S55396.
RefSeq	NP_001138135.1. NM_001144663.1. NP_004054.3. NM_004063.3.
UniGene	Hs.591853.
3D structure databases
ProteinModelPortal	Q12864.
SMR	Q12864. Positions 24-765.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000027335.
PTM databases
PhosphoSite	Q12864.
Polymorphism databases
DMDM	308153624.
Proteomic databases
PaxDb	Q12864.
PRIDE	Q12864.
Protocols and materials databases
DNASU	1015.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000027335; ENSP00000027335; ENSG00000079112. ENST00000450165; ENSP00000401468; ENSG00000079112.
GeneID	1015.
KEGG	hsa:1015.
UCSC	uc003ygh.2. human.
Organism-specific databases
CTD	1015.
GeneCards	GC08M095208.
H-InvDB	HIX0025563.
HGNC	HGNC:1756. CDH17.
HPA	CAB025143. HPA023614. HPA023616. HPA026556.
MIM	603017. gene.
neXtProt	NX_Q12864.
PharmGKB	PA26290.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG313822.
HOGENOM	HOG000231613.
HOVERGEN	HBG050767.
InParanoid	Q12864.
KO	K06811.
OMA	GKFSGPL.
PhylomeDB	Q12864.
Gene expression databases
ArrayExpress	Q12864.
Bgee	Q12864.
CleanEx	HS_CDH17.
Genevestigator	Q12864.
GermOnline	ENSG00000079112. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 7 hits.
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CDH17. human.
GenomeRNAi	1015.
NextBio	4265.
SOURCE	Search...

Entry information

Entry name

CAD17_HUMAN

Accession

Primary (citable) accession number: Q12864
Secondary accession number(s): Q15336, Q2M2E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.