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Protein

Cadherin-17

Gene

CDH17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • integrin binding Source: UniProtKB
  • proton-dependent oligopeptide secondary active transmembrane transporter activity Source: UniProtKB
  • transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079112-MONOMER.
ReactomeiR-HSA-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-17
Alternative name(s):
Intestinal peptide-associated transporter HPT-1
Liver-intestine cadherin
Short name:
LI-cadherin
Gene namesi
Name:CDH17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:1756. CDH17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 787ExtracellularSequence analysisAdd BLAST765
Transmembranei788 – 808HelicalSequence analysisAdd BLAST21
Topological domaini809 – 832CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1015.
OpenTargetsiENSG00000079112.
PharmGKBiPA26290.

Polymorphism and mutation databases

BioMutaiCDH17.
DMDMi308153624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000381223 – 832Cadherin-17Add BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi250N-linked (GlcNAc...)Sequence analysis1
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Glycosylationi546N-linked (GlcNAc...)Sequence analysis1
Glycosylationi587N-linked (GlcNAc...)Sequence analysis1
Glycosylationi722N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ12864.
PaxDbiQ12864.
PeptideAtlasiQ12864.
PRIDEiQ12864.

PTM databases

iPTMnetiQ12864.
PhosphoSitePlusiQ12864.

Expressioni

Tissue specificityi

Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.1 Publication

Gene expression databases

BgeeiENSG00000079112.
CleanExiHS_CDH17.
ExpressionAtlasiQ12864. baseline and differential.
GenevisibleiQ12864. HS.

Organism-specific databases

HPAiCAB025143.
HPA023614.
HPA023616.
HPA026556.

Interactioni

GO - Molecular functioni

  • integrin binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ12864. 1 interactor.
MINTiMINT-5000411.
STRINGi9606.ENSP00000027335.

Structurei

3D structure databases

ProteinModelPortaliQ12864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 128Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini129 – 244Cadherin 2PROSITE-ProRule annotationAdd BLAST116
Domaini245 – 340Cadherin 3PROSITE-ProRule annotationAdd BLAST96
Domaini341 – 449Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Domaini450 – 566Cadherin 5PROSITE-ProRule annotationAdd BLAST117
Domaini567 – 667Cadherin 6PROSITE-ProRule annotationAdd BLAST101
Domaini668 – 777Cadherin 7PROSITE-ProRule annotationAdd BLAST110

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 7 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050767.
InParanoidiQ12864.
KOiK06811.
OMAiGKPFMYV.
OrthoDBiEOG091G033T.
PhylomeDBiQ12864.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ
60 70 80 90 100
FKANPPAVTF ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD
110 120 130 140 150
ANGIIVEGPV PITIKVKDIN DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA
160 170 180 190 200
TDLDDPATPN GQLYYQIVIQ LPMINNVMYF QINNKTGAIS LTREGSQELN
210 220 230 240 250
PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK APKPVEMVEN
260 270 280 290 300
STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR
310 320 330 340 350
EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ
360 370 380 390 400
ENERLGNSIG TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA
410 420 430 440 450
GMLQLAKQSL KKQDTPQYNL TIEVSDKDFK TLCFVQINVI DINDQIPIFE
460 470 480 490 500
KSDYGNLTLA EDTNIGSTIL TIQATDADEP FTGSSKILYH IIKGDSEGRL
510 520 530 540 550
GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV FGVKYNASSF
560 570 580 590 600
AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY
610 620 630 640 650
SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV
660 670 680 690 700
SEFHLILMDV NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG
710 720 730 740 750
PHFTFSLGSG SLQNDWEVSK INGTHARLST RHTEFEEREY VVLIRINDGG
760 770 780 790 800
RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT GIPTVGMAVG ILLTTLLVIG
810 820 830
IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS
Length:832
Mass (Da):92,219
Last modified:October 5, 2010 - v3
Checksum:i2707547DD2DB4202
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055567115K → E.2 PublicationsCorresponds to variant rs2243518dbSNPEnsembl.1
Natural variantiVAR_031694446I → T.1 PublicationCorresponds to variant rs1131829dbSNPEnsembl.1
Natural variantiVAR_031695734E → D.2 PublicationsCorresponds to variant rs1051623dbSNPEnsembl.1
Natural variantiVAR_031696739E → A.Corresponds to variant rs1051624dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07969 mRNA. Translation: AAA19021.1.
X83228 mRNA. Translation: CAA58231.1.
AP003351 Genomic DNA. No translation available.
AP003478 Genomic DNA. No translation available.
BC112013 mRNA. Translation: AAI12014.1.
BC113464 mRNA. Translation: AAI13465.1.
CCDSiCCDS6260.1.
PIRiS55396.
RefSeqiNP_001138135.1. NM_001144663.1.
NP_004054.3. NM_004063.3.
UniGeneiHs.591853.

Genome annotation databases

EnsembliENST00000027335; ENSP00000027335; ENSG00000079112.
ENST00000450165; ENSP00000401468; ENSG00000079112.
GeneIDi1015.
KEGGihsa:1015.
UCSCiuc003ygh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07969 mRNA. Translation: AAA19021.1.
X83228 mRNA. Translation: CAA58231.1.
AP003351 Genomic DNA. No translation available.
AP003478 Genomic DNA. No translation available.
BC112013 mRNA. Translation: AAI12014.1.
BC113464 mRNA. Translation: AAI13465.1.
CCDSiCCDS6260.1.
PIRiS55396.
RefSeqiNP_001138135.1. NM_001144663.1.
NP_004054.3. NM_004063.3.
UniGeneiHs.591853.

3D structure databases

ProteinModelPortaliQ12864.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ12864. 1 interactor.
MINTiMINT-5000411.
STRINGi9606.ENSP00000027335.

PTM databases

iPTMnetiQ12864.
PhosphoSitePlusiQ12864.

Polymorphism and mutation databases

BioMutaiCDH17.
DMDMi308153624.

Proteomic databases

MaxQBiQ12864.
PaxDbiQ12864.
PeptideAtlasiQ12864.
PRIDEiQ12864.

Protocols and materials databases

DNASUi1015.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000027335; ENSP00000027335; ENSG00000079112.
ENST00000450165; ENSP00000401468; ENSG00000079112.
GeneIDi1015.
KEGGihsa:1015.
UCSCiuc003ygh.3. human.

Organism-specific databases

CTDi1015.
DisGeNETi1015.
GeneCardsiCDH17.
H-InvDBHIX0025563.
HGNCiHGNC:1756. CDH17.
HPAiCAB025143.
HPA023614.
HPA023616.
HPA026556.
MIMi603017. gene.
neXtProtiNX_Q12864.
OpenTargetsiENSG00000079112.
PharmGKBiPA26290.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050767.
InParanoidiQ12864.
KOiK06811.
OMAiGKPFMYV.
OrthoDBiEOG091G033T.
PhylomeDBiQ12864.
TreeFamiTF316817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079112-MONOMER.
ReactomeiR-HSA-418990. Adherens junctions interactions.

Miscellaneous databases

ChiTaRSiCDH17. human.
GeneWikiiCDH17.
GenomeRNAii1015.
PROiQ12864.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079112.
CleanExiHS_CDH17.
ExpressionAtlasiQ12864. baseline and differential.
GenevisibleiQ12864. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD17_HUMAN
AccessioniPrimary (citable) accession number: Q12864
Secondary accession number(s): Q15336, Q2M2E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.