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Q12864

- CAD17_HUMAN

UniProt

Q12864 - CAD17_HUMAN

Protein

Cadherin-17

Gene

CDH17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: UniProt
    3. transporter activity Source: ProtInc

    GO - Biological processi

    1. calcium-dependent cell-cell adhesion Source: UniProt
    2. cell adhesion Source: ProtInc
    3. homophilic cell adhesion Source: UniProt
    4. oligopeptide transmembrane transport Source: UniProt
    5. oligopeptide transport Source: UniProt
    6. transport Source: ProtInc

    Keywords - Biological processi

    Cell adhesion, Transport

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_19195. Adherens junctions interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-17
    Alternative name(s):
    Intestinal peptide-associated transporter HPT-1
    Liver-intestine cadherin
    Short name:
    LI-cadherin
    Gene namesi
    Name:CDH17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:1756. CDH17.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26290.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 832810Cadherin-17PRO_0000003812Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi587 – 5871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi722 – 7221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ12864.
    PaxDbiQ12864.
    PRIDEiQ12864.

    PTM databases

    PhosphoSiteiQ12864.

    Expressioni

    Tissue specificityi

    Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.1 Publication

    Gene expression databases

    ArrayExpressiQ12864.
    BgeeiQ12864.
    CleanExiHS_CDH17.
    GenevestigatoriQ12864.

    Organism-specific databases

    HPAiCAB025143.
    HPA023614.
    HPA023616.
    HPA026556.

    Interactioni

    Protein-protein interaction databases

    BioGridi107450. 1 interaction.
    MINTiMINT-5000411.
    STRINGi9606.ENSP00000027335.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12864.
    SMRiQ12864. Positions 40-765.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 787765ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini809 – 83224CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei788 – 80821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 12899Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini129 – 244116Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini245 – 34096Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini341 – 449109Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini450 – 566117Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini567 – 667101Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini668 – 777110Cadherin 7PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 7 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG313822.
    HOGENOMiHOG000231613.
    HOVERGENiHBG050767.
    InParanoidiQ12864.
    KOiK06811.
    OMAiGKPFMYV.
    OrthoDBiEOG7KWSH1.
    PhylomeDBiQ12864.
    TreeFamiTF316817.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 7 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q12864-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ    50
    FKANPPAVTF ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD 100
    ANGIIVEGPV PITIKVKDIN DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA 150
    TDLDDPATPN GQLYYQIVIQ LPMINNVMYF QINNKTGAIS LTREGSQELN 200
    PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK APKPVEMVEN 250
    STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR 300
    EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ 350
    ENERLGNSIG TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA 400
    GMLQLAKQSL KKQDTPQYNL TIEVSDKDFK TLCFVQINVI DINDQIPIFE 450
    KSDYGNLTLA EDTNIGSTIL TIQATDADEP FTGSSKILYH IIKGDSEGRL 500
    GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV FGVKYNASSF 550
    AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY 600
    SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV 650
    SEFHLILMDV NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG 700
    PHFTFSLGSG SLQNDWEVSK INGTHARLST RHTEFEEREY VVLIRINDGG 750
    RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT GIPTVGMAVG ILLTTLLVIG 800
    IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS 832
    Length:832
    Mass (Da):92,219
    Last modified:October 5, 2010 - v3
    Checksum:i2707547DD2DB4202
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti115 – 1151K → E.2 Publications
    Corresponds to variant rs2243518 [ dbSNP | Ensembl ].
    VAR_055567
    Natural varianti446 – 4461I → T.1 Publication
    Corresponds to variant rs1131829 [ dbSNP | Ensembl ].
    VAR_031694
    Natural varianti734 – 7341E → D.2 Publications
    Corresponds to variant rs1051623 [ dbSNP | Ensembl ].
    VAR_031695
    Natural varianti739 – 7391E → A.
    Corresponds to variant rs1051624 [ dbSNP | Ensembl ].
    VAR_031696

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07969 mRNA. Translation: AAA19021.1.
    X83228 mRNA. Translation: CAA58231.1.
    AP003351 Genomic DNA. No translation available.
    AP003478 Genomic DNA. No translation available.
    BC112013 mRNA. Translation: AAI12014.1.
    BC113464 mRNA. Translation: AAI13465.1.
    CCDSiCCDS6260.1.
    PIRiS55396.
    RefSeqiNP_001138135.1. NM_001144663.1.
    NP_004054.3. NM_004063.3.
    UniGeneiHs.591853.

    Genome annotation databases

    EnsembliENST00000027335; ENSP00000027335; ENSG00000079112.
    ENST00000450165; ENSP00000401468; ENSG00000079112.
    GeneIDi1015.
    KEGGihsa:1015.
    UCSCiuc003ygh.2. human.

    Polymorphism databases

    DMDMi308153624.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07969 mRNA. Translation: AAA19021.1 .
    X83228 mRNA. Translation: CAA58231.1 .
    AP003351 Genomic DNA. No translation available.
    AP003478 Genomic DNA. No translation available.
    BC112013 mRNA. Translation: AAI12014.1 .
    BC113464 mRNA. Translation: AAI13465.1 .
    CCDSi CCDS6260.1.
    PIRi S55396.
    RefSeqi NP_001138135.1. NM_001144663.1.
    NP_004054.3. NM_004063.3.
    UniGenei Hs.591853.

    3D structure databases

    ProteinModelPortali Q12864.
    SMRi Q12864. Positions 40-765.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107450. 1 interaction.
    MINTi MINT-5000411.
    STRINGi 9606.ENSP00000027335.

    PTM databases

    PhosphoSitei Q12864.

    Polymorphism databases

    DMDMi 308153624.

    Proteomic databases

    MaxQBi Q12864.
    PaxDbi Q12864.
    PRIDEi Q12864.

    Protocols and materials databases

    DNASUi 1015.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000027335 ; ENSP00000027335 ; ENSG00000079112 .
    ENST00000450165 ; ENSP00000401468 ; ENSG00000079112 .
    GeneIDi 1015.
    KEGGi hsa:1015.
    UCSCi uc003ygh.2. human.

    Organism-specific databases

    CTDi 1015.
    GeneCardsi GC08M095208.
    H-InvDB HIX0025563.
    HGNCi HGNC:1756. CDH17.
    HPAi CAB025143.
    HPA023614.
    HPA023616.
    HPA026556.
    MIMi 603017. gene.
    neXtProti NX_Q12864.
    PharmGKBi PA26290.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313822.
    HOGENOMi HOG000231613.
    HOVERGENi HBG050767.
    InParanoidi Q12864.
    KOi K06811.
    OMAi GKPFMYV.
    OrthoDBi EOG7KWSH1.
    PhylomeDBi Q12864.
    TreeFami TF316817.

    Enzyme and pathway databases

    Reactomei REACT_19195. Adherens junctions interactions.

    Miscellaneous databases

    ChiTaRSi CDH17. human.
    GeneWikii CDH17.
    GenomeRNAii 1015.
    NextBioi 4265.
    PROi Q12864.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q12864.
    Bgeei Q12864.
    CleanExi HS_CDH17.
    Genevestigatori Q12864.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 7 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Association of intestinal peptide transport with a protein related to the cadherin superfamily."
      Dantzig A.H., Hoskins J., Tabas L.B., Bright S., Shepard R.L., Jenkins I.L., Duckworth D.C., Sportsman J.R., MacKensen D., Rosteck P.R. Jr., Skatrud P.L.
      Science 264:430-433(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS GLU-115 AND ASP-734.
      Tissue: Colon adenocarcinoma.
    2. "Molecular cloning of human LI-cadherin: evidence for a novel type of cadherin within the cadherin superfamily."
      Boettinger A., Kreft B., Fieger C., Dlouhy B., Berndorff D., Goessner R., Tauber R.
      Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-446.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-115 AND ASP-734.
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiCAD17_HUMAN
    AccessioniPrimary (citable) accession number: Q12864
    Secondary accession number(s): Q15336, Q2M2E0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3