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Q12860

- CNTN1_HUMAN

UniProt

Q12860 - CNTN1_HUMAN

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Protein

Contactin-1

Gene

CNTN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: Ensembl

GO - Biological processi

  1. axon guidance Source: Reactome
  2. cell adhesion Source: ProtInc
  3. cerebellum development Source: Ensembl
  4. Notch signaling pathway Source: Reactome
  5. positive regulation of gene expression Source: Ensembl
  6. positive regulation of neuron projection development Source: Ensembl
  7. positive regulation of sodium ion transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Notch signaling pathway

Enzyme and pathway databases

ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_22205. L1CAM interactions.
REACT_22312. Neurofascin interactions.
SignaLinkiQ12860.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-1
Alternative name(s):
Glycoprotein gp135
Neural cell surface protein F3
Gene namesi
Name:CNTN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:2171. CNTN1.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProtKB
  3. membrane Source: ProtInc
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Myopathy, congenital, Compton-North (MYPCN) [MIM:612540]: A lethal, autosomal recessive, congenital myopathy characterized by fetal akinesia, neonatal hypotonia, severe muscle weakness, loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma and disruption of sarcomeres with disorganization of the Z band.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi612540. phenotype.
Orphaneti210163. Congenital lethal myopathy, Compton-North type.
PharmGKBiPA26685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – ?993973Contactin-1PRO_0000014685Add
BLAST
Propeptidei?994 – 101825Removed in mature formPRO_0000014686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 114PROSITE-ProRule annotation
Disulfide bondi158 ↔ 211PROSITE-ProRule annotation
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi263 ↔ 310PROSITE-ProRule annotation
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi352 ↔ 391PROSITE-ProRule annotation
Disulfide bondi436 ↔ 484PROSITE-ProRule annotation
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi494 – 4941N-linked (GlcNAc...) (complex)2 Publications
Glycosylationi521 – 5211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi526 ↔ 583PROSITE-ProRule annotation
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi933 – 9331N-linked (GlcNAc...)Sequence Analysis
Lipidationi993 – 9931GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ12860.
PaxDbiQ12860.
PRIDEiQ12860.

PTM databases

PhosphoSiteiQ12860.

Expressioni

Tissue specificityi

Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.2 Publications

Gene expression databases

BgeeiQ12860.
CleanExiHS_CNTN1.
ExpressionAtlasiQ12860. baseline and differential.
GenevestigatoriQ12860.

Organism-specific databases

HPAiCAB025200.
HPA041060.

Interactioni

Subunit structurei

Monomer. Interacts with CNTNAP1 in cis form. Interacts with NOTCH1 and TNR (By similarity). Binds to the carbonic-anhydrase like domain of PTPRZ1.By similarity2 Publications

Protein-protein interaction databases

BioGridi107672. 19 interactions.
DIPiDIP-59714N.
IntActiQ12860. 4 interactions.
MINTiMINT-2806030.
STRINGi9606.ENSP00000325660.

Structurei

Secondary structure

1
1018
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi146 – 1494Combined sources
Beta strandi154 – 1563Combined sources
Beta strandi162 – 1665Combined sources
Beta strandi169 – 1768Combined sources
Beta strandi184 – 1896Combined sources
Turni191 – 1933Combined sources
Beta strandi196 – 2005Combined sources
Helixi203 – 2053Combined sources
Beta strandi207 – 2159Combined sources
Helixi216 – 2183Combined sources
Beta strandi220 – 2234Combined sources
Beta strandi227 – 2326Combined sources
Beta strandi240 – 2478Combined sources
Beta strandi251 – 2544Combined sources
Beta strandi259 – 26911Combined sources
Beta strandi272 – 2776Combined sources
Beta strandi287 – 2893Combined sources
Turni290 – 2934Combined sources
Beta strandi294 – 2974Combined sources
Helixi302 – 3043Combined sources
Beta strandi306 – 3149Combined sources
Beta strandi317 – 32812Combined sources
Beta strandi816 – 8216Combined sources
Beta strandi824 – 8285Combined sources
Beta strandi839 – 84911Combined sources
Helixi851 – 8533Combined sources
Beta strandi855 – 8606Combined sources
Beta strandi864 – 8685Combined sources
Beta strandi876 – 8849Combined sources
Beta strandi886 – 8883Combined sources
Beta strandi896 – 8994Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EE2NMR-A798-903[»]
3S97X-ray2.30C/D133-329[»]
ProteinModelPortaliQ12860.
SMRiQ12860. Positions 37-1001.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12860.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 13191Ig-like C2-type 1Add
BLAST
Domaini137 – 22387Ig-like C2-type 2Add
BLAST
Domaini241 – 32686Ig-like C2-type 3Add
BLAST
Domaini331 – 40777Ig-like C2-type 4Add
BLAST
Domaini413 – 50088Ig-like C2-type 5Add
BLAST
Domaini504 – 60198Ig-like C2-type 6Add
BLAST
Domaini606 – 70499Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini709 – 80698Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini811 – 90696Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini907 – 100094Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi602 – 6098Gly/Pro-rich

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG293951.
GeneTreeiENSGT00760000118840.
HOVERGENiHBG051047.
InParanoidiQ12860.
KOiK06759.
OMAiFTWYRRY.
OrthoDBiEOG7J17Z5.
PhylomeDBiQ12860.
TreeFamiTF351103.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q12860-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMWLLVSHL VIISITTCLA EFTWYRRYGH GVSEEDKGFG PIFEEQPINT
60 70 80 90 100
IYPEESLEGK VSLNCRARAS PFPVYKWRMN NGDVDLTSDR YSMVGGNLVI
110 120 130 140 150
NNPDKQKDAG IYYCLASNNY GMVRSTEATL SFGYLDPFPP EERPEVRVKE
160 170 180 190 200
GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF ITMDKRRFVS QTNGNLYIAN
210 220 230 240 250
VEASDKGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY PADIVVQFKD
260 270 280 290 300
VYALMGQNVT LECFALGNPV PDIRWRKVLE PMPSTAEIST SGAVLKIFNI
310 320 330 340 350
QLEDEGIYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW
360 370 380 390 400
PCVATGKPIP TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENTYGAI
410 420 430 440 450
YANAELKILA LAPTFEMNPM KKKILAAKGG RVIIECKPKA APKPKFSWSK
460 470 480 490 500
GTEWLVNSSR ILIWEDGSLE INNITRNDGG IYTCFAENNR GKANSTGTLV
510 520 530 540 550
ITDPTRIILA PINADITVGE NATMQCAASF DPALDLTFVW SFNGYVIDFN
560 570 580 590 600
KENIHYQRNF MLDSNGELLI RNAQLKHAGR YTCTAQTIVD NSSASADLVV
610 620 630 640 650
RGPPGPPGGL RIEDIRATSV ALTWSRGSDN HSPISKYTIQ TKTILSDDWK
660 670 680 690 700
DAKTDPPIIE GNMEAARAVD LIPWMEYEFR VVATNTLGRG EPSIPSNRIK
710 720 730 740 750
TDGAAPNVAP SDVGGGGGRN RELTITWAPL SREYHYGNNF GYIVAFKPFD
760 770 780 790 800
GEEWKKVTVT NPDTGRYVHK DETMSPSTAF QVKVKAFNNK GDGPYSLVAV
810 820 830 840 850
INSAQDAPSE APTEVGVKVL SSSEISVHWE HVLEKIVESY QIRYWAAHDK
860 870 880 890 900
EEAANRVQVT SQEYSARLEN LLPDTQYFIE VGACNSAGCG PPSDMIEAFT
910 920 930 940 950
KKAPPSQPPR IISSVRSGSR YIITWDHVVA LSNESTVTGY KVLYRPDGQH
960 970 980 990 1000
DGKLYSTHKH SIEVPIPRDG EYVVEVRAHS DGGDGVVSQV KISGAPTLSP
1010
SLLGLLLPAF GILVYLEF
Length:1,018
Mass (Da):113,320
Last modified:November 1, 1996 - v1
Checksum:i4B8FDC5BFD434ED5
GO
Isoform 2 (identifier: Q12860-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-31: Missing.

Show »
Length:1,007
Mass (Da):111,867
Checksum:i0078E9F82F498EE0
GO
Isoform 3 (identifier: Q12860-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     603-627: PPGPPGGLRIEDIRATSVALTWSRG → KNRKGGEKNMVDSFLPVCASLPPTW
     628-1018: Missing.

Show »
Length:627
Mass (Da):70,604
Checksum:i86825008EAAA085A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti682 – 6821V → I AA sequence (PubMed:2026173)Curated
Sequence conflicti687 – 6871L → P AA sequence (PubMed:2026173)Curated
Sequence conflicti689 – 6891R → I AA sequence (PubMed:2026173)Curated
Sequence conflicti692 – 6921P → F AA sequence (PubMed:2026173)Curated
Isoform 3 (identifier: Q12860-3)
Sequence conflicti610 – 6101K → I in BAF82233. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti794 – 7941P → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035506
Natural varianti798 – 7981V → L.
Corresponds to variant rs1056020 [ dbSNP | Ensembl ].
VAR_011722
Natural varianti824 – 8241E → G.
Corresponds to variant rs11553341 [ dbSNP | Ensembl ].
VAR_049866

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei21 – 3111Missing in isoform 2. 1 PublicationVSP_002500Add
BLAST
Alternative sequencei603 – 62725PPGPP…TWSRG → KNRKGGEKNMVDSFLPVCAS LPPTW in isoform 3. 2 PublicationsVSP_011959Add
BLAST
Alternative sequencei628 – 1018391Missing in isoform 3. 2 PublicationsVSP_011960Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21488 mRNA. Translation: CAA79696.1.
U07819 mRNA. Translation: AAA67920.1.
U07820 mRNA. Translation: AAA67921.1.
AK289544 mRNA. Translation: BAF82233.1.
AK289698 mRNA. Translation: BAF82387.1.
BC036569 mRNA. Translation: AAH36569.1.
CCDSiCCDS58225.1. [Q12860-3]
CCDS8737.1. [Q12860-1]
CCDS8738.1. [Q12860-2]
PIRiA54744.
S15394.
RefSeqiNP_001242992.1. NM_001256063.1. [Q12860-3]
NP_001242993.1. NM_001256064.1. [Q12860-3]
NP_001834.2. NM_001843.3. [Q12860-1]
NP_778203.1. NM_175038.2. [Q12860-2]
XP_005268708.1. XM_005268651.1. [Q12860-1]
XP_006719304.1. XM_006719241.1. [Q12860-1]
UniGeneiHs.143434.
Hs.739161.
Hs.741112.

Genome annotation databases

EnsembliENST00000347616; ENSP00000325660; ENSG00000018236. [Q12860-1]
ENST00000348761; ENSP00000261160; ENSG00000018236. [Q12860-2]
ENST00000547702; ENSP00000448004; ENSG00000018236. [Q12860-3]
ENST00000547849; ENSP00000448653; ENSG00000018236. [Q12860-3]
ENST00000551295; ENSP00000447006; ENSG00000018236. [Q12860-1]
GeneIDi1272.
KEGGihsa:1272.
UCSCiuc001rmm.2. human. [Q12860-1]
uc001rmo.4. human. [Q12860-3]
uc031qgz.1. human. [Q12860-2]

Polymorphism databases

DMDMi2497301.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21488 mRNA. Translation: CAA79696.1 .
U07819 mRNA. Translation: AAA67920.1 .
U07820 mRNA. Translation: AAA67921.1 .
AK289544 mRNA. Translation: BAF82233.1 .
AK289698 mRNA. Translation: BAF82387.1 .
BC036569 mRNA. Translation: AAH36569.1 .
CCDSi CCDS58225.1. [Q12860-3 ]
CCDS8737.1. [Q12860-1 ]
CCDS8738.1. [Q12860-2 ]
PIRi A54744.
S15394.
RefSeqi NP_001242992.1. NM_001256063.1. [Q12860-3 ]
NP_001242993.1. NM_001256064.1. [Q12860-3 ]
NP_001834.2. NM_001843.3. [Q12860-1 ]
NP_778203.1. NM_175038.2. [Q12860-2 ]
XP_005268708.1. XM_005268651.1. [Q12860-1 ]
XP_006719304.1. XM_006719241.1. [Q12860-1 ]
UniGenei Hs.143434.
Hs.739161.
Hs.741112.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EE2 NMR - A 798-903 [» ]
3S97 X-ray 2.30 C/D 133-329 [» ]
ProteinModelPortali Q12860.
SMRi Q12860. Positions 37-1001.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107672. 19 interactions.
DIPi DIP-59714N.
IntActi Q12860. 4 interactions.
MINTi MINT-2806030.
STRINGi 9606.ENSP00000325660.

PTM databases

PhosphoSitei Q12860.

Polymorphism databases

DMDMi 2497301.

Proteomic databases

MaxQBi Q12860.
PaxDbi Q12860.
PRIDEi Q12860.

Protocols and materials databases

DNASUi 1272.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347616 ; ENSP00000325660 ; ENSG00000018236 . [Q12860-1 ]
ENST00000348761 ; ENSP00000261160 ; ENSG00000018236 . [Q12860-2 ]
ENST00000547702 ; ENSP00000448004 ; ENSG00000018236 . [Q12860-3 ]
ENST00000547849 ; ENSP00000448653 ; ENSG00000018236 . [Q12860-3 ]
ENST00000551295 ; ENSP00000447006 ; ENSG00000018236 . [Q12860-1 ]
GeneIDi 1272.
KEGGi hsa:1272.
UCSCi uc001rmm.2. human. [Q12860-1 ]
uc001rmo.4. human. [Q12860-3 ]
uc031qgz.1. human. [Q12860-2 ]

Organism-specific databases

CTDi 1272.
GeneCardsi GC12P041086.
HGNCi HGNC:2171. CNTN1.
HPAi CAB025200.
HPA041060.
MIMi 600016. gene.
612540. phenotype.
neXtProti NX_Q12860.
Orphaneti 210163. Congenital lethal myopathy, Compton-North type.
PharmGKBi PA26685.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293951.
GeneTreei ENSGT00760000118840.
HOVERGENi HBG051047.
InParanoidi Q12860.
KOi K06759.
OMAi FTWYRRY.
OrthoDBi EOG7J17Z5.
PhylomeDBi Q12860.
TreeFami TF351103.

Enzyme and pathway databases

Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_22205. L1CAM interactions.
REACT_22312. Neurofascin interactions.
SignaLinki Q12860.

Miscellaneous databases

ChiTaRSi CNTN1. human.
EvolutionaryTracei Q12860.
GeneWikii CNTN1.
GenomeRNAii 1272.
NextBioi 5153.
PROi Q12860.
SOURCEi Search...

Gene expression databases

Bgeei Q12860.
CleanExi HS_CNTN1.
ExpressionAtlasi Q12860. baseline and differential.
Genevestigatori Q12860.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the human cell adhesion molecule contactin."
    Reid R.A., Bronson D.D., Young K.M., Hemperly J.J.
    Brain Res. Mol. Brain Res. 21:1-8(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Neuroblastoma.
  2. "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12."
    Berglund E.O., Ranscht B.
    Genomics 21:571-582(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Amygdala and Cerebellum.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  5. "Isolation and characterization of a membrane glycoprotein from human brain with sequence similarities to cell adhesion proteins from chicken and mouse."
    Berglund E., Stigbrand T., Carlsson S.R.
    Eur. J. Biochem. 197:549-554(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-40 AND 679-693 (ISOFORM 1), SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Brain cortex.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-494.
    Tissue: Plasma.
  7. Cited for: GLYCOSYLATION AT ASN-494.
  8. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
    Bouyain S., Watkins D.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPRZ1.
  9. "Solution structures of the FN3 domain of human contactin 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (AUG-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 791-903.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-794.
  11. "Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy."
    Compton A.G., Albrecht D.E., Seto J.T., Cooper S.T., Ilkovski B., Jones K.J., Challis D., Mowat D., Ranscht B., Bahlo M., Froehner S.C., North K.N.
    Am. J. Hum. Genet. 83:714-724(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN MYPCN.

Entry informationi

Entry nameiCNTN1_HUMAN
AccessioniPrimary (citable) accession number: Q12860
Secondary accession number(s): A8K0H9
, A8K0Y3, Q12861, Q14030, Q7M4P0, Q8N466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3