Q12860 (CNTN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Contactin-1

Alternative name(s):
Glycoprotein gp135
Neural cell surface protein F3

Gene names

Name:

CNTN1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1018 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth By similarity.
Subunit structure	Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR By similarity. Ref.5
Subcellular location	Isoform 1: Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side. Isoform 2: Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side.
Tissue specificity	Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. Ref.1 Ref.5
Involvement in disease	Compton-North congenital myopathy (CNCM) [MIM:612540]: Familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9
Sequence similarities	Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Cell adhesion Notch signaling pathway
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Traceable author statement. Source: Reactome axon guidance Traceable author statement. Source: Reactome cell adhesion Non-traceable author statement Ref.2. Source: ProtInc cerebellum development Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara positive regulation of neuron projection development Inferred from electronic annotation. Source: Compara positive regulation of sodium ion transport Inferred from electronic annotation. Source: Compara
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Traceable author statement Ref.2. Source: ProtInc plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12860-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12860-2)

The sequence of this isoform differs from the canonical sequence as follows:
     21-31: Missing.

Isoform 3 (identifier: Q12860-3)

The sequence of this isoform differs from the canonical sequence as follows:
     603-627: PPGPPGGLRIEDIRATSVALTWSRG → KNRKGGEKNMVDSFLPVCASLPPTW
     628-1018: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Ref.5

Chain

21 – ?993

973

Contactin-1

PRO_0000014685

Propeptide

?994 – 1018

25

Removed in mature form

PRO_0000014686

Regions

Domain

41 – 131

91

Ig-like C2-type 1

Domain

137 – 223

87

Ig-like C2-type 2

Domain

241 – 326

86

Ig-like C2-type 3

Domain

331 – 407

77

Ig-like C2-type 4

Domain

413 – 500

88

Ig-like C2-type 5

Domain

504 – 601

98

Ig-like C2-type 6

Domain

603 – 699

97

Fibronectin type-III 1

Domain

706 – 803

98

Fibronectin type-III 2

Domain

808 – 899

92

Fibronectin type-III 3

Domain

904 – 996

93

Fibronectin type-III 4

Compositional bias

602 – 609

8

Gly/Pro-rich

Amino acid modifications

Lipidation

993

1

GPI-anchor amidated serine Potential

Glycosylation

208

1

N-linked (GlcNAc...) Potential

Glycosylation

258

1

N-linked (GlcNAc...) Potential

Glycosylation

338

1

N-linked (GlcNAc...) Potential

Glycosylation

457

1

N-linked (GlcNAc...) Potential

Glycosylation

473

1

N-linked (GlcNAc...) Potential

Glycosylation

494

1

N-linked (GlcNAc...) Ref.6

Glycosylation

521

1

N-linked (GlcNAc...) Potential

Glycosylation

591

1

N-linked (GlcNAc...) Potential

Glycosylation

933

1

N-linked (GlcNAc...) Potential

Disulfide bond

65 ↔ 114

By similarity

Disulfide bond

158 ↔ 211

By similarity

Disulfide bond

263 ↔ 310

By similarity

Disulfide bond

352 ↔ 391

By similarity

Disulfide bond

436 ↔ 484

By similarity

Disulfide bond

526 ↔ 583

By similarity

Natural variations

Alternative sequence

21 – 31

11

Missing in isoform 2.

VSP_002500

Alternative sequence

603 – 627

25

PPGPP…TWSRG → KNRKGGEKNMVDSFLPVCAS LPPTW in isoform 3.

VSP_011959

Alternative sequence

628 – 1018

391

Missing in isoform 3.

VSP_011960

Natural variant

794

1

P → H in a colorectal cancer sample; somatic mutation. Ref.8

VAR_035506

Natural variant

798

1

V → L.
Corresponds to variant rs1056020 [ dbSNP | Ensembl ].

VAR_011722

Natural variant

824

1

E → G.
Corresponds to variant rs11553341 [ dbSNP | Ensembl ].

VAR_049866

Experimental info

Sequence conflict

682

1

V → I AA sequence Ref.5

Sequence conflict

687

1

L → P AA sequence Ref.5

Sequence conflict

689

1

R → I AA sequence Ref.5

Sequence conflict

692

1

P → F AA sequence Ref.5

Isoform 3:

Sequence conflict

610

1

K → I in BAF82233. Ref.3

Secondary structure

1

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1018

Helix Strand Turn

Details...

Beta strand

146 – 149

4

Beta strand

154 – 156

3

Beta strand

162 – 166

5

Beta strand

169 – 176

8

Beta strand

184 – 189

6

Turn

191 – 193

3

Beta strand

196 – 200

5

Helix

203 – 205

3

Beta strand

207 – 215

9

Helix

216 – 218

3

Beta strand

220 – 223

4

Beta strand

227 – 232

6

Beta strand

240 – 247

8

Beta strand

251 – 254

4

Beta strand

259 – 269

11

Beta strand

272 – 277

6

Beta strand

287 – 289

3

Turn

290 – 293

4

Beta strand

294 – 297

4

Helix

302 – 304

3

Beta strand

306 – 314

9

Beta strand

317 – 328

12

Beta strand

816 – 821

6

Beta strand

824 – 828

5

Beta strand

839 – 849

11

Helix

851 – 853

3

Beta strand

855 – 860

6

Beta strand

864 – 868

5

Beta strand

876 – 884

9

Beta strand

886 – 888

3

Beta strand

896 – 899

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4B8FDC5BFD434ED5	FASTA	1,018	113,320
	10 20 30 40 50 60 MKMWLLVSHL VIISITTCLA EFTWYRRYGH GVSEEDKGFG PIFEEQPINT IYPEESLEGK 70 80 90 100 110 120 VSLNCRARAS PFPVYKWRMN NGDVDLTSDR YSMVGGNLVI NNPDKQKDAG IYYCLASNNY 130 140 150 160 170 180 GMVRSTEATL SFGYLDPFPP EERPEVRVKE GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF 190 200 210 220 230 240 ITMDKRRFVS QTNGNLYIAN VEASDKGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY 250 260 270 280 290 300 PADIVVQFKD VYALMGQNVT LECFALGNPV PDIRWRKVLE PMPSTAEIST SGAVLKIFNI 310 320 330 340 350 360 QLEDEGIYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW PCVATGKPIP 370 380 390 400 410 420 TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENTYGAI YANAELKILA LAPTFEMNPM 430 440 450 460 470 480 KKKILAAKGG RVIIECKPKA APKPKFSWSK GTEWLVNSSR ILIWEDGSLE INNITRNDGG 490 500 510 520 530 540 IYTCFAENNR GKANSTGTLV ITDPTRIILA PINADITVGE NATMQCAASF DPALDLTFVW 550 560 570 580 590 600 SFNGYVIDFN KENIHYQRNF MLDSNGELLI RNAQLKHAGR YTCTAQTIVD NSSASADLVV 610 620 630 640 650 660 RGPPGPPGGL RIEDIRATSV ALTWSRGSDN HSPISKYTIQ TKTILSDDWK DAKTDPPIIE 670 680 690 700 710 720 GNMEAARAVD LIPWMEYEFR VVATNTLGRG EPSIPSNRIK TDGAAPNVAP SDVGGGGGRN 730 740 750 760 770 780 RELTITWAPL SREYHYGNNF GYIVAFKPFD GEEWKKVTVT NPDTGRYVHK DETMSPSTAF 790 800 810 820 830 840 QVKVKAFNNK GDGPYSLVAV INSAQDAPSE APTEVGVKVL SSSEISVHWE HVLEKIVESY 850 860 870 880 890 900 QIRYWAAHDK EEAANRVQVT SQEYSARLEN LLPDTQYFIE VGACNSAGCG PPSDMIEAFT 910 920 930 940 950 960 KKAPPSQPPR IISSVRSGSR YIITWDHVVA LSNESTVTGY KVLYRPDGQH DGKLYSTHKH 970 980 990 1000 1010 SIEVPIPRDG EYVVEVRAHS DGGDGVVSQV KISGAPTLSP SLLGLLLPAF GILVYLEF
	Isoform 2 [UniParc]. Checksum: 0078E9F82F498EE0	FASTA	1,007	111,867
	10 20 30 40 50 60 MKMWLLVSHL VIISITTCLA VSEEDKGFGP IFEEQPINTI YPEESLEGKV SLNCRARASP 70 80 90 100 110 120 FPVYKWRMNN GDVDLTSDRY SMVGGNLVIN NPDKQKDAGI YYCLASNNYG MVRSTEATLS 130 140 150 160 170 180 FGYLDPFPPE ERPEVRVKEG KGMVLLCDPP YHFPDDLSYR WLLNEFPVFI TMDKRRFVSQ 190 200 210 220 230 240 TNGNLYIANV EASDKGNYSC FVSSPSITKS VFSKFIPLIP IPERTTKPYP ADIVVQFKDV 250 260 270 280 290 300 YALMGQNVTL ECFALGNPVP DIRWRKVLEP MPSTAEISTS GAVLKIFNIQ LEDEGIYECE 310 320 330 340 350 360 AENIRGKDKH QARIYVQAFP EWVEHINDTE VDIGSDLYWP CVATGKPIPT IRWLKNGYAY 370 380 390 400 410 420 HKGELRLYDV TFENAGMYQC IAENTYGAIY ANAELKILAL APTFEMNPMK KKILAAKGGR 430 440 450 460 470 480 VIIECKPKAA PKPKFSWSKG TEWLVNSSRI LIWEDGSLEI NNITRNDGGI YTCFAENNRG 490 500 510 520 530 540 KANSTGTLVI TDPTRIILAP INADITVGEN ATMQCAASFD PALDLTFVWS FNGYVIDFNK 550 560 570 580 590 600 ENIHYQRNFM LDSNGELLIR NAQLKHAGRY TCTAQTIVDN SSASADLVVR GPPGPPGGLR 610 620 630 640 650 660 IEDIRATSVA LTWSRGSDNH SPISKYTIQT KTILSDDWKD AKTDPPIIEG NMEAARAVDL 670 680 690 700 710 720 IPWMEYEFRV VATNTLGRGE PSIPSNRIKT DGAAPNVAPS DVGGGGGRNR ELTITWAPLS 730 740 750 760 770 780 REYHYGNNFG YIVAFKPFDG EEWKKVTVTN PDTGRYVHKD ETMSPSTAFQ VKVKAFNNKG 790 800 810 820 830 840 DGPYSLVAVI NSAQDAPSEA PTEVGVKVLS SSEISVHWEH VLEKIVESYQ IRYWAAHDKE 850 860 870 880 890 900 EAANRVQVTS QEYSARLENL LPDTQYFIEV GACNSAGCGP PSDMIEAFTK KAPPSQPPRI 910 920 930 940 950 960 ISSVRSGSRY IITWDHVVAL SNESTVTGYK VLYRPDGQHD GKLYSTHKHS IEVPIPRDGE 970 980 990 1000 YVVEVRAHSD GGDGVVSQVK ISGAPTLSPS LLGLLLPAFG ILVYLEF
	Isoform 3 [UniParc]. Checksum: 86825008EAAA085A	FASTA	627	70,604
	10 20 30 40 50 60 MKMWLLVSHL VIISITTCLA EFTWYRRYGH GVSEEDKGFG PIFEEQPINT IYPEESLEGK 70 80 90 100 110 120 VSLNCRARAS PFPVYKWRMN NGDVDLTSDR YSMVGGNLVI NNPDKQKDAG IYYCLASNNY 130 140 150 160 170 180 GMVRSTEATL SFGYLDPFPP EERPEVRVKE GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF 190 200 210 220 230 240 ITMDKRRFVS QTNGNLYIAN VEASDKGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY 250 260 270 280 290 300 PADIVVQFKD VYALMGQNVT LECFALGNPV PDIRWRKVLE PMPSTAEIST SGAVLKIFNI 310 320 330 340 350 360 QLEDEGIYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW PCVATGKPIP 370 380 390 400 410 420 TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENTYGAI YANAELKILA LAPTFEMNPM 430 440 450 460 470 480 KKKILAAKGG RVIIECKPKA APKPKFSWSK GTEWLVNSSR ILIWEDGSLE INNITRNDGG 490 500 510 520 530 540 IYTCFAENNR GKANSTGTLV ITDPTRIILA PINADITVGE NATMQCAASF DPALDLTFVW 550 560 570 580 590 600 SFNGYVIDFN KENIHYQRNF MLDSNGELLI RNAQLKHAGR YTCTAQTIVD NSSASADLVV 610 620 RGKNRKGGEK NMVDSFLPVC ASLPPTW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of the human cell adhesion molecule contactin." Reid R.A., Bronson D.D., Young K.M., Hemperly J.J. Brain Res. Mol. Brain Res. 21:1-8(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Neuroblastoma.
[2]	"Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12." Berglund E.O., Ranscht B. Genomics 21:571-582(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Amygdala and Cerebellum.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[5]	"Isolation and characterization of a membrane glycoprotein from human brain with sequence similarities to cell adhesion proteins from chicken and mouse." Berglund E., Stigbrand T., Carlsson S.R. Eur. J. Biochem. 197:549-554(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-40 AND 679-693 (ISOFORM 1), SUBUNIT, TISSUE SPECIFICITY. Tissue: Brain cortex.
[6]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-494, MASS SPECTROMETRY. Tissue: Plasma.
[7]	"Solution structures of the FN3 domain of human contactin 1." RIKEN structural genomics initiative (RSGI) Submitted (AUG-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 791-903.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-794.
[9]	"Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy." Compton A.G., Albrecht D.E., Seto J.T., Cooper S.T., Ilkovski B., Jones K.J., Challis D., Mowat D., Ranscht B., Bahlo M., Froehner S.C., North K.N. Am. J. Hum. Genet. 83:714-724(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CNCM.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z21488 mRNA. Translation: CAA79696.1.
U07819 mRNA. Translation: AAA67920.1.
U07820 mRNA. Translation: AAA67921.1.
AK289544 mRNA. Translation: BAF82233.1.
AK289698 mRNA. Translation: BAF82387.1.
BC036569 mRNA. Translation: AAH36569.1.

IPI

IPI00029751.
IPI00216641.
IPI00479304.

PIR

A54744.
S15394.

RefSeq

NP_001242992.1. NM_001256063.1.
NP_001242993.1. NM_001256064.1.
NP_001834.2. NM_001843.3.
NP_778203.1. NM_175038.2.

UniGene

Hs.143434.
Hs.741112.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EE2	NMR	-	A	798-903	[»]
3S97	X-ray	2.30	C/D	133-329	[»]

ProteinModelPortal

Q12860.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-59714N.

IntAct

Q12860. 1 interaction.

STRING

9606.ENSP00000325660.

PTM databases

PhosphoSite

Q12860.

Polymorphism databases

DMDM

2497301.

Proteomic databases

PaxDb

Q12860.

PRIDE

Q12860.

Protocols and materials databases

DNASU

1272.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000347616; ENSP00000325660; ENSG00000018236.
ENST00000348761; ENSP00000261160; ENSG00000018236.
ENST00000360099; ENSP00000353213; ENSG00000018236.
ENST00000547702; ENSP00000448004; ENSG00000018236.
ENST00000547849; ENSP00000448653; ENSG00000018236.
ENST00000551295; ENSP00000447006; ENSG00000018236.

GeneID

1272.

KEGG

hsa:1272.

UCSC

uc001rmm.1. human.
uc001rmn.1. human.
uc001rmo.3. human.

Organism-specific databases

CTD

1272.

GeneCards

GC12P041086.

HGNC

HGNC:2171. CNTN1.

HPA

CAB025200.
HPA041060.

MIM

600016. gene.
612540. phenotype.

neXtProt

NX_Q12860.

Orphanet

210163. Congenital lethal myopathy, Compton-North type.

PharmGKB

PA26685.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG293951.

HOVERGEN

HBG051047.

InParanoid

Q12860.

KO

K06759.

OMA

DTQYFIE.

PhylomeDB

Q12860.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.
REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

Q12860.

Bgee

Q12860.

CleanEx

HS_CNTN1.

Genevestigator

Q12860.

GermOnline

ENSG00000018236. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 10 hits.

InterPro

IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]

Pfam

PF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view]

SMART

SM00060. FN3. 4 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 4 hits.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 4 hits.

PROSITE

PS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q12860.

GenomeRNAi

1272.

NextBio

5153.

SOURCE

Search...

Entry information

Entry name

CNTN1_HUMAN

Accession

Primary (citable) accession number: Q12860
Secondary accession number(s): A8K0H9 , A8K0Y3, Q12861, Q14030, Q7M4P0, Q8N466

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 131 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.