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Protein

Contactin-1

Gene

CNTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Notch signaling pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000018236-MONOMER.
ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-HSA-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.
R-HSA-373760. L1CAM interactions.
R-HSA-447043. Neurofascin interactions.
SignaLinkiQ12860.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-1
Alternative name(s):
Glycoprotein gp135
Neural cell surface protein F3
Gene namesi
Name:CNTN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:2171. CNTN1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • membrane Source: ProtInc
  • membrane raft Source: Ensembl
  • myelin sheath Source: Ensembl
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Myopathy, congenital, Compton-North (MYPCN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA lethal, autosomal recessive, congenital myopathy characterized by fetal akinesia, neonatal hypotonia, severe muscle weakness, loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma and disruption of sarcomeres with disorganization of the Z band.
See also OMIM:612540

Organism-specific databases

DisGeNETi1272.
MalaCardsiCNTN1.
MIMi612540. phenotype.
OpenTargetsiENSG00000018236.
Orphaneti210163. Congenital lethal myopathy, Compton-North type.
PharmGKBiPA26685.

Polymorphism and mutation databases

BioMutaiCNTN1.
DMDMi2497301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001468521 – ?993Contactin-1Add BLAST973
PropeptideiPRO_0000014686?994 – 1018Removed in mature formAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 114PROSITE-ProRule annotation
Disulfide bondi158 ↔ 211PROSITE-ProRule annotation
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi263 ↔ 310PROSITE-ProRule annotation
Glycosylationi338N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi352 ↔ 391PROSITE-ProRule annotation
Disulfide bondi436 ↔ 484PROSITE-ProRule annotation
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi473N-linked (GlcNAc...)Sequence analysis1
Glycosylationi494N-linked (GlcNAc...) (complex)2 Publications1
Glycosylationi521N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi526 ↔ 583PROSITE-ProRule annotation
Glycosylationi591N-linked (GlcNAc...)Sequence analysis1
Glycosylationi933N-linked (GlcNAc...)Sequence analysis1
Lipidationi993GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ12860.
MaxQBiQ12860.
PaxDbiQ12860.
PeptideAtlasiQ12860.
PRIDEiQ12860.
TopDownProteomicsiQ12860-3. [Q12860-3]

PTM databases

iPTMnetiQ12860.
PhosphoSitePlusiQ12860.
SwissPalmiQ12860.

Expressioni

Tissue specificityi

Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000018236.
CleanExiHS_CNTN1.
ExpressionAtlasiQ12860. baseline and differential.
GenevisibleiQ12860. HS.

Organism-specific databases

HPAiCAB025200.
HPA041060.

Interactioni

Subunit structurei

Monomer. Interacts with CNTNAP1 in cis form (By similarity). Binds to the carbonic-anhydrase like domain of PTPRZ1 (PubMed:20133774). Interacts with NOTCH1 and TNR. Detected in a complex with NRCAM and PTPRB (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi107672. 24 interactors.
DIPiDIP-59714N.
IntActiQ12860. 4 interactors.
MINTiMINT-2806030.
STRINGi9606.ENSP00000325660.

Structurei

Secondary structure

11018
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi146 – 149Combined sources4
Beta strandi154 – 156Combined sources3
Beta strandi162 – 166Combined sources5
Beta strandi169 – 176Combined sources8
Beta strandi184 – 189Combined sources6
Turni191 – 193Combined sources3
Beta strandi196 – 200Combined sources5
Helixi203 – 205Combined sources3
Beta strandi207 – 215Combined sources9
Helixi216 – 218Combined sources3
Beta strandi220 – 223Combined sources4
Beta strandi227 – 232Combined sources6
Beta strandi240 – 247Combined sources8
Beta strandi251 – 254Combined sources4
Beta strandi259 – 269Combined sources11
Beta strandi272 – 277Combined sources6
Beta strandi287 – 289Combined sources3
Turni290 – 293Combined sources4
Beta strandi294 – 297Combined sources4
Helixi302 – 304Combined sources3
Beta strandi306 – 314Combined sources9
Beta strandi317 – 328Combined sources12
Beta strandi816 – 821Combined sources6
Beta strandi824 – 828Combined sources5
Beta strandi839 – 849Combined sources11
Helixi851 – 853Combined sources3
Beta strandi855 – 860Combined sources6
Beta strandi864 – 868Combined sources5
Beta strandi876 – 884Combined sources9
Beta strandi886 – 888Combined sources3
Beta strandi896 – 899Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EE2NMR-A798-903[»]
3S97X-ray2.30C/D133-329[»]
ProteinModelPortaliQ12860.
SMRiQ12860.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12860.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 131Ig-like C2-type 1Add BLAST91
Domaini137 – 223Ig-like C2-type 2Add BLAST87
Domaini241 – 326Ig-like C2-type 3Add BLAST86
Domaini331 – 407Ig-like C2-type 4Add BLAST77
Domaini413 – 500Ig-like C2-type 5Add BLAST88
Domaini504 – 601Ig-like C2-type 6Add BLAST98
Domaini606 – 704Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini709 – 806Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini811 – 906Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini907 – 1000Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi602 – 609Gly/Pro-rich8

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOVERGENiHBG051047.
InParanoidiQ12860.
KOiK06759.
OMAiFTWYRRY.
OrthoDBiEOG091G00X7.
PhylomeDBiQ12860.
TreeFamiTF351103.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032991. Contactin-1.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF531. PTHR10489:SF531. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12860-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMWLLVSHL VIISITTCLA EFTWYRRYGH GVSEEDKGFG PIFEEQPINT
60 70 80 90 100
IYPEESLEGK VSLNCRARAS PFPVYKWRMN NGDVDLTSDR YSMVGGNLVI
110 120 130 140 150
NNPDKQKDAG IYYCLASNNY GMVRSTEATL SFGYLDPFPP EERPEVRVKE
160 170 180 190 200
GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF ITMDKRRFVS QTNGNLYIAN
210 220 230 240 250
VEASDKGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY PADIVVQFKD
260 270 280 290 300
VYALMGQNVT LECFALGNPV PDIRWRKVLE PMPSTAEIST SGAVLKIFNI
310 320 330 340 350
QLEDEGIYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW
360 370 380 390 400
PCVATGKPIP TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENTYGAI
410 420 430 440 450
YANAELKILA LAPTFEMNPM KKKILAAKGG RVIIECKPKA APKPKFSWSK
460 470 480 490 500
GTEWLVNSSR ILIWEDGSLE INNITRNDGG IYTCFAENNR GKANSTGTLV
510 520 530 540 550
ITDPTRIILA PINADITVGE NATMQCAASF DPALDLTFVW SFNGYVIDFN
560 570 580 590 600
KENIHYQRNF MLDSNGELLI RNAQLKHAGR YTCTAQTIVD NSSASADLVV
610 620 630 640 650
RGPPGPPGGL RIEDIRATSV ALTWSRGSDN HSPISKYTIQ TKTILSDDWK
660 670 680 690 700
DAKTDPPIIE GNMEAARAVD LIPWMEYEFR VVATNTLGRG EPSIPSNRIK
710 720 730 740 750
TDGAAPNVAP SDVGGGGGRN RELTITWAPL SREYHYGNNF GYIVAFKPFD
760 770 780 790 800
GEEWKKVTVT NPDTGRYVHK DETMSPSTAF QVKVKAFNNK GDGPYSLVAV
810 820 830 840 850
INSAQDAPSE APTEVGVKVL SSSEISVHWE HVLEKIVESY QIRYWAAHDK
860 870 880 890 900
EEAANRVQVT SQEYSARLEN LLPDTQYFIE VGACNSAGCG PPSDMIEAFT
910 920 930 940 950
KKAPPSQPPR IISSVRSGSR YIITWDHVVA LSNESTVTGY KVLYRPDGQH
960 970 980 990 1000
DGKLYSTHKH SIEVPIPRDG EYVVEVRAHS DGGDGVVSQV KISGAPTLSP
1010
SLLGLLLPAF GILVYLEF
Length:1,018
Mass (Da):113,320
Last modified:November 1, 1996 - v1
Checksum:i4B8FDC5BFD434ED5
GO
Isoform 2 (identifier: Q12860-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-31: Missing.

Show »
Length:1,007
Mass (Da):111,867
Checksum:i0078E9F82F498EE0
GO
Isoform 3 (identifier: Q12860-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     603-627: PPGPPGGLRIEDIRATSVALTWSRG → KNRKGGEKNMVDSFLPVCASLPPTW
     628-1018: Missing.

Show »
Length:627
Mass (Da):70,604
Checksum:i86825008EAAA085A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti682V → I AA sequence (PubMed:2026173).Curated1
Sequence conflicti687L → P AA sequence (PubMed:2026173).Curated1
Sequence conflicti689R → I AA sequence (PubMed:2026173).Curated1
Sequence conflicti692P → F AA sequence (PubMed:2026173).Curated1
Isoform 3 (identifier: Q12860-3)
Sequence conflicti610K → I in BAF82233 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035506794P → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_011722798V → L.Corresponds to variant rs1056020dbSNPEnsembl.1
Natural variantiVAR_049866824E → G.Corresponds to variant rs11553341dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00250021 – 31Missing in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_011959603 – 627PPGPP…TWSRG → KNRKGGEKNMVDSFLPVCAS LPPTW in isoform 3. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_011960628 – 1018Missing in isoform 3. 2 PublicationsAdd BLAST391

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21488 mRNA. Translation: CAA79696.1.
U07819 mRNA. Translation: AAA67920.1.
U07820 mRNA. Translation: AAA67921.1.
AK289544 mRNA. Translation: BAF82233.1.
AK289698 mRNA. Translation: BAF82387.1.
BC036569 mRNA. Translation: AAH36569.1.
CCDSiCCDS58225.1. [Q12860-3]
CCDS8737.1. [Q12860-1]
CCDS8738.1. [Q12860-2]
PIRiA54744.
S15394.
RefSeqiNP_001242992.1. NM_001256063.1. [Q12860-3]
NP_001242993.1. NM_001256064.1. [Q12860-3]
NP_001834.2. NM_001843.3. [Q12860-1]
NP_778203.1. NM_175038.2. [Q12860-2]
XP_005268708.1. XM_005268651.2. [Q12860-1]
XP_006719304.1. XM_006719241.2. [Q12860-1]
XP_011536228.1. XM_011537926.2. [Q12860-1]
XP_011536229.1. XM_011537927.2. [Q12860-1]
XP_016874314.1. XM_017018825.1. [Q12860-3]
XP_016874315.1. XM_017018826.1. [Q12860-3]
XP_016874316.1. XM_017018827.1. [Q12860-3]
UniGeneiHs.143434.
Hs.739161.
Hs.741112.

Genome annotation databases

EnsembliENST00000347616; ENSP00000325660; ENSG00000018236. [Q12860-1]
ENST00000348761; ENSP00000261160; ENSG00000018236. [Q12860-2]
ENST00000547702; ENSP00000448004; ENSG00000018236. [Q12860-3]
ENST00000547849; ENSP00000448653; ENSG00000018236. [Q12860-3]
ENST00000551295; ENSP00000447006; ENSG00000018236. [Q12860-1]
GeneIDi1272.
KEGGihsa:1272.
UCSCiuc001rmm.3. human. [Q12860-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21488 mRNA. Translation: CAA79696.1.
U07819 mRNA. Translation: AAA67920.1.
U07820 mRNA. Translation: AAA67921.1.
AK289544 mRNA. Translation: BAF82233.1.
AK289698 mRNA. Translation: BAF82387.1.
BC036569 mRNA. Translation: AAH36569.1.
CCDSiCCDS58225.1. [Q12860-3]
CCDS8737.1. [Q12860-1]
CCDS8738.1. [Q12860-2]
PIRiA54744.
S15394.
RefSeqiNP_001242992.1. NM_001256063.1. [Q12860-3]
NP_001242993.1. NM_001256064.1. [Q12860-3]
NP_001834.2. NM_001843.3. [Q12860-1]
NP_778203.1. NM_175038.2. [Q12860-2]
XP_005268708.1. XM_005268651.2. [Q12860-1]
XP_006719304.1. XM_006719241.2. [Q12860-1]
XP_011536228.1. XM_011537926.2. [Q12860-1]
XP_011536229.1. XM_011537927.2. [Q12860-1]
XP_016874314.1. XM_017018825.1. [Q12860-3]
XP_016874315.1. XM_017018826.1. [Q12860-3]
XP_016874316.1. XM_017018827.1. [Q12860-3]
UniGeneiHs.143434.
Hs.739161.
Hs.741112.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EE2NMR-A798-903[»]
3S97X-ray2.30C/D133-329[»]
ProteinModelPortaliQ12860.
SMRiQ12860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107672. 24 interactors.
DIPiDIP-59714N.
IntActiQ12860. 4 interactors.
MINTiMINT-2806030.
STRINGi9606.ENSP00000325660.

PTM databases

iPTMnetiQ12860.
PhosphoSitePlusiQ12860.
SwissPalmiQ12860.

Polymorphism and mutation databases

BioMutaiCNTN1.
DMDMi2497301.

Proteomic databases

EPDiQ12860.
MaxQBiQ12860.
PaxDbiQ12860.
PeptideAtlasiQ12860.
PRIDEiQ12860.
TopDownProteomicsiQ12860-3. [Q12860-3]

Protocols and materials databases

DNASUi1272.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347616; ENSP00000325660; ENSG00000018236. [Q12860-1]
ENST00000348761; ENSP00000261160; ENSG00000018236. [Q12860-2]
ENST00000547702; ENSP00000448004; ENSG00000018236. [Q12860-3]
ENST00000547849; ENSP00000448653; ENSG00000018236. [Q12860-3]
ENST00000551295; ENSP00000447006; ENSG00000018236. [Q12860-1]
GeneIDi1272.
KEGGihsa:1272.
UCSCiuc001rmm.3. human. [Q12860-1]

Organism-specific databases

CTDi1272.
DisGeNETi1272.
GeneCardsiCNTN1.
HGNCiHGNC:2171. CNTN1.
HPAiCAB025200.
HPA041060.
MalaCardsiCNTN1.
MIMi600016. gene.
612540. phenotype.
neXtProtiNX_Q12860.
OpenTargetsiENSG00000018236.
Orphaneti210163. Congenital lethal myopathy, Compton-North type.
PharmGKBiPA26685.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOVERGENiHBG051047.
InParanoidiQ12860.
KOiK06759.
OMAiFTWYRRY.
OrthoDBiEOG091G00X7.
PhylomeDBiQ12860.
TreeFamiTF351103.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000018236-MONOMER.
ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-HSA-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.
R-HSA-373760. L1CAM interactions.
R-HSA-447043. Neurofascin interactions.
SignaLinkiQ12860.

Miscellaneous databases

ChiTaRSiCNTN1. human.
EvolutionaryTraceiQ12860.
GeneWikiiCNTN1.
GenomeRNAii1272.
PROiQ12860.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000018236.
CleanExiHS_CNTN1.
ExpressionAtlasiQ12860. baseline and differential.
GenevisibleiQ12860. HS.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032991. Contactin-1.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF531. PTHR10489:SF531. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN1_HUMAN
AccessioniPrimary (citable) accession number: Q12860
Secondary accession number(s): A8K0H9
, A8K0Y3, Q12861, Q14030, Q7M4P0, Q8N466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.