Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q12852

- M3K12_HUMAN

UniProt

Q12852 - M3K12_HUMAN

Protein

Mitogen-activated protein kinase kinase kinase 12

Gene

MAP3K12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei152 – 1521ATPPROSITE-ProRule annotation
    Active sitei236 – 2361Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi131 – 1399ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase kinase activity Source: UniProtKB-EC
    3. protein binding Source: IntAct
    4. protein homodimerization activity Source: UniProtKB
    5. protein kinase activity Source: ProtInc
    6. protein kinase binding Source: UniProtKB
    7. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. histone phosphorylation Source: UniProtKB
    2. intracellular signal transduction Source: ProtInc
    3. JNK cascade Source: UniProtKB
    4. peptidyl-serine phosphorylation Source: UniProtKB
    5. peptidyl-threonine phosphorylation Source: UniProtKB
    6. protein autophosphorylation Source: UniProtKB
    7. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ12852.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 12 (EC:2.7.11.25)
    Alternative name(s):
    Dual leucine zipper bearing kinase
    Short name:
    DLK
    Leucine-zipper protein kinase
    Short name:
    ZPK
    MAPK-upstream kinase
    Short name:
    MUK
    Mixed lineage kinase
    Gene namesi
    Name:MAP3K12
    Synonyms:ZPK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6851. MAP3K12.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: ProtInc
    3. cytosol Source: UniProtKB
    4. growth cone Source: Ensembl
    5. membrane Source: UniProtKB
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30595.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859Mitogen-activated protein kinase kinase kinase 12PRO_0000086261Add
    BLAST

    Post-translational modificationi

    Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ12852.
    PRIDEiQ12852.

    PTM databases

    PhosphoSiteiQ12852.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and kidney.

    Gene expression databases

    ArrayExpressiQ12852.
    BgeeiQ12852.
    CleanExiHS_MAP3K12.
    GenevestigatoriQ12852.

    Organism-specific databases

    HPAiHPA039936.

    Interactioni

    Subunit structurei

    Interacts with MBIP.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FRA10AC1Q70Z532EBI-710223,EBI-710176

    Protein-protein interaction databases

    BioGridi113566. 13 interactions.
    IntActiQ12852. 9 interactions.
    MINTiMINT-1382019.
    STRINGi9606.ENSP00000267079.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12852.
    SMRiQ12852. Positions 68-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 366242Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni390 – 41122Leucine-zipper 1Add
    BLAST
    Regioni443 – 46422Leucine-zipper 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi665 – 6684Poly-Pro
    Compositional biasi720 – 73112Glu-rich (acidic)Add
    BLAST

    Domaini

    Interacts with MBIP through the leucine-zipper motif.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000113435.
    HOVERGENiHBG052383.
    InParanoidiQ12852.
    KOiK04423.
    OMAiRSDDMCS.
    OrthoDBiEOG7B8S3P.
    PhylomeDBiQ12852.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR017419. MAP3K12_MAP3K13.
    IPR027257. MAPKKK12.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500741. MAPKKK12. 1 hit.
    PIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q12852-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTHVLQL    50
    HEQDAGGPGG AAGSPESRAS RVRADEVRLQ CQSGSGFLEG LFGCLRPVWT 100
    MIGKAYSTEH KQQQEDLWEV PFEEILDLQW VGSGAQGAVF LGRFHGEEVA 150
    VKKVRDLKET DIKHLRKLKH PNIITFKGVC TQAPCYCILM EFCAQGQLYE 200
    VLRAGRPVTP SLLVDWSMGI AGGMNYLHLH KIIHRDLKSP NMLITYDDVV 250
    KISDFGTSKE LSDKSTKMSF AGTVAWMAPE VIRNEPVSEK VDIWSFGVVL 300
    WELLTGEIPY KDVDSSAIIW GVGSNSLHLP VPSSCPDGFK ILLRQCWNSK 350
    PRNRPSFRQI LLHLDIASAD VLSTPQETYF KSQAEWREEV KLHFEKIKSE 400
    GTCLHRLEEE LVMRRREELR HALDIREHYE RKLERANNLY MELNALMLQL 450
    ELKERELLRR EQALERRCPG LLKPHPSRGL LHGNTMEKLI KKRNVPQKLS 500
    PHSKRPDILK TESLLPKLDA ALSGVGLPGC PKGPPSPGRS RRGKTRHRKA 550
    SAKGSCGDLP GLRTAVPPHE PGGPGSPGGL GGGPSAWEAC PPALRGLHHD 600
    LLLRKMSSSS PDLLSAALGS RGRGATGGAG DPGSPPPARG DTPPSEGSAP 650
    GSTSPDSPGG AKGEPPPPVG PGEGVGLLGT GREGTSGRGG SRAGSQHLTP 700
    AALLYRAAVT RSQKRGISSE EEEGEVDSEV ELTSSQRWPQ SLNMRQSLST 750
    FSSENPSDGE EGTASEPSPS GTPEVGSTNT DERPDERSDD MCSQGSEIPL 800
    DPPPSEVIPG PEPSSLPIPH QELLRERGPP NSEDSDCDST ELDNSNSVDA 850
    LRPPASLPP 859
    Length:859
    Mass (Da):93,219
    Last modified:October 17, 2006 - v2
    Checksum:i1E1BCAD2F6DFCFE8
    GO
    Isoform 2 (identifier: Q12852-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         46-46: H → QCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANS

    Note: No experimental confirmation available.

    Show »
    Length:892
    Mass (Da):96,322
    Checksum:iEA0C10CFE2461876
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti355 – 3551P → S in BAG52841. (PubMed:14702039)Curated
    Sequence conflicti498 – 4981K → N in AAA67343. (PubMed:8037767)Curated
    Sequence conflicti504 – 5041K → Q in AAA67343. (PubMed:8037767)Curated
    Sequence conflicti511 – 5111T → A in AAA67343. (PubMed:8037767)Curated
    Sequence conflicti533 – 5331G → A in AAA67343. (PubMed:8037767)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti409 – 4091E → K in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication
    VAR_040705
    Natural varianti628 – 6281G → R.1 Publication
    Corresponds to variant rs34366500 [ dbSNP | Ensembl ].
    VAR_040706
    Natural varianti640 – 6401G → S.1 Publication
    Corresponds to variant rs55794887 [ dbSNP | Ensembl ].
    VAR_040707

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei46 – 461H → QCVLRDVVPLGGQGGGGPSP SPGGEPPPEPFANS in isoform 2. 1 PublicationVSP_044646

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07358 mRNA. Translation: AAA67343.1.
    AF283475 Genomic DNA. Translation: AAL67158.1.
    AK094195 mRNA. Translation: BAG52841.1.
    AC023509 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96715.1.
    BC050050 mRNA. Translation: AAH50050.1. Sequence problems.
    CCDSiCCDS55831.1. [Q12852-2]
    CCDS8860.1. [Q12852-1]
    PIRiJC2363.
    RefSeqiNP_001180440.1. NM_001193511.1. [Q12852-2]
    NP_006292.3. NM_006301.3. [Q12852-1]
    XP_005269195.1. XM_005269138.1. [Q12852-2]
    XP_006719651.1. XM_006719588.1. [Q12852-2]
    UniGeneiHs.713539.

    Genome annotation databases

    EnsembliENST00000267079; ENSP00000267079; ENSG00000139625. [Q12852-1]
    ENST00000547035; ENSP00000448689; ENSG00000139625. [Q12852-2]
    ENST00000547488; ENSP00000449038; ENSG00000139625. [Q12852-2]
    GeneIDi7786.
    KEGGihsa:7786.
    UCSCiuc001sdm.2. human. [Q12852-1]
    uc001sdn.2. human.

    Polymorphism databases

    DMDMi116242624.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07358 mRNA. Translation: AAA67343.1 .
    AF283475 Genomic DNA. Translation: AAL67158.1 .
    AK094195 mRNA. Translation: BAG52841.1 .
    AC023509 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96715.1 .
    BC050050 mRNA. Translation: AAH50050.1 . Sequence problems.
    CCDSi CCDS55831.1. [Q12852-2 ]
    CCDS8860.1. [Q12852-1 ]
    PIRi JC2363.
    RefSeqi NP_001180440.1. NM_001193511.1. [Q12852-2 ]
    NP_006292.3. NM_006301.3. [Q12852-1 ]
    XP_005269195.1. XM_005269138.1. [Q12852-2 ]
    XP_006719651.1. XM_006719588.1. [Q12852-2 ]
    UniGenei Hs.713539.

    3D structure databases

    ProteinModelPortali Q12852.
    SMRi Q12852. Positions 68-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113566. 13 interactions.
    IntActi Q12852. 9 interactions.
    MINTi MINT-1382019.
    STRINGi 9606.ENSP00000267079.

    Chemistry

    BindingDBi Q12852.
    ChEMBLi CHEMBL1908389.
    GuidetoPHARMACOLOGYi 2072.

    PTM databases

    PhosphoSitei Q12852.

    Polymorphism databases

    DMDMi 116242624.

    Proteomic databases

    PaxDbi Q12852.
    PRIDEi Q12852.

    Protocols and materials databases

    DNASUi 7786.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267079 ; ENSP00000267079 ; ENSG00000139625 . [Q12852-1 ]
    ENST00000547035 ; ENSP00000448689 ; ENSG00000139625 . [Q12852-2 ]
    ENST00000547488 ; ENSP00000449038 ; ENSG00000139625 . [Q12852-2 ]
    GeneIDi 7786.
    KEGGi hsa:7786.
    UCSCi uc001sdm.2. human. [Q12852-1 ]
    uc001sdn.2. human.

    Organism-specific databases

    CTDi 7786.
    GeneCardsi GC12M053870.
    H-InvDB HIX0010672.
    HGNCi HGNC:6851. MAP3K12.
    HPAi HPA039936.
    MIMi 600447. gene.
    neXtProti NX_Q12852.
    PharmGKBi PA30595.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000113435.
    HOVERGENi HBG052383.
    InParanoidi Q12852.
    KOi K04423.
    OMAi RSDDMCS.
    OrthoDBi EOG7B8S3P.
    PhylomeDBi Q12852.

    Enzyme and pathway databases

    SignaLinki Q12852.

    Miscellaneous databases

    ChiTaRSi MAP3K12. human.
    GeneWikii MAP3K12.
    GenomeRNAii 7786.
    NextBioi 30143.
    PROi Q12852.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q12852.
    Bgeei Q12852.
    CleanExi HS_MAP3K12.
    Genevestigatori Q12852.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR017419. MAP3K12_MAP3K13.
    IPR027257. MAPKKK12.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500741. MAPKKK12. 1 hit.
    PIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel putative protein kinase having a leucine zipper domain from human brain."
      Reddy U.R., Pleasure D.
      Biochem. Biophys. Res. Commun. 202:613-620(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    2. "SP3 acts as a positive regulator on the core promoter of human ZPK gene."
      Itoh A., Wang Z., Ito Y., Reddy U.R., Itoh T.
      Biochem. Biophys. Res. Commun. 313:612-618(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    7. "MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase."
      Fukuyama K., Yoshida M., Yamashita A., Deyama T., Baba M., Suzuki A., Mohri H., Ikezawa Z., Nakajima H., Hirai S., Ohno S.
      J. Biol. Chem. 275:21247-21254(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MBIP.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-409; ARG-628 AND SER-640.

    Entry informationi

    Entry nameiM3K12_HUMAN
    AccessioniPrimary (citable) accession number: Q12852
    Secondary accession number(s): B3KSS9
    , G3V1Y2, Q86VQ5, Q8WY25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3