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Q12846

- STX4_HUMAN

UniProt

Q12846 - STX4_HUMAN

Protein

Syntaxin-4

Gene

STX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes By similarity. May also play a role in docking of synaptic vesicles at presynaptic active zones.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. intracellular protein transport Source: InterPro
    3. membrane organization Source: Reactome
    4. neurotransmitter transport Source: UniProtKB-KW
    5. platelet activation Source: Reactome
    6. post-Golgi vesicle-mediated transport Source: Reactome

    Keywords - Biological processi

    Neurotransmitter transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_1178. Disinhibition of SNARE formation.
    REACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_19187. Clathrin derived vesicle budding.

    Protein family/group databases

    TCDBi1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-4
    Alternative name(s):
    Renal carcinoma antigen NY-REN-31
    Gene namesi
    Name:STX4
    Synonyms:STX4A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:11439. STX4.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: HGNC
    2. cell surface Source: UniProtKB
    3. cytosol Source: Reactome
    4. extracellular vesicular exosome Source: UniProt
    5. integral component of membrane Source: UniProtKB-KW
    6. lateral loop Source: Ensembl
    7. membrane Source: ProtInc
    8. myelin sheath adaxonal region Source: Ensembl
    9. perinuclear region of cytoplasm Source: Ensembl
    10. plasma membrane Source: HPA
    11. SNARE complex Source: UniProtKB
    12. specific granule Source: UniProtKB
    13. trans-Golgi network Source: Ensembl
    14. vacuole Source: HGNC

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36236.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Syntaxin-4PRO_0000210202Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141Phosphoserine2 Publications
    Modified residuei15 – 151Phosphoserine2 Publications
    Modified residuei117 – 1171Phosphoserine1 Publication
    Modified residuei248 – 2481PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ12846.
    PaxDbiQ12846.
    PRIDEiQ12846.

    2D gel databases

    OGPiQ12846.

    PTM databases

    PhosphoSiteiQ12846.

    Expressioni

    Tissue specificityi

    Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.1 Publication

    Gene expression databases

    ArrayExpressiQ12846.
    BgeeiQ12846.
    CleanExiHS_STX4.
    GenevestigatoriQ12846.

    Organism-specific databases

    HPAiHPA001330.

    Interactioni

    Subunit structurei

    Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NAPAP549202EBI-744942,EBI-749652

    Protein-protein interaction databases

    BioGridi112679. 31 interactions.
    IntActiQ12846. 11 interactions.
    MINTiMINT-1454763.
    STRINGi9606.ENSP00000317714.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12846.
    SMRiQ12846. Positions 39-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 275275CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 2971ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei276 – 29621Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini200 – 26263t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni154 – 297144Interaction with CENPFBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili43 – 163121Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiQ12846.
    KOiK13502.
    OMAiRMIQQRT.
    PhylomeDBiQ12846.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q12846-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRDRTHELRQ GDDSSDEEDK ERVALVVHPG TARLGSPDEE FFHKVRTIRQ    50
    TIVKLGNKVQ ELEKQQVTIL ATPLPEESMK QELQNLRDEI KQLGREIRLQ 100
    LKAIEPQKEE ADENYNSVNT RMRKTQHGVL SQQFVELINK CNSMQSEYRE 150
    KNVERIRRQL KITNAGMVSD EELEQMLDSG QSEVFVSNIL KDTQVTRQAL 200
    NEISARHSEI QQLERSIREL HDIFTFLATE VEMQGEMINR IEKNILSSAD 250
    YVERGQEHVK TALENQKKAR KKKVLIAICV SITVVLLAVI IGVTVVG 297
    Length:297
    Mass (Da):34,180
    Last modified:July 15, 1998 - v2
    Checksum:i5084FD1C49A86BAA
    GO
    Isoform 2 (identifier: Q12846-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-44: MRDRTHELRQ...GSPDEEFFHK → MGMTARTKRT...STSPLGHPPQ

    Note: No experimental confirmation available.

    Show »
    Length:295
    Mass (Da):33,841
    Checksum:i0E0B617DAB04A56C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1741E → D in AAA20967. (PubMed:8206394)Curated
    Sequence conflicti269 – 2691A → V in AAA20967. (PubMed:8206394)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4444MRDRT…EFFHK → MGMTARTKRTRSGSRWWCTR ARHGWGARTRSSSTSPLGHP PQ in isoform 2. 1 PublicationVSP_054603Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07158 mRNA. Translation: AAA20967.1.
    X85784 mRNA. Translation: CAA59769.1.
    AJ000541 mRNA. Translation: CAA04174.1.
    AF026007 mRNA. Translation: AAB88810.1.
    AF318489 Transcribed RNA. Translation: AAG40313.1.
    BT007326 mRNA. Translation: AAP35990.1.
    AK091833 mRNA. Translation: BAG52424.1.
    AK315716 mRNA. Translation: BAG38075.1.
    CR541806 mRNA. Translation: CAG46605.1.
    AC135050 Genomic DNA. No translation available.
    CH471192 Genomic DNA. Translation: EAW52176.1.
    CH471192 Genomic DNA. Translation: EAW52177.1.
    BC002436 mRNA. Translation: AAH02436.1.
    CCDSiCCDS10700.1. [Q12846-1]
    CCDS61916.1. [Q12846-2]
    PIRiI38517.
    S52726.
    RefSeqiNP_001259025.1. NM_001272096.1. [Q12846-2]
    NP_004595.2. NM_004604.4. [Q12846-1]
    UniGeneiHs.83734.

    Genome annotation databases

    EnsembliENST00000313843; ENSP00000317714; ENSG00000103496. [Q12846-1]
    ENST00000394998; ENSP00000378447; ENSG00000103496. [Q12846-2]
    GeneIDi6810.
    KEGGihsa:6810.
    UCSCiuc002eak.4. human.
    uc002eal.4. human. [Q12846-1]

    Polymorphism databases

    DMDMi3041737.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07158 mRNA. Translation: AAA20967.1 .
    X85784 mRNA. Translation: CAA59769.1 .
    AJ000541 mRNA. Translation: CAA04174.1 .
    AF026007 mRNA. Translation: AAB88810.1 .
    AF318489 Transcribed RNA. Translation: AAG40313.1 .
    BT007326 mRNA. Translation: AAP35990.1 .
    AK091833 mRNA. Translation: BAG52424.1 .
    AK315716 mRNA. Translation: BAG38075.1 .
    CR541806 mRNA. Translation: CAG46605.1 .
    AC135050 Genomic DNA. No translation available.
    CH471192 Genomic DNA. Translation: EAW52176.1 .
    CH471192 Genomic DNA. Translation: EAW52177.1 .
    BC002436 mRNA. Translation: AAH02436.1 .
    CCDSi CCDS10700.1. [Q12846-1 ]
    CCDS61916.1. [Q12846-2 ]
    PIRi I38517.
    S52726.
    RefSeqi NP_001259025.1. NM_001272096.1. [Q12846-2 ]
    NP_004595.2. NM_004604.4. [Q12846-1 ]
    UniGenei Hs.83734.

    3D structure databases

    ProteinModelPortali Q12846.
    SMRi Q12846. Positions 39-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112679. 31 interactions.
    IntActi Q12846. 11 interactions.
    MINTi MINT-1454763.
    STRINGi 9606.ENSP00000317714.

    Protein family/group databases

    TCDBi 1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

    PTM databases

    PhosphoSitei Q12846.

    Polymorphism databases

    DMDMi 3041737.

    2D gel databases

    OGPi Q12846.

    Proteomic databases

    MaxQBi Q12846.
    PaxDbi Q12846.
    PRIDEi Q12846.

    Protocols and materials databases

    DNASUi 6810.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313843 ; ENSP00000317714 ; ENSG00000103496 . [Q12846-1 ]
    ENST00000394998 ; ENSP00000378447 ; ENSG00000103496 . [Q12846-2 ]
    GeneIDi 6810.
    KEGGi hsa:6810.
    UCSCi uc002eak.4. human.
    uc002eal.4. human. [Q12846-1 ]

    Organism-specific databases

    CTDi 6810.
    GeneCardsi GC16P031044.
    HGNCi HGNC:11439. STX4.
    HPAi HPA001330.
    MIMi 186591. gene.
    neXtProti NX_Q12846.
    PharmGKBi PA36236.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5074.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi Q12846.
    KOi K13502.
    OMAi RMIQQRT.
    PhylomeDBi Q12846.
    TreeFami TF313763.

    Enzyme and pathway databases

    Reactomei REACT_1178. Disinhibition of SNARE formation.
    REACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_19187. Clathrin derived vesicle budding.

    Miscellaneous databases

    ChiTaRSi STX4. human.
    GeneWikii STX4.
    GenomeRNAii 6810.
    NextBioi 26573.
    PROi Q12846.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q12846.
    Bgeei Q12846.
    CleanExi HS_STX4.
    Genevestigatori Q12846.

    Family and domain databases

    InterProi IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence analysis of the human syntaxin-encoding gene."
      Li H., Hodge D.R., Pei G.K., Seth A.
      Gene 143:303-304(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2."
      Jagadish M.N., Fernandez C.S., Hewish D.R., Macaulay S.L., Gough K.H., Grusovin J., Verkuylen A., Cosgrove L., Alafaci A., Frenkel M.J., Ward C.W.
      Biochem. J. 317:945-954(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    3. "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1."
      Martin-Martin B., Nabokina S.M., Lazo P.A., Mollinedo F.
      J. Leukoc. Biol. 65:397-406(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Peripheral blood neutrophil.
    4. Rae J.L., Shepard A.R.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lens epithelium.
    5. "Expression of syntaxins in kidney MDCK cells."
      Zhang Z., Loh E., Low S.H., Li X., Miura M., An F., Weimbs T.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung and Testis.
    8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    9. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    12. Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN.
      Tissue: Renal cell carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-15 AND SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTX4_HUMAN
    AccessioniPrimary (citable) accession number: Q12846
    Secondary accession number(s): A8MXY0, Q15525, Q6FHE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

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