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Q12841 (FSTL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene names
Name:FSTL1
Synonyms:FRP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.

Subunit structure

Interacts with SCN10A.

Subcellular location

Secreted Potential.

Tissue specificity

Overexpressed in synovial tissues from rheumatoid arthritis. Ref.3

Sequence similarities

Contains 2 EF-hand domains.

Contains 1 follistatin-like domain.

Contains 1 Kazal-like domain.

Contains 1 VWFC domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q12841-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q12841-2)

The sequence of this isoform differs from the canonical sequence as follows:
     22-56: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.8
Chain21 – 308288Follistatin-related protein 1
PRO_0000010111

Regions

Domain30 – 5324Follistatin-like
Domain48 – 10053Kazal-like
Domain144 – 17835EF-hand 1
Domain193 – 22836EF-hand 2
Domain233 – 28755VWFC

Amino acid modifications

Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Ref.9
Glycosylation1801N-linked (GlcNAc...) Ref.9
Disulfide bond54 ↔ 84 By similarity
Disulfide bond58 ↔ 77 By similarity
Disulfide bond66 ↔ 98 By similarity

Natural variations

Alternative sequence22 – 5635Missing in isoform 2.
VSP_055075

Experimental info

Sequence conflict2211C → S in BAF83827. Ref.4
Sequence conflict2261F → S in BAF83827. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BD4C651FAFF24800

FASTA30834,986
        10         20         30         40         50         60 
MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP TCLCIEQCKP 

        70         80         90        100        110        120 
HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE KKSVSPSASP VVCYQSNRDE 

       130        140        150        160        170        180 
LRRRIIQWLE AEIIPDGWFS KGSNYSEILD KYFKNFDNGD SRLDSSEFLK FVEQNETAIN 

       190        200        210        220        230        240 
ITTYPDQENN KLLRGLCVDA LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY 

       250        260        270        280        290        300 
ADGAETEVDC NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT 


KRVSTKEI 

« Hide

Isoform 2 [UniParc].

Checksum: ED93DC06FC411A39
Show »

FASTA27331,228

References

« Hide 'large scale' references
[1]"Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue."
Zwijsen A., Blockx H., van Arnhem W., Willems J., Fransen L., Devos K., Raymackers J., van de Voorde A., Slegers H.
Eur. J. Biochem. 225:937-946(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases."
Tanaka M., Ozaki S., Osakada F., Mori K., Okubo M., Nakao K.
Int. Immunol. 10:1305-1314(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Synovium.
[3]"Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility."
Ehara Y., Sakurai D., Tsuchiya N., Nakano K., Tanaka Y., Yamaguchi A., Tokunaga K.
Clin. Exp. Rheumatol. 22:707-712(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Placenta.
[5]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-35.
[9]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-175 AND ASN-180.
Tissue: Plasma.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06863 mRNA. Translation: AAA66062.1.
D89937 mRNA. Translation: BAA28707.1.
AB119283 Genomic DNA. Translation: BAD12167.1.
AK289388 mRNA. Translation: BAF82077.1.
AK291138 mRNA. Translation: BAF83827.1.
AK300356 mRNA. Translation: BAG62097.1.
AK312261 mRNA. Translation: BAG35192.1.
AC063952 Genomic DNA. No translation available.
AC078982 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79526.1.
CH471052 Genomic DNA. Translation: EAW79527.1.
BC000055 mRNA. Translation: AAH00055.1.
CCDSCCDS2998.1.
PIRS51362.
RefSeqNP_009016.1. NM_007085.4.
UniGeneHs.269512.

3D structure databases

ProteinModelPortalQ12841.
SMRQ12841. Positions 29-99, 147-223.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116338. 1 interaction.
IntActQ12841. 15 interactions.
MINTMINT-7990618.
STRING9606.ENSP00000295633.

Protein family/group databases

MEROPSI01.967.

PTM databases

PhosphoSiteQ12841.

Polymorphism databases

DMDM2498390.

Proteomic databases

MaxQBQ12841.
PaxDbQ12841.
PeptideAtlasQ12841.
PRIDEQ12841.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295633; ENSP00000295633; ENSG00000163430.
ENST00000424703; ENSP00000394355; ENSG00000163430.
GeneID11167.
KEGGhsa:11167.
UCSCuc003eds.3. human.

Organism-specific databases

CTD11167.
GeneCardsGC03M120111.
HGNCHGNC:3972. FSTL1.
HPAHPA035251.
MIM605547. gene.
neXtProtNX_Q12841.
PharmGKBPA28389.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148907.
HOGENOMHOG000007780.
HOVERGENHBG051665.
InParanoidQ12841.
OMARGLCIDA.
OrthoDBEOG7WT427.
PhylomeDBQ12841.
TreeFamTF106409.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ12841.
BgeeQ12841.
CleanExHS_FSTL1.
GenevestigatorQ12841.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFSTL1. human.
GeneWikiFSTL1.
GenomeRNAi11167.
NextBio42487.
PMAP-CutDBQ12841.
PROQ12841.
SOURCESearch...

Entry information

Entry nameFSTL1_HUMAN
AccessionPrimary (citable) accession number: Q12841
Secondary accession number(s): A8K523 expand/collapse secondary AC list , B4DTT5, D3DN90, Q549Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM