Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q12841

- FSTL1_HUMAN

UniProt

Q12841 - FSTL1_HUMAN

Protein

Follistatin-related protein 1

Gene

FSTL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. BMP signaling pathway Source: Reactome

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_12034. Signaling by BMP.

    Protein family/group databases

    MEROPSiI01.967.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Follistatin-related protein 1
    Alternative name(s):
    Follistatin-like protein 1
    Gene namesi
    Name:FSTL1
    Synonyms:FRP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:3972. FSTL1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28389.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 308288Follistatin-related protein 1PRO_0000010111Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 84PROSITE-ProRule annotation
    Disulfide bondi58 ↔ 77PROSITE-ProRule annotation
    Disulfide bondi66 ↔ 98PROSITE-ProRule annotation
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi175 – 1751N-linked (GlcNAc...)1 Publication
    Glycosylationi180 – 1801N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ12841.
    PaxDbiQ12841.
    PeptideAtlasiQ12841.
    PRIDEiQ12841.

    PTM databases

    PhosphoSiteiQ12841.

    Miscellaneous databases

    PMAP-CutDBQ12841.

    Expressioni

    Tissue specificityi

    Overexpressed in synovial tissues from rheumatoid arthritis.1 Publication

    Gene expression databases

    ArrayExpressiQ12841.
    BgeeiQ12841.
    CleanExiHS_FSTL1.
    GenevestigatoriQ12841.

    Organism-specific databases

    HPAiHPA035251.

    Interactioni

    Subunit structurei

    Interacts with SCN10A.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BMP2P126432EBI-2349801,EBI-1029262
    CD14P085713EBI-2349801,EBI-3905196
    DIP2AQ146894EBI-2349801,EBI-2564275
    INHBAA4D1W72EBI-2349801,EBI-8307749
    TGFB1P011372EBI-2349801,EBI-779636

    Protein-protein interaction databases

    BioGridi116338. 1 interaction.
    IntActiQ12841. 15 interactions.
    MINTiMINT-7990618.
    STRINGi9606.ENSP00000295633.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12841.
    SMRiQ12841. Positions 29-99, 147-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 5324Follistatin-likeAdd
    BLAST
    Domaini48 – 10053Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 17835EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini193 – 22836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini233 – 28755VWFCAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 follistatin-like domain.Curated
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG148907.
    HOGENOMiHOG000007780.
    HOVERGENiHBG051665.
    InParanoidiQ12841.
    OMAiRGLCIDA.
    OrthoDBiEOG7WT427.
    PhylomeDBiQ12841.
    TreeFamiTF106409.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view]
    PfamiPF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q12841-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP    50
    TCLCIEQCKP HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE 100
    KKSVSPSASP VVCYQSNRDE LRRRIIQWLE AEIIPDGWFS KGSNYSEILD 150
    KYFKNFDNGD SRLDSSEFLK FVEQNETAIN ITTYPDQENN KLLRGLCVDA 200
    LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY ADGAETEVDC 250
    NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT 300
    KRVSTKEI 308
    Length:308
    Mass (Da):34,986
    Last modified:November 1, 1996 - v1
    Checksum:iBD4C651FAFF24800
    GO
    Isoform 2 (identifier: Q12841-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         22-56: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:273
    Mass (Da):31,228
    Checksum:iED93DC06FC411A39
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti221 – 2211C → S in BAF83827. (PubMed:14702039)Curated
    Sequence conflicti226 – 2261F → S in BAF83827. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei22 – 5635Missing in isoform 2. 1 PublicationVSP_055075Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06863 mRNA. Translation: AAA66062.1.
    D89937 mRNA. Translation: BAA28707.1.
    AB119283 Genomic DNA. Translation: BAD12167.1.
    AK289388 mRNA. Translation: BAF82077.1.
    AK291138 mRNA. Translation: BAF83827.1.
    AK300356 mRNA. Translation: BAG62097.1.
    AK312261 mRNA. Translation: BAG35192.1.
    AC063952 Genomic DNA. No translation available.
    AC078982 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79526.1.
    CH471052 Genomic DNA. Translation: EAW79527.1.
    BC000055 mRNA. Translation: AAH00055.1.
    CCDSiCCDS2998.1. [Q12841-1]
    PIRiS51362.
    RefSeqiNP_009016.1. NM_007085.4.
    UniGeneiHs.269512.

    Genome annotation databases

    EnsembliENST00000295633; ENSP00000295633; ENSG00000163430. [Q12841-1]
    ENST00000424703; ENSP00000394355; ENSG00000163430. [Q12841-2]
    GeneIDi11167.
    KEGGihsa:11167.
    UCSCiuc003eds.3. human. [Q12841-1]

    Polymorphism databases

    DMDMi2498390.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06863 mRNA. Translation: AAA66062.1 .
    D89937 mRNA. Translation: BAA28707.1 .
    AB119283 Genomic DNA. Translation: BAD12167.1 .
    AK289388 mRNA. Translation: BAF82077.1 .
    AK291138 mRNA. Translation: BAF83827.1 .
    AK300356 mRNA. Translation: BAG62097.1 .
    AK312261 mRNA. Translation: BAG35192.1 .
    AC063952 Genomic DNA. No translation available.
    AC078982 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79526.1 .
    CH471052 Genomic DNA. Translation: EAW79527.1 .
    BC000055 mRNA. Translation: AAH00055.1 .
    CCDSi CCDS2998.1. [Q12841-1 ]
    PIRi S51362.
    RefSeqi NP_009016.1. NM_007085.4.
    UniGenei Hs.269512.

    3D structure databases

    ProteinModelPortali Q12841.
    SMRi Q12841. Positions 29-99, 147-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116338. 1 interaction.
    IntActi Q12841. 15 interactions.
    MINTi MINT-7990618.
    STRINGi 9606.ENSP00000295633.

    Protein family/group databases

    MEROPSi I01.967.

    PTM databases

    PhosphoSitei Q12841.

    Polymorphism databases

    DMDMi 2498390.

    Proteomic databases

    MaxQBi Q12841.
    PaxDbi Q12841.
    PeptideAtlasi Q12841.
    PRIDEi Q12841.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295633 ; ENSP00000295633 ; ENSG00000163430 . [Q12841-1 ]
    ENST00000424703 ; ENSP00000394355 ; ENSG00000163430 . [Q12841-2 ]
    GeneIDi 11167.
    KEGGi hsa:11167.
    UCSCi uc003eds.3. human. [Q12841-1 ]

    Organism-specific databases

    CTDi 11167.
    GeneCardsi GC03M120111.
    HGNCi HGNC:3972. FSTL1.
    HPAi HPA035251.
    MIMi 605547. gene.
    neXtProti NX_Q12841.
    PharmGKBi PA28389.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148907.
    HOGENOMi HOG000007780.
    HOVERGENi HBG051665.
    InParanoidi Q12841.
    OMAi RGLCIDA.
    OrthoDBi EOG7WT427.
    PhylomeDBi Q12841.
    TreeFami TF106409.

    Enzyme and pathway databases

    Reactomei REACT_12034. Signaling by BMP.

    Miscellaneous databases

    ChiTaRSi FSTL1. human.
    GeneWikii FSTL1.
    GenomeRNAii 11167.
    NextBioi 35464179.
    PMAP-CutDB Q12841.
    PROi Q12841.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q12841.
    Bgeei Q12841.
    CleanExi HS_FSTL1.
    Genevestigatori Q12841.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view ]
    Pfami PF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue."
      Zwijsen A., Blockx H., van Arnhem W., Willems J., Fransen L., Devos K., Raymackers J., van de Voorde A., Slegers H.
      Eur. J. Biochem. 225:937-946(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases."
      Tanaka M., Ozaki S., Osakada F., Mori K., Okubo M., Nakao K.
      Int. Immunol. 10:1305-1314(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Synovium.
    3. "Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility."
      Ehara Y., Sakurai D., Tsuchiya N., Nakano K., Tanaka Y., Yamaguchi A., Tokunaga K.
      Clin. Exp. Rheumatol. 22:707-712(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-35.
    9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-175 AND ASN-180.
      Tissue: Plasma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFSTL1_HUMAN
    AccessioniPrimary (citable) accession number: Q12841
    Secondary accession number(s): A8K523
    , B4DTT5, D3DN90, Q549Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3