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Q12841

- FSTL1_HUMAN

UniProt

Q12841 - FSTL1_HUMAN

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Protein

Follistatin-related protein 1

Gene

FSTL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: ProtInc

GO - Biological processi

  1. BMP signaling pathway Source: Reactome
  2. response to starvation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_12034. Signaling by BMP.

Protein family/group databases

MEROPSiI01.967.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene namesi
Name:FSTL1
Synonyms:FRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:3972. FSTL1.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProt
  3. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 308288Follistatin-related protein 1PRO_0000010111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 84PROSITE-ProRule annotation
Disulfide bondi58 ↔ 77PROSITE-ProRule annotation
Disulfide bondi66 ↔ 98PROSITE-ProRule annotation
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)1 Publication
Glycosylationi180 – 1801N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ12841.
PaxDbiQ12841.
PeptideAtlasiQ12841.
PRIDEiQ12841.

PTM databases

PhosphoSiteiQ12841.

Miscellaneous databases

PMAP-CutDBQ12841.

Expressioni

Tissue specificityi

Overexpressed in synovial tissues from rheumatoid arthritis.1 Publication

Gene expression databases

BgeeiQ12841.
CleanExiHS_FSTL1.
ExpressionAtlasiQ12841. baseline and differential.
GenevestigatoriQ12841.

Organism-specific databases

HPAiHPA035251.

Interactioni

Subunit structurei

Interacts with SCN10A.

Binary interactionsi

WithEntry#Exp.IntActNotes
BMP2P126432EBI-2349801,EBI-1029262
CD14P085713EBI-2349801,EBI-3905196
DIP2AQ146894EBI-2349801,EBI-2564275
INHBAA4D1W72EBI-2349801,EBI-8307749
TGFB1P011372EBI-2349801,EBI-779636

Protein-protein interaction databases

BioGridi116338. 4 interactions.
IntActiQ12841. 15 interactions.
MINTiMINT-7990618.
STRINGi9606.ENSP00000295633.

Structurei

3D structure databases

ProteinModelPortaliQ12841.
SMRiQ12841. Positions 29-99, 147-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 5324Follistatin-likeAdd
BLAST
Domaini48 – 10053Kazal-likePROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17835EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini193 – 22836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini233 – 28755VWFCAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 follistatin-like domain.Curated
Contains 1 Kazal-like domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG148907.
GeneTreeiENSGT00530000063333.
HOGENOMiHOG000007780.
HOVERGENiHBG051665.
InParanoidiQ12841.
OMAiRGLCIDA.
OrthoDBiEOG7WT427.
PhylomeDBiQ12841.
TreeFamiTF106409.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q12841-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP
60 70 80 90 100
TCLCIEQCKP HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE
110 120 130 140 150
KKSVSPSASP VVCYQSNRDE LRRRIIQWLE AEIIPDGWFS KGSNYSEILD
160 170 180 190 200
KYFKNFDNGD SRLDSSEFLK FVEQNETAIN ITTYPDQENN KLLRGLCVDA
210 220 230 240 250
LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY ADGAETEVDC
260 270 280 290 300
NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT

KRVSTKEI
Length:308
Mass (Da):34,986
Last modified:November 1, 1996 - v1
Checksum:iBD4C651FAFF24800
GO
Isoform 2 (identifier: Q12841-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-56: Missing.

Note: No experimental confirmation available.

Show »
Length:273
Mass (Da):31,228
Checksum:iED93DC06FC411A39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211C → S in BAF83827. (PubMed:14702039)Curated
Sequence conflicti226 – 2261F → S in BAF83827. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 5635Missing in isoform 2. 1 PublicationVSP_055075Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06863 mRNA. Translation: AAA66062.1.
D89937 mRNA. Translation: BAA28707.1.
AB119283 Genomic DNA. Translation: BAD12167.1.
AK289388 mRNA. Translation: BAF82077.1.
AK291138 mRNA. Translation: BAF83827.1.
AK300356 mRNA. Translation: BAG62097.1.
AK312261 mRNA. Translation: BAG35192.1.
AC063952 Genomic DNA. No translation available.
AC078982 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79526.1.
CH471052 Genomic DNA. Translation: EAW79527.1.
BC000055 mRNA. Translation: AAH00055.1.
CCDSiCCDS2998.1. [Q12841-1]
PIRiS51362.
RefSeqiNP_009016.1. NM_007085.4. [Q12841-1]
UniGeneiHs.269512.

Genome annotation databases

EnsembliENST00000295633; ENSP00000295633; ENSG00000163430. [Q12841-1]
ENST00000424703; ENSP00000394355; ENSG00000163430. [Q12841-2]
GeneIDi11167.
KEGGihsa:11167.
UCSCiuc003eds.3. human. [Q12841-1]
uc011bjh.2. human.

Polymorphism databases

DMDMi2498390.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06863 mRNA. Translation: AAA66062.1 .
D89937 mRNA. Translation: BAA28707.1 .
AB119283 Genomic DNA. Translation: BAD12167.1 .
AK289388 mRNA. Translation: BAF82077.1 .
AK291138 mRNA. Translation: BAF83827.1 .
AK300356 mRNA. Translation: BAG62097.1 .
AK312261 mRNA. Translation: BAG35192.1 .
AC063952 Genomic DNA. No translation available.
AC078982 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79526.1 .
CH471052 Genomic DNA. Translation: EAW79527.1 .
BC000055 mRNA. Translation: AAH00055.1 .
CCDSi CCDS2998.1. [Q12841-1 ]
PIRi S51362.
RefSeqi NP_009016.1. NM_007085.4. [Q12841-1 ]
UniGenei Hs.269512.

3D structure databases

ProteinModelPortali Q12841.
SMRi Q12841. Positions 29-99, 147-223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116338. 4 interactions.
IntActi Q12841. 15 interactions.
MINTi MINT-7990618.
STRINGi 9606.ENSP00000295633.

Protein family/group databases

MEROPSi I01.967.

PTM databases

PhosphoSitei Q12841.

Polymorphism databases

DMDMi 2498390.

Proteomic databases

MaxQBi Q12841.
PaxDbi Q12841.
PeptideAtlasi Q12841.
PRIDEi Q12841.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295633 ; ENSP00000295633 ; ENSG00000163430 . [Q12841-1 ]
ENST00000424703 ; ENSP00000394355 ; ENSG00000163430 . [Q12841-2 ]
GeneIDi 11167.
KEGGi hsa:11167.
UCSCi uc003eds.3. human. [Q12841-1 ]
uc011bjh.2. human.

Organism-specific databases

CTDi 11167.
GeneCardsi GC03M120111.
HGNCi HGNC:3972. FSTL1.
HPAi HPA035251.
MIMi 605547. gene.
neXtProti NX_Q12841.
PharmGKBi PA28389.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148907.
GeneTreei ENSGT00530000063333.
HOGENOMi HOG000007780.
HOVERGENi HBG051665.
InParanoidi Q12841.
OMAi RGLCIDA.
OrthoDBi EOG7WT427.
PhylomeDBi Q12841.
TreeFami TF106409.

Enzyme and pathway databases

Reactomei REACT_12034. Signaling by BMP.

Miscellaneous databases

ChiTaRSi FSTL1. human.
GeneWikii FSTL1.
GenomeRNAii 11167.
NextBioi 35464179.
PMAP-CutDB Q12841.
PROi Q12841.
SOURCEi Search...

Gene expression databases

Bgeei Q12841.
CleanExi HS_FSTL1.
ExpressionAtlasi Q12841. baseline and differential.
Genevestigatori Q12841.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view ]
Pfami PF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue."
    Zwijsen A., Blockx H., van Arnhem W., Willems J., Fransen L., Devos K., Raymackers J., van de Voorde A., Slegers H.
    Eur. J. Biochem. 225:937-946(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases."
    Tanaka M., Ozaki S., Osakada F., Mori K., Okubo M., Nakao K.
    Int. Immunol. 10:1305-1314(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Synovium.
  3. "Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility."
    Ehara Y., Sakurai D., Tsuchiya N., Nakano K., Tanaka Y., Yamaguchi A., Tokunaga K.
    Clin. Exp. Rheumatol. 22:707-712(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-35.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-175 AND ASN-180.
    Tissue: Plasma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFSTL1_HUMAN
AccessioniPrimary (citable) accession number: Q12841
Secondary accession number(s): A8K523
, B4DTT5, D3DN90, Q549Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3