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Protein

Follistatin-related protein 1

Gene

FSTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • heparin binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163430-MONOMER.
ReactomeiR-HSA-201451. Signaling by BMP.

Protein family/group databases

MEROPSiI01.967.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene namesi
Name:FSTL1
Synonyms:FRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:3972. FSTL1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11167.
OpenTargetsiENSG00000163430.
PharmGKBiPA28389.

Polymorphism and mutation databases

BioMutaiFSTL1.
DMDMi2498390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001011121 – 308Follistatin-related protein 1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 84PROSITE-ProRule annotation
Disulfide bondi58 ↔ 77PROSITE-ProRule annotation
Disulfide bondi66 ↔ 98PROSITE-ProRule annotation
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Modified residuei165Phosphoserine; by FAM20C1 Publication1
Glycosylationi175N-linked (GlcNAc...)1 Publication1
Glycosylationi180N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ12841.
MaxQBiQ12841.
PaxDbiQ12841.
PeptideAtlasiQ12841.
PRIDEiQ12841.

PTM databases

iPTMnetiQ12841.
PhosphoSitePlusiQ12841.

Miscellaneous databases

PMAP-CutDBQ12841.

Expressioni

Tissue specificityi

Overexpressed in synovial tissues from rheumatoid arthritis.1 Publication

Gene expression databases

BgeeiENSG00000163430.
CleanExiHS_FSTL1.
ExpressionAtlasiQ12841. baseline and differential.
GenevisibleiQ12841. HS.

Organism-specific databases

HPAiHPA035251.

Interactioni

Subunit structurei

Interacts with SCN10A.

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926247EBI-2349801,EBI-743771
BMP2P126432EBI-2349801,EBI-1029262
CD14P085713EBI-2349801,EBI-3905196
DIP2AQ146894EBI-2349801,EBI-2564275
INHBAA4D1W72EBI-2349801,EBI-8307749
TGFB1P011372EBI-2349801,EBI-779636

Protein-protein interaction databases

BioGridi116338. 26 interactors.
IntActiQ12841. 18 interactors.
MINTiMINT-7990618.
STRINGi9606.ENSP00000295633.

Structurei

3D structure databases

ProteinModelPortaliQ12841.
SMRiQ12841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 53Follistatin-likeAdd BLAST24
Domaini48 – 100Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini144 – 178EF-hand 1PROSITE-ProRule annotationAdd BLAST35
Domaini193 – 228EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini233 – 287VWFCAdd BLAST55

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 follistatin-like domain.Curated
Contains 1 Kazal-like domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIPU. Eukaryota.
ENOG410ZJ7W. LUCA.
GeneTreeiENSGT00530000063333.
HOGENOMiHOG000007780.
HOVERGENiHBG051665.
InParanoidiQ12841.
OMAiWVHAEEE.
OrthoDBiEOG091G0YXX.
PhylomeDBiQ12841.
TreeFamiTF106409.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12841-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP
60 70 80 90 100
TCLCIEQCKP HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE
110 120 130 140 150
KKSVSPSASP VVCYQSNRDE LRRRIIQWLE AEIIPDGWFS KGSNYSEILD
160 170 180 190 200
KYFKNFDNGD SRLDSSEFLK FVEQNETAIN ITTYPDQENN KLLRGLCVDA
210 220 230 240 250
LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY ADGAETEVDC
260 270 280 290 300
NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT

KRVSTKEI
Length:308
Mass (Da):34,986
Last modified:November 1, 1996 - v1
Checksum:iBD4C651FAFF24800
GO
Isoform 2 (identifier: Q12841-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-56: Missing.

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):31,228
Checksum:iED93DC06FC411A39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221C → S in BAF83827 (PubMed:14702039).Curated1
Sequence conflicti226F → S in BAF83827 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05507522 – 56Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06863 mRNA. Translation: AAA66062.1.
D89937 mRNA. Translation: BAA28707.1.
AB119283 Genomic DNA. Translation: BAD12167.1.
AK289388 mRNA. Translation: BAF82077.1.
AK291138 mRNA. Translation: BAF83827.1.
AK300356 mRNA. Translation: BAG62097.1.
AK312261 mRNA. Translation: BAG35192.1.
AC063952 Genomic DNA. No translation available.
AC078982 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79526.1.
CH471052 Genomic DNA. Translation: EAW79527.1.
BC000055 mRNA. Translation: AAH00055.1.
CCDSiCCDS2998.1. [Q12841-1]
PIRiS51362.
RefSeqiNP_009016.1. NM_007085.4. [Q12841-1]
UniGeneiHs.269512.

Genome annotation databases

EnsembliENST00000295633; ENSP00000295633; ENSG00000163430. [Q12841-1]
ENST00000424703; ENSP00000394355; ENSG00000163430. [Q12841-2]
GeneIDi11167.
KEGGihsa:11167.
UCSCiuc003eds.4. human. [Q12841-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06863 mRNA. Translation: AAA66062.1.
D89937 mRNA. Translation: BAA28707.1.
AB119283 Genomic DNA. Translation: BAD12167.1.
AK289388 mRNA. Translation: BAF82077.1.
AK291138 mRNA. Translation: BAF83827.1.
AK300356 mRNA. Translation: BAG62097.1.
AK312261 mRNA. Translation: BAG35192.1.
AC063952 Genomic DNA. No translation available.
AC078982 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79526.1.
CH471052 Genomic DNA. Translation: EAW79527.1.
BC000055 mRNA. Translation: AAH00055.1.
CCDSiCCDS2998.1. [Q12841-1]
PIRiS51362.
RefSeqiNP_009016.1. NM_007085.4. [Q12841-1]
UniGeneiHs.269512.

3D structure databases

ProteinModelPortaliQ12841.
SMRiQ12841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116338. 26 interactors.
IntActiQ12841. 18 interactors.
MINTiMINT-7990618.
STRINGi9606.ENSP00000295633.

Protein family/group databases

MEROPSiI01.967.

PTM databases

iPTMnetiQ12841.
PhosphoSitePlusiQ12841.

Polymorphism and mutation databases

BioMutaiFSTL1.
DMDMi2498390.

Proteomic databases

EPDiQ12841.
MaxQBiQ12841.
PaxDbiQ12841.
PeptideAtlasiQ12841.
PRIDEiQ12841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295633; ENSP00000295633; ENSG00000163430. [Q12841-1]
ENST00000424703; ENSP00000394355; ENSG00000163430. [Q12841-2]
GeneIDi11167.
KEGGihsa:11167.
UCSCiuc003eds.4. human. [Q12841-1]

Organism-specific databases

CTDi11167.
DisGeNETi11167.
GeneCardsiFSTL1.
HGNCiHGNC:3972. FSTL1.
HPAiHPA035251.
MIMi605547. gene.
neXtProtiNX_Q12841.
OpenTargetsiENSG00000163430.
PharmGKBiPA28389.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIPU. Eukaryota.
ENOG410ZJ7W. LUCA.
GeneTreeiENSGT00530000063333.
HOGENOMiHOG000007780.
HOVERGENiHBG051665.
InParanoidiQ12841.
OMAiWVHAEEE.
OrthoDBiEOG091G0YXX.
PhylomeDBiQ12841.
TreeFamiTF106409.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163430-MONOMER.
ReactomeiR-HSA-201451. Signaling by BMP.

Miscellaneous databases

ChiTaRSiFSTL1. human.
GeneWikiiFSTL1.
GenomeRNAii11167.
PMAP-CutDBQ12841.
PROiQ12841.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163430.
CleanExiHS_FSTL1.
ExpressionAtlasiQ12841. baseline and differential.
GenevisibleiQ12841. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFSTL1_HUMAN
AccessioniPrimary (citable) accession number: Q12841
Secondary accession number(s): A8K523
, B4DTT5, D3DN90, Q549Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.