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Protein

Kinesin heavy chain isoform 5A

Gene

KIF5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 938ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
  • motor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_15550. Insulin processing.
REACT_25201. Kinesins.
REACT_355321. RHO GTPases activate KTN1.
SignaLinkiQ12840.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin heavy chain isoform 5A
Alternative name(s):
Kinesin heavy chain neuron-specific 1
Neuronal kinesin heavy chain
Short name:
NKHC
Gene namesi
Name:KIF5A
Synonyms:NKHC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6323. KIF5A.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • kinesin complex Source: ProtInc
  • membrane Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Spastic paraplegia 10, autosomal dominant (SPG10)7 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.

See also OMIM:604187
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631Y → C in SPG10; complicated form. 1 Publication
VAR_058741
Natural varianti198 – 1981M → T in SPG10; complicated form. 1 Publication
VAR_058742
Natural varianti203 – 2031S → C in SPG10. 1 Publication
VAR_066616
Natural varianti204 – 2041R → Q in SPG10; complicated form. 1 Publication
VAR_058743
Natural varianti251 – 2511E → K in SPG10; complicated form. 1 Publication
VAR_058744
Natural varianti253 – 2531K → N in SPG10; decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications
VAR_046744
Natural varianti256 – 2561N → S in SPG10; slightly decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications
VAR_032842
Natural varianti256 – 2561Missing in SPG10. 1 Publication
VAR_058745
Natural varianti257 – 2571K → N in SPG10; complicated form. 1 Publication
VAR_058746
Natural varianti276 – 2761Y → C in SPG10. 1 Publication
VAR_033108
Natural varianti280 – 2801R → C in SPG10. 2 Publications
VAR_032843
Natural varianti280 – 2801R → H in SPG10; complicated form. 1 Publication
VAR_058747
Natural varianti280 – 2801R → L in SPG10; pure form. 1 Publication
VAR_058748
Natural varianti361 – 3611A → V in SPG10; does not affect microtubule affinity; does not affect gliding velocity; does not affect microtubule-dependent ATP turnover. 2 Publications
Corresponds to variant rs121434444 [ dbSNP | Ensembl ].
VAR_032844

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi280 – 2801R → S: Strongly reduces microtubule affinity; slightly reduces gliding velocity. 1 Publication

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

MIMi604187. phenotype.
Orphaneti324611. Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation.
100991. Autosomal dominant spastic paraplegia type 10.
PharmGKBiPA30107.

Polymorphism and mutation databases

BioMutaiKIF5A.
DMDMi143811412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 10321031Kinesin heavy chain isoform 5APRO_0000125353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei931 – 9311PhosphoserineBy similarity
Modified residuei949 – 9491PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ12840.
PaxDbiQ12840.
PRIDEiQ12840.

PTM databases

PhosphoSiteiQ12840.

Expressioni

Tissue specificityi

Distributed throughout the CNS but is highly enriched in subsets of neurons.

Gene expression databases

BgeeiQ12840.
CleanExiHS_KIF5A.
ExpressionAtlasiQ12840. baseline and differential.
GenevisibleiQ12840. HS.

Organism-specific databases

HPAiCAB015157.
HPA004469.

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD27Q96NW44EBI-713468,EBI-6125599
Trak2Q8R2H72EBI-713468,EBI-1396483From a different organism.

Protein-protein interaction databases

BioGridi109999. 23 interactions.
DIPiDIP-37584N.
IntActiQ12840. 17 interactions.
MINTiMINT-1370533.
STRINGi9606.ENSP00000408979.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UXTelectron microscopy7.40C1-340[»]
4UXYelectron microscopy6.50C1-340[»]
4UY0electron microscopy7.70C1-340[»]
ProteinModelPortaliQ12840.
SMRiQ12840. Positions 7-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 327319Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 315142Microtubule-bindingAdd
BLAST
Regioni907 – 1032126GlobularAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili331 – 906576Add
BLAST

Domaini

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOGENOMiHOG000216718.
HOVERGENiHBG006210.
InParanoidiQ12840.
KOiK10396.
OMAiEVQMESH.
OrthoDBiEOG7T4MJD.
PhylomeDBiQ12840.
TreeFamiTF105225.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETNNECSI KVLCRFRPLN QAEILRGDKF IPIFQGDDSV VIGGKPYVFD
60 70 80 90 100
RVFPPNTTQE QVYHACAMQI VKDVLAGYNG TIFAYGQTSS GKTHTMEGKL
110 120 130 140 150
HDPQLMGIIP RIARDIFNHI YSMDENLEFH IKVSYFEIYL DKIRDLLDVT
160 170 180 190 200
KTNLSVHEDK NRVPFVKGCT ERFVSSPEEI LDVIDEGKSN RHVAVTNMNE
210 220 230 240 250
HSSRSHSIFL INIKQENMET EQKLSGKLYL VDLAGSEKVS KTGAEGAVLD
260 270 280 290 300
EAKNINKSLS ALGNVISALA EGTKSYVPYR DSKMTRILQD SLGGNCRTTM
310 320 330 340 350
FICCSPSSYN DAETKSTLMF GQRAKTIKNT ASVNLELTAE QWKKKYEKEK
360 370 380 390 400
EKTKAQKETI AKLEAELSRW RNGENVPETE RLAGEEAALG AELCEETPVN
410 420 430 440 450
DNSSIVVRIA PEERQKYEEE IRRLYKQLDD KDDEINQQSQ LIEKLKQQML
460 470 480 490 500
DQEELLVSTR GDNEKVQREL SHLQSENDAA KDEVKEVLQA LEELAVNYDQ
510 520 530 540 550
KSQEVEEKSQ QNQLLVDELS QKVATMLSLE SELQRLQEVS GHQRKRIAEV
560 570 580 590 600
LNGLMKDLSE FSVIVGNGEI KLPVEISGAI EEEFTVARLY ISKIKSEVKS
610 620 630 640 650
VVKRCRQLEN LQVECHRKME VTGRELSSCQ LLISQHEAKI RSLTEYMQSV
660 670 680 690 700
ELKKRHLEES YDSLSDELAK LQAQETVHEV ALKDKEPDTQ DADEVKKALE
710 720 730 740 750
LQMESHREAH HRQLARLRDE INEKQKTIDE LKDLNQKLQL ELEKLQADYE
760 770 780 790 800
KLKSEEHEKS TKLQELTFLY ERHEQSKQDL KGLEETVARE LQTLHNLRKL
810 820 830 840 850
FVQDVTTRVK KSAEMEPEDS GGIHSQKQKI SFLENNLEQL TKVHKQLVRD
860 870 880 890 900
NADLRCELPK LEKRLRATAE RVKALEGALK EAKEGAMKDK RRYQQEVDRI
910 920 930 940 950
KEAVRYKSSG KRGHSAQIAK PVRPGHYPAS SPTNPYGTRS PECISYTNSL
960 970 980 990 1000
FQNYQNLYLQ ATPSSTSDMY FANSCTSSGA TSSGGPLASY QKANMDNGNA
1010 1020 1030
TDINDNRSDL PCGYEAEDQA KLFPLHQETA AS
Length:1,032
Mass (Da):117,378
Last modified:April 3, 2007 - v2
Checksum:iC4C6C12342040796
GO

Sequence cautioni

The sequence BAE06127.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti490 – 4901A → V in BAE06127 (Ref. 2) Curated
Sequence conflicti913 – 9131G → A in AAA20231 (PubMed:7514426).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631Y → C in SPG10; complicated form. 1 Publication
VAR_058741
Natural varianti198 – 1981M → T in SPG10; complicated form. 1 Publication
VAR_058742
Natural varianti203 – 2031S → C in SPG10. 1 Publication
VAR_066616
Natural varianti204 – 2041R → Q in SPG10; complicated form. 1 Publication
VAR_058743
Natural varianti251 – 2511E → K in SPG10; complicated form. 1 Publication
VAR_058744
Natural varianti253 – 2531K → N in SPG10; decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications
VAR_046744
Natural varianti256 – 2561N → S in SPG10; slightly decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications
VAR_032842
Natural varianti256 – 2561Missing in SPG10. 1 Publication
VAR_058745
Natural varianti257 – 2571K → N in SPG10; complicated form. 1 Publication
VAR_058746
Natural varianti276 – 2761Y → C in SPG10. 1 Publication
VAR_033108
Natural varianti280 – 2801R → C in SPG10. 2 Publications
VAR_032843
Natural varianti280 – 2801R → H in SPG10; complicated form. 1 Publication
VAR_058747
Natural varianti280 – 2801R → L in SPG10; pure form. 1 Publication
VAR_058748
Natural varianti361 – 3611A → V in SPG10; does not affect microtubule affinity; does not affect gliding velocity; does not affect microtubule-dependent ATP turnover. 2 Publications
Corresponds to variant rs121434444 [ dbSNP | Ensembl ].
VAR_032844

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06698 mRNA. Translation: AAA20231.1.
AB210045 mRNA. Translation: BAE06127.1. Different initiation.
CH471054 Genomic DNA. Translation: EAW97030.1.
BC146670 mRNA. Translation: AAI46671.1.
BC150208 mRNA. Translation: AAI50209.1.
CCDSiCCDS8945.1.
PIRiI38510.
RefSeqiNP_004975.2. NM_004984.2.
UniGeneiHs.151219.

Genome annotation databases

EnsembliENST00000455537; ENSP00000408979; ENSG00000155980.
GeneIDi3798.
KEGGihsa:3798.
UCSCiuc001sor.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06698 mRNA. Translation: AAA20231.1.
AB210045 mRNA. Translation: BAE06127.1. Different initiation.
CH471054 Genomic DNA. Translation: EAW97030.1.
BC146670 mRNA. Translation: AAI46671.1.
BC150208 mRNA. Translation: AAI50209.1.
CCDSiCCDS8945.1.
PIRiI38510.
RefSeqiNP_004975.2. NM_004984.2.
UniGeneiHs.151219.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UXTelectron microscopy7.40C1-340[»]
4UXYelectron microscopy6.50C1-340[»]
4UY0electron microscopy7.70C1-340[»]
ProteinModelPortaliQ12840.
SMRiQ12840. Positions 7-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109999. 23 interactions.
DIPiDIP-37584N.
IntActiQ12840. 17 interactions.
MINTiMINT-1370533.
STRINGi9606.ENSP00000408979.

Chemistry

BindingDBiQ12840.
ChEMBLiCHEMBL5295.

PTM databases

PhosphoSiteiQ12840.

Polymorphism and mutation databases

BioMutaiKIF5A.
DMDMi143811412.

Proteomic databases

MaxQBiQ12840.
PaxDbiQ12840.
PRIDEiQ12840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000455537; ENSP00000408979; ENSG00000155980.
GeneIDi3798.
KEGGihsa:3798.
UCSCiuc001sor.1. human.

Organism-specific databases

CTDi3798.
GeneCardsiGC12P057943.
H-InvDBHIX0036852.
HGNCiHGNC:6323. KIF5A.
HPAiCAB015157.
HPA004469.
MIMi602821. gene.
604187. phenotype.
neXtProtiNX_Q12840.
Orphaneti324611. Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation.
100991. Autosomal dominant spastic paraplegia type 10.
PharmGKBiPA30107.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOGENOMiHOG000216718.
HOVERGENiHBG006210.
InParanoidiQ12840.
KOiK10396.
OMAiEVQMESH.
OrthoDBiEOG7T4MJD.
PhylomeDBiQ12840.
TreeFamiTF105225.

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_15550. Insulin processing.
REACT_25201. Kinesins.
REACT_355321. RHO GTPases activate KTN1.
SignaLinkiQ12840.

Miscellaneous databases

ChiTaRSiKIF5A. human.
GeneWikiiKIF5A.
GenomeRNAii3798.
NextBioi14913.
PROiQ12840.
SOURCEiSearch...

Gene expression databases

BgeeiQ12840.
CleanExiHS_KIF5A.
ExpressionAtlasiQ12840. baseline and differential.
GenevisibleiQ12840. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and localization of a conventional kinesin motor expressed exclusively in neurons."
    Niclas J., Navone F., Hom-Booher N., Vale R.D.
    Neuron 12:1059-1072(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  2. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: VARIANT SPG10 SER-256.
  8. "Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia."
    Fichera M., Lo Giudice M., Falco M., Sturnio M., Amata S., Calabrese O., Bigoni S., Calzolari E., Neri M.
    Neurology 63:1108-1110(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPG10 CYS-280.
  9. "A missense mutation in the coiled-coil domain of the KIF5A gene and late-onset hereditary spastic paraplegia."
    Lo Giudice M., Neri M., Falco M., Sturnio M., Calzolari E., Di Benedetto D., Fichera M.
    Arch. Neurol. 63:284-287(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPG10 VAL-361.
  10. "Mutation in KIF5A can also cause adult-onset hereditary spastic paraplegia."
    Blair M.A., Ma S., Hedera P.
    Neurogenetics 7:47-50(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPG10 CYS-276.
  11. "Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity."
    Ebbing B., Mann K., Starosta A., Jaud J., Schoels L., Schuele R., Woehlke G.
    Hum. Mol. Genet. 17:1245-1252(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-253, CHARACTERIZATION OF VARIANT ASN-253, CHARACTERIZATION OF VARIANTS SPG10 SER-256 AND VAL-361, MUTAGENESIS OF ARG-280.
  12. Cited for: VARIANTS SPG10 ASN-253 AND ASN-256 DEL.
  13. "Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10."
    Goizet C., Boukhris A., Mundwiller E., Tallaksen C., Forlani S., Toutain A., Carriere N., Paquis V., Depienne C., Durr A., Stevanin G., Brice A.
    Hum. Mutat. 30:E376-E385(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SPG10 CYS-63; THR-198; GLN-204; LYS-251; ASN-257; CYS-280; LEU-280 AND HIS-280.
  14. "A novel mutation in KIF5A gene causing hereditary spastic paraplegia with axonal neuropathy."
    Musumeci O., Bassi M.T., Mazzeo A., Grandis M., Crimella C., Martinuzzi A., Toscano A.
    Neurol. Sci. 32:665-668(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPG10 CYS-203.

Entry informationi

Entry nameiKIF5A_HUMAN
AccessioniPrimary (citable) accession number: Q12840
Secondary accession number(s): A6H8M5, Q4LE26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2007
Last modified: June 24, 2015
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.