SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q12840

- KIF5A_HUMAN

UniProt

Q12840 - KIF5A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Kinesin heavy chain isoform 5A

Gene
KIF5A, NKHC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 938ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: InterPro
  3. motor activity Source: ProtInc
  4. protein binding Source: IntAct

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. blood coagulation Source: Reactome
  3. cell death Source: UniProtKB-KW
  4. metabolic process Source: GOC
  5. microtubule-based movement Source: Reactome
  6. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_15550. Insulin processing.
REACT_25201. Kinesins.
SignaLinkiQ12840.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin heavy chain isoform 5A
Alternative name(s):
Kinesin heavy chain neuron-specific 1
Neuronal kinesin heavy chain
Short name:
NKHC
Gene namesi
Name:KIF5A
Synonyms:NKHC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6323. KIF5A.

Subcellular locationi

Cytoplasmperinuclear region By similarity. Cytoplasmcytoskeleton By similarity
Note: Concentrated in the cell body of the neurons, particularly in the perinuclear region By similarity.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. kinesin complex Source: ProtInc
  3. membrane Source: ProtInc
  4. microtubule Source: UniProtKB-KW
  5. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Spastic paraplegia 10, autosomal dominant (SPG10) [MIM:604187]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Note: The disease is caused by mutations affecting the gene represented in this entry.8 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631Y → C in SPG10; complicated form. 1 Publication
VAR_058741
Natural varianti198 – 1981M → T in SPG10; complicated form. 1 Publication
VAR_058742
Natural varianti203 – 2031S → C in SPG10. 1 Publication
VAR_066616
Natural varianti204 – 2041R → Q in SPG10; complicated form. 1 Publication
VAR_058743
Natural varianti251 – 2511E → K in SPG10; complicated form. 1 Publication
VAR_058744
Natural varianti253 – 2531K → N in SPG10; decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications
VAR_046744
Natural varianti256 – 2561N → S in SPG10; slightly decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications
VAR_032842
Natural varianti256 – 2561Missing in SPG10. 1 Publication
VAR_058745
Natural varianti257 – 2571K → N in SPG10; complicated form. 1 Publication
VAR_058746
Natural varianti276 – 2761Y → C in SPG10. 1 Publication
VAR_033108
Natural varianti280 – 2801R → C in SPG10. 2 Publications
VAR_032843
Natural varianti280 – 2801R → H in SPG10; complicated form. 1 Publication
VAR_058747
Natural varianti280 – 2801R → L in SPG10; pure form. 1 Publication
VAR_058748
Natural varianti361 – 3611A → V in SPG10; does not affect microtubule affinity; does not affect gliding velocity; does not affect microtubule-dependent ATP turnover. 2 Publications
Corresponds to variant rs121434444 [ dbSNP | Ensembl ].
VAR_032844

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi280 – 2801R → S: Strongly reduces microtubule affinity; slightly reduces gliding velocity. 1 Publication

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

MIMi604187. phenotype.
Orphaneti324611. Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation.
100991. Autosomal dominant spastic paraplegia type 10.
PharmGKBiPA30107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 10321031Kinesin heavy chain isoform 5APRO_0000125353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ12840.
PaxDbiQ12840.
PRIDEiQ12840.

PTM databases

PhosphoSiteiQ12840.

Expressioni

Tissue specificityi

Distributed throughout the CNS but is highly enriched in subsets of neurons.

Gene expression databases

ArrayExpressiQ12840.
BgeeiQ12840.
CleanExiHS_KIF5A.
GenevestigatoriQ12840.

Organism-specific databases

HPAiCAB015157.
HPA004469.

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD27Q96NW44EBI-713468,EBI-6125599
Trak2Q8R2H72EBI-713468,EBI-1396483From a different organism.

Protein-protein interaction databases

BioGridi109999. 18 interactions.
DIPiDIP-37584N.
IntActiQ12840. 15 interactions.
MINTiMINT-1370533.
STRINGi9606.ENSP00000286452.

Structurei

3D structure databases

ProteinModelPortaliQ12840.
SMRiQ12840. Positions 7-339.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 327319Kinesin motorAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 315142Microtubule-bindingAdd
BLAST
Regioni907 – 1032126GlobularAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili331 – 906576Add
BLAST

Domaini

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
HOGENOMiHOG000216718.
HOVERGENiHBG006210.
InParanoidiQ12840.
KOiK10396.
OMAiEVQMESH.
OrthoDBiEOG7T4MJD.
PhylomeDBiQ12840.
TreeFamiTF105225.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12840-1 [UniParc]FASTAAdd to Basket

« Hide

MAETNNECSI KVLCRFRPLN QAEILRGDKF IPIFQGDDSV VIGGKPYVFD     50
RVFPPNTTQE QVYHACAMQI VKDVLAGYNG TIFAYGQTSS GKTHTMEGKL 100
HDPQLMGIIP RIARDIFNHI YSMDENLEFH IKVSYFEIYL DKIRDLLDVT 150
KTNLSVHEDK NRVPFVKGCT ERFVSSPEEI LDVIDEGKSN RHVAVTNMNE 200
HSSRSHSIFL INIKQENMET EQKLSGKLYL VDLAGSEKVS KTGAEGAVLD 250
EAKNINKSLS ALGNVISALA EGTKSYVPYR DSKMTRILQD SLGGNCRTTM 300
FICCSPSSYN DAETKSTLMF GQRAKTIKNT ASVNLELTAE QWKKKYEKEK 350
EKTKAQKETI AKLEAELSRW RNGENVPETE RLAGEEAALG AELCEETPVN 400
DNSSIVVRIA PEERQKYEEE IRRLYKQLDD KDDEINQQSQ LIEKLKQQML 450
DQEELLVSTR GDNEKVQREL SHLQSENDAA KDEVKEVLQA LEELAVNYDQ 500
KSQEVEEKSQ QNQLLVDELS QKVATMLSLE SELQRLQEVS GHQRKRIAEV 550
LNGLMKDLSE FSVIVGNGEI KLPVEISGAI EEEFTVARLY ISKIKSEVKS 600
VVKRCRQLEN LQVECHRKME VTGRELSSCQ LLISQHEAKI RSLTEYMQSV 650
ELKKRHLEES YDSLSDELAK LQAQETVHEV ALKDKEPDTQ DADEVKKALE 700
LQMESHREAH HRQLARLRDE INEKQKTIDE LKDLNQKLQL ELEKLQADYE 750
KLKSEEHEKS TKLQELTFLY ERHEQSKQDL KGLEETVARE LQTLHNLRKL 800
FVQDVTTRVK KSAEMEPEDS GGIHSQKQKI SFLENNLEQL TKVHKQLVRD 850
NADLRCELPK LEKRLRATAE RVKALEGALK EAKEGAMKDK RRYQQEVDRI 900
KEAVRYKSSG KRGHSAQIAK PVRPGHYPAS SPTNPYGTRS PECISYTNSL 950
FQNYQNLYLQ ATPSSTSDMY FANSCTSSGA TSSGGPLASY QKANMDNGNA 1000
TDINDNRSDL PCGYEAEDQA KLFPLHQETA AS 1032
Length:1,032
Mass (Da):117,378
Last modified:April 3, 2007 - v2
Checksum:iC4C6C12342040796
GO

Sequence cautioni

The sequence BAE06127.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631Y → C in SPG10; complicated form. 1 Publication
VAR_058741
Natural varianti198 – 1981M → T in SPG10; complicated form. 1 Publication
VAR_058742
Natural varianti203 – 2031S → C in SPG10. 1 Publication
VAR_066616
Natural varianti204 – 2041R → Q in SPG10; complicated form. 1 Publication
VAR_058743
Natural varianti251 – 2511E → K in SPG10; complicated form. 1 Publication
VAR_058744
Natural varianti253 – 2531K → N in SPG10; decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications
VAR_046744
Natural varianti256 – 2561N → S in SPG10; slightly decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications
VAR_032842
Natural varianti256 – 2561Missing in SPG10. 1 Publication
VAR_058745
Natural varianti257 – 2571K → N in SPG10; complicated form. 1 Publication
VAR_058746
Natural varianti276 – 2761Y → C in SPG10. 1 Publication
VAR_033108
Natural varianti280 – 2801R → C in SPG10. 2 Publications
VAR_032843
Natural varianti280 – 2801R → H in SPG10; complicated form. 1 Publication
VAR_058747
Natural varianti280 – 2801R → L in SPG10; pure form. 1 Publication
VAR_058748
Natural varianti361 – 3611A → V in SPG10; does not affect microtubule affinity; does not affect gliding velocity; does not affect microtubule-dependent ATP turnover. 2 Publications
Corresponds to variant rs121434444 [ dbSNP | Ensembl ].
VAR_032844

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti490 – 4901A → V in BAE06127. 1 Publication
Sequence conflicti913 – 9131G → A in AAA20231. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06698 mRNA. Translation: AAA20231.1.
AB210045 mRNA. Translation: BAE06127.1. Different initiation.
CH471054 Genomic DNA. Translation: EAW97030.1.
BC146670 mRNA. Translation: AAI46671.1.
BC150208 mRNA. Translation: AAI50209.1.
CCDSiCCDS8945.1.
PIRiI38510.
RefSeqiNP_004975.2. NM_004984.2.
UniGeneiHs.151219.

Genome annotation databases

EnsembliENST00000455537; ENSP00000408979; ENSG00000155980.
GeneIDi3798.
KEGGihsa:3798.
UCSCiuc001sor.1. human.

Polymorphism databases

DMDMi143811412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06698 mRNA. Translation: AAA20231.1 .
AB210045 mRNA. Translation: BAE06127.1 . Different initiation.
CH471054 Genomic DNA. Translation: EAW97030.1 .
BC146670 mRNA. Translation: AAI46671.1 .
BC150208 mRNA. Translation: AAI50209.1 .
CCDSi CCDS8945.1.
PIRi I38510.
RefSeqi NP_004975.2. NM_004984.2.
UniGenei Hs.151219.

3D structure databases

ProteinModelPortali Q12840.
SMRi Q12840. Positions 7-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109999. 18 interactions.
DIPi DIP-37584N.
IntActi Q12840. 15 interactions.
MINTi MINT-1370533.
STRINGi 9606.ENSP00000286452.

Chemistry

BindingDBi Q12840.
ChEMBLi CHEMBL5295.

PTM databases

PhosphoSitei Q12840.

Polymorphism databases

DMDMi 143811412.

Proteomic databases

MaxQBi Q12840.
PaxDbi Q12840.
PRIDEi Q12840.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000455537 ; ENSP00000408979 ; ENSG00000155980 .
GeneIDi 3798.
KEGGi hsa:3798.
UCSCi uc001sor.1. human.

Organism-specific databases

CTDi 3798.
GeneCardsi GC12P057943.
H-InvDB HIX0036852.
HGNCi HGNC:6323. KIF5A.
HPAi CAB015157.
HPA004469.
MIMi 602821. gene.
604187. phenotype.
neXtProti NX_Q12840.
Orphaneti 324611. Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation.
100991. Autosomal dominant spastic paraplegia type 10.
PharmGKBi PA30107.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
HOGENOMi HOG000216718.
HOVERGENi HBG006210.
InParanoidi Q12840.
KOi K10396.
OMAi EVQMESH.
OrthoDBi EOG7T4MJD.
PhylomeDBi Q12840.
TreeFami TF105225.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_15550. Insulin processing.
REACT_25201. Kinesins.
SignaLinki Q12840.

Miscellaneous databases

ChiTaRSi KIF5A. human.
GeneWikii KIF5A.
GenomeRNAii 3798.
NextBioi 14913.
PROi Q12840.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q12840.
Bgeei Q12840.
CleanExi HS_KIF5A.
Genevestigatori Q12840.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and localization of a conventional kinesin motor expressed exclusively in neurons."
    Niclas J., Navone F., Hom-Booher N., Vale R.D.
    Neuron 12:1059-1072(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  2. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: VARIANT SPG10 SER-256.
  8. "Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia."
    Fichera M., Lo Giudice M., Falco M., Sturnio M., Amata S., Calabrese O., Bigoni S., Calzolari E., Neri M.
    Neurology 63:1108-1110(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPG10 CYS-280.
  9. "A missense mutation in the coiled-coil domain of the KIF5A gene and late-onset hereditary spastic paraplegia."
    Lo Giudice M., Neri M., Falco M., Sturnio M., Calzolari E., Di Benedetto D., Fichera M.
    Arch. Neurol. 63:284-287(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPG10 VAL-361.
  10. "Mutation in KIF5A can also cause adult-onset hereditary spastic paraplegia."
    Blair M.A., Ma S., Hedera P.
    Neurogenetics 7:47-50(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPG10 CYS-276.
  11. "Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity."
    Ebbing B., Mann K., Starosta A., Jaud J., Schoels L., Schuele R., Woehlke G.
    Hum. Mol. Genet. 17:1245-1252(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-253, CHARACTERIZATION OF VARIANT ASN-253, CHARACTERIZATION OF VARIANTS SPG10 SER-256 AND VAL-361, MUTAGENESIS OF ARG-280.
  12. Cited for: VARIANTS SPG10 ASN-253 AND ASN-256 DEL.
  13. "Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10."
    Goizet C., Boukhris A., Mundwiller E., Tallaksen C., Forlani S., Toutain A., Carriere N., Paquis V., Depienne C., Durr A., Stevanin G., Brice A.
    Hum. Mutat. 30:E376-E385(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SPG10 CYS-63; THR-198; GLN-204; LYS-251; ASN-257; CYS-280; LEU-280 AND HIS-280.
  14. "A novel mutation in KIF5A gene causing hereditary spastic paraplegia with axonal neuropathy."
    Musumeci O., Bassi M.T., Mazzeo A., Grandis M., Crimella C., Martinuzzi A., Toscano A.
    Neurol. Sci. 32:665-668(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPG10 CYS-203.

Entry informationi

Entry nameiKIF5A_HUMAN
AccessioniPrimary (citable) accession number: Q12840
Secondary accession number(s): A6H8M5, Q4LE26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi