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Protein

POU domain, class 4, transcription factor 2

Gene

POU4F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi345 – 404HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151615-MONOMER.
ReactomeiR-HSA-6804759. Regulation of TP53 Activity through Association with Co-factors.
SignaLinkiQ12837.
SIGNORiQ12837.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 4, transcription factor 2
Alternative name(s):
Brain-specific homeobox/POU domain protein 3B
Short name:
Brain-3B
Short name:
Brn-3B
Gene namesi
Name:POU4F2
Synonyms:BRN3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:9219. POU4F2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi171 – 185Missing : Absent from nuclear speckle; no change in transcriptional activity. 1 PublicationAdd BLAST15

Organism-specific databases

DisGeNETi5458.
OpenTargetsiENSG00000151615.
PharmGKBiPA33543.

Polymorphism and mutation databases

BioMutaiPOU4F2.
DMDMi290457652.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007401 – 409POU domain, class 4, transcription factor 2Add BLAST409

Proteomic databases

PaxDbiQ12837.
PeptideAtlasiQ12837.
PRIDEiQ12837.

PTM databases

iPTMnetiQ12837.
PhosphoSitePlusiQ12837.

Expressioni

Tissue specificityi

Brain. Seems to be specific to the retina.

Gene expression databases

BgeeiENSG00000151615.
CleanExiHS_POU4F2.
GenevisibleiQ12837. HS.

Organism-specific databases

HPAiCAB001983.

Interactioni

Protein-protein interaction databases

BioGridi111454. 1 interactor.
STRINGi9606.ENSP00000281321.

Structurei

3D structure databases

ProteinModelPortaliQ12837.
SMRiQ12837.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 327POU-specificPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi110 – 119POU-IV box10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 4Poly-Met4
Compositional biasi43 – 51Poly-Ser9
Compositional biasi54 – 68Poly-GlyAdd BLAST15
Compositional biasi70 – 79Poly-Ser10
Compositional biasi80 – 83Poly-Gly4
Compositional biasi126 – 129Poly-His4
Compositional biasi155 – 158Poly-Ser4
Compositional biasi171 – 182Poly-HisAdd BLAST12

Domaini

The polyhistidine repeat acts as a targeting signal to nuclear speckles.1 Publication

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG1168. Eukaryota.
ENOG410XPNX. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ12837.
KOiK09366.
OMAiTHAPHMA.
OrthoDBiEOG091G0WBK.
PhylomeDBiQ12837.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMMSLNSKQ AFSMPHGGSL HVEPKYSALH STSPGSSAPI APSASSPSSS
60 70 80 90 100
SNAGGGGGGG GGGGGGGGRS SSSSSSGSSG GGGSEAMRRA CLPTPPSNIF
110 120 130 140 150
GGLDESLLAR AEALAAVDIV SQSKSHHHHP PHHSPFKPDA TYHTMNTIPC
160 170 180 190 200
TSAASSSSVP ISHPSALAGT HHHHHHHHHH HHQPHQALEG ELLEHLSPGL
210 220 230 240 250
ALGAMAGPDG AVVSTPAHAP HMATMNPMHQ AALSMAHAHG LPSHMGCMSD
260 270 280 290 300
VDADPRDLEA FAERFKQRRI KLGVTQADVG SALANLKIPG VGSLSQSTIC
310 320 330 340 350
RFESLTLSHN NMIALKPILQ AWLEEAEKSH REKLTKPELF NGAEKKRKRT
360 370 380 390 400
SIAAPEKRSL EAYFAIQPRP SSEKIAAIAE KLDLKKNVVR VWFCNQRQKQ

KRMKYSAGI
Length:409
Mass (Da):43,087
Last modified:March 2, 2010 - v2
Checksum:i42E2C174674E8DFC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54G → GG in AAA16509 (PubMed:7691107).Curated1
Sequence conflicti54G → GG in BAG37481 (PubMed:14702039).Curated1
Sequence conflicti54G → GG in AAI36345 (PubMed:14702039).Curated1
Sequence conflicti54G → GG in AAI36346 (PubMed:14702039).Curated1
Sequence conflicti165S → C in AAA16509 (PubMed:7691107).Curated1
Sequence conflicti182Missing in CAA50589 (PubMed:8332509).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05932140I → T.Corresponds to variant rs13152799dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06233 mRNA. Translation: AAA16509.1.
AK314982 mRNA. Translation: BAG37481.1.
AC093887 Genomic DNA. No translation available.
BC136344 mRNA. Translation: AAI36345.1.
BC136345 mRNA. Translation: AAI36346.1.
EU439706 mRNA. Translation: ACA49233.1.
X71488 mRNA. Translation: CAA50589.1.
L20434 mRNA. Translation: AAA36393.1.
CCDSiCCDS34074.1.
PIRiI38502.
RefSeqiNP_004566.2. NM_004575.2.
UniGeneiHs.266.

Genome annotation databases

EnsembliENST00000281321; ENSP00000281321; ENSG00000151615.
GeneIDi5458.
KEGGihsa:5458.
UCSCiuc003ikv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06233 mRNA. Translation: AAA16509.1.
AK314982 mRNA. Translation: BAG37481.1.
AC093887 Genomic DNA. No translation available.
BC136344 mRNA. Translation: AAI36345.1.
BC136345 mRNA. Translation: AAI36346.1.
EU439706 mRNA. Translation: ACA49233.1.
X71488 mRNA. Translation: CAA50589.1.
L20434 mRNA. Translation: AAA36393.1.
CCDSiCCDS34074.1.
PIRiI38502.
RefSeqiNP_004566.2. NM_004575.2.
UniGeneiHs.266.

3D structure databases

ProteinModelPortaliQ12837.
SMRiQ12837.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111454. 1 interactor.
STRINGi9606.ENSP00000281321.

PTM databases

iPTMnetiQ12837.
PhosphoSitePlusiQ12837.

Polymorphism and mutation databases

BioMutaiPOU4F2.
DMDMi290457652.

Proteomic databases

PaxDbiQ12837.
PeptideAtlasiQ12837.
PRIDEiQ12837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281321; ENSP00000281321; ENSG00000151615.
GeneIDi5458.
KEGGihsa:5458.
UCSCiuc003ikv.4. human.

Organism-specific databases

CTDi5458.
DisGeNETi5458.
GeneCardsiPOU4F2.
H-InvDBHIX0031516.
HGNCiHGNC:9219. POU4F2.
HPAiCAB001983.
MIMi113725. gene.
neXtProtiNX_Q12837.
OpenTargetsiENSG00000151615.
PharmGKBiPA33543.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1168. Eukaryota.
ENOG410XPNX. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG031829.
InParanoidiQ12837.
KOiK09366.
OMAiTHAPHMA.
OrthoDBiEOG091G0WBK.
PhylomeDBiQ12837.
TreeFamiTF316413.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151615-MONOMER.
ReactomeiR-HSA-6804759. Regulation of TP53 Activity through Association with Co-factors.
SignaLinkiQ12837.
SIGNORiQ12837.

Miscellaneous databases

GeneWikiiPOU4F2.
GenomeRNAii5458.
PROiQ12837.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151615.
CleanExiHS_POU4F2.
GenevisibleiQ12837. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPO4F2_HUMAN
AccessioniPrimary (citable) accession number: Q12837
Secondary accession number(s): B1PJR6
, B2RC84, Q13883, Q14987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.