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Protein

Ras-related protein Rab-40B

Gene

RAB40B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPBy similarity8
Nucleotide bindingi69 – 73GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719. RAB geranylgeranylation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-40B
Alternative name(s):
SOCS box-containing protein RAR
Short name:
Protein Rar
Gene namesi
Name:RAB40B
Synonyms:SEC4L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18284. RAB40B.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: GO_Central
  • nuclear envelope Source: ParkinsonsUK-UCL
  • perinuclear region of cytoplasm Source: ParkinsonsUK-UCL
  • plasma membrane Source: GO_Central
  • synaptic vesicle Source: GO_Central

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10966.
OpenTargetsiENSG00000141542.
PharmGKBiPA34138.

Polymorphism and mutation databases

BioMutaiRAB40B.
DMDMi27734453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212591 – 278Ras-related protein Rab-40BAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi270S-palmitoyl cysteineSequence analysis1
Lipidationi275S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Prenylation

Proteomic databases

EPDiQ12829.
PaxDbiQ12829.
PeptideAtlasiQ12829.
PRIDEiQ12829.

PTM databases

iPTMnetiQ12829.
PhosphoSitePlusiQ12829.

Expressioni

Gene expression databases

BgeeiENSG00000141542.
CleanExiHS_RAB40B.
ExpressionAtlasiQ12829. baseline and differential.
GenevisibleiQ12829. HS.

Interactioni

Protein-protein interaction databases

BioGridi116165. 14 interactors.
IntActiQ12829. 2 interactors.
STRINGi9606.ENSP00000461785.

Structurei

3D structure databases

ProteinModelPortaliQ12829.
SMRiQ12829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 228SOCS boxPROSITE-ProRule annotationAdd BLAST54

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
GeneTreeiENSGT00870000136378.
HOVERGENiHBG009351.
InParanoidiQ12829.
KOiK07928.
OMAiLWRPNKV.
OrthoDBiEOG091G0DGV.
PhylomeDBiQ12829.
TreeFamiTF323230.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR001496. SOCS_box.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PF07525. SOCS_box. 1 hit.
SMARTiView protein in SMART
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.
PS50225. SOCS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALGSPVRA YDFLLKFLLV GDSDVGKGEI LASLQDGAAE SPYGHPAGID
60 70 80 90 100
YKTTTILLDG RRVKLQLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW
110 120 130 140 150
SFDGIDRWIK EIDEHAPGVP KILVGNRLHL AFKRQVPTEQ AQAYAERLGV
160 170 180 190 200
TFFEVSPLCN FNITESFTEL ARIVLLRHGM DRLWRPSKVL SLQDLCCRAV
210 220 230 240 250
VSCTPVHLVD KLPLPIALRS HLKSFSMANG LNARMMHGGS YSLTTSSTHK
260 270
RSSLRKVKLV RPPQSPPKNC TRNSCKIS
Length:278
Mass (Da):30,956
Last modified:November 1, 1996 - v1
Checksum:i8AC3CD180C0CCA2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42P → T in AAH18039 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05227 mRNA. Translation: AAA17031.1.
BC018039 mRNA. Translation: AAH18039.1.
CCDSiCCDS11816.1.
PIRiG01251.
RefSeqiNP_006813.1. NM_006822.2.
UniGeneiHs.484068.

Genome annotation databases

EnsembliENST00000571995; ENSP00000461785; ENSG00000141542.
GeneIDi10966.
KEGGihsa:10966.
UCSCiuc002kft.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05227 mRNA. Translation: AAA17031.1.
BC018039 mRNA. Translation: AAH18039.1.
CCDSiCCDS11816.1.
PIRiG01251.
RefSeqiNP_006813.1. NM_006822.2.
UniGeneiHs.484068.

3D structure databases

ProteinModelPortaliQ12829.
SMRiQ12829.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116165. 14 interactors.
IntActiQ12829. 2 interactors.
STRINGi9606.ENSP00000461785.

PTM databases

iPTMnetiQ12829.
PhosphoSitePlusiQ12829.

Polymorphism and mutation databases

BioMutaiRAB40B.
DMDMi27734453.

Proteomic databases

EPDiQ12829.
PaxDbiQ12829.
PeptideAtlasiQ12829.
PRIDEiQ12829.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000571995; ENSP00000461785; ENSG00000141542.
GeneIDi10966.
KEGGihsa:10966.
UCSCiuc002kft.4. human.

Organism-specific databases

CTDi10966.
DisGeNETi10966.
GeneCardsiRAB40B.
HGNCiHGNC:18284. RAB40B.
neXtProtiNX_Q12829.
OpenTargetsiENSG00000141542.
PharmGKBiPA34138.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
GeneTreeiENSGT00870000136378.
HOVERGENiHBG009351.
InParanoidiQ12829.
KOiK07928.
OMAiLWRPNKV.
OrthoDBiEOG091G0DGV.
PhylomeDBiQ12829.
TreeFamiTF323230.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-8873719. RAB geranylgeranylation.

Miscellaneous databases

ChiTaRSiRAB40B. human.
GenomeRNAii10966.
PROiPR:Q12829.

Gene expression databases

BgeeiENSG00000141542.
CleanExiHS_RAB40B.
ExpressionAtlasiQ12829. baseline and differential.
GenevisibleiQ12829. HS.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR001496. SOCS_box.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PF07525. SOCS_box. 1 hit.
SMARTiView protein in SMART
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.
PS50225. SOCS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRB40B_HUMAN
AccessioniPrimary (citable) accession number: Q12829
Secondary accession number(s): Q8WVG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1996
Last modified: April 12, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.