Q12829 (RB40B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-40B

Alternative name(s):
SOCS box-containing protein RAR
Short name=Protein Rar

Gene names

Name:	RAB40B
Synonyms:	SEC4L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Palmitate Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Ras-related protein Rab-40B		PRO_0000121259
Regions
	Domain	175 – 228	54	SOCS box
	Nucleotide binding	21 – 28	8	GTP By similarity
	Nucleotide binding	69 – 73	5	GTP By similarity
	Nucleotide binding	126 – 129	4	GTP By similarity
Amino acid modifications
	Lipidation	270	1	S-palmitoyl cysteine Potential
	Lipidation	275	1	S-geranylgeranyl cysteine By similarity
Experimental info
	Sequence conflict	42	1	P → T in AAH18039. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q12829 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8AC3CD180C0CCA2C	FASTA	278	30,956
	10 20 30 40 50 60 MSALGSPVRA YDFLLKFLLV GDSDVGKGEI LASLQDGAAE SPYGHPAGID YKTTTILLDG 70 80 90 100 110 120 RRVKLQLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFDGIDRWIK EIDEHAPGVP 130 140 150 160 170 180 KILVGNRLHL AFKRQVPTEQ AQAYAERLGV TFFEVSPLCN FNITESFTEL ARIVLLRHGM 190 200 210 220 230 240 DRLWRPSKVL SLQDLCCRAV VSCTPVHLVD KLPLPIALRS HLKSFSMANG LNARMMHGGS 250 260 270 YSLTTSSTHK RSSLRKVKLV RPPQSPPKNC TRNSCKIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a human hippocampus cDNA clone encoding a novel SEC-4 like protein." Peng H., Lee J., Chang H. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U05227 mRNA. Translation: AAA17031.1. BC018039 mRNA. Translation: AAH18039.1.
IPI	IPI00009953.
PIR	G01251.
RefSeq	NP_006813.1. NM_006822.2.
UniGene	Hs.484068.
3D structure databases
ProteinModelPortal	Q12829.
SMR	Q12829. Positions 12-178.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q12829. 2 interactions.
STRING	Q12829.
PTM databases
PhosphoSite	Q12829.
Polymorphism databases
DMDM	27734453.
Proteomic databases
PRIDE	Q12829.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269347; ENSP00000269347; ENSG00000141542.
GeneID	10966.
KEGG	hsa:10966.
UCSC	uc002kft.1. human.
Organism-specific databases
CTD	10966.
GeneCards	GC17M080614.
HGNC	HGNC:18284. RAB40B.
neXtProt	NX_Q12829.
PharmGKB	PA34138.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17227.
HOVERGEN	HBG009351.
InParanoid	Q12829.
OMA	PYGHPAG.
OrthoDB	EOG45QHDR.
PhylomeDB	Q12829.
Gene expression databases
ArrayExpress	Q12829.
Bgee	Q12829.
CleanEx	HS_RAB40B.
Genevestigator	Q12829.
GermOnline	ENSG00000141542. Homo sapiens.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. IPR001496. SOCS_C. [Graphical view]
KO	K07928.
Pfam	PF00071. Ras. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. SM00253. SOCS. 1 hit. SM00969. SOCS_box. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	41674.

Entry information

Entry name

RB40B_HUMAN

Accession

Primary (citable) accession number: Q12829
Secondary accession number(s): Q8WVG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.