Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-40B

Gene

RAB40B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPBy similarity8
Nucleotide bindingi69 – 73GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • multi-organism toxin transport Source: ParkinsonsUK-UCL
  • protein localization to plasma membrane Source: GO_Central
  • protein ubiquitination Source: UniProtKB-UniPathway

Keywordsi

Biological processUbl conjugation pathway
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-40B
Alternative name(s):
SOCS box-containing protein RAR
Short name:
Protein Rar
Gene namesi
Name:RAB40B
Synonyms:SEC4L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141542.10
HGNCiHGNC:18284 RAB40B
neXtProtiNX_Q12829

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10966
OpenTargetsiENSG00000141542
PharmGKBiPA34138

Polymorphism and mutation databases

BioMutaiRAB40B
DMDMi27734453

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212591 – 278Ras-related protein Rab-40BAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi270S-palmitoyl cysteineSequence analysis1
Lipidationi275S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Prenylation

Proteomic databases

EPDiQ12829
PaxDbiQ12829
PeptideAtlasiQ12829
PRIDEiQ12829

PTM databases

iPTMnetiQ12829
PhosphoSitePlusiQ12829

Expressioni

Gene expression databases

BgeeiENSG00000141542
CleanExiHS_RAB40B
ExpressionAtlasiQ12829 baseline and differential
GenevisibleiQ12829 HS

Interactioni

Protein-protein interaction databases

BioGridi116165, 15 interactors
IntActiQ12829, 2 interactors
STRINGi9606.ENSP00000461785

Structurei

3D structure databases

ProteinModelPortaliQ12829
SMRiQ12829
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 228SOCS boxPROSITE-ProRule annotationAdd BLAST54

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0078 Eukaryota
ENOG410XPUI LUCA
GeneTreeiENSGT00900000140786
HOVERGENiHBG009351
InParanoidiQ12829
KOiK07928
OMAiDGINRWI
OrthoDBiEOG091G0DGV
PhylomeDBiQ12829
TreeFamiTF323230

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q12829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALGSPVRA YDFLLKFLLV GDSDVGKGEI LASLQDGAAE SPYGHPAGID
60 70 80 90 100
YKTTTILLDG RRVKLQLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW
110 120 130 140 150
SFDGIDRWIK EIDEHAPGVP KILVGNRLHL AFKRQVPTEQ AQAYAERLGV
160 170 180 190 200
TFFEVSPLCN FNITESFTEL ARIVLLRHGM DRLWRPSKVL SLQDLCCRAV
210 220 230 240 250
VSCTPVHLVD KLPLPIALRS HLKSFSMANG LNARMMHGGS YSLTTSSTHK
260 270
RSSLRKVKLV RPPQSPPKNC TRNSCKIS
Length:278
Mass (Da):30,956
Last modified:November 1, 1996 - v1
Checksum:i8AC3CD180C0CCA2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42P → T in AAH18039 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05227 mRNA Translation: AAA17031.1
BC018039 mRNA Translation: AAH18039.1
CCDSiCCDS11816.1
PIRiG01251
RefSeqiNP_006813.1, NM_006822.2
UniGeneiHs.484068

Genome annotation databases

EnsembliENST00000571995; ENSP00000461785; ENSG00000141542
GeneIDi10966
KEGGihsa:10966
UCSCiuc002kft.4 human

Similar proteinsi

Entry informationi

Entry nameiRB40B_HUMAN
AccessioniPrimary (citable) accession number: Q12829
Secondary accession number(s): Q8WVG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health