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UniProtKB - Q12816 (TROP_HUMAN)

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Protein

Trophinin

Gene

TRO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.

GO - Biological processi

  • embryo implantation Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
  • negative regulation of cell growth Source: Ensembl
Complete GO annotation...

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Trophinin
Alternative name(s):
MAGE-D3 antigen
Gene namesi
Name:TRO
Synonyms:KIAA1114, MAGED3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12326. TRO.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • nucleus Source: Ensembl
  • plasma membrane Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7216.
OpenTargetsiENSG00000067445.
PharmGKBiPA37002.

Polymorphism and mutation databases

DMDMi152031714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567421 – 1431TrophininAdd BLAST1431

Proteomic databases

EPDiQ12816.
MaxQBiQ12816.
PaxDbiQ12816.
PeptideAtlasiQ12816.
PRIDEiQ12816.

PTM databases

iPTMnetiQ12816.
PhosphoSitePlusiQ12816.

Expressioni

Tissue specificityi

Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi. Also found in macrophages.

Gene expression databases

BgeeiENSG00000067445.
CleanExiHS_TRO.
ExpressionAtlasiQ12816. baseline and differential.
GenevisibleiQ12816. HS.

Organism-specific databases

HPAiCAB033947.
HPA053358.

Interactioni

Subunit structurei

Directly binds bystin, and indirectly tastin.

Binary interactionsi

WithEntry#Exp.IntActNotes
BYSLQ138954EBI-950001,EBI-358049

Protein-protein interaction databases

BioGridi113067. 24 interactors.
IntActiQ12816. 9 interactors.
MINTiMINT-2805982.
STRINGi9606.ENSP00000173898.

Structurei

3D structure databases

ProteinModelPortaliQ12816.
SMRiQ12816.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini444 – 642MAGEPROSITE-ProRule annotationAdd BLAST199
Repeati751 – 760110
Repeati769 – 778210
Repeati779 – 7863; approximate8
Repeati787 – 796410
Repeati805 – 814510
Repeati823 – 8336; approximateAdd BLAST11
Repeati841 – 850710
Repeati859 – 8708; approximateAdd BLAST12
Repeati879 – 8909; approximateAdd BLAST12
Repeati901 – 9101010
Repeati911 – 9201110
Repeati921 – 9301210
Repeati931 – 9401310
Repeati941 – 9501410
Repeati951 – 96015; approximate10
Repeati961 – 9701610
Repeati971 – 9801710
Repeati981 – 9901810
Repeati991 – 10001910
Repeati1001 – 10102010
Repeati1011 – 10202110
Repeati1021 – 103022; approximate10
Repeati1031 – 10402310
Repeati1041 – 10502410
Repeati1051 – 10602510
Repeati1061 – 10702610
Repeati1071 – 108027; approximate10
Repeati1081 – 109028; approximate10
Repeati1091 – 11002910
Repeati1101 – 11103010
Repeati1111 – 11203110
Repeati1121 – 11303210
Repeati1131 – 11403310
Repeati1141 – 11503410
Repeati1151 – 11603510
Repeati1161 – 11703610
Repeati1171 – 118037; approximate10
Repeati1181 – 119038; approximate10
Repeati1191 – 12003910
Repeati1201 – 12104010
Repeati1211 – 12204110
Repeati1221 – 123042; approximate10
Repeati1231 – 124043; approximate10
Repeati1241 – 12504410
Repeati1251 – 12604510
Repeati1261 – 127046; approximate10
Repeati1271 – 12804710
Repeati1281 – 12904810
Repeati1291 – 13004910
Repeati1301 – 131050; approximate10
Repeati1311 – 13205110
Repeati1321 – 133052; approximate10
Repeati1331 – 134053; approximate10
Repeati1341 – 135054; approximate10
Repeati1351 – 136055; approximate10
Repeati1361 – 137056; approximate10
Repeati1371 – 138057; approximate10
Repeati1381 – 139058; approximate10
Repeati1391 – 140059; approximate10
Repeati1401 – 141060; approximate10
Repeati1411 – 142061; approximate10
Repeati1421 – 143062; approximate10

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni751 – 143062 X 10 AA approximate tandem repeatsAdd BLAST680

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000049038.
HOVERGENiHBG003714.
InParanoidiQ12816.
OMAiNNELIEC.
OrthoDBiEOG091G09D3.
PhylomeDBiQ12816.
TreeFamiTF352132.

Family and domain databases

InterProiView protein in InterPro
IPR002190. MHD_dom.
PfamiView protein in Pfam
PF01454. MAGE. 1 hit.
SMARTiView protein in SMART
SM01373. MAGE. 1 hit.
PROSITEiView protein in PROSITE
PS50838. MAGE. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12816-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRRNDYGYR VPLFQGPLPP PGSLGLPFPP DIQTETTEED SVLLMHTLLA 
        60         70         80         90        100
ATKDSLAMDP PVVNRPKKSK TKKAPIKTIT KAAPAAPPVP AANEIATNKP 
       110        120        130        140        150
KITWQALNLP VITQISQALP TTEVTNTQAS SVTAQPKKAN KMKRVTAKAA 
       160        170        180        190        200
QGSQSPTGHE GGTIQLKSPL QVLKLPVISQ NIHAPIANES ASSQALITSI 
       210        220        230        240        250
KPKKASKAKK AANKAIASAT EVSLAATATH TATTQGQITN ETASIHTTAA 
       260        270        280        290        300
SIRTKKASKA RKTIAKVINT DTEHIEALNV TDAATRQIEA SVVAIRPKKS 
       310        320        330        340        350
KGKKAASRGP NSVSEISEAP LATQIVTNQA LAATLRVKRG SRARKAATKA 
       360        370        380        390        400
RATESQTPNA DQGAQAKIAS AQTNVSALET QVAAAVQALA DDYLAQLSLE 
       410        420        430        440        450
PTTRTRGKRN RKSKHLNGDE RSGSNYRRIP WGRRPAPPRD VAILQERANK 
       460        470        480        490        500
LVKYLLVKDQ TKIPIKRSDM LRDVIQEYDE YFPEIIERAS YTLEKMFRVN 
       510        520        530        540        550
LKEIDKQSSL YILISTQESS AGILGTTKDT PKLGLLMVIL SVIFMNGNKA 
       560        570        580        590        600
SEAVIWEVLR KLGLRPGVRH SLFGEVRKLI TDEFVKQKYL EYKRVPNSRP 
       610        620        630        640        650
PEYEFFWGLR SYHETSKMKV LKFACRVQKK DPKDWAVQYR EAVEMEVQAA 
       660        670        680        690        700
AVAVAEAEAR AEARAQMGIG EEAVAGPWNW DDMDIDCLTR EELGDDAQAW 
       710        720        730        740        750
SRFSFEIEAR AQENADASTN VNFSRGASTR AGFSDGASIS FNGAPSSSGG 
       760        770        780        790        800
FSGGPGITFG VAPSTSASFS NTASISFGGT LSTSSSFSSA ASISFGCAHS 
       810        820        830        840        850
TSTSFSSEAS ISFGGMPCTS ASFSGGVSSS FSGPLSTSAT FSGGASSGFG 
       860        870        880        890        900
GTLSTTAGFS GVLSTSTSFG SAPTTSTVFS SALSTSTGFG GILSTSVCFG 
       910        920        930        940        950
GSPSSSGSFG GTLSTSICFG GSPCTSTGFG GTLSTSVSFG GSSSTSANFG 
       960        970        980        990       1000
GTLSTSICFD GSPSTGAGFG GALNTSASFG SVLNTSTGFG GAMSTSADFG 
      1010       1020       1030       1040       1050
GTLSTSVCFG GSPGTSVSFG SALNTNAGYG GAVSTNTDFG GTLSTSVCFG 
      1060       1070       1080       1090       1100
GSPSTSAGFG GALNTNASFG CAVSTSASFS GAVSTSACFS GAPITNPGFG 
      1110       1120       1130       1140       1150
GAFSTSAGFG GALSTAADFG GTPSNSIGFG AAPSTSVSFG GAHGTSLCFG 
      1160       1170       1180       1190       1200
GAPSTSLCFG SASNTNLCFG GPPSTSACFS GATSPSFCDG PSTSTGFSFG 
      1210       1220       1230       1240       1250
NGLSTNAGFG GGLNTSAGFG GGLGTSAGFS GGLSTSSGFD GGLGTSAGFG 
      1260       1270       1280       1290       1300
GGPGTSTGFG GGLGTSAGFS GGLGTSAGFG GGLVTSDGFG GGLGTNASFG 
      1310       1320       1330       1340       1350
STLGTSAGFS GGLSTSDGFG SRPNASFDRG LSTIIGFGSG SNTSTGFTGE 
      1360       1370       1380       1390       1400
PSTSTGFSSG PSSIVGFSGG PSTGVGFCSG PSTSGFSGGP STGAGFGGGP 
      1410       1420       1430 
NTGAGFGGGP STSAGFGSGA ASLGACGFSY G
Length:1,431
Mass (Da):143,716
Last modified:July 10, 2007 - v3
Checksum:i00FB9BFAC34A1699
GO
Isoform 2 (identifier: Q12816-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     663-705: ARAQMGIGEE...DAQAWSRFSF → IYSPCLQIPL...SYGQSAEGVM
     706-1431: Missing.

Note: No experimental confirmation available.
Show »
Length:706
Mass (Da):77,025
Checksum:i0F4A0E6B2F33B8FA
GO
Isoform 3 (identifier: Q12816-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.

Show »
Length:962
Mass (Da):93,745
Checksum:iC70C6D46F1D5FFB5
GO
Isoform 4 (identifier: Q12816-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-412: Missing.

Show »
Length:1,034
Mass (Da):102,278
Checksum:i5DA3F570544D2A00
GO
Isoform 5 (identifier: Q12816-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-412: Missing.
     663-705: ARAQMGIGEE...DAQAWSRFSF → IYSPCLQIPL...SYGQSAEGVM
     706-1431: Missing.

Show »
Length:309
Mass (Da):35,586
Checksum:i75B892ABEED362F2
GO

Sequence cautioni

The sequence AAA79334 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA83066 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti747S → T in AAA79334 (PubMed:7758945).Curated1
Sequence conflicti768S → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti812S → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti824S → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti1026N → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti1056S → G in BAA83066 (PubMed:10470851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06212265R → W. Corresponds to variant dbSNP:rs60674633Ensembl.1
Natural variantiVAR_053510738S → G1 PublicationCorresponds to variant dbSNP:rs17297490Ensembl.1
Natural variantiVAR_076264951G → S1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0539371 – 469Missing in isoform 3. CuratedAdd BLAST469
Alternative sequenceiVSP_05393816 – 412Missing in isoform 4 and isoform 5. CuratedAdd BLAST397
Alternative sequenceiVSP_043513663 – 705ARAQM…SRFSF → IYSPCLQIPLINCSSPSHGA KVHPWNLCPHSSQGSYGQSA EGVM in isoform 2 and isoform 5. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_043514706 – 1431Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST726

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029037 mRNA. Translation: BAA83066.3. Different initiation.
AK027489 mRNA. Translation: BAB55149.1.
AL049732 Genomic DNA. Translation: CAB86651.2.
AL049732 Genomic DNA. Translation: CAM26850.1.
CH471154 Genomic DNA. Translation: EAW93200.1.
CH471154 Genomic DNA. Translation: EAW93205.1.
U04811 mRNA. Translation: AAA79334.2. Different initiation.
CCDSiCCDS43958.1. [Q12816-2]
CCDS43959.1. [Q12816-1]
CCDS59527.1. [Q12816-5]
CCDS59528.1. [Q12816-4]
CCDS59529.1. [Q12816-3]
PIRiI38488.
RefSeqiNP_001034794.1. NM_001039705.2. [Q12816-1]
NP_001258112.1. NM_001271183.1. [Q12816-3]
NP_057241.2. NM_016157.3. [Q12816-2]
NP_808224.1. NM_177556.2. [Q12816-2]
NP_808225.1. NM_177557.2. [Q12816-5]
XP_006724663.1. XM_006724600.2. [Q12816-1]
XP_011529110.1. XM_011530808.1. [Q12816-1]
XP_011529111.1. XM_011530809.1. [Q12816-1]
XP_011529113.1. XM_011530811.2. [Q12816-1]
XP_011529114.1. XM_011530812.1. [Q12816-1]
XP_011529115.1. XM_011530813.1. [Q12816-1]
XP_016885256.1. XM_017029767.1. [Q12816-1]
XP_016885258.1. XM_017029769.1. [Q12816-2]
XP_016885259.1. XM_017029770.1. [Q12816-2]
XP_016885260.1. XM_017029771.1. [Q12816-2]
UniGeneiHs.633653.
Hs.743294.

Genome annotation databases

EnsembliENST00000173898; ENSP00000173898; ENSG00000067445. [Q12816-1]
ENST00000319167; ENSP00000318278; ENSG00000067445. [Q12816-2]
ENST00000375022; ENSP00000364162; ENSG00000067445. [Q12816-2]
ENST00000375041; ENSP00000364181; ENSG00000067445. [Q12816-4]
ENST00000399736; ENSP00000382641; ENSG00000067445. [Q12816-5]
ENST00000420798; ENSP00000405126; ENSG00000067445. [Q12816-3]
GeneIDi7216.
KEGGihsa:7216.
UCSCiuc004dtq.6. human. [Q12816-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTROP_HUMAN
AccessioniPrimary (citable) accession number: Q12816
Secondary accession number(s): B1AKE9
, B1AKF1, F5GY27, Q96SX2, Q9NU89, Q9UPN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: June 7, 2017
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot