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UniProtKB - Q12816 (TROP_HUMAN)

UniProt

Q12816 - TROP_HUMAN

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Protein

Trophinin

Gene

TRO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.

GO - Biological processi

  • embryo implantation Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
  • negative regulation of cell growth Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Trophinin
Alternative name(s):
MAGE-D3 antigen
Gene namesi
Name:TRO
Synonyms:KIAA1114, MAGED3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12326. TRO.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • nucleus Source: Ensembl
  • plasma membrane Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37002.

Polymorphism and mutation databases

DMDMi152031714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14311431TrophininPRO_0000156742Add
BLAST

Proteomic databases

EPDiQ12816.
MaxQBiQ12816.
PaxDbiQ12816.
PeptideAtlasiQ12816.
PRIDEiQ12816.

PTM databases

iPTMnetiQ12816.
PhosphoSiteiQ12816.

Expressioni

Tissue specificityi

Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi. Also found in macrophages.

Gene expression databases

BgeeiENSG00000067445.
CleanExiHS_TRO.
ExpressionAtlasiQ12816. baseline and differential.
GenevisibleiQ12816. HS.

Organism-specific databases

HPAiCAB033947.
HPA053358.

Interactioni

Subunit structurei

Directly binds bystin, and indirectly tastin.

Binary interactionsi

WithEntry#Exp.IntActNotes
BYSLQ138954EBI-950001,EBI-358049

Protein-protein interaction databases

BioGridi113067. 24 interactions.
IntActiQ12816. 6 interactions.
MINTiMINT-2805982.
STRINGi9606.ENSP00000173898.

Structurei

3D structure databases

ProteinModelPortaliQ12816.
SMRiQ12816. Positions 438-650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini444 – 642199MAGEPROSITE-ProRule annotationAdd
BLAST
Repeati751 – 760101
Repeati769 – 778102
Repeati779 – 78683; approximate
Repeati787 – 796104
Repeati805 – 814105
Repeati823 – 833116; approximateAdd
BLAST
Repeati841 – 850107
Repeati859 – 870128; approximateAdd
BLAST
Repeati879 – 890129; approximateAdd
BLAST
Repeati901 – 9101010
Repeati911 – 9201011
Repeati921 – 9301012
Repeati931 – 9401013
Repeati941 – 9501014
Repeati951 – 9601015; approximate
Repeati961 – 9701016
Repeati971 – 9801017
Repeati981 – 9901018
Repeati991 – 10001019
Repeati1001 – 10101020
Repeati1011 – 10201021
Repeati1021 – 10301022; approximate
Repeati1031 – 10401023
Repeati1041 – 10501024
Repeati1051 – 10601025
Repeati1061 – 10701026
Repeati1071 – 10801027; approximate
Repeati1081 – 10901028; approximate
Repeati1091 – 11001029
Repeati1101 – 11101030
Repeati1111 – 11201031
Repeati1121 – 11301032
Repeati1131 – 11401033
Repeati1141 – 11501034
Repeati1151 – 11601035
Repeati1161 – 11701036
Repeati1171 – 11801037; approximate
Repeati1181 – 11901038; approximate
Repeati1191 – 12001039
Repeati1201 – 12101040
Repeati1211 – 12201041
Repeati1221 – 12301042; approximate
Repeati1231 – 12401043; approximate
Repeati1241 – 12501044
Repeati1251 – 12601045
Repeati1261 – 12701046; approximate
Repeati1271 – 12801047
Repeati1281 – 12901048
Repeati1291 – 13001049
Repeati1301 – 13101050; approximate
Repeati1311 – 13201051
Repeati1321 – 13301052; approximate
Repeati1331 – 13401053; approximate
Repeati1341 – 13501054; approximate
Repeati1351 – 13601055; approximate
Repeati1361 – 13701056; approximate
Repeati1371 – 13801057; approximate
Repeati1381 – 13901058; approximate
Repeati1391 – 14001059; approximate
Repeati1401 – 14101060; approximate
Repeati1411 – 14201061; approximate
Repeati1421 – 14301062; approximate

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni751 – 143068062 X 10 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000049038.
HOVERGENiHBG003714.
InParanoidiQ12816.
OMAiMIGESCK.
OrthoDBiEOG091G09D3.
PhylomeDBiQ12816.
TreeFamiTF352132.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12816-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRRNDYGYR VPLFQGPLPP PGSLGLPFPP DIQTETTEED SVLLMHTLLA 
        60         70         80         90        100
ATKDSLAMDP PVVNRPKKSK TKKAPIKTIT KAAPAAPPVP AANEIATNKP 
       110        120        130        140        150
KITWQALNLP VITQISQALP TTEVTNTQAS SVTAQPKKAN KMKRVTAKAA 
       160        170        180        190        200
QGSQSPTGHE GGTIQLKSPL QVLKLPVISQ NIHAPIANES ASSQALITSI 
       210        220        230        240        250
KPKKASKAKK AANKAIASAT EVSLAATATH TATTQGQITN ETASIHTTAA 
       260        270        280        290        300
SIRTKKASKA RKTIAKVINT DTEHIEALNV TDAATRQIEA SVVAIRPKKS 
       310        320        330        340        350
KGKKAASRGP NSVSEISEAP LATQIVTNQA LAATLRVKRG SRARKAATKA 
       360        370        380        390        400
RATESQTPNA DQGAQAKIAS AQTNVSALET QVAAAVQALA DDYLAQLSLE 
       410        420        430        440        450
PTTRTRGKRN RKSKHLNGDE RSGSNYRRIP WGRRPAPPRD VAILQERANK 
       460        470        480        490        500
LVKYLLVKDQ TKIPIKRSDM LRDVIQEYDE YFPEIIERAS YTLEKMFRVN 
       510        520        530        540        550
LKEIDKQSSL YILISTQESS AGILGTTKDT PKLGLLMVIL SVIFMNGNKA 
       560        570        580        590        600
SEAVIWEVLR KLGLRPGVRH SLFGEVRKLI TDEFVKQKYL EYKRVPNSRP 
       610        620        630        640        650
PEYEFFWGLR SYHETSKMKV LKFACRVQKK DPKDWAVQYR EAVEMEVQAA 
       660        670        680        690        700
AVAVAEAEAR AEARAQMGIG EEAVAGPWNW DDMDIDCLTR EELGDDAQAW 
       710        720        730        740        750
SRFSFEIEAR AQENADASTN VNFSRGASTR AGFSDGASIS FNGAPSSSGG 
       760        770        780        790        800
FSGGPGITFG VAPSTSASFS NTASISFGGT LSTSSSFSSA ASISFGCAHS 
       810        820        830        840        850
TSTSFSSEAS ISFGGMPCTS ASFSGGVSSS FSGPLSTSAT FSGGASSGFG 
       860        870        880        890        900
GTLSTTAGFS GVLSTSTSFG SAPTTSTVFS SALSTSTGFG GILSTSVCFG 
       910        920        930        940        950
GSPSSSGSFG GTLSTSICFG GSPCTSTGFG GTLSTSVSFG GSSSTSANFG 
       960        970        980        990       1000
GTLSTSICFD GSPSTGAGFG GALNTSASFG SVLNTSTGFG GAMSTSADFG 
      1010       1020       1030       1040       1050
GTLSTSVCFG GSPGTSVSFG SALNTNAGYG GAVSTNTDFG GTLSTSVCFG 
      1060       1070       1080       1090       1100
GSPSTSAGFG GALNTNASFG CAVSTSASFS GAVSTSACFS GAPITNPGFG 
      1110       1120       1130       1140       1150
GAFSTSAGFG GALSTAADFG GTPSNSIGFG AAPSTSVSFG GAHGTSLCFG 
      1160       1170       1180       1190       1200
GAPSTSLCFG SASNTNLCFG GPPSTSACFS GATSPSFCDG PSTSTGFSFG 
      1210       1220       1230       1240       1250
NGLSTNAGFG GGLNTSAGFG GGLGTSAGFS GGLSTSSGFD GGLGTSAGFG 
      1260       1270       1280       1290       1300
GGPGTSTGFG GGLGTSAGFS GGLGTSAGFG GGLVTSDGFG GGLGTNASFG 
      1310       1320       1330       1340       1350
STLGTSAGFS GGLSTSDGFG SRPNASFDRG LSTIIGFGSG SNTSTGFTGE 
      1360       1370       1380       1390       1400
PSTSTGFSSG PSSIVGFSGG PSTGVGFCSG PSTSGFSGGP STGAGFGGGP 
      1410       1420       1430 
NTGAGFGGGP STSAGFGSGA ASLGACGFSY G
Length:1,431
Mass (Da):143,716
Last modified:July 10, 2007 - v3
Checksum:i00FB9BFAC34A1699
GO
Isoform 2 (identifier: Q12816-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     663-705: ARAQMGIGEE...DAQAWSRFSF → IYSPCLQIPL...SYGQSAEGVM
     706-1431: Missing.

Note: No experimental confirmation available.
Show »
Length:706
Mass (Da):77,025
Checksum:i0F4A0E6B2F33B8FA
GO
Isoform 3 (identifier: Q12816-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.

Show »
Length:962
Mass (Da):93,745
Checksum:iC70C6D46F1D5FFB5
GO
Isoform 4 (identifier: Q12816-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-412: Missing.

Show »
Length:1,034
Mass (Da):102,278
Checksum:i5DA3F570544D2A00
GO
Isoform 5 (identifier: Q12816-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-412: Missing.
     663-705: ARAQMGIGEE...DAQAWSRFSF → IYSPCLQIPL...SYGQSAEGVM
     706-1431: Missing.

Show »
Length:309
Mass (Da):35,586
Checksum:i75B892ABEED362F2
GO

Sequence cautioni

The sequence AAA79334 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA83066 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti747 – 7471S → T in AAA79334 (PubMed:7758945).Curated
Sequence conflicti768 – 7681S → G in BAA83066 (PubMed:10470851).Curated
Sequence conflicti812 – 8121S → G in BAA83066 (PubMed:10470851).Curated
Sequence conflicti824 – 8241S → G in BAA83066 (PubMed:10470851).Curated
Sequence conflicti1026 – 10261N → G in BAA83066 (PubMed:10470851).Curated
Sequence conflicti1056 – 10561S → G in BAA83066 (PubMed:10470851).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651R → W.
Corresponds to variant rs60674633 [ dbSNP | Ensembl ].		VAR_062122
Natural varianti738 – 7381S → G.1 Publication
Corresponds to variant rs17297490 [ dbSNP | Ensembl ].		VAR_053510
Natural varianti951 – 9511G → S.1 Publication
VAR_076264

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 469469Missing in isoform 3. CuratedVSP_053937Add
BLAST
Alternative sequencei16 – 412397Missing in isoform 4 and isoform 5. CuratedVSP_053938Add
BLAST
Alternative sequencei663 – 70543ARAQM…SRFSF → IYSPCLQIPLINCSSPSHGA KVHPWNLCPHSSQGSYGQSA EGVM in isoform 2 and isoform 5. 1 PublicationVSP_043513Add
BLAST
Alternative sequencei706 – 1431726Missing in isoform 2 and isoform 5. 1 PublicationVSP_043514Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029037 mRNA. Translation: BAA83066.3. Different initiation.
AK027489 mRNA. Translation: BAB55149.1.
AL049732 Genomic DNA. Translation: CAB86651.2.
AL049732 Genomic DNA. Translation: CAM26850.1.
CH471154 Genomic DNA. Translation: EAW93200.1.
CH471154 Genomic DNA. Translation: EAW93205.1.
U04811 mRNA. Translation: AAA79334.2. Different initiation.
CCDSiCCDS43958.1. [Q12816-2]
CCDS43959.1. [Q12816-1]
CCDS59527.1. [Q12816-5]
CCDS59528.1. [Q12816-4]
CCDS59529.1. [Q12816-3]
PIRiI38488.
RefSeqiNP_001034794.1. NM_001039705.2. [Q12816-1]
NP_001258112.1. NM_001271183.1. [Q12816-3]
NP_057241.2. NM_016157.3. [Q12816-2]
NP_808224.1. NM_177556.2. [Q12816-2]
NP_808225.1. NM_177557.2. [Q12816-5]
XP_006724663.1. XM_006724600.2. [Q12816-1]
XP_011529110.1. XM_011530808.1. [Q12816-1]
XP_011529111.1. XM_011530809.1. [Q12816-1]
XP_011529113.1. XM_011530811.2. [Q12816-1]
XP_011529114.1. XM_011530812.1. [Q12816-1]
XP_011529115.1. XM_011530813.1. [Q12816-1]
UniGeneiHs.633653.
Hs.743294.

Genome annotation databases

EnsembliENST00000173898; ENSP00000173898; ENSG00000067445. [Q12816-1]
ENST00000319167; ENSP00000318278; ENSG00000067445. [Q12816-2]
ENST00000375022; ENSP00000364162; ENSG00000067445. [Q12816-2]
ENST00000375041; ENSP00000364181; ENSG00000067445. [Q12816-4]
ENST00000399736; ENSP00000382641; ENSG00000067445. [Q12816-5]
ENST00000420798; ENSP00000405126; ENSG00000067445. [Q12816-3]
GeneIDi7216.
KEGGihsa:7216.
UCSCiuc004dtq.6. human. [Q12816-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029037 mRNA. Translation: BAA83066.3. Different initiation.
AK027489 mRNA. Translation: BAB55149.1.
AL049732 Genomic DNA. Translation: CAB86651.2.
AL049732 Genomic DNA. Translation: CAM26850.1.
CH471154 Genomic DNA. Translation: EAW93200.1.
CH471154 Genomic DNA. Translation: EAW93205.1.
U04811 mRNA. Translation: AAA79334.2. Different initiation.
CCDSiCCDS43958.1. [Q12816-2]
CCDS43959.1. [Q12816-1]
CCDS59527.1. [Q12816-5]
CCDS59528.1. [Q12816-4]
CCDS59529.1. [Q12816-3]
PIRiI38488.
RefSeqiNP_001034794.1. NM_001039705.2. [Q12816-1]
NP_001258112.1. NM_001271183.1. [Q12816-3]
NP_057241.2. NM_016157.3. [Q12816-2]
NP_808224.1. NM_177556.2. [Q12816-2]
NP_808225.1. NM_177557.2. [Q12816-5]
XP_006724663.1. XM_006724600.2. [Q12816-1]
XP_011529110.1. XM_011530808.1. [Q12816-1]
XP_011529111.1. XM_011530809.1. [Q12816-1]
XP_011529113.1. XM_011530811.2. [Q12816-1]
XP_011529114.1. XM_011530812.1. [Q12816-1]
XP_011529115.1. XM_011530813.1. [Q12816-1]
UniGeneiHs.633653.
Hs.743294.

3D structure databases

ProteinModelPortaliQ12816.
SMRiQ12816. Positions 438-650.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113067. 24 interactions.
IntActiQ12816. 6 interactions.
MINTiMINT-2805982.
STRINGi9606.ENSP00000173898.

PTM databases

iPTMnetiQ12816.
PhosphoSiteiQ12816.

Polymorphism and mutation databases

DMDMi152031714.

Proteomic databases

EPDiQ12816.
MaxQBiQ12816.
PaxDbiQ12816.
PeptideAtlasiQ12816.
PRIDEiQ12816.

Protocols and materials databases

DNASUi7216.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000173898; ENSP00000173898; ENSG00000067445. [Q12816-1]
ENST00000319167; ENSP00000318278; ENSG00000067445. [Q12816-2]
ENST00000375022; ENSP00000364162; ENSG00000067445. [Q12816-2]
ENST00000375041; ENSP00000364181; ENSG00000067445. [Q12816-4]
ENST00000399736; ENSP00000382641; ENSG00000067445. [Q12816-5]
ENST00000420798; ENSP00000405126; ENSG00000067445. [Q12816-3]
GeneIDi7216.
KEGGihsa:7216.
UCSCiuc004dtq.6. human. [Q12816-1]

Organism-specific databases

CTDi7216.
GeneCardsiTRO.
H-InvDBHIX0176771.
HGNCiHGNC:12326. TRO.
HPAiCAB033947.
HPA053358.
MIMi300132. gene.
neXtProtiNX_Q12816.
PharmGKBiPA37002.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000049038.
HOVERGENiHBG003714.
InParanoidiQ12816.
OMAiMIGESCK.
OrthoDBiEOG091G09D3.
PhylomeDBiQ12816.
TreeFamiTF352132.

Miscellaneous databases

ChiTaRSiTRO. human.
GeneWikiiTRO_(gene).
GenomeRNAii7216.
PROiQ12816.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067445.
CleanExiHS_TRO.
ExpressionAtlasiQ12816. baseline and differential.
GenevisibleiQ12816. HS.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTROP_HUMAN
AccessioniPrimary (citable) accession number: Q12816
Secondary accession number(s): B1AKE9
, B1AKF1, F5GY27, Q96SX2, Q9NU89, Q9UPN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.