UniProtKB - Q12816 (TROP_HUMAN)
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Protein
Trophinin
Gene
TRO
Organism
Homo sapiens (Human)
Status
Functioni
Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.
GO - Biological processi
- embryo implantation Source: ProtInc
- homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
Keywordsi
Biological process | Cell adhesion |
Names & Taxonomyi
Protein namesi | Recommended name: TrophininAlternative name(s): MAGE-D3 antigen |
Gene namesi | Name:TRO Synonyms:KIAA1114, MAGED3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000067445.20. |
HGNCi | HGNC:12326. TRO. |
MIMi | 300132. gene. |
neXtProti | NX_Q12816. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7216. |
OpenTargetsi | ENSG00000067445. |
PharmGKBi | PA37002. |
Polymorphism and mutation databases
DMDMi | 152031714. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156742 | 1 – 1431 | TrophininAdd BLAST | 1431 |
Proteomic databases
EPDi | Q12816. |
MaxQBi | Q12816. |
PaxDbi | Q12816. |
PeptideAtlasi | Q12816. |
PRIDEi | Q12816. |
PTM databases
iPTMneti | Q12816. |
PhosphoSitePlusi | Q12816. |
Expressioni
Tissue specificityi
Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi. Also found in macrophages.
Gene expression databases
Bgeei | ENSG00000067445. |
CleanExi | HS_TRO. |
ExpressionAtlasi | Q12816. baseline and differential. |
Genevisiblei | Q12816. HS. |
Organism-specific databases
HPAi | CAB033947. HPA053358. |
Interactioni
Subunit structurei
Directly binds bystin, and indirectly tastin.
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
BYSL | Q13895 | 4 | EBI-950001,EBI-358049 |
Protein-protein interaction databases
BioGridi | 113067. 28 interactors. |
IntActi | Q12816. 9 interactors. |
MINTi | Q12816. |
STRINGi | 9606.ENSP00000173898. |
Structurei
3D structure databases
ProteinModelPortali | Q12816. |
SMRi | Q12816. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 444 – 642 | MAGEPROSITE-ProRule annotationAdd BLAST | 199 | |
Repeati | 751 – 760 | 1 | 10 | |
Repeati | 769 – 778 | 2 | 10 | |
Repeati | 779 – 786 | 3; approximate | 8 | |
Repeati | 787 – 796 | 4 | 10 | |
Repeati | 805 – 814 | 5 | 10 | |
Repeati | 823 – 833 | 6; approximateAdd BLAST | 11 | |
Repeati | 841 – 850 | 7 | 10 | |
Repeati | 859 – 870 | 8; approximateAdd BLAST | 12 | |
Repeati | 879 – 890 | 9; approximateAdd BLAST | 12 | |
Repeati | 901 – 910 | 10 | 10 | |
Repeati | 911 – 920 | 11 | 10 | |
Repeati | 921 – 930 | 12 | 10 | |
Repeati | 931 – 940 | 13 | 10 | |
Repeati | 941 – 950 | 14 | 10 | |
Repeati | 951 – 960 | 15; approximate | 10 | |
Repeati | 961 – 970 | 16 | 10 | |
Repeati | 971 – 980 | 17 | 10 | |
Repeati | 981 – 990 | 18 | 10 | |
Repeati | 991 – 1000 | 19 | 10 | |
Repeati | 1001 – 1010 | 20 | 10 | |
Repeati | 1011 – 1020 | 21 | 10 | |
Repeati | 1021 – 1030 | 22; approximate | 10 | |
Repeati | 1031 – 1040 | 23 | 10 | |
Repeati | 1041 – 1050 | 24 | 10 | |
Repeati | 1051 – 1060 | 25 | 10 | |
Repeati | 1061 – 1070 | 26 | 10 | |
Repeati | 1071 – 1080 | 27; approximate | 10 | |
Repeati | 1081 – 1090 | 28; approximate | 10 | |
Repeati | 1091 – 1100 | 29 | 10 | |
Repeati | 1101 – 1110 | 30 | 10 | |
Repeati | 1111 – 1120 | 31 | 10 | |
Repeati | 1121 – 1130 | 32 | 10 | |
Repeati | 1131 – 1140 | 33 | 10 | |
Repeati | 1141 – 1150 | 34 | 10 | |
Repeati | 1151 – 1160 | 35 | 10 | |
Repeati | 1161 – 1170 | 36 | 10 | |
Repeati | 1171 – 1180 | 37; approximate | 10 | |
Repeati | 1181 – 1190 | 38; approximate | 10 | |
Repeati | 1191 – 1200 | 39 | 10 | |
Repeati | 1201 – 1210 | 40 | 10 | |
Repeati | 1211 – 1220 | 41 | 10 | |
Repeati | 1221 – 1230 | 42; approximate | 10 | |
Repeati | 1231 – 1240 | 43; approximate | 10 | |
Repeati | 1241 – 1250 | 44 | 10 | |
Repeati | 1251 – 1260 | 45 | 10 | |
Repeati | 1261 – 1270 | 46; approximate | 10 | |
Repeati | 1271 – 1280 | 47 | 10 | |
Repeati | 1281 – 1290 | 48 | 10 | |
Repeati | 1291 – 1300 | 49 | 10 | |
Repeati | 1301 – 1310 | 50; approximate | 10 | |
Repeati | 1311 – 1320 | 51 | 10 | |
Repeati | 1321 – 1330 | 52; approximate | 10 | |
Repeati | 1331 – 1340 | 53; approximate | 10 | |
Repeati | 1341 – 1350 | 54; approximate | 10 | |
Repeati | 1351 – 1360 | 55; approximate | 10 | |
Repeati | 1361 – 1370 | 56; approximate | 10 | |
Repeati | 1371 – 1380 | 57; approximate | 10 | |
Repeati | 1381 – 1390 | 58; approximate | 10 | |
Repeati | 1391 – 1400 | 59; approximate | 10 | |
Repeati | 1401 – 1410 | 60; approximate | 10 | |
Repeati | 1411 – 1420 | 61; approximate | 10 | |
Repeati | 1421 – 1430 | 62; approximate | 10 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 751 – 1430 | 62 X 10 AA approximate tandem repeatsAdd BLAST | 680 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4562. Eukaryota. ENOG4111S70. LUCA. |
GeneTreei | ENSGT00760000118824. |
HOGENOMi | HOG000049038. |
HOVERGENi | HBG003714. |
InParanoidi | Q12816. |
OMAi | NNELIEC. |
OrthoDBi | EOG091G09D3. |
PhylomeDBi | Q12816. |
TreeFami | TF352132. |
Family and domain databases
InterProi | View protein in InterPro IPR037445. MAGE. IPR002190. MHD_dom. |
PANTHERi | PTHR11736. PTHR11736. 4 hits. |
Pfami | View protein in Pfam PF01454. MAGE. 1 hit. |
SMARTi | View protein in SMART SM01373. MAGE. 1 hit. |
PROSITEi | View protein in PROSITE PS50838. MAGE. 1 hit. |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q12816-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDRRNDYGYR VPLFQGPLPP PGSLGLPFPP DIQTETTEED SVLLMHTLLA
60 70 80 90 100
ATKDSLAMDP PVVNRPKKSK TKKAPIKTIT KAAPAAPPVP AANEIATNKP
110 120 130 140 150
KITWQALNLP VITQISQALP TTEVTNTQAS SVTAQPKKAN KMKRVTAKAA
160 170 180 190 200
QGSQSPTGHE GGTIQLKSPL QVLKLPVISQ NIHAPIANES ASSQALITSI
210 220 230 240 250
KPKKASKAKK AANKAIASAT EVSLAATATH TATTQGQITN ETASIHTTAA
260 270 280 290 300
SIRTKKASKA RKTIAKVINT DTEHIEALNV TDAATRQIEA SVVAIRPKKS
310 320 330 340 350
KGKKAASRGP NSVSEISEAP LATQIVTNQA LAATLRVKRG SRARKAATKA
360 370 380 390 400
RATESQTPNA DQGAQAKIAS AQTNVSALET QVAAAVQALA DDYLAQLSLE
410 420 430 440 450
PTTRTRGKRN RKSKHLNGDE RSGSNYRRIP WGRRPAPPRD VAILQERANK
460 470 480 490 500
LVKYLLVKDQ TKIPIKRSDM LRDVIQEYDE YFPEIIERAS YTLEKMFRVN
510 520 530 540 550
LKEIDKQSSL YILISTQESS AGILGTTKDT PKLGLLMVIL SVIFMNGNKA
560 570 580 590 600
SEAVIWEVLR KLGLRPGVRH SLFGEVRKLI TDEFVKQKYL EYKRVPNSRP
610 620 630 640 650
PEYEFFWGLR SYHETSKMKV LKFACRVQKK DPKDWAVQYR EAVEMEVQAA
660 670 680 690 700
AVAVAEAEAR AEARAQMGIG EEAVAGPWNW DDMDIDCLTR EELGDDAQAW
710 720 730 740 750
SRFSFEIEAR AQENADASTN VNFSRGASTR AGFSDGASIS FNGAPSSSGG
760 770 780 790 800
FSGGPGITFG VAPSTSASFS NTASISFGGT LSTSSSFSSA ASISFGCAHS
810 820 830 840 850
TSTSFSSEAS ISFGGMPCTS ASFSGGVSSS FSGPLSTSAT FSGGASSGFG
860 870 880 890 900
GTLSTTAGFS GVLSTSTSFG SAPTTSTVFS SALSTSTGFG GILSTSVCFG
910 920 930 940 950
GSPSSSGSFG GTLSTSICFG GSPCTSTGFG GTLSTSVSFG GSSSTSANFG
960 970 980 990 1000
GTLSTSICFD GSPSTGAGFG GALNTSASFG SVLNTSTGFG GAMSTSADFG
1010 1020 1030 1040 1050
GTLSTSVCFG GSPGTSVSFG SALNTNAGYG GAVSTNTDFG GTLSTSVCFG
1060 1070 1080 1090 1100
GSPSTSAGFG GALNTNASFG CAVSTSASFS GAVSTSACFS GAPITNPGFG
1110 1120 1130 1140 1150
GAFSTSAGFG GALSTAADFG GTPSNSIGFG AAPSTSVSFG GAHGTSLCFG
1160 1170 1180 1190 1200
GAPSTSLCFG SASNTNLCFG GPPSTSACFS GATSPSFCDG PSTSTGFSFG
1210 1220 1230 1240 1250
NGLSTNAGFG GGLNTSAGFG GGLGTSAGFS GGLSTSSGFD GGLGTSAGFG
1260 1270 1280 1290 1300
GGPGTSTGFG GGLGTSAGFS GGLGTSAGFG GGLVTSDGFG GGLGTNASFG
1310 1320 1330 1340 1350
STLGTSAGFS GGLSTSDGFG SRPNASFDRG LSTIIGFGSG SNTSTGFTGE
1360 1370 1380 1390 1400
PSTSTGFSSG PSSIVGFSGG PSTGVGFCSG PSTSGFSGGP STGAGFGGGP
1410 1420 1430
NTGAGFGGGP STSAGFGSGA ASLGACGFSY G
Sequence cautioni
The sequence AAA79334 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA83066 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 747 | S → T in AAA79334 (PubMed:7758945).Curated | 1 | |
Sequence conflicti | 768 | S → G in BAA83066 (PubMed:10470851).Curated | 1 | |
Sequence conflicti | 812 | S → G in BAA83066 (PubMed:10470851).Curated | 1 | |
Sequence conflicti | 824 | S → G in BAA83066 (PubMed:10470851).Curated | 1 | |
Sequence conflicti | 1026 | N → G in BAA83066 (PubMed:10470851).Curated | 1 | |
Sequence conflicti | 1056 | S → G in BAA83066 (PubMed:10470851).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062122 | 65 | R → W. Corresponds to variant dbSNP:rs60674633Ensembl. | 1 | |
Natural variantiVAR_053510 | 738 | S → G1 PublicationCorresponds to variant dbSNP:rs17297490Ensembl. | 1 | |
Natural variantiVAR_076264 | 951 | G → S1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053937 | 1 – 469 | Missing in isoform 3. CuratedAdd BLAST | 469 | |
Alternative sequenceiVSP_053938 | 16 – 412 | Missing in isoform 4 and isoform 5. CuratedAdd BLAST | 397 | |
Alternative sequenceiVSP_043513 | 663 – 705 | ARAQM…SRFSF → IYSPCLQIPLINCSSPSHGA KVHPWNLCPHSSQGSYGQSA EGVM in isoform 2 and isoform 5. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_043514 | 706 – 1431 | Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST | 726 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | TROP_HUMAN | |
Accessioni | Q12816Primary (citable) accession number: Q12816 Secondary accession number(s): B1AKE9 Q9UPN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | July 10, 2007 | |
Last modified: | February 28, 2018 | |
This is version 144 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |