Reviewed, UniProtKB/Swiss-Prot Q12802 (AKP13_HUMAN)

Names and origin

Protein names

Recommended name:
    A-kinase anchor protein 13
      Short name=AKAP 13
Alternative name(s):
    Protein kinase A-anchoring protein 13
    Breast cancer nuclear receptor-binding auxiliary protein
    Human thyroid-anchoring protein 31
    Guanine nucleotide exchange factor Lbc
    AKAP-Lbc
    P47
    Lymphoid blast crisis oncogene
      Short name=LBC oncogene
    Non-oncogenic Rho GTPase-specific GTP exchange factor

Gene names

Name:	AKAP13
Synonyms:	BRX, HT31, LBC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2813 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. Ref.2 Ref.3 Ref.6 Ref.11
Subunit structure	Binds cAMP-dependent protein kinase (PKA) and to the RII-alpha regulatory subunit of PKA. Interacts with ESR1, ESR2, THRA, PPARA, RHOA and NME2. Ref.2 Ref.6 Ref.11 Ref.5 Ref.12
Subcellular location	Isoform 3: Cytoplasm. Nucleus. Ref.2 Ref.3 Ref.6 Isoform 2: Cytoplasm. Ref.2 Ref.3 Ref.6 Isoform 6: Cytoplasm. Ref.2 Ref.3 Ref.6 Isoform 7: Membrane. Ref.2 Ref.3 Ref.6
Tissue specificity	Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver, pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Ref.2 Ref.3 Ref.6
Domain	Both the DH and PH domains are required for transforming activity. Ref.3
Sequence similarities	Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 phorbol-ester/DAG-type zinc finger.
Sequence caution	The sequence AAD21311.1 differs from that shown. Reason: Frameshift at positions 2614 and 2647. The sequence AAL40923.1 differs from that shown. Reason: Frameshift at positions 2614 and 2647.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Proto-oncogene
Domain	Coiled coil Phorbol-ester binding Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell membrane fraction Ref.3 Traceable author statement. Source: ProtInc nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro cAMP-dependent protein kinase activity Ref.9 Non-traceable author statement. Source: UniProtKB diacylglycerol binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct signal transducer activity Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAK1	Q16611	1	EBI-1373806,EBI-519866
TGM2	P21980	3	EBI-1373806,EBI-727668
YWHAB	P31946	1	EBI-1373806,EBI-359815

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12802-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12802-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1583-1598: SMRVLGDVVRRPPIHR → MSWCPSGVQYSAGLSADFNY

Isoform 3 (identifier: Q12802-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1384: Missing.
     1385-1387: TQA → MLY

Isoform 4 (identifier: Q12802-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1581-1598: Missing.
     1950-1951: Missing.

Isoform 5 (identifier: Q12802-5)

The sequence of this isoform differs from the canonical sequence as follows:
     160-179: DAGPRETLMHFAVRLGLLRL → GENLYDLQTHFKFVIFLLFF
     180-2813: Missing.

Isoform 6 (identifier: Q12802-6)

Also known as: LBC;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1918: Missing.
     1950-1951: Missing.
     2336-2344: NRDEDEGIP → SGNGWRCFN
     2345-2813: Missing.

Isoform 7 (identifier: Q12802-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1918: Missing.
     1950-1951: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2813	2813	A-kinase anchor protein 13		PRO_0000080963
Regions
	Domain	1994 – 2191	198	DH
	Domain	2231 – 2333	103	PH
	Zinc finger	1791 – 1838	48	Phorbol-ester/DAG-type
	Region	494 – 516	23	RII-binding
	Region	1919 – 2813	895	Interaction with ESR1
	Coiled coil	1758 – 1790	33	Potential
	Coiled coil	2345 – 2381	37	Potential
	Coiled coil	2568 – 2683	116	Potential
	Compositional bias	1471 – 1474	4	Poly-Ser
	Compositional bias	1534 – 1537	4	Poly-Glu
	Compositional bias	2778 – 2790	13	Poly-Lys
Amino acid modifications
	Modified residue	983	1	Phosphoserine Ref.14 Ref.15 Ref.16
	Modified residue	1559	1	Phosphoserine Ref.16
	Modified residue	1645	1	Phosphoserine Ref.16
	Modified residue	1647	1	Phosphoserine Ref.16
	Modified residue	1876	1	Phosphoserine Ref.16
	Modified residue	1929	1	Phosphoserine Ref.16 Ref.13
	Modified residue	1932	1	Phosphoserine Ref.16 Ref.13
	Modified residue	2398	1	Phosphoserine Ref.16
	Modified residue	2402	1	Phosphoserine Ref.16
	Modified residue	2703	1	Phosphoserine Ref.16
	Modified residue	2709	1	Phosphoserine Ref.16
	Modified residue	2728	1	Phosphoserine Ref.14 Ref.16
Natural variations
	Alternative sequence	1 – 1918	1918	Missing in isoform 6 and isoform 7.		VSP_023484
	Alternative sequence	1 – 1384	1384	Missing in isoform 3.		VSP_023485
	Alternative sequence	160 – 179	20	DAGPR…GLLRL → GENLYDLQTHFKFVIFLLFF in isoform 5.		VSP_023486
	Alternative sequence	180 – 2813	2634	Missing in isoform 5.		VSP_023487
	Alternative sequence	1385 – 1387	3	TQA → MLY in isoform 3.		VSP_023488
	Alternative sequence	1581 – 1598	18	Missing in isoform 4.		VSP_023489
	Alternative sequence	1583 – 1598	16	SMRVL…PPIHR → MSWCPSGVQYSAGLSADFNY in isoform 2.		VSP_023490
	Alternative sequence	1950 – 1951	2	Missing in isoform 4, isoform 6 and isoform 7.		VSP_023491
	Alternative sequence	2336 – 2344	9	NRDEDEGIP → SGNGWRCFN in isoform 6.		VSP_023492
	Alternative sequence	2345 – 2813	469	Missing in isoform 6.		VSP_023493
	Natural variant	452	1	M → T: dbSNP rs2061821. Ref.7		VAR_030925
	Natural variant	494	1	W → R: dbSNP rs2061822. Ref.7		VAR_030926
	Natural variant	526	1	K → Q: dbSNP rs34434221.		VAR_051986
	Natural variant	574	1	R → C: dbSNP rs2061824. Ref.5 Ref.7		VAR_030927
	Natural variant	624	1	G → V: dbSNP rs745191. Ref.6		VAR_030928
	Natural variant	689	1	E → K: dbSNP rs7177107. Ref.7		VAR_030929
	Natural variant	845	1	V → A: dbSNP rs4075256. Ref.7		VAR_030930
	Natural variant	897	1	V → M: dbSNP rs4075254. Ref.6 Ref.7		VAR_030931
	Natural variant	1062	1	P → A: dbSNP rs4843074. Ref.7		VAR_030932
	Natural variant	1086	1	D → N: dbSNP rs4843075. Ref.7		VAR_030933
	Natural variant	1216	1	M → T: dbSNP rs7162168. Ref.7		VAR_030934
	Natural variant	1525	1	S → G: dbSNP rs35079107.		VAR_051987
	Natural variant	2457	1	G → S: dbSNP rs2241268. Ref.2 Ref.6 Ref.5 Ref.10		VAR_030935
	Natural variant	2801	1	A → T: dbSNP rs2614668.		VAR_030936
Experimental info
	Mutagenesis	1251	1	A → P: Loss of PKA anchoring; when associated with P-1260. Ref.6
	Mutagenesis	1260	1	I → P: Loss of PKA anchoring; when associated with P-1251. Ref.6
	Mutagenesis	1265	1	A → P: Abolishes RII-binding. Ref.9
	Mutagenesis	2153	1	Y → F: Loss of interaction with RHOA. Ref.6
	Sequence conflict	191	1	G → R in AAL40923. Ref.5
	Sequence conflict	354	1	C → R in AAL40923. Ref.5
	Sequence conflict	609	1	A → V in AAL40923. Ref.5
	Sequence conflict	614	1	A → T in AAL40923. Ref.5
	Sequence conflict	618	1	S → P in AAL40923. Ref.5
	Sequence conflict	619	1	D → A in AAL11723. Ref.6
	Sequence conflict	755	1	M → S in AAA58670. Ref.9
	Sequence conflict	1547	1	N → H in BAD92651. Ref.10
	Sequence conflict	2035	1	V → D in AAD21311. Ref.2
	Sequence conflict	2488	1	D → G in AAD21311. Ref.2
	Sequence conflict	2667 – 2668	2	QL → HV in AAD21311. Ref.2
	Sequence conflict	2667 – 2668	2	QL → HV in BAB62913. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 6, 2007. Version 2. Checksum: 6A8FDAC9A3D3B1F2	FASTA	2,813	307,550
	10 20 30 40 50 60 MKLNPQQAPL YGDCVVTVLL AEEDKAEDDV VFYLVFLGST LRHCTSTRKV SSDTLETIAP 70 80 90 100 110 120 GHDCCETVKV QLCASKEGLP VFVVAEEDFH FVQDEAYDAA QFLATSAGNQ QALNFTRFLD 130 140 150 160 170 180 QSGPPSGDVN SLDKKLVLAF RHLKLPTEWN VLGTDQSLHD AGPRETLMHF AVRLGLLRLT 190 200 210 220 230 240 WFLLQKPGGR GALSIHNQEG ATPVSLALER GYHKLHQLLT EENAGEPDSW SSLSYEIPYG 250 260 270 280 290 300 DCSVRHHREL DIYTLTSESD SHHEHPFPGD GCTGPIFKLM NIQQQLMKTN LKQMDSLMPL 310 320 330 340 350 360 MMTAQDPSSA PETDGQFLPC APEPTDPQRL SSSEETESTQ CCPGSPVAQT ESPCDLSSIV 370 380 390 400 410 420 EEENTDRSCR KKNKGVERKG EEVEPAPIVD SGTVSDQDSC LQSLPDCGVK GTEGLSSCGN 430 440 450 460 470 480 RNEETGTKSS GMPTDQESLS SGDAVLQRDL VMEPGTAQYS SGGELGGIST TNVSTPDTAG 490 500 510 520 530 540 EMEHGLMNPD ATVWKNVLQG GESTKERFEN SNIGTAGASD VHVTSKPVDK ISVPNCAPAA 550 560 570 580 590 600 SSLDGNKPAE SSLAFSNEET STEKTAETET SRSREESADA PVDQNSVVIP AAAKDKISDG 610 620 630 640 650 660 LEPYTLLAAG IGEAMSPSDL ALLGLEEDVM PHQNSETNSS HAQSQKGKSS PICSTTGDDK 670 680 690 700 710 720 LCADSACQQN TVTSSGDLVA KLCDNIVSES ESTTARQPSS QDPPDASHCE DPQAHTVTSD 730 740 750 760 770 780 PVRDTQERAD FCPFKVVDNK GQRKDVKLDK PLTNMLEVVS HPHPVVPKME KELVPDQAVI 790 800 810 820 830 840 SDSTFSLANS PGSESVTKDD ALSFVPSQKE KGTATPELHT ATDYRDGPDG NSNEPDTRPL 850 860 870 880 890 900 EDRAVGLSTS STAAELQHGM GNTSLTGLGG EHEGPAPPAI PEALNIKGNT DSSLQSVGKA 910 920 930 940 950 960 TLALDSVLTE EGKLLVVSES SAAQEQDKDK AVTCSSIKEN ALSSGTLQEE QRTPPPGQDT 970 980 990 1000 1010 1020 QQFHEKSISA DCAKDKALQL SNSPGASSAF LKAETEHNKE VAPQVSLLTQ GGAAQSLVPP 1030 1040 1050 1060 1070 1080 GASLATESRQ EALGAEHNSS ALLPCLLPDG SDGSDALNCS QPSPLDVGVK NTQSQGKTSA 1090 1100 1110 1120 1130 1140 CEVSGDVTVD VTGVNALQGM AEPRRENISH NTQDILIPNV LLSQEKNAVL GLPVALQDKA 1150 1160 1170 1180 1190 1200 VTDPQGVGTP EMIPLDWEKG KLEGADHSCT MGDAEEAQID DEAHPVLLQP VAKELPTDME 1210 1220 1230 1240 1250 1260 LSAHDDGAPA GVREVMRAPP SGRERSTPSL PCMVSAQDAP LPKGADLIEE AASRIVDAVI 1270 1280 1290 1300 1310 1320 EQVKAAGALL TEGEACHMSL SSPELGPLTK GLESAFTEKV STFPPGESLP MGSTPEEATG 1330 1340 1350 1360 1370 1380 SLAGCFAGRE EPEKIILPVQ GPEPAAEMPD VKAEDEVDFR ASSISEEVAV GSIAATLKMK 1390 1400 1410 1420 1430 1440 QGPMTQAINR ENWCTIEPCP DAASLLASKQ SPECENFLDV GLGRECTSKQ GVLKRESGSD 1450 1460 1470 1480 1490 1500 SDLFHSPSDD MDSIIFPKPE EEHLACDITG SSSSTDDTAS LDRHSSHGSD VSLSQILKPN 1510 1520 1530 1540 1550 1560 RSRDRQSLDG FYSHGMGAEG RESESEPADP GDVEEEEMDS ITEVPANCSV LRSSMRSLSP 1570 1580 1590 1600 1610 1620 FRRHSWGPGK NAASDAEMNH RSSMRVLGDV VRRPPIHRRS FSLEGLTGGA GVGNKPSSSL 1630 1640 1650 1660 1670 1680 EVSSANAEEL RHPFSGEERV DSLVSLSEED LESDQREHRM FDQQICHRSK QQGFNYCTSA 1690 1700 1710 1720 1730 1740 ISSPLTKSIS LMTISHPGLD NSRPFHSTFH NTSANLTESI TEENYNFLPH SPSKKDSEWK 1750 1760 1770 1780 1790 1800 SGTKVSRTFS YIKNKMSSSK KSKEKEKEKD KIKEKEKDSK DKEKDKKTVN GHTFSSIPVV 1810 1820 1830 1840 1850 1860 GPISCSQCMK PFTNKDAYTC ANCSAFVHKG CRESLASCAK VKMKQPKGSL QAHDTSSLPT 1870 1880 1890 1900 1910 1920 VIMRNKPSQP KERPRSAVLL VDETATTPIF ANRRSQQSVS LSKSVSIQNI TGVGNDENMS 1930 1940 1950 1960 1970 1980 NTWKFLSHST DSLNKISKVN ESTESLTDEG VGTDMNEGQL LGDFEIESKQ LEAESWSRII 1990 2000 2010 2020 2030 2040 DSKFLKQQKK DVVKRQEVIY ELMQTEFHHV RTLKIMSGVY SQGMMADLLF EQQMVEKLFP 2050 2060 2070 2080 2090 2100 CLDELISIHS QFFQRILERK KESLVDKSEK NFLIKRIGDV LVNQFSGENA ERLKKTYGKF 2110 2120 2130 2140 2150 2160 CGQHNQSVNY FKDLYAKDKR FQAFVKKKMS SSVVRRLGIP ECILLVTQRI TKYPVLFQRI 2170 2180 2190 2200 2210 2220 LQCTKDNEVE QEDLAQSLSL VKDVIGAVDS KVASYEKKVR LNEIYTKTDS KSIMRMKSGQ 2230 2240 2250 2260 2270 2280 MFAKEDLKRK KLVRDGSVFL KNAAGRLKEV QAVLLTDILV FLQEKDQKYI FASLDQKSTV 2290 2300 2310 2320 2330 2340 ISLKKLIVRE VAHEEKGLFL ISMGMTDPEM VEVHASSKEE RNSWIQIIQD TINTLNRDED 2350 2360 2370 2380 2390 2400 EGIPSENEEE KKMLDTRARE LKEQLHQKDQ KILLLLEEKE MIFRDMAECS TPLPEDCSPT 2410 2420 2430 2440 2450 2460 HSPRVLFRSN TEEALKGGPL MKSAINEVEI LQGLVSGNLG GTLGPTVSSP IEQDVVGPVS 2470 2480 2490 2500 2510 2520 LPRRAETFGG FDSHQMNASK GGEKEEGDDG QDLRRTESDS GLKKGGNANL VFMLKRNSEQ 2530 2540 2550 2560 2570 2580 VVQSVVHLYE LLSALQGVVL QQDSYIEDQK LVLSERALTR SLSRPSSLIE QEKQRSLEKQ 2590 2600 2610 2620 2630 2640 RQDLANLQKQ QAQYLEEKRR REREWEARER ELREREALLA QREEEVQQGQ QDLEKEREEL 2650 2660 2670 2680 2690 2700 QQKKGTYQYD LERLRAAQKQ LEREQEQLRR EAERLSQRQT ERDLCQVSHP HTKLMRIPSF 2710 2720 2730 2740 2750 2760 FPSPEEPPSP SAPSIAKSGS LDSELSVSPK RNSISRTHKD KGPFHILSST SQTNKGPEGQ 2770 2780 2790 2800 2810 SQAPASTSAS TRLFGLTKPK EKKEKKKKNK TSRSQPGDGP ASEVSAEGEE IFC
	Isoform 2. Checksum: 4EA29B253C76698E	FASTA	2,817	307,845
	10 20 30 40 50 60 MKLNPQQAPL YGDCVVTVLL AEEDKAEDDV VFYLVFLGST LRHCTSTRKV SSDTLETIAP 70 80 90 100 110 120 GHDCCETVKV QLCASKEGLP VFVVAEEDFH FVQDEAYDAA QFLATSAGNQ QALNFTRFLD 130 140 150 160 170 180 QSGPPSGDVN SLDKKLVLAF RHLKLPTEWN VLGTDQSLHD AGPRETLMHF AVRLGLLRLT 190 200 210 220 230 240 WFLLQKPGGR GALSIHNQEG ATPVSLALER GYHKLHQLLT EENAGEPDSW SSLSYEIPYG 250 260 270 280 290 300 DCSVRHHREL DIYTLTSESD SHHEHPFPGD GCTGPIFKLM NIQQQLMKTN LKQMDSLMPL 310 320 330 340 350 360 MMTAQDPSSA PETDGQFLPC APEPTDPQRL SSSEETESTQ CCPGSPVAQT ESPCDLSSIV 370 380 390 400 410 420 EEENTDRSCR KKNKGVERKG EEVEPAPIVD SGTVSDQDSC LQSLPDCGVK GTEGLSSCGN 430 440 450 460 470 480 RNEETGTKSS GMPTDQESLS SGDAVLQRDL VMEPGTAQYS SGGELGGIST TNVSTPDTAG 490 500 510 520 530 540 EMEHGLMNPD ATVWKNVLQG GESTKERFEN SNIGTAGASD VHVTSKPVDK ISVPNCAPAA 550 560 570 580 590 600 SSLDGNKPAE SSLAFSNEET STEKTAETET SRSREESADA PVDQNSVVIP AAAKDKISDG 610 620 630 640 650 660 LEPYTLLAAG IGEAMSPSDL ALLGLEEDVM PHQNSETNSS HAQSQKGKSS PICSTTGDDK 670 680 690 700 710 720 LCADSACQQN TVTSSGDLVA KLCDNIVSES ESTTARQPSS QDPPDASHCE DPQAHTVTSD 730 740 750 760 770 780 PVRDTQERAD FCPFKVVDNK GQRKDVKLDK PLTNMLEVVS HPHPVVPKME KELVPDQAVI 790 800 810 820 830 840 SDSTFSLANS PGSESVTKDD ALSFVPSQKE KGTATPELHT ATDYRDGPDG NSNEPDTRPL 850 860 870 880 890 900 EDRAVGLSTS STAAELQHGM GNTSLTGLGG EHEGPAPPAI PEALNIKGNT DSSLQSVGKA 910 920 930 940 950 960 TLALDSVLTE EGKLLVVSES SAAQEQDKDK AVTCSSIKEN ALSSGTLQEE QRTPPPGQDT 970 980 990 1000 1010 1020 QQFHEKSISA DCAKDKALQL SNSPGASSAF LKAETEHNKE VAPQVSLLTQ GGAAQSLVPP 1030 1040 1050 1060 1070 1080 GASLATESRQ EALGAEHNSS ALLPCLLPDG SDGSDALNCS QPSPLDVGVK NTQSQGKTSA 1090 1100 1110 1120 1130 1140 CEVSGDVTVD VTGVNALQGM AEPRRENISH NTQDILIPNV LLSQEKNAVL GLPVALQDKA 1150 1160 1170 1180 1190 1200 VTDPQGVGTP EMIPLDWEKG KLEGADHSCT MGDAEEAQID DEAHPVLLQP VAKELPTDME 1210 1220 1230 1240 1250 1260 LSAHDDGAPA GVREVMRAPP SGRERSTPSL PCMVSAQDAP LPKGADLIEE AASRIVDAVI 1270 1280 1290 1300 1310 1320 EQVKAAGALL TEGEACHMSL SSPELGPLTK GLESAFTEKV STFPPGESLP MGSTPEEATG 1330 1340 1350 1360 1370 1380 SLAGCFAGRE EPEKIILPVQ GPEPAAEMPD VKAEDEVDFR ASSISEEVAV GSIAATLKMK 1390 1400 1410 1420 1430 1440 QGPMTQAINR ENWCTIEPCP DAASLLASKQ SPECENFLDV GLGRECTSKQ GVLKRESGSD 1450 1460 1470 1480 1490 1500 SDLFHSPSDD MDSIIFPKPE EEHLACDITG SSSSTDDTAS LDRHSSHGSD VSLSQILKPN 1510 1520 1530 1540 1550 1560 RSRDRQSLDG FYSHGMGAEG RESESEPADP GDVEEEEMDS ITEVPANCSV LRSSMRSLSP 1570 1580 1590 1600 1610 1620 FRRHSWGPGK NAASDAEMNH RSMSWCPSGV QYSAGLSADF NYRSFSLEGL TGGAGVGNKP 1630 1640 1650 1660 1670 1680 SSSLEVSSAN AEELRHPFSG EERVDSLVSL SEEDLESDQR EHRMFDQQIC HRSKQQGFNY 1690 1700 1710 1720 1730 1740 CTSAISSPLT KSISLMTISH PGLDNSRPFH STFHNTSANL TESITEENYN FLPHSPSKKD 1750 1760 1770 1780 1790 1800 SEWKSGTKVS RTFSYIKNKM SSSKKSKEKE KEKDKIKEKE KDSKDKEKDK KTVNGHTFSS 1810 1820 1830 1840 1850 1860 IPVVGPISCS QCMKPFTNKD AYTCANCSAF VHKGCRESLA SCAKVKMKQP KGSLQAHDTS 1870 1880 1890 1900 1910 1920 SLPTVIMRNK PSQPKERPRS AVLLVDETAT TPIFANRRSQ QSVSLSKSVS IQNITGVGND 1930 1940 1950 1960 1970 1980 ENMSNTWKFL SHSTDSLNKI SKVNESTESL TDEGVGTDMN EGQLLGDFEI ESKQLEAESW 1990 2000 2010 2020 2030 2040 SRIIDSKFLK QQKKDVVKRQ EVIYELMQTE FHHVRTLKIM SGVYSQGMMA DLLFEQQMVE 2050 2060 2070 2080 2090 2100 KLFPCLDELI SIHSQFFQRI LERKKESLVD KSEKNFLIKR IGDVLVNQFS GENAERLKKT 2110 2120 2130 2140 2150 2160 YGKFCGQHNQ SVNYFKDLYA KDKRFQAFVK KKMSSSVVRR LGIPECILLV TQRITKYPVL 2170 2180 2190 2200 2210 2220 FQRILQCTKD NEVEQEDLAQ SLSLVKDVIG AVDSKVASYE KKVRLNEIYT KTDSKSIMRM 2230 2240 2250 2260 2270 2280 KSGQMFAKED LKRKKLVRDG SVFLKNAAGR LKEVQAVLLT DILVFLQEKD QKYIFASLDQ 2290 2300 2310 2320 2330 2340 KSTVISLKKL IVREVAHEEK GLFLISMGMT DPEMVEVHAS SKEERNSWIQ IIQDTINTLN 2350 2360 2370 2380 2390 2400 RDEDEGIPSE NEEEKKMLDT RARELKEQLH QKDQKILLLL EEKEMIFRDM AECSTPLPED 2410 2420 2430 2440 2450 2460 CSPTHSPRVL FRSNTEEALK GGPLMKSAIN EVEILQGLVS GNLGGTLGPT VSSPIEQDVV 2470 2480 2490 2500 2510 2520 GPVSLPRRAE TFGGFDSHQM NASKGGEKEE GDDGQDLRRT ESDSGLKKGG NANLVFMLKR 2530 2540 2550 2560 2570 2580 NSEQVVQSVV HLYELLSALQ GVVLQQDSYI EDQKLVLSER ALTRSLSRPS SLIEQEKQRS 2590 2600 2610 2620 2630 2640 LEKQRQDLAN LQKQQAQYLE EKRRREREWE ARERELRERE ALLAQREEEV QQGQQDLEKE 2650 2660 2670 2680 2690 2700 REELQQKKGT YQYDLERLRA AQKQLEREQE QLRREAERLS QRQTERDLCQ VSHPHTKLMR 2710 2720 2730 2740 2750 2760 IPSFFPSPEE PPSPSAPSIA KSGSLDSELS VSPKRNSISR THKDKGPFHI LSSTSQTNKG 2770 2780 2790 2800 2810 PEGQSQAPAS TSASTRLFGL TKPKEKKEKK KKNKTSRSQP GDGPASEVSA EGEEIFC
	Isoform 3. Checksum: 2E29FC699A72A6C5	FASTA	1,429	161,184
	10 20 30 40 50 60 MLYINRENWC TIEPCPDAAS LLASKQSPEC ENFLDVGLGR ECTSKQGVLK RESGSDSDLF 70 80 90 100 110 120 HSPSDDMDSI IFPKPEEEHL ACDITGSSSS TDDTASLDRH SSHGSDVSLS QILKPNRSRD 130 140 150 160 170 180 RQSLDGFYSH GMGAEGRESE SEPADPGDVE EEEMDSITEV PANCSVLRSS MRSLSPFRRH 190 200 210 220 230 240 SWGPGKNAAS DAEMNHRSSM RVLGDVVRRP PIHRRSFSLE GLTGGAGVGN KPSSSLEVSS 250 260 270 280 290 300 ANAEELRHPF SGEERVDSLV SLSEEDLESD QREHRMFDQQ ICHRSKQQGF NYCTSAISSP 310 320 330 340 350 360 LTKSISLMTI SHPGLDNSRP FHSTFHNTSA NLTESITEEN YNFLPHSPSK KDSEWKSGTK 370 380 390 400 410 420 VSRTFSYIKN KMSSSKKSKE KEKEKDKIKE KEKDSKDKEK DKKTVNGHTF SSIPVVGPIS 430 440 450 460 470 480 CSQCMKPFTN KDAYTCANCS AFVHKGCRES LASCAKVKMK QPKGSLQAHD TSSLPTVIMR 490 500 510 520 530 540 NKPSQPKERP RSAVLLVDET ATTPIFANRR SQQSVSLSKS VSIQNITGVG NDENMSNTWK 550 560 570 580 590 600 FLSHSTDSLN KISKVNESTE SLTDEGVGTD MNEGQLLGDF EIESKQLEAE SWSRIIDSKF 610 620 630 640 650 660 LKQQKKDVVK RQEVIYELMQ TEFHHVRTLK IMSGVYSQGM MADLLFEQQM VEKLFPCLDE 670 680 690 700 710 720 LISIHSQFFQ RILERKKESL VDKSEKNFLI KRIGDVLVNQ FSGENAERLK KTYGKFCGQH 730 740 750 760 770 780 NQSVNYFKDL YAKDKRFQAF VKKKMSSSVV RRLGIPECIL LVTQRITKYP VLFQRILQCT 790 800 810 820 830 840 KDNEVEQEDL AQSLSLVKDV IGAVDSKVAS YEKKVRLNEI YTKTDSKSIM RMKSGQMFAK 850 860 870 880 890 900 EDLKRKKLVR DGSVFLKNAA GRLKEVQAVL LTDILVFLQE KDQKYIFASL DQKSTVISLK 910 920 930 940 950 960 KLIVREVAHE EKGLFLISMG MTDPEMVEVH ASSKEERNSW IQIIQDTINT LNRDEDEGIP 970 980 990 1000 1010 1020 SENEEEKKML DTRARELKEQ LHQKDQKILL LLEEKEMIFR DMAECSTPLP EDCSPTHSPR 1030 1040 1050 1060 1070 1080 VLFRSNTEEA LKGGPLMKSA INEVEILQGL VSGNLGGTLG PTVSSPIEQD VVGPVSLPRR 1090 1100 1110 1120 1130 1140 AETFGGFDSH QMNASKGGEK EEGDDGQDLR RTESDSGLKK GGNANLVFML KRNSEQVVQS 1150 1160 1170 1180 1190 1200 VVHLYELLSA LQGVVLQQDS YIEDQKLVLS ERALTRSLSR PSSLIEQEKQ RSLEKQRQDL 1210 1220 1230 1240 1250 1260 ANLQKQQAQY LEEKRRRERE WEARERELRE REALLAQREE EVQQGQQDLE KEREELQQKK 1270 1280 1290 1300 1310 1320 GTYQYDLERL RAAQKQLERE QEQLRREAER LSQRQTERDL CQVSHPHTKL MRIPSFFPSP 1330 1340 1350 1360 1370 1380 EEPPSPSAPS IAKSGSLDSE LSVSPKRNSI SRTHKDKGPF HILSSTSQTN KGPEGQSQAP 1390 1400 1410 1420 ASTSASTRLF GLTKPKEKKE KKKKNKTSRS QPGDGPASEV SAEGEEIFC
	Isoform 4. Checksum: 117C84737CE9A79B	FASTA	2,793	305,281
	10 20 30 40 50 60 MKLNPQQAPL YGDCVVTVLL AEEDKAEDDV VFYLVFLGST LRHCTSTRKV SSDTLETIAP 70 80 90 100 110 120 GHDCCETVKV QLCASKEGLP VFVVAEEDFH FVQDEAYDAA QFLATSAGNQ QALNFTRFLD 130 140 150 160 170 180 QSGPPSGDVN SLDKKLVLAF RHLKLPTEWN VLGTDQSLHD AGPRETLMHF AVRLGLLRLT 190 200 210 220 230 240 WFLLQKPGGR GALSIHNQEG ATPVSLALER GYHKLHQLLT EENAGEPDSW SSLSYEIPYG 250 260 270 280 290 300 DCSVRHHREL DIYTLTSESD SHHEHPFPGD GCTGPIFKLM NIQQQLMKTN LKQMDSLMPL 310 320 330 340 350 360 MMTAQDPSSA PETDGQFLPC APEPTDPQRL SSSEETESTQ CCPGSPVAQT ESPCDLSSIV 370 380 390 400 410 420 EEENTDRSCR KKNKGVERKG EEVEPAPIVD SGTVSDQDSC LQSLPDCGVK GTEGLSSCGN 430 440 450 460 470 480 RNEETGTKSS GMPTDQESLS SGDAVLQRDL VMEPGTAQYS SGGELGGIST TNVSTPDTAG 490 500 510 520 530 540 EMEHGLMNPD ATVWKNVLQG GESTKERFEN SNIGTAGASD VHVTSKPVDK ISVPNCAPAA 550 560 570 580 590 600 SSLDGNKPAE SSLAFSNEET STEKTAETET SRSREESADA PVDQNSVVIP AAAKDKISDG 610 620 630 640 650 660 LEPYTLLAAG IGEAMSPSDL ALLGLEEDVM PHQNSETNSS HAQSQKGKSS PICSTTGDDK 670 680 690 700 710 720 LCADSACQQN TVTSSGDLVA KLCDNIVSES ESTTARQPSS QDPPDASHCE DPQAHTVTSD 730 740 750 760 770 780 PVRDTQERAD FCPFKVVDNK GQRKDVKLDK PLTNMLEVVS HPHPVVPKME KELVPDQAVI 790 800 810 820 830 840 SDSTFSLANS PGSESVTKDD ALSFVPSQKE KGTATPELHT ATDYRDGPDG NSNEPDTRPL 850 860 870 880 890 900 EDRAVGLSTS STAAELQHGM GNTSLTGLGG EHEGPAPPAI PEALNIKGNT DSSLQSVGKA 910 920 930 940 950 960 TLALDSVLTE EGKLLVVSES SAAQEQDKDK AVTCSSIKEN ALSSGTLQEE QRTPPPGQDT 970 980 990 1000 1010 1020 QQFHEKSISA DCAKDKALQL SNSPGASSAF LKAETEHNKE VAPQVSLLTQ GGAAQSLVPP 1030 1040 1050 1060 1070 1080 GASLATESRQ EALGAEHNSS ALLPCLLPDG SDGSDALNCS QPSPLDVGVK NTQSQGKTSA 1090 1100 1110 1120 1130 1140 CEVSGDVTVD VTGVNALQGM AEPRRENISH NTQDILIPNV LLSQEKNAVL GLPVALQDKA 1150 1160 1170 1180 1190 1200 VTDPQGVGTP EMIPLDWEKG KLEGADHSCT MGDAEEAQID DEAHPVLLQP VAKELPTDME 1210 1220 1230 1240 1250 1260 LSAHDDGAPA GVREVMRAPP SGRERSTPSL PCMVSAQDAP LPKGADLIEE AASRIVDAVI 1270 1280 1290 1300 1310 1320 EQVKAAGALL TEGEACHMSL SSPELGPLTK GLESAFTEKV STFPPGESLP MGSTPEEATG 1330 1340 1350 1360 1370 1380 SLAGCFAGRE EPEKIILPVQ GPEPAAEMPD VKAEDEVDFR ASSISEEVAV GSIAATLKMK 1390 1400 1410 1420 1430 1440 QGPMTQAINR ENWCTIEPCP DAASLLASKQ SPECENFLDV GLGRECTSKQ GVLKRESGSD 1450 1460 1470 1480 1490 1500 SDLFHSPSDD MDSIIFPKPE EEHLACDITG SSSSTDDTAS LDRHSSHGSD VSLSQILKPN 1510 1520 1530 1540 1550 1560 RSRDRQSLDG FYSHGMGAEG RESESEPADP GDVEEEEMDS ITEVPANCSV LRSSMRSLSP 1570 1580 1590 1600 1610 1620 FRRHSWGPGK NAASDAEMNH RSFSLEGLTG GAGVGNKPSS SLEVSSANAE ELRHPFSGEE 1630 1640 1650 1660 1670 1680 RVDSLVSLSE EDLESDQREH RMFDQQICHR SKQQGFNYCT SAISSPLTKS ISLMTISHPG 1690 1700 1710 1720 1730 1740 LDNSRPFHST FHNTSANLTE SITEENYNFL PHSPSKKDSE WKSGTKVSRT FSYIKNKMSS 1750 1760 1770 1780 1790 1800 SKKSKEKEKE KDKIKEKEKD SKDKEKDKKT VNGHTFSSIP VVGPISCSQC MKPFTNKDAY 1810 1820 1830 1840 1850 1860 TCANCSAFVH KGCRESLASC AKVKMKQPKG SLQAHDTSSL PTVIMRNKPS QPKERPRSAV 1870 1880 1890 1900 1910 1920 LLVDETATTP IFANRRSQQS VSLSKSVSIQ NITGVGNDEN MSNTWKFLSH STDSLNKISK 1930 1940 1950 1960 1970 1980 VNESTESLTD EGTDMNEGQL LGDFEIESKQ LEAESWSRII DSKFLKQQKK DVVKRQEVIY 1990 2000 2010 2020 2030 2040 ELMQTEFHHV RTLKIMSGVY SQGMMADLLF EQQMVEKLFP CLDELISIHS QFFQRILERK 2050 2060 2070 2080 2090 2100 KESLVDKSEK NFLIKRIGDV LVNQFSGENA ERLKKTYGKF CGQHNQSVNY FKDLYAKDKR 2110 2120 2130 2140 2150 2160 FQAFVKKKMS SSVVRRLGIP ECILLVTQRI TKYPVLFQRI LQCTKDNEVE QEDLAQSLSL 2170 2180 2190 2200 2210 2220 VKDVIGAVDS KVASYEKKVR LNEIYTKTDS KSIMRMKSGQ MFAKEDLKRK KLVRDGSVFL 2230 2240 2250 2260 2270 2280 KNAAGRLKEV QAVLLTDILV FLQEKDQKYI FASLDQKSTV ISLKKLIVRE VAHEEKGLFL 2290 2300 2310 2320 2330 2340 ISMGMTDPEM VEVHASSKEE RNSWIQIIQD TINTLNRDED EGIPSENEEE KKMLDTRARE 2350 2360 2370 2380 2390 2400 LKEQLHQKDQ KILLLLEEKE MIFRDMAECS TPLPEDCSPT HSPRVLFRSN TEEALKGGPL 2410 2420 2430 2440 2450 2460 MKSAINEVEI LQGLVSGNLG GTLGPTVSSP IEQDVVGPVS LPRRAETFGG FDSHQMNASK 2470 2480 2490 2500 2510 2520 GGEKEEGDDG QDLRRTESDS GLKKGGNANL VFMLKRNSEQ VVQSVVHLYE LLSALQGVVL 2530 2540 2550 2560 2570 2580 QQDSYIEDQK LVLSERALTR SLSRPSSLIE QEKQRSLEKQ RQDLANLQKQ QAQYLEEKRR 2590 2600 2610 2620 2630 2640 REREWEARER ELREREALLA QREEEVQQGQ QDLEKEREEL QQKKGTYQYD LERLRAAQKQ 2650 2660 2670 2680 2690 2700 LEREQEQLRR EAERLSQRQT ERDLCQVSHP HTKLMRIPSF FPSPEEPPSP SAPSIAKSGS 2710 2720 2730 2740 2750 2760 LDSELSVSPK RNSISRTHKD KGPFHILSST SQTNKGPEGQ SQAPASTSAS TRLFGLTKPK 2770 2780 2790 EKKEKKKKNK TSRSQPGDGP ASEVSAEGEE IFC
	Isoform 5. Checksum: D441A72053F1EBC5	FASTA	179	19,992
	10 20 30 40 50 60 MKLNPQQAPL YGDCVVTVLL AEEDKAEDDV VFYLVFLGST LRHCTSTRKV SSDTLETIAP 70 80 90 100 110 120 GHDCCETVKV QLCASKEGLP VFVVAEEDFH FVQDEAYDAA QFLATSAGNQ QALNFTRFLD 130 140 150 160 170 QSGPPSGDVN SLDKKLVLAF RHLKLPTEWN VLGTDQSLHG ENLYDLQTHF KFVIFLLFF
	Isoform 6 (LBC). Checksum: B2DD30E911F457C7	FASTA	424	49,053
	10 20 30 40 50 60 MSNTWKFLSH STDSLNKISK VNESTESLTD EGTDMNEGQL LGDFEIESKQ LEAESWSRII 70 80 90 100 110 120 DSKFLKQQKK DVVKRQEVIY ELMQTEFHHV RTLKIMSGVY SQGMMADLLF EQQMVEKLFP 130 140 150 160 170 180 CLDELISIHS QFFQRILERK KESLVDKSEK NFLIKRIGDV LVNQFSGENA ERLKKTYGKF 190 200 210 220 230 240 CGQHNQSVNY FKDLYAKDKR FQAFVKKKMS SSVVRRLGIP ECILLVTQRI TKYPVLFQRI 250 260 270 280 290 300 LQCTKDNEVE QEDLAQSLSL VKDVIGAVDS KVASYEKKVR LNEIYTKTDS KSIMRMKSGQ 310 320 330 340 350 360 MFAKEDLKRK KLVRDGSVFL KNAAGRLKEV QAVLLTDILV FLQEKDQKYI FASLDQKSTV 370 380 390 400 410 420 ISLKKLIVRE VAHEEKGLFL ISMGMTDPEM VEVHASSKEE RNSWIQIIQD TINTLSGNGW RCFN
	Isoform 7. Checksum: 321808E409BAACEE	FASTA	893	102,125
	10 20 30 40 50 60 MSNTWKFLSH STDSLNKISK VNESTESLTD EGTDMNEGQL LGDFEIESKQ LEAESWSRII 70 80 90 100 110 120 DSKFLKQQKK DVVKRQEVIY ELMQTEFHHV RTLKIMSGVY SQGMMADLLF EQQMVEKLFP 130 140 150 160 170 180 CLDELISIHS QFFQRILERK KESLVDKSEK NFLIKRIGDV LVNQFSGENA ERLKKTYGKF 190 200 210 220 230 240 CGQHNQSVNY FKDLYAKDKR FQAFVKKKMS SSVVRRLGIP ECILLVTQRI TKYPVLFQRI 250 260 270 280 290 300 LQCTKDNEVE QEDLAQSLSL VKDVIGAVDS KVASYEKKVR LNEIYTKTDS KSIMRMKSGQ 310 320 330 340 350 360 MFAKEDLKRK KLVRDGSVFL KNAAGRLKEV QAVLLTDILV FLQEKDQKYI FASLDQKSTV 370 380 390 400 410 420 ISLKKLIVRE VAHEEKGLFL ISMGMTDPEM VEVHASSKEE RNSWIQIIQD TINTLNRDED 430 440 450 460 470 480 EGIPSENEEE KKMLDTRARE LKEQLHQKDQ KILLLLEEKE MIFRDMAECS TPLPEDCSPT 490 500 510 520 530 540 HSPRVLFRSN TEEALKGGPL MKSAINEVEI LQGLVSGNLG GTLGPTVSSP IEQDVVGPVS 550 560 570 580 590 600 LPRRAETFGG FDSHQMNASK GGEKEEGDDG QDLRRTESDS GLKKGGNANL VFMLKRNSEQ 610 620 630 640 650 660 VVQSVVHLYE LLSALQGVVL QQDSYIEDQK LVLSERALTR SLSRPSSLIE QEKQRSLEKQ 670 680 690 700 710 720 RQDLANLQKQ QAQYLEEKRR REREWEARER ELREREALLA QREEEVQQGQ QDLEKEREEL 730 740 750 760 770 780 QQKKGTYQYD LERLRAAQKQ LEREQEQLRR EAERLSQRQT ERDLCQVSHP HTKLMRIPSF 790 800 810 820 830 840 FPSPEEPPSP SAPSIAKSGS LDSELSVSPK RNSISRTHKD KGPFHILSST SQTNKGPEGQ 850 860 870 880 890 SQAPASTSAS TRLFGLTKPK EKKEKKKKNK TSRSQPGDGP ASEVSAEGEE IFC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products." Toksoz D., Williams D.A. Oncogene 9:621-628(1994) [PubMed: 8290273] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[2]	"Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action." Rubino D., Driggers P., Arbit D., Kemp L., Miller B., Coso O., Pagliai K., Gray K., Gutkind S., Segars J. Oncogene 16:2513-2526(1998) [PubMed: 9627117] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH ESR1; THRA AND PPARA, VARIANT SER-2457. Tissue: Testis.
[3]	"Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting." Sterpetti P., Hack A.A., Bashar M.P., Park B., Cheng S.-D., Knoll J.H.M., Urano T., Feig L.A., Toksoz D. Mol. Cell. Biol. 19:1334-1345(1999) [PubMed: 9891067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), ALTERNATIVE SPLICING (ISOFORM 6), FUNCTION, SUBCELLULAR LOCATION, DOMAIN, TISSUE SPECIFICITY. Tissue: Skeletal muscle.
[4]	Erratum Sterpetti P., Hack A.A., Bashar M.P., Park B., Cheng S.D., Knoll J.H., Urano T., Feig L.A., Toksoz D. Mol. Cell. Biol. 19:3930-3930(1999)
[5]	"Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling." Klussmann E., Edemir B., Pepperle B., Tamma G., Henn V., Klauschenz E., Hundsrucker C., Maric K., Rosenthal W. FEBS Lett. 507:264-268(2001) [PubMed: 11696353] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RHOA, VARIANTS CYS-574 AND SER-2457.
[6]	"AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation." Diviani D., Soderling J., Scott J.D. J. Biol. Chem. 276:44247-44257(2001) [PubMed: 11546812] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH RHOA; RHOB AND RHOC, MUTAGENESIS OF ALA-1251; ILE-1260 AND TYR-2153, VARIANTS VAL-624; MET-897 AND SER-2457.
[7]	Miyamoto M., Ono Y. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS THR-452; ARG-494; CYS-574; LYS-689; ALA-845; MET-897; ALA-1062; ASN-1086 AND THR-1216. Tissue: Lung.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[9]	"Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain." Carr D.W., Hausken Z.E., Fraser I.D.C., Stofko-Hahn R.E., Scott J.D. J. Biol. Chem. 267:13376-13382(1992) [PubMed: 1618839] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 754-1768, PKA AND RII BINDING, MUTAGENESIS OF ALA-1265. Tissue: Thyroid.
[10]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1486-2813 (ISOFORM 4), VARIANT SER-2457. Tissue: Brain.
[11]	"The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway." Driggers P.H., Segars J.H., Rubino D.M. J. Biol. Chem. 276:46792-46797(2001) [PubMed: 11579095] [Abstract] Cited for: FUNCTION, INTERACTION WITH ESR2.
[12]	"Lbc proto-oncogene product binds to and could be negatively regulated by metastasis suppressor nm23-H2." Iwashita S., Fujii M., Mukai H., Ono Y., Miyamoto M. Biochem. Biophys. Res. Commun. 320:1063-1068(2004) [PubMed: 15249197] [Abstract] Cited for: INTERACTION WITH NME2.
[13]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1929 AND SER-1932, MASS SPECTROMETRY. Tissue: Epithelium.
[14]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983 AND SER-2728, MASS SPECTROMETRY. Tissue: Epithelium.
[15]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983, MASS SPECTROMETRY.
[16]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983; SER-1559; SER-1645; SER-1647; SER-1876; SER-1929; SER-1932; SER-2398; SER-2402; SER-2703; SER-2709 AND SER-2728, MASS SPECTROMETRY.
[17]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[18]	"A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes." Newlon M.G., Roy M., Morikis D., Carr D.W., Westphal R., Scott J.D., Jennings P.A. EMBO J. 20:1651-1662(2001) [PubMed: 11285229] [Abstract] Cited for: STRUCTURE BY NMR OF 493-516.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

U03634 mRNA. Translation: AAC50065.1.
AF126008 mRNA. Translation: AAD21311.1. Frameshift.
AF127481 mRNA. Translation: AAD40799.1.
AF387101 mRNA. Translation: AAL40923.1. Frameshift.
AF406992 mRNA. Translation: AAL11723.1.
AB055890 mRNA. Translation: BAB62913.1.
BC050312 mRNA. Translation: AAH50312.1.
M90360 mRNA. Translation: AAA58670.1. Different termination.
AB209414 mRNA. Translation: BAD92651.1.

IPI

IPI00065931.
IPI00329783.
IPI00375281.
IPI00384381.
IPI00829717.
IPI00829774.
IPI00829853.

PIR

A42915.
I38434.

RefSeq

NP_006729.4.
NP_009131.2.
NP_658913.1.

UniGene

Hs.459211
Hs.710656

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DRN	NMR	-	C	1246-1268	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q12802. 4 interactions.

PTM databases

PhosphoSite

Q12802.

Proteomic databases

PRIDE

Q12802.

Genome annotation databases

Ensembl

ENSG00000170776. Homo sapiens. [Contig view]

GeneID

11214.

KEGG

hsa:11214.

Organism-specific databases

GeneCards

GC15P083724.

HGNC

HGNC:371. AKAP13.

MIM

604686. gene.

PharmGKB

PA24665.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q12802.

OMA

Q12802. QQLMKTN.

Enzyme and pathway databases

Reactome

REACT_11044. Signaling by Rho GTPases.

Gene expression databases

ArrayExpress

Q12802.

Bgee

Q12802.

Family and domain databases

InterPro

IPR002219. DAG_PE_bd.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
IPR015721. RhoGEF-like.
IPR018459. RII_binding_1.
[Graphical view]

Gene3D

G3DSA:2.30.29.30. PH_type. 1 hit.
G3DSA:1.20.900.10. RhoGEF. 1 hit.

PANTHER

PTHR22825. RhoGEF_like. 1 hit.

Pfam

PF00130. C1_1. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF10522. RII_binding_1. 1 hit.
[Graphical view]

SMART

SM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]

PROSITE

PS00741. DH_1. False negative.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

42679.

SOURCE

Search...

Entry information

Entry name

AKP13_HUMAN

Accession

Primary (citable) accession number: Q12802
Secondary accession number(s): Q14572 , Q59FP6, Q86W90, Q8WXQ6, Q96JP6, Q96P79, Q9Y5T0, Q9Y5T6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	March 6, 2007
Last modified:	June 16, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)