Reviewed, UniProtKB/Swiss-Prot Q12802 (AKP13_HUMAN)

Names and origin

Protein names

Recommended name:
    A-kinase anchor protein 13
      Short name=AKAP 13
Alternative name(s):
    Protein kinase A-anchoring protein 13
    Breast cancer nuclear receptor-binding auxiliary protein
    Human thyroid-anchoring protein 31
    Guanine nucleotide exchange factor Lbc
    AKAP-Lbc
    P47
    Lymphoid blast crisis oncogene
      Short name=LBC oncogene
    Non-oncogenic Rho GTPase-specific GTP exchange factor

Gene names

Name:	AKAP13
Synonyms:	BRX, HT31, LBC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2813 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.
Subunit structure	Binds cAMP-dependent protein kinase (PKA) and to the RII-alpha regulatory subunit of PKA. Interacts with ESR1, ESR2, THRA, PPARA, RHOA and NME2.
Subcellular location	Isoform 3: Cytoplasm. Nucleus. Isoform 2: Cytoplasm. Isoform 6: Cytoplasm. Isoform 7: Membrane.
Tissue specificity	Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver, pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver.
Domain	Both the DH and PH domains are required for transforming activity.
Sequence similarities	Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 phorbol-ester/DAG-type zinc finger.
Sequence caution	The sequence AAD21311.1 differs from that shown. Reason: Frameshift at positions 2614 and 2647. The sequence AAL40923.1 differs from that shown. Reason: Frameshift at positions 2614 and 2647.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Proto-oncogene
Domain	Coiled coil Phorbol-ester binding Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Cellular component	membrane fraction Ref.3 Traceable author statement. Source: ProtInc
Molecular function	cAMP-dependent protein kinase activity Ref.9 Non-traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct signal transducer activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAK1	Q16611	1	EBI-1373806,EBI-519866
TGM2	P21980	3	EBI-1373806,EBI-727668
YWHAB	P31946	1	EBI-1373806,EBI-359815

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12802-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12802-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1583-1598: SMRVLGDVVRRPPIHR → MSWCPSGVQYSAGLSADFNY

Isoform 3 (identifier: Q12802-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1384: Missing.
     1385-1387: TQA → MLY

Isoform 4 (identifier: Q12802-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1581-1598: Missing.
     1950-1951: Missing.

Isoform 5 (identifier: Q12802-5)

The sequence of this isoform differs from the canonical sequence as follows:
     160-179: DAGPRETLMHFAVRLGLLRL → GENLYDLQTHFKFVIFLLFF
     180-2813: Missing.

Isoform 6 (identifier: Q12802-6)

Also known as: LBC;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1918: Missing.
     1950-1951: Missing.
     2336-2344: NRDEDEGIP → SGNGWRCFN
     2345-2813: Missing.

Isoform 7 (identifier: Q12802-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1918: Missing.
     1950-1951: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 2813	2813	A-kinase anchor protein 13
Regions
	Domain	1994 – 2191	198	DH
	Domain	2231 – 2333	103	PH
	Zinc finger	1791 – 1838	48	Phorbol-ester/DAG-type
	Region	494 – 516	23	RII-binding
	Region	1919 – 2813	895	Interaction with ESR1
	Coiled coil	1758 – 1790	33	Potential
	Coiled coil	2345 – 2381	37	Potential
	Coiled coil	2568 – 2683	116	Potential
	Compositional bias	1471 – 1474	4	Poly-Ser
	Compositional bias	1534 – 1537	4	Poly-Glu
	Compositional bias	2778 – 2790	13	Poly-Lys
Amino acid modifications
	Modified residue	983	1	Phosphoserine
	Modified residue	1929	1	Phosphoserine
	Modified residue	1932	1	Phosphoserine
	Modified residue	2728	1	Phosphoserine
Natural variations
	Alternative sequence	1 – 1918	1918	Missing in isoform 6 and isoform 7.
	Alternative sequence	1 – 1384	1384	Missing in isoform 3.
	Alternative sequence	160 – 179	20	DAGPR…GLLRL → GENLYDLQTHFKFVIFLLFF in isoform 5.
	Alternative sequence	180 – 2813	2634	Missing in isoform 5.
	Alternative sequence	1385 – 1387	3	TQA → MLY in isoform 3.
	Alternative sequence	1581 – 1598	18	Missing in isoform 4.
	Alternative sequence	1583 – 1598	16	SMRVL…PPIHR → MSWCPSGVQYSAGLSADFNY in isoform 2.
	Alternative sequence	1950 – 1951	2	Missing in isoform 4, isoform 6 and isoform 7.
	Alternative sequence	2336 – 2344	9	NRDEDEGIP → SGNGWRCFN in isoform 6.
	Alternative sequence	2345 – 2813	469	Missing in isoform 6.
	Natural variant	452	1	M → T: dbSNP rs2061821.
	Natural variant	494	1	W → R: dbSNP rs2061822.
	Natural variant	574	1	R → C: dbSNP rs2061824.
	Natural variant	624	1	G → V: dbSNP rs745191.
	Natural variant	689	1	E → K: dbSNP rs7177107.
	Natural variant	845	1	V → A: dbSNP rs4075256.
	Natural variant	897	1	V → M: dbSNP rs4075254.
	Natural variant	1062	1	P → A: dbSNP rs4843074.
	Natural variant	1086	1	D → N: dbSNP rs4843075.
	Natural variant	1216	1	M → T: dbSNP rs7162168.
	Natural variant	2457	1	G → S: dbSNP rs2241268.
	Natural variant	2801	1	A → T: dbSNP rs2614668.
Experimental info
	Mutagenesis	1251	1	A → P: Loss of PKA anchoring; when associated with P-1260
	Mutagenesis	1260	1	I → P: Loss of PKA anchoring; when associated with P-1251
	Mutagenesis	1265	1	A → P: Abolishes RII-binding
	Mutagenesis	2153	1	Y → F: Loss of interaction with RHOA
	Sequence conflict	191	1	G → R in AAL40923. Ref.5
	Sequence conflict	354	1	C → R in AAL40923. Ref.5
	Sequence conflict	609	1	A → V in AAL40923. Ref.5
	Sequence conflict	614	1	A → T in AAL40923. Ref.5
	Sequence conflict	618	1	S → P in AAL40923. Ref.5
	Sequence conflict	619	1	D → A in AAL11723. Ref.6
	Sequence conflict	755	1	M → S in AAA58670. Ref.9
	Sequence conflict	1547	1	N → H in BAD92651. Ref.10
	Sequence conflict	2035	1	V → D in AAD21311. Ref.2
	Sequence conflict	2488	1	D → G in AAD21311. Ref.2
	Sequence conflict	2667 – 2668	2	QL → HV in AAD21311. Ref.2
	Sequence conflict	2667 – 2668	2	QL → HV in BAB62913. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 6, 2007. Version 2. Checksum: 6A8FDAC9A3D3B1F2	FASTA	2,813	307,550
	10 20 30 40 50 60 MKLNPQQAPL YGDCVVTVLL AEEDKAEDDV VFYLVFLGST LRHCTSTRKV SSDTLETIAP 70 80 90 100 110 120 GHDCCETVKV QLCASKEGLP VFVVAEEDFH FVQDEAYDAA QFLATSAGNQ QALNFTRFLD 130 140 150 160 170 180 QSGPPSGDVN SLDKKLVLAF RHLKLPTEWN VLGTDQSLHD AGPRETLMHF AVRLGLLRLT 190 200 210 220 230 240 WFLLQKPGGR GALSIHNQEG ATPVSLALER GYHKLHQLLT EENAGEPDSW SSLSYEIPYG 250 260 270 280 290 300 DCSVRHHREL DIYTLTSESD SHHEHPFPGD GCTGPIFKLM NIQQQLMKTN LKQMDSLMPL 310 320 330 340 350 360 MMTAQDPSSA PETDGQFLPC APEPTDPQRL SSSEETESTQ CCPGSPVAQT ESPCDLSSIV 370 380 390 400 410 420 EEENTDRSCR KKNKGVERKG EEVEPAPIVD SGTVSDQDSC LQSLPDCGVK GTEGLSSCGN 430 440 450 460 470 480 RNEETGTKSS GMPTDQESLS SGDAVLQRDL VMEPGTAQYS SGGELGGIST TNVSTPDTAG 490 500 510 520 530 540 EMEHGLMNPD ATVWKNVLQG GESTKERFEN SNIGTAGASD VHVTSKPVDK ISVPNCAPAA 550 560 570 580 590 600 SSLDGNKPAE SSLAFSNEET STEKTAETET SRSREESADA PVDQNSVVIP AAAKDKISDG 610 620 630 640 650 660 LEPYTLLAAG IGEAMSPSDL ALLGLEEDVM PHQNSETNSS HAQSQKGKSS PICSTTGDDK 670 680 690 700 710 720 LCADSACQQN TVTSSGDLVA KLCDNIVSES ESTTARQPSS QDPPDASHCE DPQAHTVTSD 730 740 750 760 770 780 PVRDTQERAD FCPFKVVDNK GQRKDVKLDK PLTNMLEVVS HPHPVVPKME KELVPDQAVI 790 800 810 820 830 840 SDSTFSLANS PGSESVTKDD ALSFVPSQKE KGTATPELHT ATDYRDGPDG NSNEPDTRPL 850 860 870 880 890 900 EDRAVGLSTS STAAELQHGM GNTSLTGLGG EHEGPAPPAI PEALNIKGNT DSSLQSVGKA 910 920 930 940 950 960 TLALDSVLTE EGKLLVVSES SAAQEQDKDK AVTCSSIKEN ALSSGTLQEE QRTPPPGQDT 970 980 990 1000 1010 1020 QQFHEKSISA DCAKDKALQL SNSPGASSAF LKAETEHNKE VAPQVSLLTQ GGAAQSLVPP 1030 1040 1050 1060 1070 1080 GASLATESRQ EALGAEHNSS ALLPCLLPDG SDGSDALNCS QPSPLDVGVK NTQSQGKTSA 1090 1100 1110 1120 1130 1140 CEVSGDVTVD VTGVNALQGM AEPRRENISH NTQDILIPNV LLSQEKNAVL GLPVALQDKA 1150 1160 1170 1180 1190 1200 VTDPQGVGTP EMIPLDWEKG KLEGADHSCT MGDAEEAQID DEAHPVLLQP VAKELPTDME 1210 1220 1230 1240 1250 1260 LSAHDDGAPA GVREVMRAPP SGRERSTPSL PCMVSAQDAP LPKGADLIEE AASRIVDAVI 1270 1280 1290 1300 1310 1320 EQVKAAGALL TEGEACHMSL SSPELGPLTK GLESAFTEKV STFPPGESLP MGSTPEEATG 1330 1340 1350 1360 1370 1380 SLAGCFAGRE EPEKIILPVQ GPEPAAEMPD VKAEDEVDFR ASSISEEVAV GSIAATLKMK 1390 1400 1410 1420 1430 1440 QGPMTQAINR ENWCTIEPCP DAASLLASKQ SPECENFLDV GLGRECTSKQ GVLKRESGSD 1450 1460 1470 1480 1490 1500 SDLFHSPSDD MDSIIFPKPE EEHLACDITG SSSSTDDTAS LDRHSSHGSD VSLSQILKPN 1510 1520 1530 1540 1550 1560 RSRDRQSLDG FYSHGMGAEG RESESEPADP GDVEEEEMDS ITEVPANCSV LRSSMRSLSP 1570 1580 1590 1600 1610 1620 FRRHSWGPGK NAASDAEMNH RSSMRVLGDV VRRPPIHRRS FSLEGLTGGA GVGNKPSSSL 1630 1640 1650 1660 1670 1680 EVSSANAEEL RHPFSGEERV DSLVSLSEED LESDQREHRM FDQQICHRSK QQGFNYCTSA 1690 1700 1710 1720 1730 1740 ISSPLTKSIS LMTISHPGLD NSRPFHSTFH NTSANLTESI TEENYNFLPH SPSKKDSEWK 1750 1760 1770 1780 1790 1800 SGTKVSRTFS YIKNKMSSSK KSKEKEKEKD KIKEKEKDSK DKEKDKKTVN GHTFSSIPVV 1810 1820 1830 1840 1850 1860 GPISCSQCMK PFTNKDAYTC ANCSAFVHKG CRESLASCAK VKMKQPKGSL QAHDTSSLPT 1870 1880 1890 1900 1910 1920 VIMRNKPSQP KERPRSAVLL VDETATTPIF ANRRSQQSVS LSKSVSIQNI TGVGNDENMS 1930 1940 1950 1960 1970 1980 NTWKFLSHST DSLNKISKVN ESTESLTDEG VGTDMNEGQL LGDFEIESKQ LEAESWSRII 1990 2000 2010 2020 2030 2040 DSKFLKQQKK DVVKRQEVIY ELMQTEFHHV RTLKIMSGVY SQGMMADLLF EQQMVEKLFP 2050 2060 2070 2080 2090 2100 CLDELISIHS QFFQRILERK KESLVDKSEK NFLIKRIGDV LVNQFSGENA ERLKKTYGKF 2110 2120 2130 2140 2150 2160 CGQHNQSVNY FKDLYAKDKR FQAFVKKKMS SSVVRRLGIP ECILLVTQRI TKYPVLFQRI 2170 2180 2190 2200 2210 2220 LQCTKDNEVE QEDLAQSLSL VKDVIGAVDS KVASYEKKVR LNEIYTKTDS KSIMRMKSGQ 2230 2240 2250 2260 2270 2280 MFAKEDLKRK KLVRDGSVFL KNAAGRLKEV QAVLLTDILV FLQEKDQKYI FASLDQKSTV 2290 2300 2310 2320 2330 2340 ISLKKLIVRE VAHEEKGLFL ISMGMTDPEM VEVHASSKEE RNSWIQIIQD TINTLNRDED 2350 2360 2370 2380 2390 2400 EGIPSENEEE KKMLDTRARE LKEQLHQKDQ KILLLLEEKE MIFRDMAECS TPLPEDCSPT 2410 2420 2430 2440 2450 2460 HSPRVLFRSN TEEALKGGPL MKSAINEVEI LQGLVSGNLG GTLGPTVSSP IEQDVVGPVS 2470 2480 2490 2500 2510 2520 LPRRAETFGG FDSHQMNASK GGEKEEGDDG QDLRRTESDS GLKKGGNANL VFMLKRNSEQ 2530 2540 2550 2560 2570 2580 VVQSVVHLYE LLSALQGVVL QQDSYIEDQK LVLSERALTR SLSRPSSLIE QEKQRSLEKQ 2590 2600 2610 2620 2630 2640 RQDLANLQKQ QAQYLEEKRR REREWEARER ELREREALLA QREEEVQQGQ QDLEKEREEL 2650 2660 2670 2680 2690 2700 QQKKGTYQYD LERLRAAQKQ LEREQEQLRR EAERLSQRQT ERDLCQVSHP HTKLMRIPSF 2710 2720 2730 2740 2750 2760 FPSPEEPPSP SAPSIAKSGS LDSELSVSPK RNSISRTHKD KGPFHILSST SQTNKGPEGQ 2770 2780 2790 2800 2810 SQAPASTSAS TRLFGLTKPK EKKEKKKKNK TSRSQPGDGP ASEVSAEGEE IFC
	Isoform 2 [UniParc]. Checksum: 4EA29B253C76698E		2,817	307,845
	10 20 30 40 50 60 MKLNPQQAPL YGDCVVTVLL AEEDKAEDDV VFYLVFLGST LRHCTSTRKV SSDTLETIAP 70 80 90 100 110 120 GHDCCETVKV QLCASKEGLP VFVVAEEDFH FVQDEAYDAA QFLATSAGNQ QALNFTRFLD 130 140 150 160 170 180 QSGPPSGDVN SLDKKLVLAF RHLKLPTEWN VLGTDQSLHD AGPRETLMHF AVRLGLLRLT 190 200 210 220 230 240 WFLLQKPGGR GALSIHNQEG ATPVSLALER GYHKLHQLLT EENAGEPDSW SSLSYEIPYG 250 260 270 280 290 300 DCSVRHHREL DIYTLTSESD SHHEHPFPGD GCTGPIFKLM NIQQQLMKTN LKQMDSLMPL 310 320 330 340 350 360 MMTAQDPSSA PETDGQFLPC APEPTDPQRL SSSEETESTQ CCPGSPVAQT ESPCDLSSIV 370 380 390 400 410 420 EEENTDRSCR KKNKGVERKG EEVEPAPIVD SGTVSDQDSC LQSLPDCGVK GTEGLSSCGN 430 440 450 460 470 480 RNEETGTKSS GMPTDQESLS SGDAVLQRDL VMEPGTAQYS SGGELGGIST TNVSTPDTAG 490 500 510 520 530 540 EMEHGLMNPD ATVWKNVLQG GESTKERFEN SNIGTAGASD VHVTSKPVDK ISVPNCAPAA 550 560 570 580 590 600 SSLDGNKPAE SSLAFSNEET STEKTAETET SRSREESADA PVDQNSVVIP AAAKDKISDG 610 620 630 640 650 660 LEPYTLLAAG IGEAMSPSDL ALLGLEEDVM PHQNSETNSS HAQSQKGKSS PICSTTGDDK 670 680 690 700 710 720 LCADSACQQN TVTSSGDLVA KLCDNIVSES ESTTARQPSS QDPPDASHCE DPQAHTVTSD 730 740 750 760 770 780 PVRDTQERAD FCPFKVVDNK GQRKDVKLDK PLTNMLEVVS HPHPVVPKME KELVPDQAVI 790 800 810 820 830 840 SDSTFSLANS PGSESVTKDD ALSFVPSQKE KGTATPELHT ATDYRDGPDG NSNEPDTRPL 850 860 870 880 890 900 EDRAVGLSTS STAAELQHGM GNTSLTGLGG EHEGPAPPAI PEALNIKGNT DSSLQSVGKA 910 920 930 940 950 960 TLALDSVLTE EGKLLVVSES SAAQEQDKDK AVTCSSIKEN ALSSGTLQEE QRTPPPGQDT 970 980 990 1000 1010 1020 QQFHEKSISA DCAKDKALQL SNSPGASSAF LKAETEHNKE VAPQVSLLTQ GGAAQSLVPP 1030 1040 1050 1060 1070 1080 GASLATESRQ EALGAEHNSS ALLPCLLPDG SDGSDALNCS QPSPLDVGVK NTQSQGKTSA 1090 1100 1110 1120 1130 1140 CEVSGDVTVD VTGVNALQGM AEPRRENISH NTQDILIPNV LLSQEKNAVL GLPVALQDKA 1150 1160 1170 1180 1190 1200 VTDPQGVGTP EMIPLDWEKG KLEGADHSCT MGDAEEAQID DEAHPVLLQP VAKELPTDME 1210 1220 1230 1240 1250 1260 LSAHDDGAPA GVREVMRAPP SGRERSTPSL PCMVSAQDAP LPKGADLIEE AASRIVDAVI 1270 1280 1290 1300 1310 1320 EQVKAAGALL TEGEACHMSL SSPELGPLTK GLESAFTEKV STFPPGESLP MGSTPEEATG 1330 1340 1350 1360 1370 1380 SLAGCFAGRE EPEKIILPVQ GPEPAAEMPD VKAEDEVDFR ASSISEEVAV GSIAATLKMK 1390 1400 1410 1420 1430 1440 QGPMTQAINR ENWCTIEPCP DAASLLASKQ SPECENFLDV GLGRECTSKQ GVLKRESGSD 1450 1460 1470 1480 1490 1500 SDLFHSPSDD MDSIIFPKPE EEHLACDITG SSSSTDDTAS LDRHSSHGSD VSLSQILKPN 1510 1520 1530 1540 1550 1560 RSRDRQSLDG FYSHGMGAEG RESESEPADP GDVEEEEMDS ITEVPANCSV LRSSMRSLSP 1570 1580 1590 1600 1610 1620 FRRHSWGPGK NAASDAEMNH RSMSWCPSGV QYSAGLSADF NYRSFSLEGL TGGAGVGNKP 1630 1640 1650 1660 1670 1680 SSSLEVSSAN AEELRHPFSG EERVDSLVSL SEEDLESDQR EHRMFDQQIC HRSKQQGFNY 1690 1700 1710 1720 1730 1740 CTSAISSPLT KSISLMTISH PGLDNSRPFH STFHNTSANL TESITEENYN FLPHSPSKKD 1750 1760 1770 1780 1790 1800 SEWKSGTKVS RTFSYIKNKM SSSKKSKEKE KEKDKIKEKE KDSKDKEKDK KTVNGHTFSS 1810 1820 1830 1840 1850 1860 IPVVGPISCS QCMKPFTNKD AYTCANCSAF VHKGCRESLA SCAKVKMKQP KGSLQAHDTS 1870 1880 1890 1900 1910 1920 SLPTVIMRNK PSQPKERPRS AVLLVDETAT TPIFANRRSQ QSVSLSKSVS IQNITGVGND 1930 1940 1950 1960 1970 1980 ENMSNTWKFL SHSTDSLNKI SKVNESTESL TDEGVGTDMN EGQLLGDFEI ESKQLEAESW 1990 2000 2010 2020 2030 2040 SRIIDSKFLK QQKKDVVKRQ EVIYELMQTE FHHVRTLKIM SGVYSQGMMA DLLFEQQMVE 2050 2060 2070 2080 2090 2100 KLFPCLDELI SIHSQFFQRI LERKKESLVD KSEKNFLIKR IGDVLVNQFS GENAERLKKT 2110 2120 2130 2140 2150 2160 YGKFCGQHNQ SVNYFKDLYA KDKRFQAFVK KKMSSSVVRR LGIPECILLV TQRITKYPVL 2170 2180 2190 2200 2210 2220 FQRILQCTKD NEVEQEDLAQ SLSLVKDVIG AVDSKVASYE KKVRLNEIYT KTDSKSIMRM 2230 2240 2250 2260 2270 2280 KSGQMFAKED LKRKKLVRDG SVFLKNAAGR LKEVQAVLLT DILVFLQEKD QKYIFASLDQ 2290 2300 2310 2320 2330 2340 KSTVISLKKL IVREVAHEEK GLFLISMGMT DPEMVEVHAS SKEERNSWIQ IIQDTINTLN 2350 2360 2370 2380 2390 2400 RDEDEGIPSE NEEEKKMLDT RARELKEQLH QKDQKILLLL EEKEMIFRDM AECSTPLPED 2410 2420 2430 2440 2450 2460 CSPTHSPRVL FRSNTEEALK GGPLMKSAIN EVEILQGLVS GNLGGTLGPT VSSPIEQDVV 2470 2480 2490 2500 2510 2520 GPVSLPRRAE TFGGFDSHQM NASKGGEKEE GDDGQDLRRT ESDSGLKKGG NANLVFMLKR 2530 2540 2550 2560 2570 2580 NSEQVVQSVV HLYELLSALQ GVVLQQDSYI EDQKLVLSER ALTRSLSRPS SLIEQEKQRS 2590 2600 2610 2620 2630 2640 LEKQRQDLAN LQKQQAQYLE EKRRREREWE ARERELRERE ALLAQREEEV QQGQQDLEKE 2650 2660 2670 2680 2690 2700 REELQQKKGT YQYDLERLRA AQKQLEREQE QLRREAERLS QRQTERDLCQ VSHPHTKLMR 2710 2720 2730 2740 2750 2760 IPSFFPSPEE PPSPSAPSIA KSGSLDSELS VSPKRNSISR THKDKGPFHI LSSTSQTNKG 2770 2780 2790 2800 2810 PEGQSQAPAS TSASTRLFGL TKPKEKKEKK KKNKTSRSQP GDGPASEVSA EGEEIFC
	Isoform 3 [UniParc]. Checksum: 2E29FC699A72A6C5		1,429	161,184
	10 20 30 40 50 60 MLYINRENWC TIEPCPDAAS LLASKQSPEC ENFLDVGLGR ECTSKQGVLK RESGSDSDLF 70 80 90 100 110 120 HSPSDDMDSI IFPKPEEEHL ACDITGSSSS TDDTASLDRH SSHGSDVSLS QILKPNRSRD 130 140 150 160 170 180 RQSLDGFYSH GMGAEGRESE SEPADPGDVE EEEMDSITEV PANCSVLRSS MRSLSPFRRH 190 200 210 220 230 240 SWGPGKNAAS DAEMNHRSSM RVLGDVVRRP PIHRRSFSLE GLTGGAGVGN KPSSSLEVSS 250 260 270 280 290 300 ANAEELRHPF SGEERVDSLV SLSEEDLESD QREHRMFDQQ ICHRSKQQGF NYCTSAISSP 310 320 330 340 350 360 LTKSISLMTI SHPGLDNSRP FHSTFHNTSA NLTESITEEN YNFLPHSPSK KDSEWKSGTK 370 380 390 400 410 420 VSRTFSYIKN KMSSSKKSKE KEKEKDKIKE KEKDSKDKEK DKKTVNGHTF SSIPVVGPIS 430 440 450 460 470 480 CSQCMKPFTN KDAYTCANCS AFVHKGCRES LASCAKVKMK QPKGSLQAHD TSSLPTVIMR 490 500 510 520 530 540 NKPSQPKERP RSAVLLVDET ATTPIFANRR SQQSVSLSKS VSIQNITGVG NDENMSNTWK 550 560 570 580 590 600 FLSHSTDSLN KISKVNESTE SLTDEGVGTD MNEGQLLGDF EIESKQLEAE SWSRIIDSKF 610 620 630 640 650 660 LKQQKKDVVK RQEVIYELMQ TEFHHVRTLK IMSGVYSQGM MADLLFEQQM VEKLFPCLDE 670 680 690 700 710 720 LISIHSQFFQ RILERKKESL VDKSEKNFLI KRIGDVLVNQ FSGENAERLK KTYGKFCGQH 730 740 750 760 770 780 NQSVNYFKDL YAKDKRFQAF VKKKMSSSVV RRLGIPECIL LVTQRITKYP VLFQRILQCT 790 800 810 820 830 840 KDNEVEQEDL AQSLSLVKDV IGAVDSKVAS YEKKVRLNEI YTKTDSKSIM RMKSGQMFAK 850 860 870 880 890 900 EDLKRKKLVR DGSVFLKNAA GRLKEVQAVL LTDILVFLQE KDQKYIFASL DQKSTVISLK 910 920 930 940 950 960 KLIVREVAHE EKGLFLISMG MTDPEMVEVH ASSKEERNSW IQIIQDTINT LNRDEDEGIP 970 980 990 1000 1010 1020 SENEEEKKML DTRARELKEQ LHQKDQKILL LLEEKEMIFR DMAECSTPLP EDCSPTHSPR 1030 1040 1050 1060 1070 1080 VLFRSNTEEA LKGGPLMKSA INEVEILQGL VSGNLGGTLG PTVSSPIEQD VVGPVSLPRR 1090 1100 1110 1120 1130 1140 AETFGGFDSH QMNASKGGEK EEGDDGQDLR RTESDSGLKK GGNANLVFML KRNSEQVVQS 1150 1160 1170 1180