UniProtKB - Q12798 (CETN1_HUMAN)
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Protein
Centrin-1
Gene
CETN1
Organism
Homo sapiens (Human)
Status
Functioni
Plays a fundamental role in microtubule-organizing center structure and function (PubMed:8175926). Plays a role in sperm cilia formation (By similarity).By similarity1 Publication
Miscellaneous
Binds two moles of calcium per mole of protein.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 41 – 52 | 1CuratedAdd BLAST | 12 | |
Calcium bindingi | 150 – 161 | 2CuratedAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- G-protein beta/gamma-subunit complex binding Source: Ensembl
- heterotrimeric G-protein binding Source: Ensembl
- microtubule binding Source: Ensembl
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cellular response to heat Source: Ensembl
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
SIGNORi | Q12798 |
Names & Taxonomyi
Protein namesi | Recommended name: Centrin-1Alternative name(s): Caltractin isoform 2 |
Gene namesi | Name:CETN1 Synonyms:CEN1, CETN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177143.4 |
HGNCi | HGNC:1866 CETN1 |
MIMi | 603187 gene |
neXtProti | NX_Q12798 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1068 |
OpenTargetsi | ENSG00000177143 |
PharmGKBi | PA26419 |
Polymorphism and mutation databases
BioMutai | CETN1 |
DMDMi | 2493440 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073559 | 1 – 172 | Centrin-1Add BLAST | 172 |
Proteomic databases
EPDi | Q12798 |
MaxQBi | Q12798 |
PaxDbi | Q12798 |
PeptideAtlasi | Q12798 |
PRIDEi | Q12798 |
PTM databases
iPTMneti | Q12798 |
PhosphoSitePlusi | Q12798 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177143 |
CleanExi | HS_CETN1 |
ExpressionAtlasi | Q12798 baseline and differential |
Genevisiblei | Q12798 HS |
Organism-specific databases
HPAi | CAB037244 HPA028956 |
Interactioni
Subunit structurei
Monomer (By similarity). Interacts with PIFO (PubMed:20643351).By similarity1 Publication
Binary interactionsi
GO - Molecular functioni
- microtubule binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 10749545 interactors. |
IntActi | Q12798 7 interactors. |
MINTi | Q12798 |
STRINGi | 9606.ENSP00000319052 |
Structurei
3D structure databases
ProteinModelPortali | Q12798 |
SMRi | Q12798 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 63 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 64 – 99 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 101 – 136 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 137 – 172 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the centrin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0028 Eukaryota COG5126 LUCA |
GeneTreei | ENSGT00670000097718 |
HOGENOMi | HOG000233018 |
HOVERGENi | HBG012180 |
InParanoidi | Q12798 |
KOi | K16465 |
OMAi | EPRKEEM |
OrthoDBi | EOG091G0RLZ |
PhylomeDBi | Q12798 |
TreeFami | TF101141 |
Family and domain databases
CDDi | cd00051 EFh, 2 hits |
InterProi | View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR000629 RNA-helicase_DEAD-box_CS |
Pfami | View protein in Pfam PF13499 EF-hand_7, 1 hit PF13833 EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054 EFh, 4 hits |
SUPFAMi | SSF47473 SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q12798-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGENLTDE ELQEMIDEAD
160 170
RDGDGEVNEE EFLRIMKKTS LY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03270 mRNA Translation: AAC27343.1 AK312047 mRNA Translation: BAG34983.1 CH471113 Genomic DNA Translation: EAX01727.1 BC029515 mRNA Translation: AAH29515.1 |
CCDSi | CCDS11820.1 |
PIRi | I38424 |
RefSeqi | NP_004057.1, NM_004066.2 |
UniGenei | Hs.122511 |
Genome annotation databases
Ensembli | ENST00000327228; ENSP00000319052; ENSG00000177143 |
GeneIDi | 1068 |
KEGGi | hsa:1068 |
UCSCi | uc002kko.2 human |
Similar proteinsi
Entry informationi
Entry namei | CETN1_HUMAN | |
Accessioni | Q12798Primary (citable) accession number: Q12798 Secondary accession number(s): B2R536 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |