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Protein

Centrin-1

Gene

CETN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function (PubMed:8175926). Plays a role in sperm cilia formation (By similarity).By similarity1 Publication

Miscellaneous

Binds two moles of calcium per mole of protein.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 521CuratedAdd BLAST12
Calcium bindingi150 – 1612CuratedAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandCalcium, Metal-binding

Enzyme and pathway databases

SIGNORiQ12798

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-1
Alternative name(s):
Caltractin isoform 2
Gene namesi
Name:CETN1
Synonyms:CEN1, CETN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000177143.4
HGNCiHGNC:1866 CETN1
MIMi603187 gene
neXtProtiNX_Q12798

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi1068
OpenTargetsiENSG00000177143
PharmGKBiPA26419

Polymorphism and mutation databases

BioMutaiCETN1
DMDMi2493440

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735591 – 172Centrin-1Add BLAST172

Proteomic databases

EPDiQ12798
MaxQBiQ12798
PaxDbiQ12798
PeptideAtlasiQ12798
PRIDEiQ12798

PTM databases

iPTMnetiQ12798
PhosphoSitePlusiQ12798

Expressioni

Gene expression databases

BgeeiENSG00000177143
CleanExiHS_CETN1
ExpressionAtlasiQ12798 baseline and differential
GenevisibleiQ12798 HS

Organism-specific databases

HPAiCAB037244
HPA028956

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with PIFO (PubMed:20643351).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi10749545 interactors.
IntActiQ12798 7 interactors.
MINTiQ12798
STRINGi9606.ENSP00000319052

Structurei

3D structure databases

ProteinModelPortaliQ12798
SMRiQ12798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini64 – 99EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini101 – 136EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini137 – 172EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the centrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00670000097718
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ12798
KOiK16465
OMAiEPRKEEM
OrthoDBiEOG091G0RLZ
PhylomeDBiQ12798
TreeFamiTF101141

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000629 RNA-helicase_DEAD-box_CS
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q12798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGENLTDE ELQEMIDEAD
160 170
RDGDGEVNEE EFLRIMKKTS LY
Length:172
Mass (Da):19,570
Last modified:November 1, 1997 - v1
Checksum:i9ED8193F26F18881
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03270 mRNA Translation: AAC27343.1
AK312047 mRNA Translation: BAG34983.1
CH471113 Genomic DNA Translation: EAX01727.1
BC029515 mRNA Translation: AAH29515.1
CCDSiCCDS11820.1
PIRiI38424
RefSeqiNP_004057.1, NM_004066.2
UniGeneiHs.122511

Genome annotation databases

EnsembliENST00000327228; ENSP00000319052; ENSG00000177143
GeneIDi1068
KEGGihsa:1068
UCSCiuc002kko.2 human

Similar proteinsi

Entry informationi

Entry nameiCETN1_HUMAN
AccessioniPrimary (citable) accession number: Q12798
Secondary accession number(s): B2R536
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome