Reviewed, UniProtKB/Swiss-Prot Q12798 (CETN1_HUMAN)

Names and origin

Protein names

Recommended name:
    Centrin-1
Alternative name(s):
    Caltractin isoform 2

Gene names

Name:	CETN1
Synonyms:	CEN1, CETN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays a fundamental role in microtubule-organizing center structure and function.
Subunit structure	Monomer By similarity.
Subcellular location	Centrosome. Note= Centrosome of interphase and mitotic cells.
Miscellaneous	Binds two moles of calcium per mole of protein.
Sequence similarities	Belongs to the centrin family. Contains 4 EF-hand domains.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Domain	Repeat
Ligand	Calcium
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Ref.1 Traceable author statement. Source: ProtInc mitotic centrosome separation Ref.1 Traceable author statement. Source: ProtInc
Cellular component	centrosome Ref.1 Traceable author statement. Source: ProtInc spindle pole body Ref.1 Traceable author statement. Source: ProtInc
Molecular function	calcium ion binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Centrin-1		PRO_0000073559
Regions
	Domain	28 – 63	36	EF-hand 1
	Domain	64 – 99	36	EF-hand 2
	Domain	101 – 136	36	EF-hand 3
	Domain	137 – 172	36	EF-hand 4
	Calcium binding	41 – 52	12	1 Probable
	Calcium binding	150 – 161	12	2 Probable

Sequences

	Sequence		Length	Mass (Da)
	Q12798-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 9ED8193F26F18881	FASTA	172	19,570
	10 20 30 40 50 60 MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA KELKVAMRAL 70 80 90 100 110 120 GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK DTKEEILKAF RLFDDDETGK 130 140 150 160 170 ISFKNLKRVA NELGENLTDE ELQEMIDEAD RDGDGEVNEE EFLRIMKKTS LY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles." Errabolu R., Sanders M.A., Salisbury J.L. J. Cell Sci. 107:9-16(1994) [PubMed: 8175926] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U03270 mRNA. Translation: AAC27343.1. BC029515 mRNA. Translation: AAH29515.1.
PIR	I38424.
RefSeq	NP_004057.1.
UniGene	Hs.122511
3D structure databases
HSSP	HSSP built from PDB template 1M39 based on UniProtKB P41208.
SMR	Q12798. Positions 24-172.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000177143. Homo sapiens. [Contig view]
GeneID	1068.
KEGG	hsa:1068.
Organism-specific databases
H-InvDB	HIX0018968.
HGNC	HGNC:1866. CETN1.
MIM	603187. gene.
PharmGKB	PA26419.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q12798.
HOVERGEN	Q12798.
Gene expression databases
ArrayExpress	Q12798.
CleanEx	HS_CETN1.
GermOnline	ENSG00000177143. Homo sapiens.
Family and domain databases
InterPro	IPR011992. EF-Hand_type. IPR002048. EF_hand_Ca_bd. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF00036. efhand. 4 hits. [Graphical view]
ProDom	PD000012. EF-hand. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00054. EFh. 4 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4460.
SOURCE	Search...

Entry information

Entry name

CETN1_HUMAN

Accession

Primary (citable) accession number: Q12798

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)