Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Centrin-1

Gene

CETN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi41 – 52121CuratedAdd
BLAST
Calcium bindingi150 – 161122CuratedAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-1
Alternative name(s):
Caltractin isoform 2
Gene namesi
Name:CETN1
Synonyms:CEN1, CETN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:1866. CETN1.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: MGI
  • centrosome Source: UniProtKB
  • photoreceptor connecting cilium Source: Ensembl
  • spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26419.

Polymorphism and mutation databases

BioMutaiCETN1.
DMDMi2493440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Centrin-1PRO_0000073559Add
BLAST

Proteomic databases

EPDiQ12798.
PaxDbiQ12798.
PRIDEiQ12798.

PTM databases

iPTMnetiQ12798.
PhosphoSiteiQ12798.

Expressioni

Gene expression databases

BgeeiQ12798.
CleanExiHS_CETN1.
GenevisibleiQ12798. HS.

Organism-specific databases

HPAiCAB037244.
HPA028956.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with PIFO.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
POC5Q8NA723EBI-2512818,EBI-2561090
SGSM1Q2NKQ1-43EBI-2512818,EBI-10182463

Protein-protein interaction databases

BioGridi107495. 44 interactions.
IntActiQ12798. 4 interactions.
MINTiMINT-6631514.
STRINGi9606.ENSP00000319052.

Structurei

3D structure databases

ProteinModelPortaliQ12798.
SMRiQ12798. Positions 24-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini64 – 9936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini101 – 13636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 17236EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the centrin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ12798.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG7H1JN9.
PhylomeDBiQ12798.
TreeFamiTF101141.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGENLTDE ELQEMIDEAD
160 170
RDGDGEVNEE EFLRIMKKTS LY
Length:172
Mass (Da):19,570
Last modified:November 1, 1997 - v1
Checksum:i9ED8193F26F18881
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03270 mRNA. Translation: AAC27343.1.
AK312047 mRNA. Translation: BAG34983.1.
CH471113 Genomic DNA. Translation: EAX01727.1.
BC029515 mRNA. Translation: AAH29515.1.
CCDSiCCDS11820.1.
PIRiI38424.
RefSeqiNP_004057.1. NM_004066.2.
UniGeneiHs.122511.

Genome annotation databases

EnsembliENST00000327228; ENSP00000319052; ENSG00000177143.
GeneIDi1068.
KEGGihsa:1068.
UCSCiuc002kko.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03270 mRNA. Translation: AAC27343.1.
AK312047 mRNA. Translation: BAG34983.1.
CH471113 Genomic DNA. Translation: EAX01727.1.
BC029515 mRNA. Translation: AAH29515.1.
CCDSiCCDS11820.1.
PIRiI38424.
RefSeqiNP_004057.1. NM_004066.2.
UniGeneiHs.122511.

3D structure databases

ProteinModelPortaliQ12798.
SMRiQ12798. Positions 24-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107495. 44 interactions.
IntActiQ12798. 4 interactions.
MINTiMINT-6631514.
STRINGi9606.ENSP00000319052.

PTM databases

iPTMnetiQ12798.
PhosphoSiteiQ12798.

Polymorphism and mutation databases

BioMutaiCETN1.
DMDMi2493440.

Proteomic databases

EPDiQ12798.
PaxDbiQ12798.
PRIDEiQ12798.

Protocols and materials databases

DNASUi1068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327228; ENSP00000319052; ENSG00000177143.
GeneIDi1068.
KEGGihsa:1068.
UCSCiuc002kko.2. human.

Organism-specific databases

CTDi1068.
GeneCardsiCETN1.
HGNCiHGNC:1866. CETN1.
HPAiCAB037244.
HPA028956.
MIMi603187. gene.
neXtProtiNX_Q12798.
PharmGKBiPA26419.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ12798.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG7H1JN9.
PhylomeDBiQ12798.
TreeFamiTF101141.

Miscellaneous databases

ChiTaRSiCETN1. human.
GeneWikiiCETN1.
GenomeRNAii1068.
NextBioi4460.
PROiQ12798.
SOURCEiSearch...

Gene expression databases

BgeeiQ12798.
CleanExiHS_CETN1.
GenevisibleiQ12798. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles."
    Errabolu R., Sanders M.A., Salisbury J.L.
    J. Cell Sci. 107:9-16(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: INTERACTION WITH PIFO.

Entry informationi

Entry nameiCETN1_HUMAN
AccessioniPrimary (citable) accession number: Q12798
Secondary accession number(s): B2R536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 16, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds two moles of calcium per mole of protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.