CETN1

Functionⁱ

Plays a fundamental role in microtubule-organizing center structure and function.

Miscellaneous

Binds two moles of calcium per mole of protein.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	41 – 52	1CuratedAdd BLAST		12
Calcium bindingⁱ	150 – 161	2CuratedAdd BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
G-protein beta/gamma-subunit complex binding Source: Ensembl
heterotrimeric G-protein binding Source: Ensembl
microtubule binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
cellular response to heat Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Mitosis
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

SIGNORⁱ	Q12798.

SIGNORⁱ

Q12798.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Centrin-1 Alternative name(s): Caltractin isoform 2
Gene namesⁱ	Name:CETN1 Synonyms:CEN1, CETN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1866. CETN1.

HGNCⁱ

HGNC:1866. CETN1.

Subcellular locationⁱ

Cytoplasm › cytoskeleton › microtubule organizing center › centrosome

Note:

Centrosome of interphase and mitotic cells.

GO - Cellular componentⁱ

centriole
Source: MGI
Inferred from direct assayⁱ
- 18331714
- 24421332
centrosome
Source: UniProtKB
Inferred from direct assayⁱ
- 8175926
photoreceptor connecting cilium Source: Ensembl
spindle pole
Source: UniProtKB
Inferred from direct assayⁱ
- 8175926

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1068.
Open Targets More...OpenTargetsⁱ	ENSG00000177143.
PharmGKBⁱ	PA26419.

Polymorphism and mutation databases

BioMutaⁱ	CETN1.
DMDMⁱ	2493440.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000073559	2 – 172	Centrin-1Add BLAST		171

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineBy similarity		1
Modified residueⁱ	26	PhosphothreonineBy similarity		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q12798.
PaxDbⁱ	Q12798.
PeptideAtlas More...PeptideAtlasⁱ	Q12798.
PRIDEⁱ	Q12798.

PTM databases

iPTMnetⁱ	Q12798.
PhosphoSitePlusⁱ	Q12798.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177143.
CleanExⁱ	HS_CETN1.
ExpressionAtlasⁱ	Q12798. baseline and differential.
Genevisibleⁱ	Q12798. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037244. HPA028956.

HPAⁱ

CAB037244.
HPA028956.

Interactionⁱ

Subunit structureⁱ

Monomer (By similarity). Interacts with PIFO.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
POC5	Q8NA72	3	EBI-2512818,EBI-2561090
POC5	Q8NA72-3	4	EBI-2512818,EBI-11751537
SGSM1	Q2NKQ1-4	5	EBI-2512818,EBI-10182463

Show more details

GO - Molecular functionⁱ

G-protein beta/gamma-subunit complex binding Source: Ensembl
heterotrimeric G-protein binding Source: Ensembl
microtubule binding Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	107495. 44 interactors.
IntActⁱ	Q12798. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-6631514.
STRINGⁱ	9606.ENSP00000319052.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q12798.
SMRⁱ	Q12798.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	28 – 63	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	64 – 99	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	101 – 136	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	137 – 172	EF-hand 4PROSITE-ProRule annotationAdd BLAST	36

Sequence similaritiesⁱ

Belongs to the centrin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0028. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00670000097718.
HOGENOMⁱ	HOG000233018.
HOVERGENⁱ	HBG012180.
InParanoidⁱ	Q12798.
KEGG Orthology (KO) More...KOⁱ	K16465.
OMAⁱ	EPRKEEM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RLZ.
PhylomeDBⁱ	Q12798.
TreeFamⁱ	TF101141.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051. EFh. 2 hits.
Gene3Dⁱ	1.10.150.240. 1 hit.
InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR023198. PGP_dom2. IPR000629. RNA-helicase_DEAD-box_CS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499. EF-hand_7. 1 hit. PF13833. EF-hand_8. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 4 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 4 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q12798-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA 
        60         70         80         90        100
KELKVAMRAL GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK 
       110        120        130        140        150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGENLTDE ELQEMIDEAD 
       160        170 
RDGDGEVNEE EFLRIMKKTS LY

Length:172

Mass (Da):19,570

Last modified:November 1, 1997 - v1

Checksum:ⁱ9ED8193F26F18881

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U03270 mRNA. Translation: AAC27343.1. AK312047 mRNA. Translation: BAG34983.1. CH471113 Genomic DNA. Translation: EAX01727.1. BC029515 mRNA. Translation: AAH29515.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11820.1.
PIRⁱ	I38424.
NCBI Reference Sequences More...RefSeqⁱ	NP_004057.1. NM_004066.2.
UniGeneⁱ	Hs.122511.

Genome annotation databases

Ensemblⁱ	ENST00000327228; ENSP00000319052; ENSG00000177143.
GeneIDⁱ	1068.
KEGGⁱ	hsa:1068.
UCSC genome browser More...UCSCⁱ	uc002kko.2. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U03270 mRNA. Translation: AAC27343.1. AK312047 mRNA. Translation: BAG34983.1. CH471113 Genomic DNA. Translation: EAX01727.1. BC029515 mRNA. Translation: AAH29515.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11820.1.
PIRⁱ	I38424.
NCBI Reference Sequences More...RefSeqⁱ	NP_004057.1. NM_004066.2.
UniGeneⁱ	Hs.122511.

3D structure databases

ProteinModelPortalⁱ	Q12798.
SMRⁱ	Q12798.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107495. 44 interactors.
IntActⁱ	Q12798. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-6631514.
STRINGⁱ	9606.ENSP00000319052.

PTM databases

iPTMnetⁱ	Q12798.
PhosphoSitePlusⁱ	Q12798.

Polymorphism and mutation databases

BioMutaⁱ	CETN1.
DMDMⁱ	2493440.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q12798.
PaxDbⁱ	Q12798.
PeptideAtlas More...PeptideAtlasⁱ	Q12798.
PRIDEⁱ	Q12798.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1068.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000327228; ENSP00000319052; ENSG00000177143.
GeneIDⁱ	1068.
KEGGⁱ	hsa:1068.
UCSC genome browser More...UCSCⁱ	uc002kko.2. human.

Organism-specific databases

CTDⁱ	1068.
DisGeNET More...DisGeNETⁱ	1068.
GeneCardsⁱ	CETN1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1866. CETN1.
Human Protein Atlas More...HPAⁱ	CAB037244. HPA028956.
MIMⁱ	603187. gene.
neXtProtⁱ	NX_Q12798.
Open Targets More...OpenTargetsⁱ	ENSG00000177143.
PharmGKBⁱ	PA26419.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0028. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00670000097718.
HOGENOMⁱ	HOG000233018.
HOVERGENⁱ	HBG012180.
InParanoidⁱ	Q12798.
KEGG Orthology (KO) More...KOⁱ	K16465.
OMAⁱ	EPRKEEM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RLZ.
PhylomeDBⁱ	Q12798.
TreeFamⁱ	TF101141.

Enzyme and pathway databases

SIGNORⁱ	Q12798.

SIGNORⁱ

Q12798.

Miscellaneous databases

ChiTaRSⁱ	CETN1. human.
GeneWikiⁱ	CETN1.
GenomeRNAiⁱ	1068.
Protein Ontology More...PROⁱ	PR:Q12798.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177143.
CleanExⁱ	HS_CETN1.
ExpressionAtlasⁱ	Q12798. baseline and differential.
Genevisibleⁱ	Q12798. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051. EFh. 2 hits.
Gene3Dⁱ	1.10.150.240. 1 hit.
InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR023198. PGP_dom2. IPR000629. RNA-helicase_DEAD-box_CS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499. EF-hand_7. 1 hit. PF13833. EF-hand_8. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 4 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 4 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CETN1_HUMAN
Accessionⁱ	Q12798Primary (citable) accession number: Q12798 Secondary accession number(s): B2R536
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	June 7, 2017
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q12798 (CETN1_HUMAN)

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Centrin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ