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Protein

Centrin-1

Gene

CETN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 521CuratedAdd BLAST12
Calcium bindingi150 – 1612CuratedAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177143-MONOMER.
SIGNORiQ12798.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-1
Alternative name(s):
Caltractin isoform 2
Gene namesi
Name:CETN1
Synonyms:CEN1, CETN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:1866. CETN1.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: MGI
  • centrosome Source: UniProtKB
  • photoreceptor connecting cilium Source: Ensembl
  • spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi1068.
OpenTargetsiENSG00000177143.
PharmGKBiPA26419.

Polymorphism and mutation databases

BioMutaiCETN1.
DMDMi2493440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000735592 – 172Centrin-1Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei26PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ12798.
PaxDbiQ12798.
PeptideAtlasiQ12798.
PRIDEiQ12798.

PTM databases

iPTMnetiQ12798.
PhosphoSitePlusiQ12798.

Expressioni

Gene expression databases

BgeeiENSG00000177143.
CleanExiHS_CETN1.
ExpressionAtlasiQ12798. baseline and differential.
GenevisibleiQ12798. HS.

Organism-specific databases

HPAiCAB037244.
HPA028956.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with PIFO.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
POC5Q8NA723EBI-2512818,EBI-2561090
POC5Q8NA72-34EBI-2512818,EBI-11751537
SGSM1Q2NKQ1-45EBI-2512818,EBI-10182463

Protein-protein interaction databases

BioGridi107495. 44 interactors.
IntActiQ12798. 7 interactors.
MINTiMINT-6631514.
STRINGi9606.ENSP00000319052.

Structurei

3D structure databases

ProteinModelPortaliQ12798.
SMRiQ12798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini64 – 99EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini101 – 136EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini137 – 172EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the centrin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ12798.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG091G0RLZ.
PhylomeDBiQ12798.
TreeFamiTF101141.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGENLTDE ELQEMIDEAD
160 170
RDGDGEVNEE EFLRIMKKTS LY
Length:172
Mass (Da):19,570
Last modified:November 1, 1997 - v1
Checksum:i9ED8193F26F18881
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03270 mRNA. Translation: AAC27343.1.
AK312047 mRNA. Translation: BAG34983.1.
CH471113 Genomic DNA. Translation: EAX01727.1.
BC029515 mRNA. Translation: AAH29515.1.
CCDSiCCDS11820.1.
PIRiI38424.
RefSeqiNP_004057.1. NM_004066.2.
UniGeneiHs.122511.

Genome annotation databases

EnsembliENST00000327228; ENSP00000319052; ENSG00000177143.
GeneIDi1068.
KEGGihsa:1068.
UCSCiuc002kko.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03270 mRNA. Translation: AAC27343.1.
AK312047 mRNA. Translation: BAG34983.1.
CH471113 Genomic DNA. Translation: EAX01727.1.
BC029515 mRNA. Translation: AAH29515.1.
CCDSiCCDS11820.1.
PIRiI38424.
RefSeqiNP_004057.1. NM_004066.2.
UniGeneiHs.122511.

3D structure databases

ProteinModelPortaliQ12798.
SMRiQ12798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107495. 44 interactors.
IntActiQ12798. 7 interactors.
MINTiMINT-6631514.
STRINGi9606.ENSP00000319052.

PTM databases

iPTMnetiQ12798.
PhosphoSitePlusiQ12798.

Polymorphism and mutation databases

BioMutaiCETN1.
DMDMi2493440.

Proteomic databases

MaxQBiQ12798.
PaxDbiQ12798.
PeptideAtlasiQ12798.
PRIDEiQ12798.

Protocols and materials databases

DNASUi1068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327228; ENSP00000319052; ENSG00000177143.
GeneIDi1068.
KEGGihsa:1068.
UCSCiuc002kko.2. human.

Organism-specific databases

CTDi1068.
DisGeNETi1068.
GeneCardsiCETN1.
HGNCiHGNC:1866. CETN1.
HPAiCAB037244.
HPA028956.
MIMi603187. gene.
neXtProtiNX_Q12798.
OpenTargetsiENSG00000177143.
PharmGKBiPA26419.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ12798.
KOiK16465.
OMAiMASTFRK.
OrthoDBiEOG091G0RLZ.
PhylomeDBiQ12798.
TreeFamiTF101141.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177143-MONOMER.
SIGNORiQ12798.

Miscellaneous databases

ChiTaRSiCETN1. human.
GeneWikiiCETN1.
GenomeRNAii1068.
PROiQ12798.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177143.
CleanExiHS_CETN1.
ExpressionAtlasiQ12798. baseline and differential.
GenevisibleiQ12798. HS.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR029527. CETN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000629. RNA-helicase_DEAD-box_CS.
[Graphical view]
PANTHERiPTHR23050:SF218. PTHR23050:SF218. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCETN1_HUMAN
AccessioniPrimary (citable) accession number: Q12798
Secondary accession number(s): B2R536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds two moles of calcium per mole of protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.