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Q12796

- PNRC1_HUMAN

UniProt

Q12796 - PNRC1_HUMAN

Protein

Proline-rich nuclear receptor coactivator 1

Gene

PNRC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Nuclear receptor coactivator. May play a role in signal transduction.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline-rich nuclear receptor coactivator 1
    Alternative name(s):
    Proline-rich protein 2
    Protein B4-2
    Gene namesi
    Name:PNRC1
    Synonyms:PROL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17278. PNRC1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi287 – 2871P → A: Abolishes the interaction with the nuclear receptors; when associated with A-290. 1 Publication
    Mutagenesisi290 – 2901P → A: Abolishes the interaction with the nuclear receptors; when associated with A-287. 1 Publication

    Organism-specific databases

    PharmGKBiPA33804.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Proline-rich nuclear receptor coactivator 1PRO_0000058482Add
    BLAST

    Proteomic databases

    PaxDbiQ12796.
    PRIDEiQ12796.

    Expressioni

    Tissue specificityi

    Expressed in liver, lung, fat and NK/T cells.1 Publication

    Gene expression databases

    ArrayExpressiQ12796.
    BgeeiQ12796.
    CleanExiHS_PNRC1.
    GenevestigatoriQ12796.

    Organism-specific databases

    HPAiHPA029839.

    Interactioni

    Subunit structurei

    Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Interacts with GRB2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    POLR3FQ9H1D93EBI-2827376,EBI-710067

    Protein-protein interaction databases

    BioGridi116157. 13 interactions.
    IntActiQ12796. 5 interactions.
    MINTiMINT-5209968.
    STRINGi9606.ENSP00000336931.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12796.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi94 – 1018Nuclear localization signal1 Publication
    Motifi285 – 2917SH3-binding

    Domaini

    The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif.

    Sequence similaritiesi

    Belongs to the PNRC family. PNRC1 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG28502.
    HOGENOMiHOG000059555.
    HOVERGENiHBG053626.
    InParanoidiQ12796.
    OMAiHFLGGDG.
    OrthoDBiEOG7W41CG.
    PhylomeDBiQ12796.
    TreeFamiTF333211.

    Family and domain databases

    InterProiIPR026780. PNRC1/2.
    [Graphical view]
    PANTHERiPTHR15405. PTHR15405. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q12796-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVVSVPQRE PLVLGGRLAP LGFSSRGYFG ALPMVTTAPP PLPRIPDPRA    50
    LPPTLFLPHF LGGDGPCLTP QPRAPAALPN RSLAVAGGTP RAAPKKRRKK 100
    KVRASPAGQL PSRFHQYQQH RPSLEGGRSP ATGPSGAQEV PGPAAALAPS 150
    PAAAAGTEGA SPDLAPLRPA APGQTPLRKE VLKSKMGKSE KIALPHGQLV 200
    HGIHLYEQPK INRQKSKYNL PLTKITSAKR NENNFWQDSV SSDRIQKQEK 250
    KPFKNTENIK NSHLKKSAFL TEVSQKENYA GAKFSDPPSP SVLPKPPSHW 300
    MGSTVENSNQ NRELMAVHLK TLLKVQT 327
    Length:327
    Mass (Da):35,225
    Last modified:November 1, 1996 - v1
    Checksum:i97E0D65C2E690763
    GO
    Isoform 2 (identifier: Q12796-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         102-180: Missing.

    Show »
    Length:248
    Mass (Da):27,374
    Checksum:i734F69C11B023FA7
    GO

    Sequence cautioni

    The sequence CAI16244.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti218 – 2181Y → N in AAP76184. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti252 – 2521P → L.
    Corresponds to variant rs2231277 [ dbSNP | Ensembl ].
    VAR_051284

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei102 – 18079Missing in isoform 2. 1 PublicationVSP_055501Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03105 mRNA. Translation: AAA85576.1.
    AY303779 mRNA. Translation: AAP76184.1.
    AK312665 mRNA. Translation: BAG35547.1.
    AL353135 Genomic DNA. Translation: CAI16243.1.
    AL353135 Genomic DNA. Translation: CAI16244.1. Sequence problems.
    CH471051 Genomic DNA. Translation: EAW48563.1.
    CH471051 Genomic DNA. Translation: EAW48564.1.
    BC018112 mRNA. Translation: AAH18112.1.
    CCDSiCCDS5018.1.
    PIRiS59960.
    RefSeqiNP_006804.1. NM_006813.2.
    UniGeneiHs.75969.

    Genome annotation databases

    EnsembliENST00000336032; ENSP00000336931; ENSG00000146278. [Q12796-1]
    GeneIDi10957.
    KEGGihsa:10957.
    UCSCiuc003pmv.3. human.

    Polymorphism databases

    DMDMi21362754.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03105 mRNA. Translation: AAA85576.1 .
    AY303779 mRNA. Translation: AAP76184.1 .
    AK312665 mRNA. Translation: BAG35547.1 .
    AL353135 Genomic DNA. Translation: CAI16243.1 .
    AL353135 Genomic DNA. Translation: CAI16244.1 . Sequence problems.
    CH471051 Genomic DNA. Translation: EAW48563.1 .
    CH471051 Genomic DNA. Translation: EAW48564.1 .
    BC018112 mRNA. Translation: AAH18112.1 .
    CCDSi CCDS5018.1.
    PIRi S59960.
    RefSeqi NP_006804.1. NM_006813.2.
    UniGenei Hs.75969.

    3D structure databases

    ProteinModelPortali Q12796.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116157. 13 interactions.
    IntActi Q12796. 5 interactions.
    MINTi MINT-5209968.
    STRINGi 9606.ENSP00000336931.

    Polymorphism databases

    DMDMi 21362754.

    Proteomic databases

    PaxDbi Q12796.
    PRIDEi Q12796.

    Protocols and materials databases

    DNASUi 10957.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336032 ; ENSP00000336931 ; ENSG00000146278 . [Q12796-1 ]
    GeneIDi 10957.
    KEGGi hsa:10957.
    UCSCi uc003pmv.3. human.

    Organism-specific databases

    CTDi 10957.
    GeneCardsi GC06P089790.
    HGNCi HGNC:17278. PNRC1.
    HPAi HPA029839.
    MIMi 606714. gene.
    neXtProti NX_Q12796.
    PharmGKBi PA33804.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28502.
    HOGENOMi HOG000059555.
    HOVERGENi HBG053626.
    InParanoidi Q12796.
    OMAi HFLGGDG.
    OrthoDBi EOG7W41CG.
    PhylomeDBi Q12796.
    TreeFami TF333211.

    Miscellaneous databases

    ChiTaRSi PNRC1. human.
    GeneWikii PNRC1.
    GenomeRNAii 10957.
    NextBioi 41640.
    PROi Q12796.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q12796.
    Bgeei Q12796.
    CleanExi HS_PNRC1.
    Genevestigatori Q12796.

    Family and domain databases

    InterProi IPR026780. PNRC1/2.
    [Graphical view ]
    PANTHERi PTHR15405. PTHR15405. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content."
      Chen J., Liu L., Pohajdak B.
      Biochim. Biophys. Acta 1264:19-22(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Zhou G., Ke R., Li H., Cao L., Shen C., Zheng G., Yu R., Zhong G., Huang F., Lin L., Yang S.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    7. "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)."
      Zhou D., Quach K.M., Yang C., Lee S.Y., Pohajdak B., Chen S.
      Mol. Endocrinol. 14:986-998(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NUCLEAR RECEPTORS, MUTAGENESIS OF PRO-287 AND PRO-290, NUCLEAR LOCALIZATION SIGNAL, SUBCELLULAR LOCATION.
    8. "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif."
      Zhou D., Chen S.
      Nucleic Acids Res. 29:3939-3948(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH GRB2.

    Entry informationi

    Entry nameiPNRC1_HUMAN
    AccessioniPrimary (citable) accession number: Q12796
    Secondary accession number(s): B2R6Q0
    , E1P515, Q5T7J6, Q7Z5N0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3