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Q12796 (PNRC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proline-rich nuclear receptor coactivator 1
Alternative name(s):
Proline-rich protein 2
Protein B4-2
Gene names
Name:PNRC1
Synonyms:PROL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nuclear receptor coactivator. May play a role in signal transduction. Ref.6

Subunit structure

Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Interacts with GRB2. Ref.6 Ref.7

Subcellular location

Nucleus Potential Ref.6.

Tissue specificity

Expressed in liver, lung, fat and NK/T cells. Ref.7

Domain

The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif.

Sequence similarities

Belongs to the PNRC family. PNRC1 subfamily.

Sequence caution

The sequence CAI16244.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

POLR3FQ9H1D93EBI-2827376,EBI-710067

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Proline-rich nuclear receptor coactivator 1
PRO_0000058482

Regions

Motif94 – 1018Nuclear localization signal Ref.6
Motif285 – 2917SH3-binding

Natural variations

Natural variant2521P → L.
Corresponds to variant rs2231277 [ dbSNP | Ensembl ].
VAR_051284

Experimental info

Mutagenesis2871P → A: Abolishes the interaction with the nuclear receptors; when associated with A-290. Ref.6
Mutagenesis2901P → A: Abolishes the interaction with the nuclear receptors; when associated with A-287. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q12796 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 97E0D65C2E690763

FASTA32735,225
        10         20         30         40         50         60 
MTVVSVPQRE PLVLGGRLAP LGFSSRGYFG ALPMVTTAPP PLPRIPDPRA LPPTLFLPHF 

        70         80         90        100        110        120 
LGGDGPCLTP QPRAPAALPN RSLAVAGGTP RAAPKKRRKK KVRASPAGQL PSRFHQYQQH 

       130        140        150        160        170        180 
RPSLEGGRSP ATGPSGAQEV PGPAAALAPS PAAAAGTEGA SPDLAPLRPA APGQTPLRKE 

       190        200        210        220        230        240 
VLKSKMGKSE KIALPHGQLV HGIHLYEQPK INRQKSKYNL PLTKITSAKR NENNFWQDSV 

       250        260        270        280        290        300 
SSDRIQKQEK KPFKNTENIK NSHLKKSAFL TEVSQKENYA GAKFSDPPSP SVLPKPPSHW 

       310        320 
MGSTVENSNQ NRELMAVHLK TLLKVQT 

« Hide

References

« Hide 'large scale' references
[1]"Cloning a cDNA from human NK/T cells which codes for a protein with high proline content."
Chen J., Liu L., Pohajdak B.
Biochim. Biophys. Acta 1264:19-22(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[6]"PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)."
Zhou D., Quach K.M., Yang C., Lee S.Y., Pohajdak B., Chen S.
Mol. Endocrinol. 14:986-998(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NUCLEAR RECEPTORS, MUTAGENESIS OF PRO-287 AND PRO-290, NUCLEAR LOCALIZATION SIGNAL, SUBCELLULAR LOCATION.
[7]"PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif."
Zhou D., Chen S.
Nucleic Acids Res. 29:3939-3948(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH GRB2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03105 mRNA. Translation: AAA85576.1.
AK312665 mRNA. Translation: BAG35547.1.
AL353135 Genomic DNA. Translation: CAI16243.1.
AL353135 Genomic DNA. Translation: CAI16244.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48563.1.
CH471051 Genomic DNA. Translation: EAW48564.1.
BC018112 mRNA. Translation: AAH18112.1.
PIRS59960.
RefSeqNP_006804.1. NM_006813.2.
UniGeneHs.75969.

3D structure databases

ProteinModelPortalQ12796.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116157. 11 interactions.
IntActQ12796. 5 interactions.
MINTMINT-5209968.
STRING9606.ENSP00000336931.

Polymorphism databases

DMDM21362754.

Proteomic databases

PaxDbQ12796.
PRIDEQ12796.

Protocols and materials databases

DNASU10957.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336032; ENSP00000336931; ENSG00000146278.
GeneID10957.
KEGGhsa:10957.
UCSCuc003pmv.3. human.

Organism-specific databases

CTD10957.
GeneCardsGC06P089790.
HGNCHGNC:17278. PNRC1.
HPAHPA029839.
MIM606714. gene.
neXtProtNX_Q12796.
PharmGKBPA33804.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28502.
HOGENOMHOG000059555.
HOVERGENHBG053626.
InParanoidQ12796.
OMAHFLGGDG.
OrthoDBEOG7W41CG.
PhylomeDBQ12796.
TreeFamTF333211.

Gene expression databases

ArrayExpressQ12796.
BgeeQ12796.
CleanExHS_PNRC1.
GenevestigatorQ12796.

Family and domain databases

InterProIPR028322. PNRC.
IPR026780. PNRC1/2.
[Graphical view]
PANTHERPTHR15405. PTHR15405. 1 hit.
PfamPF15365. PNRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPNRC1. human.
GeneWikiPNRC1.
GenomeRNAi10957.
NextBio41640.
PROQ12796.
SOURCESearch...

Entry information

Entry namePNRC1_HUMAN
AccessionPrimary (citable) accession number: Q12796
Secondary accession number(s): B2R6Q0, E1P515, Q5T7J6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM