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Protein

Proline-rich nuclear receptor coactivator 1

Gene

PNRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear receptor coactivator. May play a role in signal transduction.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich nuclear receptor coactivator 1
Alternative name(s):
Proline-rich protein 2
Protein B4-2
Gene namesi
Name:PNRC1
Synonyms:PROL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17278. PNRC1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi287 – 2871P → A: Abolishes the interaction with the nuclear receptors; when associated with A-290. 1 Publication
Mutagenesisi290 – 2901P → A: Abolishes the interaction with the nuclear receptors; when associated with A-287. 1 Publication

Organism-specific databases

PharmGKBiPA33804.

Polymorphism and mutation databases

BioMutaiPNRC1.
DMDMi21362754.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Proline-rich nuclear receptor coactivator 1PRO_0000058482Add
BLAST

Proteomic databases

PaxDbiQ12796.
PRIDEiQ12796.

Expressioni

Tissue specificityi

Expressed in liver, lung, fat and NK/T cells.1 Publication

Gene expression databases

BgeeiQ12796.
CleanExiHS_PNRC1.
ExpressionAtlasiQ12796. baseline and differential.
GenevestigatoriQ12796.

Organism-specific databases

HPAiHPA029839.

Interactioni

Subunit structurei

Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Interacts with GRB2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POLR3FQ9H1D93EBI-2827376,EBI-710067

Protein-protein interaction databases

BioGridi116157. 14 interactions.
IntActiQ12796. 5 interactions.
MINTiMINT-5209968.
STRINGi9606.ENSP00000336931.

Structurei

3D structure databases

ProteinModelPortaliQ12796.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 1018Nuclear localization signal1 Publication
Motifi285 – 2917SH3-binding

Domaini

The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif.

Sequence similaritiesi

Belongs to the PNRC family. PNRC1 subfamily.Curated

Phylogenomic databases

eggNOGiNOG28502.
GeneTreeiENSGT00530000063881.
HOGENOMiHOG000059555.
HOVERGENiHBG053626.
InParanoidiQ12796.
KOiK18774.
OMAiPAALPNC.
OrthoDBiEOG7W41CG.
PhylomeDBiQ12796.
TreeFamiTF333211.

Family and domain databases

InterProiIPR026780. PNRC1/2.
[Graphical view]
PANTHERiPTHR15405. PTHR15405. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12796-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVVSVPQRE PLVLGGRLAP LGFSSRGYFG ALPMVTTAPP PLPRIPDPRA
60 70 80 90 100
LPPTLFLPHF LGGDGPCLTP QPRAPAALPN RSLAVAGGTP RAAPKKRRKK
110 120 130 140 150
KVRASPAGQL PSRFHQYQQH RPSLEGGRSP ATGPSGAQEV PGPAAALAPS
160 170 180 190 200
PAAAAGTEGA SPDLAPLRPA APGQTPLRKE VLKSKMGKSE KIALPHGQLV
210 220 230 240 250
HGIHLYEQPK INRQKSKYNL PLTKITSAKR NENNFWQDSV SSDRIQKQEK
260 270 280 290 300
KPFKNTENIK NSHLKKSAFL TEVSQKENYA GAKFSDPPSP SVLPKPPSHW
310 320
MGSTVENSNQ NRELMAVHLK TLLKVQT
Length:327
Mass (Da):35,225
Last modified:November 1, 1996 - v1
Checksum:i97E0D65C2E690763
GO
Isoform 2 (identifier: Q12796-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-180: Missing.

Show »
Length:248
Mass (Da):27,374
Checksum:i734F69C11B023FA7
GO

Sequence cautioni

The sequence CAI16244.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181Y → N in AAP76184 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti252 – 2521P → L.
Corresponds to variant rs2231277 [ dbSNP | Ensembl ].
VAR_051284

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei102 – 18079Missing in isoform 2. 1 PublicationVSP_055501Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03105 mRNA. Translation: AAA85576.1.
AY303779 mRNA. Translation: AAP76184.1.
AK312665 mRNA. Translation: BAG35547.1.
AL353135 Genomic DNA. Translation: CAI16243.1.
AL353135 Genomic DNA. Translation: CAI16244.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48563.1.
CH471051 Genomic DNA. Translation: EAW48564.1.
BC018112 mRNA. Translation: AAH18112.1.
CCDSiCCDS5018.1. [Q12796-1]
PIRiS59960.
RefSeqiNP_006804.1. NM_006813.2. [Q12796-1]
UniGeneiHs.75969.

Genome annotation databases

EnsembliENST00000336032; ENSP00000336931; ENSG00000146278. [Q12796-1]
GeneIDi10957.
KEGGihsa:10957.
UCSCiuc003pmv.3. human. [Q12796-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03105 mRNA. Translation: AAA85576.1.
AY303779 mRNA. Translation: AAP76184.1.
AK312665 mRNA. Translation: BAG35547.1.
AL353135 Genomic DNA. Translation: CAI16243.1.
AL353135 Genomic DNA. Translation: CAI16244.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48563.1.
CH471051 Genomic DNA. Translation: EAW48564.1.
BC018112 mRNA. Translation: AAH18112.1.
CCDSiCCDS5018.1. [Q12796-1]
PIRiS59960.
RefSeqiNP_006804.1. NM_006813.2. [Q12796-1]
UniGeneiHs.75969.

3D structure databases

ProteinModelPortaliQ12796.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116157. 14 interactions.
IntActiQ12796. 5 interactions.
MINTiMINT-5209968.
STRINGi9606.ENSP00000336931.

Polymorphism and mutation databases

BioMutaiPNRC1.
DMDMi21362754.

Proteomic databases

PaxDbiQ12796.
PRIDEiQ12796.

Protocols and materials databases

DNASUi10957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336032; ENSP00000336931; ENSG00000146278. [Q12796-1]
GeneIDi10957.
KEGGihsa:10957.
UCSCiuc003pmv.3. human. [Q12796-1]

Organism-specific databases

CTDi10957.
GeneCardsiGC06P089790.
HGNCiHGNC:17278. PNRC1.
HPAiHPA029839.
MIMi606714. gene.
neXtProtiNX_Q12796.
PharmGKBiPA33804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28502.
GeneTreeiENSGT00530000063881.
HOGENOMiHOG000059555.
HOVERGENiHBG053626.
InParanoidiQ12796.
KOiK18774.
OMAiPAALPNC.
OrthoDBiEOG7W41CG.
PhylomeDBiQ12796.
TreeFamiTF333211.

Miscellaneous databases

ChiTaRSiPNRC1. human.
GeneWikiiPNRC1.
GenomeRNAii10957.
NextBioi41640.
PROiQ12796.
SOURCEiSearch...

Gene expression databases

BgeeiQ12796.
CleanExiHS_PNRC1.
ExpressionAtlasiQ12796. baseline and differential.
GenevestigatoriQ12796.

Family and domain databases

InterProiIPR026780. PNRC1/2.
[Graphical view]
PANTHERiPTHR15405. PTHR15405. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content."
    Chen J., Liu L., Pohajdak B.
    Biochim. Biophys. Acta 1264:19-22(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Zhou G., Ke R., Li H., Cao L., Shen C., Zheng G., Yu R., Zhong G., Huang F., Lin L., Yang S.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  7. "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)."
    Zhou D., Quach K.M., Yang C., Lee S.Y., Pohajdak B., Chen S.
    Mol. Endocrinol. 14:986-998(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NUCLEAR RECEPTORS, MUTAGENESIS OF PRO-287 AND PRO-290, NUCLEAR LOCALIZATION SIGNAL, SUBCELLULAR LOCATION.
  8. "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif."
    Zhou D., Chen S.
    Nucleic Acids Res. 29:3939-3948(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH GRB2.

Entry informationi

Entry nameiPNRC1_HUMAN
AccessioniPrimary (citable) accession number: Q12796
Secondary accession number(s): B2R6Q0
, E1P515, Q5T7J6, Q7Z5N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.