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Protein

Hyaluronidase-1

Gene

HYAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.1 Publication

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

pH dependencei

Optimum pH is about 3.8.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131Proton donorCurated1

GO - Molecular functioni

  • hyaluronan synthase activity Source: UniProtKB
  • hyalurononglucosaminidase activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • cartilage development Source: UniProtKB
  • cellular response to fibroblast growth factor stimulus Source: UniProtKB
  • cellular response to interleukin-1 Source: UniProtKB
  • cellular response to pH Source: UniProtKB
  • cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  • cellular response to tumor necrosis factor Source: UniProtKB
  • cellular response to UV-B Source: UniProtKB
  • chondroitin sulfate catabolic process Source: Reactome
  • embryonic skeletal joint morphogenesis Source: Ensembl
  • hyaluronan biosynthetic process Source: UniProtKB
  • hyaluronan catabolic process Source: UniProtKB
  • hyaluronan metabolic process Source: UniProtKB
  • inflammatory response Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of epithelial cell migration Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of growth Source: UniProtKB
  • positive regulation of hyaluranon cable assembly Source: UniProtKB
  • response to antibiotic Source: UniProtKB
  • response to reactive oxygen species Source: UniProtKB
  • response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS03763-MONOMER.
ZFISH:HS03763-MONOMER.
BRENDAi3.2.1.35. 2681.
4.2.2.1. 2681.
ReactomeiR-HSA-2024101. CS/DS degradation.
R-HSA-2160916. Hyaluronan uptake and degradation.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-1 (EC:3.2.1.35)
Short name:
Hyal-1
Alternative name(s):
Hyaluronoglucosaminidase-1
Lung carcinoma protein 1
Short name:
LuCa-1
Gene namesi
Name:HYAL1
Synonyms:LUCA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:5320. HYAL1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • hyaluranon cable Source: UniProtKB
  • lysosomal lumen Source: Reactome
  • lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

Pathology & Biotechi

Involvement in diseasei

Mucopolysaccharidosis 9 (MPS9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA lysosomal storage disease characterized by high hyaluronan concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.
See also OMIM:601492
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023643268E → K in MPS9. 1 PublicationCorresponds to variant rs104893743dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Mucopolysaccharidosis

Organism-specific databases

DisGeNETi3373.
MalaCardsiHYAL1.
MIMi601492. phenotype.
OpenTargetsiENSG00000114378.
Orphaneti67041. Hyaluronidase deficiency.
PharmGKBiPA29571.

Chemistry databases

ChEMBLiCHEMBL4528.

Polymorphism and mutation databases

BioMutaiHYAL1.
DMDMi74735617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004262222 – 435Hyaluronidase-1Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 3331 Publication
Glycosylationi99N-linked (GlcNAc...)1 Publication1
Disulfide bondi207 ↔ 2211 Publication
Glycosylationi216N-linked (GlcNAc...)1 Publication1
Glycosylationi350N-linked (GlcNAc...)1 Publication1
Disulfide bondi358 ↔ 3691 Publication
Disulfide bondi363 ↔ 4181 Publication
Disulfide bondi420 ↔ 4291 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ12794.
PaxDbiQ12794.
PeptideAtlasiQ12794.
PRIDEiQ12794.

PTM databases

iPTMnetiQ12794.
PhosphoSitePlusiQ12794.

Expressioni

Tissue specificityi

Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.3 Publications

Gene expression databases

BgeeiENSG00000114378.
ExpressionAtlasiQ12794. baseline and differential.
GenevisibleiQ12794. HS.

Organism-specific databases

HPAiHPA002112.

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109603. 8 interactors.
IntActiQ12794. 2 interactors.

Chemistry databases

BindingDBiQ12794.

Structurei

Secondary structure

1435
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 27Combined sources4
Beta strandi30 – 38Combined sources9
Helixi40 – 47Combined sources8
Beta strandi56 – 59Combined sources4
Beta strandi69 – 74Combined sources6
Beta strandi78 – 80Combined sources3
Helixi97 – 99Combined sources3
Helixi102 – 116Combined sources15
Beta strandi124 – 128Combined sources5
Helixi137 – 139Combined sources3
Helixi142 – 144Combined sources3
Helixi145 – 158Combined sources14
Beta strandi159 – 161Combined sources3
Helixi164 – 193Combined sources30
Beta strandi197 – 202Combined sources6
Helixi223 – 230Combined sources8
Helixi233 – 238Combined sources6
Beta strandi240 – 243Combined sources4
Helixi250 – 252Combined sources3
Helixi258 – 275Combined sources18
Helixi300 – 304Combined sources5
Helixi307 – 312Combined sources6
Beta strandi316 – 321Combined sources6
Helixi324 – 326Combined sources3
Beta strandi327 – 329Combined sources3
Helixi330 – 342Combined sources13
Helixi344 – 362Combined sources19
Beta strandi366 – 371Combined sources6
Turni384 – 386Combined sources3
Beta strandi387 – 391Combined sources5
Helixi393 – 395Combined sources3
Beta strandi398 – 402Combined sources5
Helixi406 – 415Combined sources10
Beta strandi416 – 420Combined sources5
Turni426 – 429Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PE4X-ray2.00A22-435[»]
ProteinModelPortaliQ12794.
SMRiQ12794.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12794.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini354 – 430EGF-likeAdd BLAST77

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiENOG410IECJ. Eukaryota.
ENOG410XPZT. LUCA.
GeneTreeiENSGT00550000074476.
HOVERGENiHBG052053.
InParanoidiQ12794.
KOiK01197.
OMAiPNYTGQC.
OrthoDBiEOG091G064G.
PhylomeDBiQ12794.
TreeFamiTF321598.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS01186. EGF_2. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12794-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAHLLPICA LFLTLLDMAQ GFRGPLLPNR PFTTVWNANT QWCLERHGVD
60 70 80 90 100
VDVSVFDVVA NPGQTFRGPD MTIFYSSQLG TYPYYTPTGE PVFGGLPQNA
110 120 130 140 150
SLIAHLARTF QDILAAIPAP DFSGLAVIDW EAWRPRWAFN WDTKDIYRQR
160 170 180 190 200
SRALVQAQHP DWPAPQVEAV AQDQFQGAAR AWMAGTLQLG RALRPRGLWG
210 220 230 240 250
FYGFPDCYNY DFLSPNYTGQ CPSGIRAQND QLGWLWGQSR ALYPSIYMPA
260 270 280 290 300
VLEGTGKSQM YVQHRVAEAF RVAVAAGDPN LPVLPYVQIF YDTTNHFLPL
310 320 330 340 350
DELEHSLGES AAQGAAGVVL WVSWENTRTK ESCQAIKEYM DTTLGPFILN
360 370 380 390 400
VTSGALLCSQ ALCSGHGRCV RRTSHPKALL LLNPASFSIQ LTPGGGPLSL
410 420 430
RGALSLEDQA QMAVEFKCRC YPGWQAPWCE RKSMW
Length:435
Mass (Da):48,368
Last modified:March 1, 2001 - v2
Checksum:i9C2B2D8DB361E0BB
GO
Isoform 2 (identifier: Q12794-2) [UniParc]FASTAAdd to basket
Also known as: HYAl1v1

The sequence of this isoform differs from the canonical sequence as follows:
     301-330: Missing.

Note: Enzymatically inactive.
Show »
Length:405
Mass (Da):45,145
Checksum:iC24DAD360D9CF032
GO
Isoform 3 (identifier: Q12794-3) [UniParc]FASTAAdd to basket
Also known as: HYAl1v2

The sequence of this isoform differs from the canonical sequence as follows:
     1-182: Missing.

Note: Enzymatically inactive.
Show »
Length:253
Mass (Da):27,958
Checksum:i441C0DB43301E03F
GO
Isoform 4 (identifier: Q12794-4) [UniParc]FASTAAdd to basket
Also known as: HYAl1v3

The sequence of this isoform differs from the canonical sequence as follows:
     208-209: YN → SG
     210-435: Missing.

Note: Enzymatically inactive.
Show »
Length:209
Mass (Da):23,338
Checksum:i5C1046F8199F3BFF
GO
Isoform 5 (identifier: Q12794-5) [UniParc]FASTAAdd to basket
Also known as: HYAl1v4

The sequence of this isoform differs from the canonical sequence as follows:
     1-259: Missing.

Note: Enzymatically inactive.
Show »
Length:176
Mass (Da):19,367
Checksum:i75F674283B175FDD
GO
Isoform 6 (identifier: Q12794-6) [UniParc]FASTAAdd to basket
Also known as: HYAl1v5

The sequence of this isoform differs from the canonical sequence as follows:
     1-339: Missing.

Note: Enzymatically inactive.
Show »
Length:96
Mass (Da):10,435
Checksum:i70AD570E4305A4E8
GO
Isoform 7 (identifier: Q12794-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-336: ESCQAI → VSLGLA
     337-435: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):37,439
Checksum:i7D19178001F20E51
GO

Sequence cautioni

The sequence AAH25774 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3A → G in CAG46731 (Ref. 6) Curated1
Sequence conflicti191R → G in AAD53277 (PubMed:8603390).Curated1
Sequence conflicti300L → Q in AAD24460 (PubMed:10702795).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023643268E → K in MPS9. 1 PublicationCorresponds to variant rs104893743dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0159151 – 339Missing in isoform 6. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_0159161 – 259Missing in isoform 5. 1 PublicationAdd BLAST259
Alternative sequenceiVSP_0159171 – 182Missing in isoform 3. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_015918208 – 209YN → SG in isoform 4. 1 Publication2
Alternative sequenceiVSP_015919210 – 435Missing in isoform 4. 1 PublicationAdd BLAST226
Alternative sequenceiVSP_015920301 – 330Missing in isoform 2. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_015921331 – 336ESCQAI → VSLGLA in isoform 7. 1 Publication6
Alternative sequenceiVSP_015922337 – 435Missing in isoform 7. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03056 mRNA. Translation: AAD09137.2.
U96078 mRNA. Translation: AAD04190.1.
AF118821 mRNA. Translation: AAD24460.1.
AF502904 mRNA. Translation: AAM60770.1.
AF502905 mRNA. Translation: AAM60771.1.
AF502906 mRNA. Translation: AAM60772.1.
AF502907 mRNA. Translation: AAM60773.1.
AF502908 mRNA. Translation: AAM60774.1.
AF173154 mRNA. Translation: AAD53277.1.
CR541933 mRNA. Translation: CAG46731.1.
AC002455 Genomic DNA. Translation: AAB67046.1.
U73167 Genomic DNA. Translation: AAC02730.1.
BC025774 mRNA. Translation: AAH25774.1. Different initiation.
BC035695 mRNA. Translation: AAH35695.1.
CCDSiCCDS2816.1. [Q12794-1]
CCDS2817.1. [Q12794-2]
CCDS46832.1. [Q12794-3]
CCDS46833.1. [Q12794-5]
PIRiJC5584.
RefSeqiNP_149349.2. NM_033159.3. [Q12794-1]
NP_695013.1. NM_153281.1. [Q12794-1]
NP_695014.1. NM_153282.2. [Q12794-2]
NP_695015.1. NM_153283.2. [Q12794-3]
NP_695017.1. NM_153285.2. [Q12794-5]
XP_011531969.1. XM_011533667.2. [Q12794-1]
XP_011531970.1. XM_011533668.2. [Q12794-1]
XP_011531971.1. XM_011533669.2. [Q12794-1]
UniGeneiHs.75619.

Genome annotation databases

EnsembliENST00000266031; ENSP00000266031; ENSG00000114378. [Q12794-1]
ENST00000320295; ENSP00000346068; ENSG00000114378. [Q12794-1]
ENST00000395143; ENSP00000378575; ENSG00000114378. [Q12794-2]
ENST00000395144; ENSP00000378576; ENSG00000114378. [Q12794-1]
ENST00000447605; ENSP00000390149; ENSG00000114378. [Q12794-5]
ENST00000457214; ENSP00000393358; ENSG00000114378. [Q12794-3]
ENST00000618175; ENSP00000477903; ENSG00000114378. [Q12794-1]
GeneIDi3373.
KEGGihsa:3373.
UCSCiuc003czm.5. human. [Q12794-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03056 mRNA. Translation: AAD09137.2.
U96078 mRNA. Translation: AAD04190.1.
AF118821 mRNA. Translation: AAD24460.1.
AF502904 mRNA. Translation: AAM60770.1.
AF502905 mRNA. Translation: AAM60771.1.
AF502906 mRNA. Translation: AAM60772.1.
AF502907 mRNA. Translation: AAM60773.1.
AF502908 mRNA. Translation: AAM60774.1.
AF173154 mRNA. Translation: AAD53277.1.
CR541933 mRNA. Translation: CAG46731.1.
AC002455 Genomic DNA. Translation: AAB67046.1.
U73167 Genomic DNA. Translation: AAC02730.1.
BC025774 mRNA. Translation: AAH25774.1. Different initiation.
BC035695 mRNA. Translation: AAH35695.1.
CCDSiCCDS2816.1. [Q12794-1]
CCDS2817.1. [Q12794-2]
CCDS46832.1. [Q12794-3]
CCDS46833.1. [Q12794-5]
PIRiJC5584.
RefSeqiNP_149349.2. NM_033159.3. [Q12794-1]
NP_695013.1. NM_153281.1. [Q12794-1]
NP_695014.1. NM_153282.2. [Q12794-2]
NP_695015.1. NM_153283.2. [Q12794-3]
NP_695017.1. NM_153285.2. [Q12794-5]
XP_011531969.1. XM_011533667.2. [Q12794-1]
XP_011531970.1. XM_011533668.2. [Q12794-1]
XP_011531971.1. XM_011533669.2. [Q12794-1]
UniGeneiHs.75619.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PE4X-ray2.00A22-435[»]
ProteinModelPortaliQ12794.
SMRiQ12794.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109603. 8 interactors.
IntActiQ12794. 2 interactors.

Chemistry databases

BindingDBiQ12794.
ChEMBLiCHEMBL4528.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

PTM databases

iPTMnetiQ12794.
PhosphoSitePlusiQ12794.

Polymorphism and mutation databases

BioMutaiHYAL1.
DMDMi74735617.

Proteomic databases

MaxQBiQ12794.
PaxDbiQ12794.
PeptideAtlasiQ12794.
PRIDEiQ12794.

Protocols and materials databases

DNASUi3373.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266031; ENSP00000266031; ENSG00000114378. [Q12794-1]
ENST00000320295; ENSP00000346068; ENSG00000114378. [Q12794-1]
ENST00000395143; ENSP00000378575; ENSG00000114378. [Q12794-2]
ENST00000395144; ENSP00000378576; ENSG00000114378. [Q12794-1]
ENST00000447605; ENSP00000390149; ENSG00000114378. [Q12794-5]
ENST00000457214; ENSP00000393358; ENSG00000114378. [Q12794-3]
ENST00000618175; ENSP00000477903; ENSG00000114378. [Q12794-1]
GeneIDi3373.
KEGGihsa:3373.
UCSCiuc003czm.5. human. [Q12794-1]

Organism-specific databases

CTDi3373.
DisGeNETi3373.
GeneCardsiHYAL1.
HGNCiHGNC:5320. HYAL1.
HPAiHPA002112.
MalaCardsiHYAL1.
MIMi601492. phenotype.
607071. gene.
neXtProtiNX_Q12794.
OpenTargetsiENSG00000114378.
Orphaneti67041. Hyaluronidase deficiency.
PharmGKBiPA29571.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IECJ. Eukaryota.
ENOG410XPZT. LUCA.
GeneTreeiENSGT00550000074476.
HOVERGENiHBG052053.
InParanoidiQ12794.
KOiK01197.
OMAiPNYTGQC.
OrthoDBiEOG091G064G.
PhylomeDBiQ12794.
TreeFamiTF321598.

Enzyme and pathway databases

BioCyciMetaCyc:HS03763-MONOMER.
ZFISH:HS03763-MONOMER.
BRENDAi3.2.1.35. 2681.
4.2.2.1. 2681.
ReactomeiR-HSA-2024101. CS/DS degradation.
R-HSA-2160916. Hyaluronan uptake and degradation.

Miscellaneous databases

EvolutionaryTraceiQ12794.
GeneWikiiHYAL1.
GenomeRNAii3373.
PROiQ12794.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114378.
ExpressionAtlasiQ12794. baseline and differential.
GenevisibleiQ12794. HS.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYAL1_HUMAN
AccessioniPrimary (citable) accession number: Q12794
Secondary accession number(s): Q6FH23
, Q6PIZ6, Q7KYU2, Q7LE34, Q8NFK5, Q8NFK6, Q8NFK7, Q8NFK8, Q8NFK9, Q93013, Q9UKD5, Q9UNI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.