Q12789 (TF3C1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
General transcription factor 3C polypeptide 1

Alternative name(s):
TF3C-alpha
TFIIIC box B-binding subunit
Transcription factor IIIC 220 kDa subunit
Short name=TFIIIC 220 kDa subunit
Short name=TFIIIC220
Transcription factor IIIC subunit alpha

Gene names

Name:

GTF3C1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2109 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.
Subunit structure	Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2. Ref.11
Subcellular location	Nucleus.
Sequence similarities	Belongs to the TFIIIC subunit 1 family.
Sequence caution	The sequence AAA17985.1 differs from that shown. Reason: Frameshift at positions 152 and 189. The sequence AAA85638.1 differs from that shown. Reason: Contaminating sequence. Potential vector sequence at the N-terminus.

Ontologies

Keywords
Biological process	Transcription
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	5S class rRNA transcription from RNA polymerase III type 1 promoter Inferred by curator PubMed 17409385. Source: HGNC tRNA transcription from RNA polymerase III promoter Inferred by curator PubMed 17409385. Source: HGNC
Cellular_component	nucleolus Inferred from direct assay. Source: HPA ribonucleoprotein complex Inferred from electronic annotation. Source: Compara transcription factor TFIIIC complex Inferred from direct assay PubMed 17409385. Source: HGNC
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12789-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12789-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1933-1957: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2109	2109	General transcription factor 3C polypeptide 1		PRO_0000209710
Regions
	Compositional bias	343 – 351	9	Asp/Glu-rich (acidic)
	Compositional bias	1205 – 1233	29	Arg/Lys-rich (basic)
	Compositional bias	1613 – 1624	12	Asp/Glu-rich (acidic)
Amino acid modifications
	Modified residue	667	1	Phosphoserine Ref.15
	Modified residue	739	1	Phosphoserine Ref.10 Ref.15
	Modified residue	1062	1	Phosphoserine Ref.10 Ref.13 Ref.15
	Modified residue	1068	1	Phosphoserine Ref.6 Ref.12 Ref.13 Ref.15
	Modified residue	1632	1	Phosphoserine Ref.10 Ref.13
	Modified residue	1653	1	Phosphoserine Ref.7 Ref.10 Ref.13
	Modified residue	1856	1	Phosphoserine Ref.10
	Modified residue	1865	1	Phosphoserine Ref.10 Ref.12 Ref.13
	Modified residue	1868	1	Phosphoserine Ref.10 Ref.12 Ref.13
	Modified residue	1969	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1933 – 1957	25	Missing in isoform 2.		VSP_021819
	Natural variant	1889	1	Q → E. Corresponds to variant rs35233306 [ dbSNP | Ensembl ].		VAR_047534
	Natural variant	1959	1	F → S. Corresponds to variant rs12919017 [ dbSNP | Ensembl ].		VAR_047535
	Natural variant	2077	1	E → K. Corresponds to variant rs2228248 [ dbSNP | Ensembl ].		VAR_047536
Experimental info
	Sequence conflict	141	1	A → P in AAA17985. Ref.1
	Sequence conflict	153	1	A → P in AAA17985. Ref.1
	Sequence conflict	156	1	A → P in AAA17985. Ref.1
	Sequence conflict	161	1	A → P in AAA17985. Ref.1
	Sequence conflict	164	1	G → A in AAA17985. Ref.1
	Sequence conflict	977	1	L → V in AAA17985. Ref.1
	Sequence conflict	1015 – 1018	4	ARSS → GRRR in AAA17985. Ref.1
	Sequence conflict	1256	1	Q → H in AAA17985. Ref.1
	Sequence conflict	1316	1	V → L in AAA17985. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 4. Checksum: 37A03135EFE695FC	FASTA	2,109	238,875
	10 20 30 40 50 60 MDALESLLDE VALEGLDGLC LPALWSRLET RVPPFPLPLE PCTQEFLWRA LATHPGISFY 70 80 90 100 110 120 EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVALEDVYPI HMILENKDGI QGSCRYFKER 130 140 150 160 170 180 KNITNDIRTK SLQPRCTMVE AFDRWGKKLI IVASQAMRYR ALIGQEGDPD LKLPDFSYCI 190 200 210 220 230 240 LERLGRSRWQ GELQRDLHTT AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI 250 260 270 280 290 300 LLLLNRFHVD RRSKYDILME KLSVMLSTRT NHIETLGKLR EELGLCERTF KRLYQYMLNA 310 320 330 340 350 360 GLAKVVSLRL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RNDHDDDEDE EVISKTVPPV 370 380 390 400 410 420 DIVFERDMLT QTYDLIERRG TKGISQAEIR VAMNVGKLEA RMLCRLLQRF KVVKGFMEDE 430 440 450 460 470 480 GRQRTTKYIS CVFAEESDLS RQYQREKARS ELLTTVSLAS MQEESLLPEG EDTFLSESDS 490 500 510 520 530 540 EEERSSSKRR GRGSQKDTRA SANLRPKTQP HHSTPTKGGW KVVNLHPLKK QPPSFPGAAE 550 560 570 580 590 600 ERACQSLASR DSLLDTSSVS EPNVSFVSHC ADSNSGDIAV IEEVRMENPK ESSSSLKTGR 610 620 630 640 650 660 HSSGQDKPHE TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV STKCCKKSIV 670 680 690 700 710 720 RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND PLVRSAIEQV RFRISNSSTA 730 740 750 760 770 780 NRVKTSQPPV PQGEAEEDSQ GKEGPSGSGD SQLSASSRSE SGRMKKSDNK MGITPLRNYH 790 800 810 820 830 840 PIVVPGLGRS LGFLPKMPRL RVVHMFLWYL IYGHPASNTV EKPSFISERR TIKQESGRAG 850 860 870 880 890 900 VRPSSSGSAW EACSEAPSKG SQDGVTWEAE VELATETVYV DDASWMRYIP PIPVHRDFGF 910 920 930 940 950 960 GWALVSDILL CLPLSIFIQI VQVSYKVDNL EEFLNDPLKK HTLIRFLPRP IRQQLLYKRR 970 980 990 1000 1010 1020 YIFSVVENLQ RLCYMGLLQF GPTEKFQDKD QVFIFLKKNA VIVDTTICDP HYNLARSSRP 1030 1040 1050 1060 1070 1080 FERRLYVLNS MQDVENYWFD LQCVCLNTPL GVVRCPRVRK NSSTDQGSDE EGSLQKEQES 1090 1100 1110 1120 1130 1140 AMDKHNLERK CAMLEYTTGS REVVDEGLIP GDGLGAAGLD SSFYGHLKRN WIWTSYIINQ 1150 1160 1170 1180 1190 1200 AKKENTAAEN GLTVRLQTFL SKRPMPLSAR GNSRLNIWGE ARVGSELCAG WEEQFEVDRE 1210 1220 1230 1240 1250 1260 PSLDRNRRVR GGKSQKRKRL KKDPGKKIKR KKKGEFPGEK SKRLRYHDEA DQSALQRMTR 1270 1280 1290 1300 1310 1320 LRVTWSMQED GLLVLCRIAS NVLNTKVKGP FVTWQVVRDI LHATFEESLD KTSHSVGRRA 1330 1340 1350 1360 1370 1380 RYIVKNPQAY LNYKVCLAEV YQDKALVGDF MNRRGDYDDP KVCANEFKEF VEKLKEKFSS 1390 1400 1410 1420 1430 1440 ALRNSNLEIP DTLQELFARY RVLAIGDEKD QTRKEDELNS VDDIHFLVLQ NLIQSTLALS 1450 1460 1470 1480 1490 1500 DSQMKSYQSF QTFRLYREYK DHVLVKAFME CQKRSLVNRR RVNHTLGPKK NRALPFVPMS 1510 1520 1530 1540 1550 1560 YQLSQTYYRI FTWRFPSTIC TESFQFLDRM RAAGKLDQPD RFSFKDQDNN EPTNDMVAFS 1570 1580 1590 1600 1610 1620 LDGPGGNCVA VLTLFSLGLI SVDVRIPEQI IVVDSSMVEN EVIKSLGKDG SLEDDEDEED 1630 1640 1650 1660 1670 1680 DLDEGVGGKR RSMEVKPAQA SHTNYLLMRG YYSPGIVSTR NLNPNDSIVV NSCQMKFQLR 1690 1700 1710 1720 1730 1740 CTPVPARLRP AAAPLEELTM GTSCLPDTFT KLINPQENTC SLEEFVLQLE LSGYSPEDLT 1750 1760 1770 1780 1790 1800 AALEILEAII ATGCFGIDKE ELRRRFSALE KAGGGRTRTF ADCIQALLEQ HQVLEVGGNT 1810 1820 1830 1840 1850 1860 ARLVAMGSAW PWLLHSVRLK DREDADIQRE DPQARPLEGS SSEDSPPEGQ APPSHSPRGT 1870 1880 1890 1900 1910 1920 KRRASWASEN GETDAEGTQM TPAKRPALQD SNLAPSLGPG AEDGAEAQAP SPPPALEDTA 1930 1940 1950 1960 1970 1980 AAGAAQEDQE GVGEFSSPGQ EQLSGQAQPP EGSEDPRGFT ESFGAANISQ AARERDCESV 1990 2000 2010 2020 2030 2040 CFIGRPWRVV DGHLNLPVCK GMMEAMLYHI MTRPGIPESS LLRHYQGVLQ PVAVLELLQG 2050 2060 2070 2080 2090 2100 LESLGCIRKR WLRKPRPVSL FSTPVVEEVE VPSSLDESPM AFYEPTLDCT LRLGRVFPHE VNWNKWIHL
	Isoform 2 [UniParc]. Checksum: D1D74F05BF1C6051	FASTA	2,084	236,278
	10 20 30 40 50 60 MDALESLLDE VALEGLDGLC LPALWSRLET RVPPFPLPLE PCTQEFLWRA LATHPGISFY 70 80 90 100 110 120 EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVALEDVYPI HMILENKDGI QGSCRYFKER 130 140 150 160 170 180 KNITNDIRTK SLQPRCTMVE AFDRWGKKLI IVASQAMRYR ALIGQEGDPD LKLPDFSYCI 190 200 210 220 230 240 LERLGRSRWQ GELQRDLHTT AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI 250 260 270 280 290 300 LLLLNRFHVD RRSKYDILME KLSVMLSTRT NHIETLGKLR EELGLCERTF KRLYQYMLNA 310 320 330 340 350 360 GLAKVVSLRL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RNDHDDDEDE EVISKTVPPV 370 380 390 400 410 420 DIVFERDMLT QTYDLIERRG TKGISQAEIR VAMNVGKLEA RMLCRLLQRF KVVKGFMEDE 430 440 450 460 470 480 GRQRTTKYIS CVFAEESDLS RQYQREKARS ELLTTVSLAS MQEESLLPEG EDTFLSESDS 490 500 510 520 530 540 EEERSSSKRR GRGSQKDTRA SANLRPKTQP HHSTPTKGGW KVVNLHPLKK QPPSFPGAAE 550 560 570 580 590 600 ERACQSLASR DSLLDTSSVS EPNVSFVSHC ADSNSGDIAV IEEVRMENPK ESSSSLKTGR 610 620 630 640 650 660 HSSGQDKPHE TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV STKCCKKSIV 670 680 690 700 710 720 RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND PLVRSAIEQV RFRISNSSTA 730 740 750 760 770 780 NRVKTSQPPV PQGEAEEDSQ GKEGPSGSGD SQLSASSRSE SGRMKKSDNK MGITPLRNYH 790 800 810 820 830 840 PIVVPGLGRS LGFLPKMPRL RVVHMFLWYL IYGHPASNTV EKPSFISERR TIKQESGRAG 850 860 870 880 890 900 VRPSSSGSAW EACSEAPSKG SQDGVTWEAE VELATETVYV DDASWMRYIP PIPVHRDFGF 910 920 930 940 950 960 GWALVSDILL CLPLSIFIQI VQVSYKVDNL EEFLNDPLKK HTLIRFLPRP IRQQLLYKRR 970 980 990 1000 1010 1020 YIFSVVENLQ RLCYMGLLQF GPTEKFQDKD QVFIFLKKNA VIVDTTICDP HYNLARSSRP 1030 1040 1050 1060 1070 1080 FERRLYVLNS MQDVENYWFD LQCVCLNTPL GVVRCPRVRK NSSTDQGSDE EGSLQKEQES 1090 1100 1110 1120 1130 1140 AMDKHNLERK CAMLEYTTGS REVVDEGLIP GDGLGAAGLD SSFYGHLKRN WIWTSYIINQ 1150 1160 1170 1180 1190 1200 AKKENTAAEN GLTVRLQTFL SKRPMPLSAR GNSRLNIWGE ARVGSELCAG WEEQFEVDRE 1210 1220 1230 1240 1250 1260 PSLDRNRRVR GGKSQKRKRL KKDPGKKIKR KKKGEFPGEK SKRLRYHDEA DQSALQRMTR 1270 1280 1290 1300 1310 1320 LRVTWSMQED GLLVLCRIAS NVLNTKVKGP FVTWQVVRDI LHATFEESLD KTSHSVGRRA 1330 1340 1350 1360 1370 1380 RYIVKNPQAY LNYKVCLAEV YQDKALVGDF MNRRGDYDDP KVCANEFKEF VEKLKEKFSS 1390 1400 1410 1420 1430 1440 ALRNSNLEIP DTLQELFARY RVLAIGDEKD QTRKEDELNS VDDIHFLVLQ NLIQSTLALS 1450 1460 1470 1480 1490 1500 DSQMKSYQSF QTFRLYREYK DHVLVKAFME CQKRSLVNRR RVNHTLGPKK NRALPFVPMS 1510 1520 1530 1540 1550 1560 YQLSQTYYRI FTWRFPSTIC TESFQFLDRM RAAGKLDQPD RFSFKDQDNN EPTNDMVAFS 1570 1580 1590 1600 1610 1620 LDGPGGNCVA VLTLFSLGLI SVDVRIPEQI IVVDSSMVEN EVIKSLGKDG SLEDDEDEED 1630 1640 1650 1660 1670 1680 DLDEGVGGKR RSMEVKPAQA SHTNYLLMRG YYSPGIVSTR NLNPNDSIVV NSCQMKFQLR 1690 1700 1710 1720 1730 1740 CTPVPARLRP AAAPLEELTM GTSCLPDTFT KLINPQENTC SLEEFVLQLE LSGYSPEDLT 1750 1760 1770 1780 1790 1800 AALEILEAII ATGCFGIDKE ELRRRFSALE KAGGGRTRTF ADCIQALLEQ HQVLEVGGNT 1810 1820 1830 1840 1850 1860 ARLVAMGSAW PWLLHSVRLK DREDADIQRE DPQARPLEGS SSEDSPPEGQ APPSHSPRGT 1870 1880 1890 1900 1910 1920 KRRASWASEN GETDAEGTQM TPAKRPALQD SNLAPSLGPG AEDGAEAQAP SPPPALEDTA 1930 1940 1950 1960 1970 1980 AAGAAQEDQE GVGFTESFGA ANISQAARER DCESVCFIGR PWRVVDGHLN LPVCKGMMEA 1990 2000 2010 2020 2030 2040 MLYHIMTRPG IPESSLLRHY QGVLQPVAVL ELLQGLESLG CIRKRWLRKP RPVSLFSTPV 2050 2060 2070 2080 VEEVEVPSSL DESPMAFYEP TLDCTLRLGR VFPHEVNWNK WIHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human transcription factor IIIC box B binding subunit." L'Etoile N.D., Fahnestock M.L., Shen Y., Aebersold R., Berk A.J. Proc. Natl. Acad. Sci. U.S.A. 91:1652-1656(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 1103-1121.
[2]	"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1107-2109 (ISOFORM 2). Tissue: Brain and Cervix.
[5]	"Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC." Lagna G., Kovelman R., Sukegawa J., Roeder R.G. Mol. Cell. Biol. 14:3053-3064(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-728 (ISOFORM 1).
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1068, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1653, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1969, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739; SER-1062; SER-1632; SER-1653; SER-1856; SER-1865 AND SER-1868, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery." de Planell-Saguer M., Schroeder D.G., Rodicio M.C., Cox G.A., Mourelatos Z. Hum. Mol. Genet. 18:2115-2126(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IGHMBP2.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1068; SER-1865 AND SER-1868, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1062; SER-1068; SER-1632; SER-1653; SER-1865 AND SER-1868, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667; SER-739; SER-1062 AND SER-1068, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U02619 mRNA. Translation: AAA17985.1. Frameshift. AC002303 Genomic DNA. Translation: AAB67637.1. AC025275 Genomic DNA. No translation available. AC002551 Genomic DNA. Translation: AAC05811.1. BC044857 mRNA. Translation: AAH44857.1. BC137229 mRNA. Translation: AAI37230.1. U06485 mRNA. Translation: AAA85638.1. Sequence problems.
IPI	IPI00414482. IPI00807491.
PIR	B56011. I38414.
RefSeq	NP_001511.2. NM_001520.3.
UniGene	Hs.371718.
3D structure databases
ProteinModelPortal	Q12789.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-38212N.
IntAct	Q12789. 21 interactions.
MINT	MINT-1154812.
STRING	9606.ENSP00000348510.
PTM databases
PhosphoSite	Q12789.
Polymorphism databases
DMDM	215274233.
Proteomic databases
PaxDb	Q12789.
PRIDE	Q12789.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356183; ENSP00000348510; ENSG00000077235. ENST00000561623; ENSP00000455417; ENSG00000077235.
GeneID	2975.
KEGG	hsa:2975.
UCSC	uc002dou.3. human. uc002dov.2. human.
Organism-specific databases
CTD	2975.
GeneCards	GC16M027471.
H-InvDB	HIX0012915.
HGNC	HGNC:4664. GTF3C1.
HPA	HPA051617.
MIM	603246. gene.
neXtProt	NX_Q12789.
PharmGKB	PA29052.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG322015.
HOGENOM	HOG000154556.
HOVERGEN	HBG057283.
KO	K15199.
OMA	VRFRISN.
OrthoDB	EOG40CHG3.
Enzyme and pathway databases
Reactome	REACT_1788. Transcription. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q12789.
Bgee	Q12789.
CleanEx	HS_GTF3C1.
Genevestigator	Q12789.
GermOnline	ENSG00000077235. Homo sapiens.
Family and domain databases
InterPro	IPR007309. TFIIIC_Bblock-bd. [Graphical view]
Pfam	PF04182. B-block_TFIIIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GTF3C1. human.
GenomeRNAi	2975.
NextBio	11798.
SOURCE	Search...

Entry information

Entry name

TF3C1_HUMAN

Accession

Primary (citable) accession number: Q12789
Secondary accession number(s): B2RP21 , Q12838, Q6DKN9, Q9Y4W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	November 25, 2008
Last modified:	April 3, 2013
This is version 108 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.