Q12770 (SCAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sterol regulatory element-binding protein cleavage-activating protein
Short name=SCAP
Short name=SREBP cleavage-activating protein

Gene names

Name:	SCAP
Synonyms:	KIAA0199
ORF Names:	PSEC0227

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1279 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway By similarity.
Subunit structure	Membrane region forms a homotetramer. Forms a stable complex with SREBF1/SREBP1 or SREBF2/SREBP2 through its C-terminal cytoplasmic domain. Forms a ternary complex with INSIG1 or INSIG2 through its transmembrane domains at high sterol concentrations. Interacts with the SEC23/SEC24 complex in a SAR1-GTP-dependent manner through an ER export signal in its third cytoplasmic loop. Binds cholesterol through its SSC domain By similarity. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts with RNF139; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP/SREBP complex. Ref.8
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle › COPII-coated vesicle membrane; Multi-pass membrane protein By similarity. Note: Moves from the endoplasmic reticulum to the Golgi in the absence of sterols By similarity.
Induction	By androgen-bound AR and glucocorticoid-bound NR3C1 in a prostate cancer cell line (LNCaP). Ref.7
Domain	Cholesterol bound to SSC domain of SCAP or oxysterol bound to INSIG1/2 leads to masking of an ER export signal on SCAP possibly by moving the signal further away from the ER membrane By similarity.
Sequence similarities	Belongs to the WD repeat SCAP family. Contains 1 SSD (sterol-sensing) domain. Contains 7 WD repeats.
Sequence caution	The sequence BAA12111.2 differs from that shown. Reason: Erroneous initiation. The sequence BAC11673.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cholesterol metabolism Lipid metabolism Steroid metabolism
Cellular component	Cytoplasmic vesicle Endoplasmic reticulum Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix WD repeat
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cholesterol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cholesterol biosynthetic process Non-traceable author statement. Source: UniProtKB positive regulation of low-density lipoprotein particle receptor biosynthetic process Non-traceable author statement. Source: UniProtKB positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway Inferred from mutant phenotype. Source: UniProtKB
Cellular component	ER to Golgi transport vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Non-traceable author statement. Source: UniProtKB
Molecular function	unfolded protein binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q12770-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q12770-2)

The sequence of this isoform differs from the canonical sequence as follows:
     29-401: Missing.
     817-817: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q12770-3)

The sequence of this isoform differs from the canonical sequence as follows:
     476-983: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q12770-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.
     817-817: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1279	1279	Sterol regulatory element-binding protein cleavage-activating protein		PRO_0000051208
Regions
	Topological domain	1 – 18	18	Cytoplasmic By similarity
	Transmembrane	19 – 39	21	Helical; Name=1; Potential
	Topological domain	40 – 279	240	Lumenal By similarity
	Transmembrane	280 – 300	21	Helical; Name=2; Potential
	Topological domain	301 – 312	12	Cytoplasmic By similarity
	Transmembrane	313 – 333	21	Helical; Name=3; Potential
	Topological domain	334 – 344	11	Lumenal By similarity
	Transmembrane	345 – 365	21	Helical; Name=4; Potential
	Topological domain	366 – 401	36	Cytoplasmic By similarity
	Transmembrane	402 – 422	21	Helical; Name=5; Potential
	Topological domain	423	1	Lumenal By similarity
	Transmembrane	424 – 444	21	Helical; Name=6; Potential
	Topological domain	445 – 518	74	Cytoplasmic By similarity
	Transmembrane	519 – 539	21	Helical; Name=7; Potential
	Topological domain	540 – 709	170	Lumenal By similarity
	Transmembrane	710 – 730	21	Helical; Name=8; Potential
	Topological domain	731 – 1279	549	Cytoplasmic By similarity
	Domain	284 – 442	159	SSD
	Repeat	771 – 811	41	WD 1
	Repeat	952 – 1002	51	WD 2
	Repeat	1005 – 1042	38	WD 3
	Repeat	1077 – 1114	38	WD 4
	Repeat	1117 – 1155	39	WD 5
	Repeat	1158 – 1195	38	WD 6
	Repeat	1197 – 1235	39	WD 7
	Region	447 – 452	6	ER export signal By similarity
	Region	731 – 1279	549	Interaction with SREBF2 By similarity
	Compositional bias	722 – 729	8	Poly-Leu
	Compositional bias	747 – 750	4	Poly-Arg
	Compositional bias	861 – 864	4	Poly-Pro
Amino acid modifications
	Modified residue	243	1	Phosphotyrosine Ref.9
	Modified residue	851	1	Phosphoserine Ref.10
	Modified residue	907	1	Phosphoserine Ref.10
	Glycosylation	263	1	N-linked (GlcNAc...) Potential
	Glycosylation	590	1	N-linked (GlcNAc...) Potential
	Glycosylation	641	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 392	392	Missing in isoform 4.		VSP_021105
	Alternative sequence	29 – 401	373	Missing in isoform 2.		VSP_007451
	Alternative sequence	476 – 983	508	Missing in isoform 3.		VSP_007452
	Alternative sequence	817	1	Missing in isoform 2 and isoform 4.		VSP_021106
	Natural variant	798	1	V → I. Ref.11 Corresponds to variant rs12487736 [ dbSNP | Ensembl ].		VAR_012203
Experimental info
	Sequence conflict	350	1	P → G in BAC11673. Ref.6
	Sequence conflict	427	1	S → T in BAC11673. Ref.6
	Sequence conflict	617	1	W → R in BAB55088. Ref.4
	Sequence conflict	753	1	L → Q in BAB55088. Ref.4
	Sequence conflict	941	1	V → A in BAB55088. Ref.4
	Sequence conflict	994	1	A → S in BAC11673. Ref.6
	Sequence conflict	1019	1	R → G in BAC11673. Ref.6
	Sequence conflict	1035	1	E → G in BAB55088. Ref.4
	Sequence conflict	1080	1	K → E in BAB55088. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 4. Checksum: 4CD73543B7D2ACB4	FASTA	1,279	139,729
	10 20 30 40 50 60 MTLTERLREK ISRAFYNHGL LCASYPIPII LFTGFCILAC CYPLLKLPLP GTGPVEFTTP 70 80 90 100 110 120 VKDYSPPPVD SDRKQGEPTE QPEWYVGAPV AYVQQIFVKS SVFPWHKNLL AVDVFRSPLS 130 140 150 160 170 180 RAFQLVEEIR NHVLRDSSGI RSLEELCLQV TDLLPGLRKL RNLLPEHGCL LLSPGNFWQN 190 200 210 220 230 240 DWERFHADPD IIGTIHQHEP KTLQTSATLK DLLFGVPGKY SGVSLYTRKR MVSYTITLVF 250 260 270 280 290 300 QHYHAKFLGS LRARLMLLHP SPNCSLRAES LVHVHFKEEI GVAELIPLVT TYIILFAYIY 310 320 330 340 350 360 FSTRKIDMVK SKWGLALAAV VTVLSSLLMS VGLCTLFGLT PTLNGGEIFP YLVVVIGLEN 370 380 390 400 410 420 VLVLTKSVVS TPVDLEVKLR IAQGLSSESW SIMKNMATEL GIILIGYFTL VPAIQEFCLF 430 440 450 460 470 480 AVVGLVSDFF LQMLFFTTVL SIDIRRMELA DLNKRLPPEA CLPSAKPVGQ PTRYERQLAV 490 500 510 520 530 540 RPSTPHTITL QPSSFRNLRL PKRLRVVYFL ARTRLAQRLI MAGTVVWIGI LVYTDPAGLR 550 560 570 580 590 600 NYLAAQVTEQ SPLGEGALAP MPVPSGMLPP SHPDPAFSIF PPDAPKLPEN QTSPGESPER 610 620 630 640 650 660 GGPAEVVHDS PVPEVTWGPE DEELWRKLSF RHWPTLFSYY NITLAKRYIS LLPVIPVTLR 670 680 690 700 710 720 LNPREALEGR HPQDGRSAWP PPGPIPAGHW EAGPKGPGGV QAHGDVTLYK VAALGLATGI 730 740 750 760 770 780 VLVLLLLCLY RVLCPRNYGQ LGGGPGRRRR GELPCDDYGY APPETEIVPL VLRGHLMDIE 790 800 810 820 830 840 CLASDGMLLV SCCLAGHVCV WDAQTGDCLT RIPRPGRQRR DSGVGSGLEA QESWERLSDG 850 860 870 880 890 900 GKAGPEEPGD SPPLRHRPRG PPPPSLFGDQ PDLTCLIDTN FSAQPRSSQP TQPEPRHRAV 910 920 930 940 950 960 CGRSRDSPGY DFSCLVQRVY QEEGLAAVCT PALRPPSPGP VLSQAPEDEG GSPEKGSPSL 970 980 990 1000 1010 1020 AWAPSAEGSI WSLELQGNLI VVGRSSGRLE VWDAIEGVLC CSSEEVSSGI TALVFLDKRI 1030 1040 1050 1060 1070 1080 VAARLNGSLD FFSLETHTAL SPLQFRGTPG RGSSPASPVY SSSDTVACHL THTVPCAHQK 1090 1100 1110 1120 1130 1140 PITALKAAAG RLVTGSQDHT LRVFRLEDSC CLFTLQGHSG AITTVYIDQT MVLASGGQDG 1150 1160 1170 1180 1190 1200 AICLWDVLTG SRVSHVFAHR GDVTSLTCTT SCVISSGLDD LISIWDRSTG IKFYSIQQDL 1210 1220 1230 1240 1250 1260 GCGASLGVIS DNLLVTGGQG CVSFWDLNYG DLLQTVYLGK NSEAQPARQI LVLDNAAIVC 1270 NFGSELSLVY VPSVLEKLD
	Isoform 2 [UniParc]. Checksum: 7998FC1DB49E4CDC	FASTA	905	97,903
	10 20 30 40 50 60 MTLTERLREK ISRAFYNHGL LCASYPIPII LIGYFTLVPA IQEFCLFAVV GLVSDFFLQM 70 80 90 100 110 120 LFFTTVLSID IRRMELADLN KRLPPEACLP SAKPVGQPTR YERQLAVRPS TPHTITLQPS 130 140 150 160 170 180 SFRNLRLPKR LRVVYFLART RLAQRLIMAG TVVWIGILVY TDPAGLRNYL AAQVTEQSPL 190 200 210 220 230 240 GEGALAPMPV PSGMLPPSHP DPAFSIFPPD APKLPENQTS PGESPERGGP AEVVHDSPVP 250 260 270 280 290 300 EVTWGPEDEE LWRKLSFRHW PTLFSYYNIT LAKRYISLLP VIPVTLRLNP REALEGRHPQ 310 320 330 340 350 360 DGRSAWPPPG PIPAGHWEAG PKGPGGVQAH GDVTLYKVAA LGLATGIVLV LLLLCLYRVL 370 380 390 400 410 420 CPRNYGQLGG GPGRRRRGEL PCDDYGYAPP ETEIVPLVLR GHLMDIECLA SDGMLLVSCC 430 440 450 460 470 480 LAGHVCVWDA QTGDCLTRIP RPGQRRDSGV GSGLEAQESW ERLSDGGKAG PEEPGDSPPL 490 500 510 520 530 540 RHRPRGPPPP SLFGDQPDLT CLIDTNFSAQ PRSSQPTQPE PRHRAVCGRS RDSPGYDFSC 550 560 570 580 590 600 LVQRVYQEEG LAAVCTPALR PPSPGPVLSQ APEDEGGSPE KGSPSLAWAP SAEGSIWSLE 610 620 630 640 650 660 LQGNLIVVGR SSGRLEVWDA IEGVLCCSSE EVSSGITALV FLDKRIVAAR LNGSLDFFSL 670 680 690 700 710 720 ETHTALSPLQ FRGTPGRGSS PASPVYSSSD TVACHLTHTV PCAHQKPITA LKAAAGRLVT 730 740 750 760 770 780 GSQDHTLRVF RLEDSCCLFT LQGHSGAITT VYIDQTMVLA SGGQDGAICL WDVLTGSRVS 790 800 810 820 830 840 HVFAHRGDVT SLTCTTSCVI SSGLDDLISI WDRSTGIKFY SIQQDLGCGA SLGVISDNLL 850 860 870 880 890 900 VTGGQGCVSF WDLNYGDLLQ TVYLGKNSEA QPARQILVLD NAAIVCNFGS ELSLVYVPSV LEKLD
	Isoform 3 [UniParc]. Checksum: DE4C276926DBA281	FASTA	771	84,773
	10 20 30 40 50 60 MTLTERLREK ISRAFYNHGL LCASYPIPII LFTGFCILAC CYPLLKLPLP GTGPVEFTTP 70 80 90 100 110 120 VKDYSPPPVD SDRKQGEPTE QPEWYVGAPV AYVQQIFVKS SVFPWHKNLL AVDVFRSPLS 130 140 150 160 170 180 RAFQLVEEIR NHVLRDSSGI RSLEELCLQV TDLLPGLRKL RNLLPEHGCL LLSPGNFWQN 190 200 210 220 230 240 DWERFHADPD IIGTIHQHEP KTLQTSATLK DLLFGVPGKY SGVSLYTRKR MVSYTITLVF 250 260 270 280 290 300 QHYHAKFLGS LRARLMLLHP SPNCSLRAES LVHVHFKEEI GVAELIPLVT TYIILFAYIY 310 320 330 340 350 360 FSTRKIDMVK SKWGLALAAV VTVLSSLLMS VGLCTLFGLT PTLNGGEIFP YLVVVIGLEN 370 380 390 400 410 420 VLVLTKSVVS TPVDLEVKLR IAQGLSSESW SIMKNMATEL GIILIGYFTL VPAIQEFCLF 430 440 450 460 470 480 AVVGLVSDFF LQMLFFTTVL SIDIRRMELA DLNKRLPPEA CLPSAKPVGQ PTRYERSSGR 490 500 510 520 530 540 LEVWDAIEGV LCCSSEEVSS GITALVFLDK RIVAARLNGS LDFFSLETHT ALSPLQFRGT 550 560 570 580 590 600 PGRGSSPASP VYSSSDTVAC HLTHTVPCAH QKPITALKAA AGRLVTGSQD HTLRVFRLED 610 620 630 640 650 660 SCCLFTLQGH SGAITTVYID QTMVLASGGQ DGAICLWDVL TGSRVSHVFA HRGDVTSLTC 670 680 690 700 710 720 TTSCVISSGL DDLISIWDRS TGIKFYSIQQ DLGCGASLGV ISDNLLVTGG QGCVSFWDLN 730 740 750 760 770 YGDLLQTVYL GKNSEAQPAR QILVLDNAAI VCNFGSELSL VYVPSVLEKL D
	Isoform 4 [UniParc]. Checksum: 5ED9E0586FA01C37	FASTA	886	95,616
	10 20 30 40 50 60 MKNMATELGI ILIGYFTLVP AIQEFCLFAV VGLVSDFFLQ MLFFTTVLSI DIRRMELADL 70 80 90 100 110 120 NKRLPPEACL PSAKPVGQPT RYERQLAVRP STPHTITLQP SSFRNLRLPK RLRVVYFLAR 130 140 150 160 170 180 TRLAQRLIMA GTVVWIGILV YTDPAGLRNY LAAQVTEQSP LGEGALAPMP VPSGMLPPSH 190 200 210 220 230 240 PDPAFSIFPP DAPKLPENQT SPGESPERGG PAEVVHDSPV PEVTWGPEDE ELWRKLSFRH 250 260 270 280 290 300 WPTLFSYYNI TLAKRYISLL PVIPVTLRLN PREALEGRHP QDGRSAWPPP GPIPAGHWEA 310 320 330 340 350 360 GPKGPGGVQA HGDVTLYKVA ALGLATGIVL VLLLLCLYRV LCPRNYGQLG GGPGRRRRGE 370 380 390 400 410 420 LPCDDYGYAP PETEIVPLVL RGHLMDIECL ASDGMLLVSC CLAGHVCVWD AQTGDCLTRI 430 440 450 460 470 480 PRPGQRRDSG VGSGLEAQES WERLSDGGKA GPEEPGDSPP LRHRPRGPPP PSLFGDQPDL 490 500 510 520 530 540 TCLIDTNFSA QPRSSQPTQP EPRHRAVCGR SRDSPGYDFS CLVQRVYQEE GLAAVCTPAL 550 560 570 580 590 600 RPPSPGPVLS QAPEDEGGSP EKGSPSLAWA PSAEGSIWSL ELQGNLIVVG RSSGRLEVWD 610 620 630 640 650 660 AIEGVLCCSS EEVSSGITAL VFLDKRIVAA RLNGSLDFFS LETHTALSPL QFRGTPGRGS 670 680 690 700 710 720 SPASPVYSSS DTVACHLTHT VPCAHQKPIT ALKAAAGRLV TGSQDHTLRV FRLEDSCCLF 730 740 750 760 770 780 TLQGHSGAIT TVYIDQTMVL ASGGQDGAIC LWDVLTGSRV SHVFAHRGDV TSLTCTTSCV 790 800 810 820 830 840 ISSGLDDLIS IWDRSTGIKF YSIQQDLGCG ASLGVISDNL LVTGGQGCVS FWDLNYGDLL 850 860 870 880 QTVYLGKNSE AQPARQILVL DNAAIVCNFG SELSLVYVPS VLEKLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene." Nakajima T., Hamakubo T., Kodama T., Inazawa J., Emi M. J. Hum. Genet. 44:402-407(1999) [PubMed: 10570913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Hepatoma.
[2]	"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed: 8724849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Teratocarcinoma.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon.
[6]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 350-1278 (ISOFORM 3). Tissue: Embryo.
[7]	"Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor." Heemers H., Verrijdt G., Organe S., Claessens F., Heyns W., Verhoeven G., Swinnen J.V. J. Biol. Chem. 279:30880-30887(2004) [PubMed: 15133039] [Abstract] Cited for: INDUCTION.
[8]	"The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage." Irisawa M., Inoue J., Ozawa N., Mori K., Sato R. J. Biol. Chem. 284:28995-29004(2009) [PubMed: 19706601] [Abstract] Cited for: INTERACTION WITH RNF139.
[9]	"Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling." Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A., Lottspeich F., Chen Z. EMBO J. 25:5058-5070(2006) [PubMed: 17053785] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-243, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-851 AND SER-907, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A common Ile796Val polymorphism of the human SREBP cleavage-activating protein (SCAP) gene." Iwaki K., Nakajima T., Ota N., Emi M. J. Hum. Genet. 44:421-422(1999) [PubMed: 10570919] [Abstract] Cited for: VARIANT ILE-798.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D83782 mRNA. Translation: BAA12111.2. Different initiation. AK027402 mRNA. Translation: BAB55088.1. BC020987 mRNA. Translation: AAH20987.1. AK075528 mRNA. Translation: BAC11673.1. Different initiation.
IPI	IPI00006280. IPI00290700. IPI00290701. IPI00396357.
RefSeq	NP_036367.2. NM_012235.2.
UniGene	Hs.531789.
3D structure databases
ProteinModelPortal	Q12770.
SMR	Q12770. Positions 771-815, 962-1273.
ModBase	Search...
Protein-protein interaction databases
STRING	Q12770.
PTM databases
PhosphoSite	Q12770.
Polymorphism databases
DMDM	116242783.
Proteomic databases
PRIDE	Q12770.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265565; ENSP00000265565; ENSG00000114650.
GeneID	22937.
KEGG	hsa:22937.
UCSC	uc003crg.2. human. uc003crh.1. human.
Organism-specific databases
CTD	22937.
GeneCards	GC03M047430.
H-InvDB	HIX0003275. HIX0031165.
HGNC	HGNC:30634. SCAP.
HPA	HPA004713.
MIM	601510. gene.
neXtProt	NX_Q12770.
PharmGKB	PA162402461.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10703.
GeneTree	ENSGT00390000000003.
HOGENOM	HBG402990.
HOVERGEN	HBG019538.
InParanoid	Q12770.
OMA	SIFPPDA.
OrthoDB	EOG42Z4PB.
PhylomeDB	Q12770.
Gene expression databases
ArrayExpress	Q12770.
Bgee	Q12770.
CleanEx	HS_SCAP.
Genevestigator	Q12770.
GermOnline	ENSG00000114650. Homo sapiens.
Family and domain databases
InterPro	IPR000731. SSD. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 3 hits.
Pfam	PF00400. WD40. 4 hits. [Graphical view]
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 2 hits.
PROSITE	PS50156. SSD. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	43683.
SOURCE	Search...

Entry information

Entry name

SCAP_HUMAN

Accession

Primary (citable) accession number: Q12770
Secondary accession number(s): Q8N2E0, Q8WUA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 114 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.