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Protein

Transmembrane protein 94

Gene

TMEM94

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177728-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 94Imported
Gene namesi
Name:TMEM94Imported
Synonyms:KIAA0195
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28983. TMEM94.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei1093 – 1113HelicalSequence analysisAdd BLAST21
Transmembranei1121 – 1141HelicalSequence analysisAdd BLAST21
Transmembranei1168 – 1188HelicalSequence analysisAdd BLAST21
Transmembranei1229 – 1249HelicalSequence analysisAdd BLAST21
Transmembranei1262 – 1282HelicalSequence analysisAdd BLAST21
Transmembranei1307 – 1327HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9772.
OpenTargetsiENSG00000177728.
PharmGKBiPA142671623.

Polymorphism and mutation databases

BioMutaiKIAA0195.
DMDMi2495718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507311 – 1356Transmembrane protein 94Add BLAST1356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei221PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Glycosylationi475N-linked (GlcNAc...)Sequence analysis1
Modified residuei513PhosphoserineCombined sources1
Glycosylationi516N-linked (GlcNAc...)Sequence analysis1
Modified residuei518PhosphoserineCombined sources1
Modified residuei798PhosphoserineCombined sources1
Modified residuei941PhosphoserineCombined sources1
Glycosylationi1202N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1205N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ12767.
PaxDbiQ12767.
PeptideAtlasiQ12767.
PRIDEiQ12767.

PTM databases

iPTMnetiQ12767.
PhosphoSitePlusiQ12767.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

BgeeiENSG00000177728.
CleanExiHS_KIAA0195.
ExpressionAtlasiQ12767. baseline and differential.
GenevisibleiQ12767. HS.

Organism-specific databases

HPAiHPA050660.

Interactioni

Protein-protein interaction databases

BioGridi115117. 7 interactors.
IntActiQ12767. 1 interactor.
STRINGi9606.ENSP00000313885.

Structurei

3D structure databases

ProteinModelPortaliQ12767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4383. Eukaryota.
ENOG410XQVD. LUCA.
GeneTreeiENSGT00390000016550.
HOVERGENiHBG052173.
InParanoidiQ12767.
PhylomeDBiQ12767.
TreeFamiTF314852.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023298. ATPase_P-typ_TM_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12767-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLKEKHLGE PPSALGLSTR KALSVLKEQL EAVLEGHLRE RKKCLTWKEV
60 70 80 90 100
WRSSFLHHSN RCSCFHWPGA SLMLLAVLLL LGCCGGQPAG SRGVGLVNAS
110 120 130 140 150
ALFLLLLLNL VLIGRQDRLK RREVERRLRG IIDQIQDALR DGREIQWPSA
160 170 180 190 200
MYPDLHMPFA PSWSLHWAYR DGHLVNLPVS LLVEGDIIAL RPGQESFASL
210 220 230 240 250
RGIKDDEHIV LEPGDLFPPF SPPPSPRGEV ERGPQSPQQH RLFRVLETPV
260 270 280 290 300
IDNIRWCLDM ALSRPVTALD NERFTVQSVM LHYAVPVVLA GFLITNALRF
310 320 330 340 350
IFSAPGVTSW QYTLLQLQVN GVLPILPLLF PVLWVLATAC GEARVLAQMS
360 370 380 390 400
KASPSSLLAK FSEDTLSSYT EAVSSQEMLR CIWGHFLRVL GGTSPTLSHS
410 420 430 440 450
SSLLHSLGSV TVLCCVDKQG ILSWPNPSPE TVLFFSGKVE PPHSSHEDLT
460 470 480 490 500
DGLSTRSFCH PEPHERDALL AGSLNNTLHL SNEQERGDWP GEAPKPPEPY
510 520 530 540 550
SHHKAHGRSK HPSGSNVSFS RDTEGGEEEP SKTQPGMESD PYEAEDFVCD
560 570 580 590 600
YHLEMLSLSQ DQQNPSCIQF DDSNWQLHLT SLKPLGLNVL LNLCDASVTE
610 620 630 640 650
RLCRFSDHLC NIALQESHSA VLPVHVPWGL CELARLIGFT PGAKELFKQE
660 670 680 690 700
NHLALYRLPS AETMKETSLG RLSCVTKRRP PLSHMISLFI KDTTTSTEQM
710 720 730 740 750
LSHGTADVVL EACTDFWDGA DIYPLSGSDR KKVLDFYQRA CLSGYCSAFA
760 770 780 790 800
YKPMNCALSS QLNGKCIELV QVPGQSSIFT MCELPSTIPI KQNARRSSWS
810 820 830 840 850
SDEGIGEVLE KEDCMQALSG QIFMGMVSSQ YQARLDIVRL IDGLVNACIR
860 870 880 890 900
FVYFSLEDEL KSKVFAEKMG LETGWNCHIS LTPNGDMPGS EIPPSSPSHA
910 920 930 940 950
GSLHDDLNQV SRDDAEGLLL MEEEGHSDLI SFQPTDSDIP SFLEDSNRAK
960 970 980 990 1000
LPRGIHQVRP HLQNIDNVPL LVPLFTDCTP ETMCEMIKIM QEYGEVTCCL
1010 1020 1030 1040 1050
GSSANLRNSC LFLQSDISIA LDPLYPSRCS WETFGYATSI SMAQASDGLS
1060 1070 1080 1090 1100
PLQLSGQLNS LPCSLTFRQE ETISIIRLIE QARHATYGIR KCFLFLLQCQ
1110 1120 1130 1140 1150
LTLVVIQFLS CLVQLPPLLS TTDILWLSCF CYPLLSISLL GKPPHSSIMS
1160 1170 1180 1190 1200
MATGKNLQSI PKKTQHYFLL CFLLKFSLTI SSCLICFGFT LQSFCDSSRD
1210 1220 1230 1240 1250
RNLTNCSSVM LPSNDDRAPA WFEDFANGLL SAQKLTAALI VLHTVFISIT
1260 1270 1280 1290 1300
HVHRTKPLWR KSPLTNLWWA VTVPVVLLGQ VVQTAVDLQL WTHRDSHVHF
1310 1320 1330 1340 1350
GLEDVPLLTW LLGCLSLVLV VVTNEIVKLH EIRVRVRYQK RQKLQFETKL

GMNSPF
Length:1,356
Mass (Da):151,151
Last modified:November 1, 1997 - v1
Checksum:i9DC0188CEE81F494
GO
Isoform 2 (identifier: Q12767-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1244-1244: T → TGERAPWEGVDDGGKGAPLWKSDPHIAPPSP

Note: No experimental confirmation available.
Show »
Length:1,386
Mass (Da):154,257
Checksum:i7958222BFF279C8D
GO

Sequence cautioni

The sequence BAA12108 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203I → M in AAH45540 (PubMed:15489334).Curated1
Sequence conflicti991Q → L in AAH45540 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0195081040I → T.Corresponds to variant rs8073809dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0110431244T → TGERAPWEGVDDGGKGAPLW KSDPHIAPPSP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83779 mRNA. Translation: BAA12108.2. Different initiation.
BC045540 mRNA. Translation: AAH45540.1.
AF070545 mRNA. Translation: AAC28636.1.
CCDSiCCDS32732.1. [Q12767-1]
RefSeqiNP_001308077.1. NM_001321148.1.
NP_001308078.1. NM_001321149.1.
NP_055553.3. NM_014738.5. [Q12767-1]
UniGeneiHs.514474.

Genome annotation databases

EnsembliENST00000314256; ENSP00000313885; ENSG00000177728. [Q12767-1]
GeneIDi9772.
KEGGihsa:9772.
UCSCiuc002jnz.5. human. [Q12767-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83779 mRNA. Translation: BAA12108.2. Different initiation.
BC045540 mRNA. Translation: AAH45540.1.
AF070545 mRNA. Translation: AAC28636.1.
CCDSiCCDS32732.1. [Q12767-1]
RefSeqiNP_001308077.1. NM_001321148.1.
NP_001308078.1. NM_001321149.1.
NP_055553.3. NM_014738.5. [Q12767-1]
UniGeneiHs.514474.

3D structure databases

ProteinModelPortaliQ12767.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115117. 7 interactors.
IntActiQ12767. 1 interactor.
STRINGi9606.ENSP00000313885.

PTM databases

iPTMnetiQ12767.
PhosphoSitePlusiQ12767.

Polymorphism and mutation databases

BioMutaiKIAA0195.
DMDMi2495718.

Proteomic databases

MaxQBiQ12767.
PaxDbiQ12767.
PeptideAtlasiQ12767.
PRIDEiQ12767.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314256; ENSP00000313885; ENSG00000177728. [Q12767-1]
GeneIDi9772.
KEGGihsa:9772.
UCSCiuc002jnz.5. human. [Q12767-1]

Organism-specific databases

CTDi9772.
DisGeNETi9772.
GeneCardsiKIAA0195.
HGNCiHGNC:28983. TMEM94.
HPAiHPA050660.
neXtProtiNX_Q12767.
OpenTargetsiENSG00000177728.
PharmGKBiPA142671623.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4383. Eukaryota.
ENOG410XQVD. LUCA.
GeneTreeiENSGT00390000016550.
HOVERGENiHBG052173.
InParanoidiQ12767.
PhylomeDBiQ12767.
TreeFamiTF314852.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177728-MONOMER.

Miscellaneous databases

ChiTaRSiKIAA0195. human.
GenomeRNAii9772.
PROiQ12767.

Gene expression databases

BgeeiENSG00000177728.
CleanExiHS_KIAA0195.
ExpressionAtlasiQ12767. baseline and differential.
GenevisibleiQ12767. HS.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023298. ATPase_P-typ_TM_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM94_HUMAN
AccessioniPrimary (citable) accession number: Q12767
Secondary accession number(s): O75536, Q86XF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.