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Protein

Transmembrane protein 94

Gene

TMEM94

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 94Imported
Gene namesi
Name:TMEM94Imported
Synonyms:KIAA0195
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28983. TMEM94.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Transmembranei1093 – 111321HelicalSequence analysisAdd
BLAST
Transmembranei1121 – 114121HelicalSequence analysisAdd
BLAST
Transmembranei1168 – 118821HelicalSequence analysisAdd
BLAST
Transmembranei1229 – 124921HelicalSequence analysisAdd
BLAST
Transmembranei1262 – 128221HelicalSequence analysisAdd
BLAST
Transmembranei1307 – 132721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671623.

Polymorphism and mutation databases

BioMutaiKIAA0195.
DMDMi2495718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13561356Transmembrane protein 94PRO_0000050731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei221 – 2211PhosphoserineCombined sources
Modified residuei225 – 2251PhosphoserineCombined sources
Modified residuei444 – 4441PhosphoserineCombined sources
Modified residuei445 – 4451PhosphoserineCombined sources
Modified residuei454 – 4541PhosphoserineCombined sources
Glycosylationi475 – 4751N-linked (GlcNAc...)Sequence analysis
Modified residuei513 – 5131PhosphoserineCombined sources
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence analysis
Modified residuei518 – 5181PhosphoserineCombined sources
Modified residuei798 – 7981PhosphoserineCombined sources
Modified residuei941 – 9411PhosphoserineCombined sources
Glycosylationi1202 – 12021N-linked (GlcNAc...)Sequence analysis
Glycosylationi1205 – 12051N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ12767.
MaxQBiQ12767.
PaxDbiQ12767.
PeptideAtlasiQ12767.
PRIDEiQ12767.

PTM databases

iPTMnetiQ12767.
PhosphoSiteiQ12767.

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

BgeeiQ12767.
CleanExiHS_KIAA0195.
ExpressionAtlasiQ12767. baseline and differential.
GenevisibleiQ12767. HS.

Organism-specific databases

HPAiHPA050660.

Interactioni

Protein-protein interaction databases

BioGridi115117. 7 interactions.
IntActiQ12767. 1 interaction.
STRINGi9606.ENSP00000313885.

Structurei

3D structure databases

ProteinModelPortaliQ12767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4383. Eukaryota.
ENOG410XQVD. LUCA.
GeneTreeiENSGT00390000016550.
HOVERGENiHBG052173.
InParanoidiQ12767.
PhylomeDBiQ12767.
TreeFamiTF314852.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023298. ATPase_P-typ_TM_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12767-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLKEKHLGE PPSALGLSTR KALSVLKEQL EAVLEGHLRE RKKCLTWKEV
60 70 80 90 100
WRSSFLHHSN RCSCFHWPGA SLMLLAVLLL LGCCGGQPAG SRGVGLVNAS
110 120 130 140 150
ALFLLLLLNL VLIGRQDRLK RREVERRLRG IIDQIQDALR DGREIQWPSA
160 170 180 190 200
MYPDLHMPFA PSWSLHWAYR DGHLVNLPVS LLVEGDIIAL RPGQESFASL
210 220 230 240 250
RGIKDDEHIV LEPGDLFPPF SPPPSPRGEV ERGPQSPQQH RLFRVLETPV
260 270 280 290 300
IDNIRWCLDM ALSRPVTALD NERFTVQSVM LHYAVPVVLA GFLITNALRF
310 320 330 340 350
IFSAPGVTSW QYTLLQLQVN GVLPILPLLF PVLWVLATAC GEARVLAQMS
360 370 380 390 400
KASPSSLLAK FSEDTLSSYT EAVSSQEMLR CIWGHFLRVL GGTSPTLSHS
410 420 430 440 450
SSLLHSLGSV TVLCCVDKQG ILSWPNPSPE TVLFFSGKVE PPHSSHEDLT
460 470 480 490 500
DGLSTRSFCH PEPHERDALL AGSLNNTLHL SNEQERGDWP GEAPKPPEPY
510 520 530 540 550
SHHKAHGRSK HPSGSNVSFS RDTEGGEEEP SKTQPGMESD PYEAEDFVCD
560 570 580 590 600
YHLEMLSLSQ DQQNPSCIQF DDSNWQLHLT SLKPLGLNVL LNLCDASVTE
610 620 630 640 650
RLCRFSDHLC NIALQESHSA VLPVHVPWGL CELARLIGFT PGAKELFKQE
660 670 680 690 700
NHLALYRLPS AETMKETSLG RLSCVTKRRP PLSHMISLFI KDTTTSTEQM
710 720 730 740 750
LSHGTADVVL EACTDFWDGA DIYPLSGSDR KKVLDFYQRA CLSGYCSAFA
760 770 780 790 800
YKPMNCALSS QLNGKCIELV QVPGQSSIFT MCELPSTIPI KQNARRSSWS
810 820 830 840 850
SDEGIGEVLE KEDCMQALSG QIFMGMVSSQ YQARLDIVRL IDGLVNACIR
860 870 880 890 900
FVYFSLEDEL KSKVFAEKMG LETGWNCHIS LTPNGDMPGS EIPPSSPSHA
910 920 930 940 950
GSLHDDLNQV SRDDAEGLLL MEEEGHSDLI SFQPTDSDIP SFLEDSNRAK
960 970 980 990 1000
LPRGIHQVRP HLQNIDNVPL LVPLFTDCTP ETMCEMIKIM QEYGEVTCCL
1010 1020 1030 1040 1050
GSSANLRNSC LFLQSDISIA LDPLYPSRCS WETFGYATSI SMAQASDGLS
1060 1070 1080 1090 1100
PLQLSGQLNS LPCSLTFRQE ETISIIRLIE QARHATYGIR KCFLFLLQCQ
1110 1120 1130 1140 1150
LTLVVIQFLS CLVQLPPLLS TTDILWLSCF CYPLLSISLL GKPPHSSIMS
1160 1170 1180 1190 1200
MATGKNLQSI PKKTQHYFLL CFLLKFSLTI SSCLICFGFT LQSFCDSSRD
1210 1220 1230 1240 1250
RNLTNCSSVM LPSNDDRAPA WFEDFANGLL SAQKLTAALI VLHTVFISIT
1260 1270 1280 1290 1300
HVHRTKPLWR KSPLTNLWWA VTVPVVLLGQ VVQTAVDLQL WTHRDSHVHF
1310 1320 1330 1340 1350
GLEDVPLLTW LLGCLSLVLV VVTNEIVKLH EIRVRVRYQK RQKLQFETKL

GMNSPF
Length:1,356
Mass (Da):151,151
Last modified:November 1, 1997 - v1
Checksum:i9DC0188CEE81F494
GO
Isoform 2 (identifier: Q12767-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1244-1244: T → TGERAPWEGVDDGGKGAPLWKSDPHIAPPSP

Note: No experimental confirmation available.
Show »
Length:1,386
Mass (Da):154,257
Checksum:i7958222BFF279C8D
GO

Sequence cautioni

The sequence BAA12108.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031I → M in AAH45540 (PubMed:15489334).Curated
Sequence conflicti991 – 9911Q → L in AAH45540 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1040 – 10401I → T.
Corresponds to variant rs8073809 [ dbSNP | Ensembl ].
VAR_019508

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1244 – 12441T → TGERAPWEGVDDGGKGAPLW KSDPHIAPPSP in isoform 2. 1 PublicationVSP_011043

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83779 mRNA. Translation: BAA12108.2. Different initiation.
BC045540 mRNA. Translation: AAH45540.1.
AF070545 mRNA. Translation: AAC28636.1.
CCDSiCCDS32732.1. [Q12767-1]
RefSeqiNP_001308077.1. NM_001321148.1.
NP_001308078.1. NM_001321149.1.
NP_055553.3. NM_014738.5. [Q12767-1]
XP_011523820.1. XM_011525518.1. [Q12767-1]
UniGeneiHs.514474.

Genome annotation databases

EnsembliENST00000314256; ENSP00000313885; ENSG00000177728. [Q12767-1]
GeneIDi9772.
KEGGihsa:9772.
UCSCiuc002jnz.5. human. [Q12767-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83779 mRNA. Translation: BAA12108.2. Different initiation.
BC045540 mRNA. Translation: AAH45540.1.
AF070545 mRNA. Translation: AAC28636.1.
CCDSiCCDS32732.1. [Q12767-1]
RefSeqiNP_001308077.1. NM_001321148.1.
NP_001308078.1. NM_001321149.1.
NP_055553.3. NM_014738.5. [Q12767-1]
XP_011523820.1. XM_011525518.1. [Q12767-1]
UniGeneiHs.514474.

3D structure databases

ProteinModelPortaliQ12767.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115117. 7 interactions.
IntActiQ12767. 1 interaction.
STRINGi9606.ENSP00000313885.

PTM databases

iPTMnetiQ12767.
PhosphoSiteiQ12767.

Polymorphism and mutation databases

BioMutaiKIAA0195.
DMDMi2495718.

Proteomic databases

EPDiQ12767.
MaxQBiQ12767.
PaxDbiQ12767.
PeptideAtlasiQ12767.
PRIDEiQ12767.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314256; ENSP00000313885; ENSG00000177728. [Q12767-1]
GeneIDi9772.
KEGGihsa:9772.
UCSCiuc002jnz.5. human. [Q12767-1]

Organism-specific databases

CTDi9772.
GeneCardsiKIAA0195.
HGNCiHGNC:28983. TMEM94.
HPAiHPA050660.
neXtProtiNX_Q12767.
PharmGKBiPA142671623.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4383. Eukaryota.
ENOG410XQVD. LUCA.
GeneTreeiENSGT00390000016550.
HOVERGENiHBG052173.
InParanoidiQ12767.
PhylomeDBiQ12767.
TreeFamiTF314852.

Miscellaneous databases

ChiTaRSiKIAA0195. human.
GenomeRNAii9772.
PROiQ12767.

Gene expression databases

BgeeiQ12767.
CleanExiHS_KIAA0195.
ExpressionAtlasiQ12767. baseline and differential.
GenevisibleiQ12767. HS.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023298. ATPase_P-typ_TM_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Andersson B., Wentland M.A., Ricafrente J.Y., Liu W., Gibbs R.A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1155-1356 (ISOFORM 2).
    Tissue: Brain.
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221 AND SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445; SER-454 AND SER-798, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225; SER-444; SER-518 AND SER-941, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTMM94_HUMAN
AccessioniPrimary (citable) accession number: Q12767
Secondary accession number(s): O75536, Q86XF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.