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Protein

HMG domain-containing protein 3

Gene

HMGXB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi288 – 356HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178032-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HMG domain-containing protein 3
Alternative name(s):
HMG box-containing protein 3
Protein SMF
Gene namesi
Name:HMGXB3
Synonyms:KIAA0194, SMF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28982. HMGXB3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22993.
OpenTargetsiENSG00000113716.
PharmGKBiPA164720627.

Polymorphism and mutation databases

BioMutaiHMGXB3.
DMDMi160112910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488061 – 1538HMG domain-containing protein 3Add BLAST1538

Proteomic databases

EPDiQ12766.
MaxQBiQ12766.
PaxDbiQ12766.
PeptideAtlasiQ12766.
PRIDEiQ12766.

PTM databases

iPTMnetiQ12766.
PhosphoSitePlusiQ12766.

Expressioni

Gene expression databases

BgeeiENSG00000113716.
ExpressionAtlasiQ12766. baseline and differential.
GenevisibleiQ12766. HS.

Organism-specific databases

HPAiHPA002354.
HPA005967.

Interactioni

Protein-protein interaction databases

BioGridi116640. 6 interactors.
IntActiQ12766. 6 interactors.
MINTiMINT-8247355.
STRINGi9606.ENSP00000421917.

Structurei

3D structure databases

ProteinModelPortaliQ12766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 239Arg-richAdd BLAST178
Compositional biasi276 – 282Poly-Lys7
Compositional biasi518 – 524Poly-Ser7
Compositional biasi1523 – 1532Poly-Glu10

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IF99. Eukaryota.
ENOG410XVX8. LUCA.
GeneTreeiENSGT00390000006983.
HOGENOMiHOG000112914.
InParanoidiQ12766.
OMAiFKGGQNS.
OrthoDBiEOG091G00QQ.
PhylomeDBiQ12766.
TreeFamiTF330893.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12766-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRTQPRPCY LNAPQQCPGA ERPGRPTAGS HSFLLRPGPL AGSSPFALLD
60 70 80 90 100
PLQAFEQFVW VRSQARAGLL RLRQGSHAVT RCRPLPVRRE GRRDGSPWRS
110 120 130 140 150
VVCRYCRCSR QTGASVTTVS LPSSSSSPGL DPRGPRQASV RSLRSEPVLL
160 170 180 190 200
FLPFRTPYRD SEEGKREGLS RLRAVCRRAG PRGRGSFSPR DARASPRLHF
210 220 230 240 250
LVAAVTTGAA SRRQRGARVR QPSPSSSRRA KRLRECERRS LHAPPAMDAS
260 270 280 290 300
YDGTEVTVVM EEIEEAYCYT SPGPPKKKKK YKIHGEKTKK PRSAYLLYYY
310 320 330 340 350
DIYLKVQQEL PHLPQSEINK KISESWRLLS VAERSYYLEK AKLEKEGLDP
360 370 380 390 400
NSKLSALTAV VPDIPGFRKI LPRSDYIIIP KSSLQEDRSC PQLELCVAQN
410 420 430 440 450
QMSPKGPPLV SNTAPETVPS HAGMAEQCLA VEALAEEVGA LTQSGAVQEI
460 470 480 490 500
ATSEILSQDV LLEDASLEVG ESHQPYQTSL VIEETLVNGS PDLPTGSLAV
510 520 530 540 550
PHPQVGESVS VVTVMRDSSE SSSSAPATQF IMLPLPAYSV VENPTSIKLT
560 570 580 590 600
TTYTRRGHGT CTSPGCSFTY VTRHKPPKCP TCGNFLGGKW IPKEKPAKVK
610 620 630 640 650
VELASGVSSK GSVVKRNQQP VTTEQNSSKE NASKLTLENS EAVSQLLNVA
660 670 680 690 700
PPREVGEESE WEEVIISDAH VLVKEAPGNC GTAVTKTPVV KSGVQPEVTL
710 720 730 740 750
GTTDNDSPGA DVPTPSEGTS TSSPLPAPKK PTGADLLTPG SRAPELKGRA
760 770 780 790 800
RGKPSLLAAA RPMRAILPAP VNVGRGSSMG LPRARQAFSL SDKTPSVRTC
810 820 830 840 850
GLKPSTLKQL GQPIQQPSGP GEVKLPSGPS NRTSQVKVVE VKPDMFPPYK
860 870 880 890 900
YSCTVTLDLG LATSRGRGKC KNPSCSYVYT NRHKPRICPS CGVNLAKDRT
910 920 930 940 950
EKTTKAIEVS SPLPDVLNAT EPLSTAQREI QRQSTLQLLR KVLQIPENES
960 970 980 990 1000
ELAEVFALIH ELNSSRLILS NVSEETVTIE QTSWSNYYES PSTQCLLCSS
1010 1020 1030 1040 1050
PLFKGGQNSL AGPQECWLLT ASRLQTVTAQ VKMCLNPHCL ALHSFIDIYT
1060 1070 1080 1090 1100
GLFNVGNKLL VSLDLLFAIR NQIKLGEDPR VSINVVLKSV QEQTEKTLTS
1110 1120 1130 1140 1150
EELSQLQELL CNGYWAFECL TVRDYNDMIC GICGVAPKVE MAQRSEENVL
1160 1170 1180 1190 1200
ALKSVEFTWP EFLGSNEVNV EDFWATMETE VIEQVAFPAS IPITKFDASV
1210 1220 1230 1240 1250
IAPFFPPLMR GAVVVNTEKD KNLDVQPVPG SGSALVRLLQ EGTCKLDEIG
1260 1270 1280 1290 1300
SYSEEKLQHL LRQCGIPFGA EDSKDQLCFS LLALYESVQN GARAIRPPRH
1310 1320 1330 1340 1350
FTGGKIYKVC PHQVVCGSKY LVRGESARDH VDLLASSRHW PPVYVVDMAT
1360 1370 1380 1390 1400
SVALCADLCY PELTNQMWGR NQGCFSSPTE PPVSVSCPEL LDQHYTVDMT
1410 1420 1430 1440 1450
ETEHSIQHPV TKTATRRIVH AGLQPNPGDP SAGHHSLALC PELAPYATIL
1460 1470 1480 1490 1500
ASIVDSKPNG VRQRPIAFDN ATHYYLYNRL MDFLTSREIV NRQIHDIVQS
1510 1520 1530
CQPGEVVIRD TLYRLGVAQI KTETEEEGEE EEVAAVAE
Length:1,538
Mass (Da):168,334
Last modified:November 13, 2007 - v2
Checksum:i966C2EBE269BA118
GO
Isoform 2 (identifier: Q12766-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.

Note: No experimental confirmation available.
Show »
Length:1,292
Mass (Da):141,106
Checksum:i2C390765939C81E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti734A → V in AAH51025 (Ref. 2) Curated1
Sequence conflicti734A → V in BAA12107 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0473371 – 246Missing in isoform 2. CuratedAdd BLAST246

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011406 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61752.1.
BC051025 mRNA. Translation: AAH51025.1.
D83778 mRNA. Translation: BAA12107.1.
U63963 Genomic DNA. Translation: AAB51697.1.
CCDSiCCDS54935.1. [Q12766-2]
RefSeqiNP_055798.2. NM_014983.2.
UniGeneiHs.719189.

Genome annotation databases

EnsembliENST00000502717; ENSP00000421917; ENSG00000113716. [Q12766-2]
ENST00000613459; ENSP00000479027; ENSG00000113716. [Q12766-1]
GeneIDi22993.
KEGGihsa:22993.
UCSCiuc003lrk.5. human. [Q12766-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011406 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61752.1.
BC051025 mRNA. Translation: AAH51025.1.
D83778 mRNA. Translation: BAA12107.1.
U63963 Genomic DNA. Translation: AAB51697.1.
CCDSiCCDS54935.1. [Q12766-2]
RefSeqiNP_055798.2. NM_014983.2.
UniGeneiHs.719189.

3D structure databases

ProteinModelPortaliQ12766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116640. 6 interactors.
IntActiQ12766. 6 interactors.
MINTiMINT-8247355.
STRINGi9606.ENSP00000421917.

PTM databases

iPTMnetiQ12766.
PhosphoSitePlusiQ12766.

Polymorphism and mutation databases

BioMutaiHMGXB3.
DMDMi160112910.

Proteomic databases

EPDiQ12766.
MaxQBiQ12766.
PaxDbiQ12766.
PeptideAtlasiQ12766.
PRIDEiQ12766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502717; ENSP00000421917; ENSG00000113716. [Q12766-2]
ENST00000613459; ENSP00000479027; ENSG00000113716. [Q12766-1]
GeneIDi22993.
KEGGihsa:22993.
UCSCiuc003lrk.5. human. [Q12766-1]

Organism-specific databases

CTDi22993.
DisGeNETi22993.
GeneCardsiHMGXB3.
HGNCiHGNC:28982. HMGXB3.
HPAiHPA002354.
HPA005967.
neXtProtiNX_Q12766.
OpenTargetsiENSG00000113716.
PharmGKBiPA164720627.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF99. Eukaryota.
ENOG410XVX8. LUCA.
GeneTreeiENSGT00390000006983.
HOGENOMiHOG000112914.
InParanoidiQ12766.
OMAiFKGGQNS.
OrthoDBiEOG091G00QQ.
PhylomeDBiQ12766.
TreeFamiTF330893.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178032-MONOMER.

Miscellaneous databases

GenomeRNAii22993.
PROiQ12766.

Gene expression databases

BgeeiENSG00000113716.
ExpressionAtlasiQ12766. baseline and differential.
GenevisibleiQ12766. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGX3_HUMAN
AccessioniPrimary (citable) accession number: Q12766
Secondary accession number(s): G5E9Y4, Q86UG3, Q9UMF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.