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Protein

Secernin-1

Gene

SCRN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136193-MONOMER.

Protein family/group databases

MEROPSiC69.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Secernin-1
Gene namesi
Name:SCRN1
Synonyms:KIAA0193
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22192. SCRN1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nuclear membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9805.
OpenTargetsiENSG00000136193.
PharmGKBiPA134874373.

Polymorphism and mutation databases

BioMutaiSCRN1.
DMDMi30923294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002214362 – 414Secernin-1Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ12765.
MaxQBiQ12765.
PaxDbiQ12765.
PeptideAtlasiQ12765.
PRIDEiQ12765.

2D gel databases

OGPiQ12765.

PTM databases

iPTMnetiQ12765.
PhosphoSitePlusiQ12765.

Expressioni

Gene expression databases

BgeeiENSG00000136193.
CleanExiHS_SCRN1.
ExpressionAtlasiQ12765. baseline and differential.
GenevisibleiQ12765. HS.

Organism-specific databases

HPAiHPA024517.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GORASP1Q9BQQ33EBI-2690712,EBI-2561458

Protein-protein interaction databases

BioGridi115145. 18 interactors.
IntActiQ12765. 2 interactors.
STRINGi9606.ENSP00000388942.

Structurei

3D structure databases

ProteinModelPortaliQ12765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGQK. Eukaryota.
COG4690. LUCA.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000223307.
HOVERGENiHBG056050.
InParanoidiQ12765.
KOiK14358.
OMAiRSFPCIH.
OrthoDBiEOG091G06OR.
PhylomeDBiQ12765.
TreeFamiTF323890.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12765-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAPPSYCF VAFPPRAKDG LVVFGKNSAR PRDEVQEVVY FSAADHEPES
60 70 80 90 100
KVECTYISID QVPRTYAIMI SRPAWLWGAE MGANEHGVCI ANEAINTREP
110 120 130 140 150
AAEIEALLGM DLVRLGLERG ETAKEALDVI VSLLEEHGQG GNYFEDANSC
160 170 180 190 200
HSFQSAYLIV DRDEAWVLET IGKYWAAEKV TEGVRCICSQ LSLTTKMDAE
210 220 230 240 250
HPELRSYAQS QGWWTGEGEF NFSEVFSPVE DHLDCGAGKD SLEKQEESIT
260 270 280 290 300
VQTMMNTLRD KASGVCIDSE FFLTTASGVS VLPQNRSSPC IHYFTGTPDP
310 320 330 340 350
SRSIFKPFIF VDDVKLVPKT QSPCFGDDDP AKKEPRFQEK PDRRHELYKA
360 370 380 390 400
HEWARAIIES DQEQGRKLRS TMLELEKQGL EAMEEILTSS EPLDPAEVGD
410
LFYDCVDTEI KFFK
Length:414
Mass (Da):46,382
Last modified:May 16, 2003 - v2
Checksum:i1B14D1007AE6BEBE
GO
Isoform 2 (identifier: Q12765-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVQDGTFKTRDSTWTCESTRM

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):48,714
Checksum:i4B4A4778214208C1
GO
Isoform 3 (identifier: Q12765-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,864
Checksum:iA45FC07486234093
GO

Sequence cautioni

The sequence BAA12106 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120G → W in BAG58182 (PubMed:14702039).Curated1
Sequence conflicti298P → H in AAH40492 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057709189S → N.Corresponds to variant rs35960711dbSNPEnsembl.1
Natural variantiVAR_029512338Q → R.Corresponds to variant rs17324153dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0444531 – 68Missing in isoform 3. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_0444541M → MVQDGTFKTRDSTWTCESTR M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071705 mRNA. Translation: BAE91926.1.
D83777 mRNA. Translation: BAA12106.2. Different initiation.
AK289514 mRNA. Translation: BAF82203.1.
AK295172 mRNA. Translation: BAG58182.1.
AK295713 mRNA. Translation: BAG58557.1.
AC004912 Genomic DNA. Translation: AAQ96874.1.
AC007285 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93926.1.
CH471073 Genomic DNA. Translation: EAW93928.1.
BC040492 mRNA. Translation: AAH40492.1.
CCDSiCCDS47567.1. [Q12765-2]
CCDS47568.1. [Q12765-3]
CCDS5422.1. [Q12765-1]
RefSeqiNP_001138985.1. NM_001145513.1. [Q12765-1]
NP_001138986.1. NM_001145514.1. [Q12765-2]
NP_001138987.1. NM_001145515.1. [Q12765-3]
NP_055581.3. NM_014766.4. [Q12765-1]
UniGeneiHs.520740.

Genome annotation databases

EnsembliENST00000242059; ENSP00000242059; ENSG00000136193. [Q12765-1]
ENST00000409497; ENSP00000386872; ENSG00000136193. [Q12765-1]
ENST00000425819; ENSP00000414245; ENSG00000136193. [Q12765-3]
ENST00000426154; ENSP00000409068; ENSG00000136193. [Q12765-1]
ENST00000434476; ENSP00000388942; ENSG00000136193. [Q12765-2]
GeneIDi9805.
KEGGihsa:9805.
UCSCiuc003tak.4. human. [Q12765-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071705 mRNA. Translation: BAE91926.1.
D83777 mRNA. Translation: BAA12106.2. Different initiation.
AK289514 mRNA. Translation: BAF82203.1.
AK295172 mRNA. Translation: BAG58182.1.
AK295713 mRNA. Translation: BAG58557.1.
AC004912 Genomic DNA. Translation: AAQ96874.1.
AC007285 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93926.1.
CH471073 Genomic DNA. Translation: EAW93928.1.
BC040492 mRNA. Translation: AAH40492.1.
CCDSiCCDS47567.1. [Q12765-2]
CCDS47568.1. [Q12765-3]
CCDS5422.1. [Q12765-1]
RefSeqiNP_001138985.1. NM_001145513.1. [Q12765-1]
NP_001138986.1. NM_001145514.1. [Q12765-2]
NP_001138987.1. NM_001145515.1. [Q12765-3]
NP_055581.3. NM_014766.4. [Q12765-1]
UniGeneiHs.520740.

3D structure databases

ProteinModelPortaliQ12765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115145. 18 interactors.
IntActiQ12765. 2 interactors.
STRINGi9606.ENSP00000388942.

Protein family/group databases

MEROPSiC69.003.

PTM databases

iPTMnetiQ12765.
PhosphoSitePlusiQ12765.

Polymorphism and mutation databases

BioMutaiSCRN1.
DMDMi30923294.

2D gel databases

OGPiQ12765.

Proteomic databases

EPDiQ12765.
MaxQBiQ12765.
PaxDbiQ12765.
PeptideAtlasiQ12765.
PRIDEiQ12765.

Protocols and materials databases

DNASUi9805.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242059; ENSP00000242059; ENSG00000136193. [Q12765-1]
ENST00000409497; ENSP00000386872; ENSG00000136193. [Q12765-1]
ENST00000425819; ENSP00000414245; ENSG00000136193. [Q12765-3]
ENST00000426154; ENSP00000409068; ENSG00000136193. [Q12765-1]
ENST00000434476; ENSP00000388942; ENSG00000136193. [Q12765-2]
GeneIDi9805.
KEGGihsa:9805.
UCSCiuc003tak.4. human. [Q12765-1]

Organism-specific databases

CTDi9805.
DisGeNETi9805.
GeneCardsiSCRN1.
HGNCiHGNC:22192. SCRN1.
HPAiHPA024517.
MIMi614965. gene.
neXtProtiNX_Q12765.
OpenTargetsiENSG00000136193.
PharmGKBiPA134874373.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQK. Eukaryota.
COG4690. LUCA.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000223307.
HOVERGENiHBG056050.
InParanoidiQ12765.
KOiK14358.
OMAiRSFPCIH.
OrthoDBiEOG091G06OR.
PhylomeDBiQ12765.
TreeFamiTF323890.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136193-MONOMER.

Miscellaneous databases

ChiTaRSiSCRN1. human.
GeneWikiiSCRN1.
GenomeRNAii9805.
PROiQ12765.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136193.
CleanExiHS_SCRN1.
ExpressionAtlasiQ12765. baseline and differential.
GenevisibleiQ12765. HS.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCRN1_HUMAN
AccessioniPrimary (citable) accession number: Q12765
Secondary accession number(s): A8K0E9
, B4DHM0, B4DIP5, C9JPG0, Q25QX7, Q8IWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2003
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Secern' is an archaic English term meaning 'secrete'.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.