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Protein

Secernin-1

Gene

SCRN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91Sequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Protein family/group databases

MEROPSiC69.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Secernin-1
Gene namesi
Name:SCRN1
Synonyms:KIAA0193
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22192. SCRN1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nuclear membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134874373.

Polymorphism and mutation databases

BioMutaiSCRN1.
DMDMi30923294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 414413Secernin-1PRO_0000221436Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ12765.
MaxQBiQ12765.
PaxDbiQ12765.
PeptideAtlasiQ12765.
PRIDEiQ12765.

2D gel databases

OGPiQ12765.

PTM databases

iPTMnetiQ12765.
PhosphoSiteiQ12765.

Expressioni

Gene expression databases

BgeeiQ12765.
CleanExiHS_SCRN1.
ExpressionAtlasiQ12765. baseline and differential.
GenevisibleiQ12765. HS.

Organism-specific databases

HPAiHPA024517.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GORASP1Q9BQQ33EBI-2690712,EBI-2561458

Protein-protein interaction databases

BioGridi115145. 18 interactions.
IntActiQ12765. 2 interactions.
STRINGi9606.ENSP00000388942.

Structurei

3D structure databases

ProteinModelPortaliQ12765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGQK. Eukaryota.
COG4690. LUCA.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000223307.
HOVERGENiHBG056050.
InParanoidiQ12765.
KOiK14358.
OMAiRSFPCIH.
OrthoDBiEOG7W1545.
PhylomeDBiQ12765.
TreeFamiTF323890.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12765-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAPPSYCF VAFPPRAKDG LVVFGKNSAR PRDEVQEVVY FSAADHEPES
60 70 80 90 100
KVECTYISID QVPRTYAIMI SRPAWLWGAE MGANEHGVCI ANEAINTREP
110 120 130 140 150
AAEIEALLGM DLVRLGLERG ETAKEALDVI VSLLEEHGQG GNYFEDANSC
160 170 180 190 200
HSFQSAYLIV DRDEAWVLET IGKYWAAEKV TEGVRCICSQ LSLTTKMDAE
210 220 230 240 250
HPELRSYAQS QGWWTGEGEF NFSEVFSPVE DHLDCGAGKD SLEKQEESIT
260 270 280 290 300
VQTMMNTLRD KASGVCIDSE FFLTTASGVS VLPQNRSSPC IHYFTGTPDP
310 320 330 340 350
SRSIFKPFIF VDDVKLVPKT QSPCFGDDDP AKKEPRFQEK PDRRHELYKA
360 370 380 390 400
HEWARAIIES DQEQGRKLRS TMLELEKQGL EAMEEILTSS EPLDPAEVGD
410
LFYDCVDTEI KFFK
Length:414
Mass (Da):46,382
Last modified:May 16, 2003 - v2
Checksum:i1B14D1007AE6BEBE
GO
Isoform 2 (identifier: Q12765-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVQDGTFKTRDSTWTCESTRM

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):48,714
Checksum:i4B4A4778214208C1
GO
Isoform 3 (identifier: Q12765-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,864
Checksum:iA45FC07486234093
GO

Sequence cautioni

The sequence BAA12106.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201G → W in BAG58182 (PubMed:14702039).Curated
Sequence conflicti298 – 2981P → H in AAH40492 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891S → N.
Corresponds to variant rs35960711 [ dbSNP | Ensembl ].
VAR_057709
Natural varianti338 – 3381Q → R.
Corresponds to variant rs17324153 [ dbSNP | Ensembl ].
VAR_029512

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6868Missing in isoform 3. 1 PublicationVSP_044453Add
BLAST
Alternative sequencei1 – 11M → MVQDGTFKTRDSTWTCESTR M in isoform 2. 1 PublicationVSP_044454

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071705 mRNA. Translation: BAE91926.1.
D83777 mRNA. Translation: BAA12106.2. Different initiation.
AK289514 mRNA. Translation: BAF82203.1.
AK295172 mRNA. Translation: BAG58182.1.
AK295713 mRNA. Translation: BAG58557.1.
AC004912 Genomic DNA. Translation: AAQ96874.1.
AC007285 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93926.1.
CH471073 Genomic DNA. Translation: EAW93928.1.
BC040492 mRNA. Translation: AAH40492.1.
CCDSiCCDS47567.1. [Q12765-2]
CCDS47568.1. [Q12765-3]
CCDS5422.1. [Q12765-1]
RefSeqiNP_001138985.1. NM_001145513.1. [Q12765-1]
NP_001138986.1. NM_001145514.1. [Q12765-2]
NP_001138987.1. NM_001145515.1. [Q12765-3]
NP_055581.3. NM_014766.4. [Q12765-1]
XP_005249975.1. XM_005249918.3. [Q12765-1]
XP_011513955.1. XM_011515653.1. [Q12765-1]
UniGeneiHs.520740.

Genome annotation databases

EnsembliENST00000242059; ENSP00000242059; ENSG00000136193. [Q12765-1]
ENST00000409497; ENSP00000386872; ENSG00000136193. [Q12765-1]
ENST00000425819; ENSP00000414245; ENSG00000136193. [Q12765-3]
ENST00000426154; ENSP00000409068; ENSG00000136193. [Q12765-1]
ENST00000434476; ENSP00000388942; ENSG00000136193. [Q12765-2]
GeneIDi9805.
KEGGihsa:9805.
UCSCiuc003tak.4. human. [Q12765-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071705 mRNA. Translation: BAE91926.1.
D83777 mRNA. Translation: BAA12106.2. Different initiation.
AK289514 mRNA. Translation: BAF82203.1.
AK295172 mRNA. Translation: BAG58182.1.
AK295713 mRNA. Translation: BAG58557.1.
AC004912 Genomic DNA. Translation: AAQ96874.1.
AC007285 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93926.1.
CH471073 Genomic DNA. Translation: EAW93928.1.
BC040492 mRNA. Translation: AAH40492.1.
CCDSiCCDS47567.1. [Q12765-2]
CCDS47568.1. [Q12765-3]
CCDS5422.1. [Q12765-1]
RefSeqiNP_001138985.1. NM_001145513.1. [Q12765-1]
NP_001138986.1. NM_001145514.1. [Q12765-2]
NP_001138987.1. NM_001145515.1. [Q12765-3]
NP_055581.3. NM_014766.4. [Q12765-1]
XP_005249975.1. XM_005249918.3. [Q12765-1]
XP_011513955.1. XM_011515653.1. [Q12765-1]
UniGeneiHs.520740.

3D structure databases

ProteinModelPortaliQ12765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115145. 18 interactions.
IntActiQ12765. 2 interactions.
STRINGi9606.ENSP00000388942.

Protein family/group databases

MEROPSiC69.003.

PTM databases

iPTMnetiQ12765.
PhosphoSiteiQ12765.

Polymorphism and mutation databases

BioMutaiSCRN1.
DMDMi30923294.

2D gel databases

OGPiQ12765.

Proteomic databases

EPDiQ12765.
MaxQBiQ12765.
PaxDbiQ12765.
PeptideAtlasiQ12765.
PRIDEiQ12765.

Protocols and materials databases

DNASUi9805.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242059; ENSP00000242059; ENSG00000136193. [Q12765-1]
ENST00000409497; ENSP00000386872; ENSG00000136193. [Q12765-1]
ENST00000425819; ENSP00000414245; ENSG00000136193. [Q12765-3]
ENST00000426154; ENSP00000409068; ENSG00000136193. [Q12765-1]
ENST00000434476; ENSP00000388942; ENSG00000136193. [Q12765-2]
GeneIDi9805.
KEGGihsa:9805.
UCSCiuc003tak.4. human. [Q12765-1]

Organism-specific databases

CTDi9805.
GeneCardsiSCRN1.
HGNCiHGNC:22192. SCRN1.
HPAiHPA024517.
MIMi614965. gene.
neXtProtiNX_Q12765.
PharmGKBiPA134874373.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQK. Eukaryota.
COG4690. LUCA.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000223307.
HOVERGENiHBG056050.
InParanoidiQ12765.
KOiK14358.
OMAiRSFPCIH.
OrthoDBiEOG7W1545.
PhylomeDBiQ12765.
TreeFamiTF323890.

Miscellaneous databases

ChiTaRSiSCRN1. human.
GeneWikiiSCRN1.
GenomeRNAii9805.
NextBioi36916.
PROiQ12765.
SOURCEiSearch...

Gene expression databases

BgeeiQ12765.
CleanExiHS_SCRN1.
ExpressionAtlasiQ12765. baseline and differential.
GenevisibleiQ12765. HS.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray."
    Suda T., Tsunoda T., Uchida N., Watanabe T., Hasegawa S., Satoh S., Ohgi S., Furukawa Y., Nakamura Y., Tahara H.
    Cancer Sci. 97:411-419(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO N-TERMINUS.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain, Cerebellum and Hippocampus.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hypothalamus.
  8. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 52-64; 99-114; 163-173 AND 186-196, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Platelet.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSCRN1_HUMAN
AccessioniPrimary (citable) accession number: Q12765
Secondary accession number(s): A8K0E9
, B4DHM0, B4DIP5, C9JPG0, Q25QX7, Q8IWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2003
Last modified: March 16, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Secern' is an archaic English term meaning 'secrete'.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.