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Protein

Ribosomal RNA-processing protein 12

Gene

RRP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In association with GSP1, required for nuclear export of both pre-40S and pre-60S ribosomal subunits. Required for the late maturation of the 18S and 5.8S rRNA of the pre-40S ribosomes and for maturation of the 25S and 5.8S rRNA of the pre-60S ribosomes.1 Publication

Miscellaneous

Present with 8170 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • ribosome biogenesis Source: SGD

Keywordsi

Molecular functionRNA-binding
Biological processRibosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33931-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA-processing protein 12
Gene namesi
Name:RRP12
Ordered Locus Names:YPL012W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL012W
SGDiS000005933 RRP12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002705631 – 1228Ribosomal RNA-processing protein 12Add BLAST1228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1067PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12754
PaxDbiQ12754
PRIDEiQ12754

PTM databases

iPTMnetiQ12754

Interactioni

Subunit structurei

Interacts with GSP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36165, 146 interactors
DIPiDIP-6497N
IntActiQ12754, 76 interactors
MINTiQ12754
STRINGi4932.YPL012W

Structurei

3D structure databases

ProteinModelPortaliQ12754
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RRP12 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013106
HOGENOMiHOG000164239
InParanoidiQ12754
KOiK14794
OMAiMRRHFRM
OrthoDBiEOG092C08DW

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR012978 Uncharacterised_NUC173
PfamiView protein in Pfam
PF08161 NUC173, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequencei

Sequence statusi: Complete.

Q12754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQDKVAFLL ELEDKLAKIR SQVNSKLENQ KHIAIILTAV EENIAGQATN
60 70 80 90 100
DVSKNIVNYI ISFMSLLDQA VDPSTHEIKD IQLASSSTYL LDLIFHYSPK
110 120 130 140 150
VLLRSKFSEI LTKIAPCITA EKANAPLIRA AIGCLESLLI AQDAQAWNNT
160 170 180 190 200
YDLNVTPKRG LQGILELSLD VRPKVRKRAL DAVHAVLLNP PVAPTAEHVA
210 220 230 240 250
AVFVADFCDK QLAGILNDLS NLSNKQLKAQ KTKEDINASV MRSLRLITSV
260 270 280 290 300
VSTGQWPSSQ IEPLCDVLLG VTKSSEQYLV SASFECFESM FKTMAETTIS
310 320 330 340 350
SGLAENKYLR VLDTIFALKP SNVDTLLTKS WIAVVIKGMS TYATHQPLKA
360 370 380 390 400
LRKIPGVFHI MCTYLASETP EVYQAASQCL ISILSESVKD DLLLYTPSVD
410 420 430 440 450
EKVFKNVDEI ISQIAKTFID FLSIRYSHCS REILKILVAA FNKFRYRSNP
460 470 480 490 500
HFLKSLKIVD TWRVNEEQFM DLRNEIELVI GASISAMGPE MILAEAPLNL
510 520 530 540 550
DNPSSERPGR AWLLPLIRDY TKNANLATFQ NELAPYIKSF QSKFDKVPEE
560 570 580 590 600
SIQLRVFQTI VDQIWSTLPR FCELPMDLRE SFTDEFASEL SSLLYSEVEL
610 620 630 640 650
RTTICHALKV LAESNVSYAE ESSSHNVLLL QRFPISEAQK NIEYLSTKST
660 670 680 690 700
NLLAVLFNVY TQTTPNARSY ILETIDQYLK ITSKEDLEKT FNNVCGLLKN
710 720 730 740 750
SMNEESSGNV NKEKKKPQLT ATLLDLIICM ITYLPVSSYS ALFSMFSLTV
760 770 780 790 800
NSADALIQKR AYRIITKLSE LKSGSTAVAQ FISDIENVMV DSASSVQTSA
810 820 830 840 850
KAARLTAIKT IVELLPLDHL DFIVRTVAEV ILSTKDVNEK SRETAFDTLI
860 870 880 890 900
CMGRKMNEPN GIIKLFQIPG YDPTTPDQSS SISEFFKIIS AGLIGESQHM
910 920 930 940 950
VSSSITGYAC LVFEFKNELD SGILMDIYDT IELYLTSNSR EIVKSAIGFT
960 970 980 990 1000
KVCVLGLPEE LMRPKVPELL LKLLRWSHEH TGHFKAKVKH IIERLIRRFG
1010 1020 1030 1040 1050
YDYIEANFPE EDRRLLTNIR KMRNRNKRKD EEVTTGVSDV AATKGSRFMS
1060 1070 1080 1090 1100
AFDEAVYGSD EENDNGSDQE ENVAGGKMKN GAKQFIVESG DNPLDLLDSQ
1110 1120 1130 1140 1150
TLAHISSTRP KKFNKNQNRA RFNDDAFNFD SEGKLVVKGQ PKPSTNVDDP
1160 1170 1180 1190 1200
LSAVTSGINA YLEAVKSGPV RGQRNKLKFR KNGKDSDEFG DDDDGEKDSR
1210 1220
LMRGRVNQGN KIGKHNKKGP KFKSRKKL
Length:1,228
Mass (Da):137,509
Last modified:November 1, 1996 - v1
Checksum:i92333BCD53CB095F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33335 Genomic DNA Translation: AAB68093.1
Z71255 Genomic DNA Translation: CAA95029.1
Z48483 Genomic DNA Translation: CAA88374.1
BK006949 Genomic DNA Translation: DAA11416.1
PIRiS59681
RefSeqiNP_015313.1, NM_001183826.1

Genome annotation databases

EnsemblFungiiYPL012W; YPL012W; YPL012W
GeneIDi856095
KEGGisce:YPL012W

Similar proteinsi

Entry informationi

Entry nameiRRP12_YEAST
AccessioniPrimary (citable) accession number: Q12754
Secondary accession number(s): D6W400, Q7LH12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health