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Q12754

- RRP12_YEAST

UniProt

Q12754 - RRP12_YEAST

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Protein

Ribosomal RNA-processing protein 12

Gene

RRP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

In association with GSP1, required for nuclear export of both pre-40S and pre-60S ribosomal subunits. Required for the late maturation of the 18S and 5.8S rRNA of the pre-40S ribosomes and for maturation of the 25S and 5.8S rRNA of the pre-60S ribosomes.1 Publication

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  2. ribosome biogenesis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33931-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA-processing protein 12
Gene namesi
Name:RRP12
Ordered Locus Names:YPL012W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPL012w.
SGDiS000005933. RRP12.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
  2. ribosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12281228Ribosomal RNA-processing protein 12PRO_0000270563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1059 – 10591Phosphoserine1 Publication
Modified residuei1067 – 10671Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12754.
PaxDbiQ12754.
PeptideAtlasiQ12754.
PRIDEiQ12754.

Expressioni

Gene expression databases

GenevestigatoriQ12754.

Interactioni

Subunit structurei

Interacts with GSP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EBP2P360491EBI-30678,EBI-6289

Protein-protein interaction databases

BioGridi36165. 115 interactions.
DIPiDIP-6497N.
IntActiQ12754. 49 interactions.
MINTiMINT-639557.
STRINGi4932.YPL012W.

Structurei

3D structure databases

ProteinModelPortaliQ12754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RRP12 family.Curated

Phylogenomic databases

eggNOGiNOG149372.
GeneTreeiENSGT00390000013106.
HOGENOMiHOG000164239.
InParanoidiQ12754.
KOiK14794.
OMAiLQPLLTW.
OrthoDBiEOG7WDN9V.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR012978. Uncharacterised_NUC173.
[Graphical view]
PfamiPF08161. NUC173. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q12754-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQDKVAFLL ELEDKLAKIR SQVNSKLENQ KHIAIILTAV EENIAGQATN
60 70 80 90 100
DVSKNIVNYI ISFMSLLDQA VDPSTHEIKD IQLASSSTYL LDLIFHYSPK
110 120 130 140 150
VLLRSKFSEI LTKIAPCITA EKANAPLIRA AIGCLESLLI AQDAQAWNNT
160 170 180 190 200
YDLNVTPKRG LQGILELSLD VRPKVRKRAL DAVHAVLLNP PVAPTAEHVA
210 220 230 240 250
AVFVADFCDK QLAGILNDLS NLSNKQLKAQ KTKEDINASV MRSLRLITSV
260 270 280 290 300
VSTGQWPSSQ IEPLCDVLLG VTKSSEQYLV SASFECFESM FKTMAETTIS
310 320 330 340 350
SGLAENKYLR VLDTIFALKP SNVDTLLTKS WIAVVIKGMS TYATHQPLKA
360 370 380 390 400
LRKIPGVFHI MCTYLASETP EVYQAASQCL ISILSESVKD DLLLYTPSVD
410 420 430 440 450
EKVFKNVDEI ISQIAKTFID FLSIRYSHCS REILKILVAA FNKFRYRSNP
460 470 480 490 500
HFLKSLKIVD TWRVNEEQFM DLRNEIELVI GASISAMGPE MILAEAPLNL
510 520 530 540 550
DNPSSERPGR AWLLPLIRDY TKNANLATFQ NELAPYIKSF QSKFDKVPEE
560 570 580 590 600
SIQLRVFQTI VDQIWSTLPR FCELPMDLRE SFTDEFASEL SSLLYSEVEL
610 620 630 640 650
RTTICHALKV LAESNVSYAE ESSSHNVLLL QRFPISEAQK NIEYLSTKST
660 670 680 690 700
NLLAVLFNVY TQTTPNARSY ILETIDQYLK ITSKEDLEKT FNNVCGLLKN
710 720 730 740 750
SMNEESSGNV NKEKKKPQLT ATLLDLIICM ITYLPVSSYS ALFSMFSLTV
760 770 780 790 800
NSADALIQKR AYRIITKLSE LKSGSTAVAQ FISDIENVMV DSASSVQTSA
810 820 830 840 850
KAARLTAIKT IVELLPLDHL DFIVRTVAEV ILSTKDVNEK SRETAFDTLI
860 870 880 890 900
CMGRKMNEPN GIIKLFQIPG YDPTTPDQSS SISEFFKIIS AGLIGESQHM
910 920 930 940 950
VSSSITGYAC LVFEFKNELD SGILMDIYDT IELYLTSNSR EIVKSAIGFT
960 970 980 990 1000
KVCVLGLPEE LMRPKVPELL LKLLRWSHEH TGHFKAKVKH IIERLIRRFG
1010 1020 1030 1040 1050
YDYIEANFPE EDRRLLTNIR KMRNRNKRKD EEVTTGVSDV AATKGSRFMS
1060 1070 1080 1090 1100
AFDEAVYGSD EENDNGSDQE ENVAGGKMKN GAKQFIVESG DNPLDLLDSQ
1110 1120 1130 1140 1150
TLAHISSTRP KKFNKNQNRA RFNDDAFNFD SEGKLVVKGQ PKPSTNVDDP
1160 1170 1180 1190 1200
LSAVTSGINA YLEAVKSGPV RGQRNKLKFR KNGKDSDEFG DDDDGEKDSR
1210 1220
LMRGRVNQGN KIGKHNKKGP KFKSRKKL
Length:1,228
Mass (Da):137,509
Last modified:November 1, 1996 - v1
Checksum:i92333BCD53CB095F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33335 Genomic DNA. Translation: AAB68093.1.
Z71255 Genomic DNA. Translation: CAA95029.1.
Z48483 Genomic DNA. Translation: CAA88374.1.
BK006949 Genomic DNA. Translation: DAA11416.1.
PIRiS59681.
RefSeqiNP_015313.1. NM_001183826.1.

Genome annotation databases

EnsemblFungiiYPL012W; YPL012W; YPL012W.
GeneIDi856095.
KEGGisce:YPL012W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33335 Genomic DNA. Translation: AAB68093.1 .
Z71255 Genomic DNA. Translation: CAA95029.1 .
Z48483 Genomic DNA. Translation: CAA88374.1 .
BK006949 Genomic DNA. Translation: DAA11416.1 .
PIRi S59681.
RefSeqi NP_015313.1. NM_001183826.1.

3D structure databases

ProteinModelPortali Q12754.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36165. 115 interactions.
DIPi DIP-6497N.
IntActi Q12754. 49 interactions.
MINTi MINT-639557.
STRINGi 4932.YPL012W.

Proteomic databases

MaxQBi Q12754.
PaxDbi Q12754.
PeptideAtlasi Q12754.
PRIDEi Q12754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPL012W ; YPL012W ; YPL012W .
GeneIDi 856095.
KEGGi sce:YPL012W.

Organism-specific databases

CYGDi YPL012w.
SGDi S000005933. RRP12.

Phylogenomic databases

eggNOGi NOG149372.
GeneTreei ENSGT00390000013106.
HOGENOMi HOG000164239.
InParanoidi Q12754.
KOi K14794.
OMAi LQPLLTW.
OrthoDBi EOG7WDN9V.

Enzyme and pathway databases

BioCyci YEAST:G3O-33931-MONOMER.

Miscellaneous databases

NextBioi 981131.
PROi Q12754.

Gene expression databases

Genevestigatori Q12754.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR012978. Uncharacterised_NUC173.
[Graphical view ]
Pfami PF08161. NUC173. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes."
    Schaefer T., Strauss D., Petfalski E., Tollervey D., Hurt E.
    EMBO J. 22:1370-1380(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits."
    Oeffinger M., Dlakic M., Tollervey D.
    Genes Dev. 18:196-209(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GSP1, SUBCELLULAR LOCATION.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1067, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1067, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1059 AND SER-1067, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRRP12_YEAST
AccessioniPrimary (citable) accession number: Q12754
Secondary accession number(s): D6W400, Q7LH12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8170 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3