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Protein

Transcriptional activator HAA1

Gene

HAA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the transcription of a set of genes, many of which encode membrane proteins. Among the genes regulated are YGR138C and YRO2. Does not seem to be dependent on copper.1 Publication

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11ZincPROSITE-ProRule annotation1
Metal bindingi14ZincPROSITE-ProRule annotation1
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi25ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1 – 40Copper-fistPROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34170-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator HAA1
Gene namesi
Name:HAA1
Ordered Locus Names:YPR008W
ORF Names:LPZ8W, YP9531.01, YP9723.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR008W
SGDiS000006212 HAA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001949331 – 694Transcriptional activator HAA1Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei291PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12753
PaxDbiQ12753
PRIDEiQ12753

PTM databases

iPTMnetiQ12753

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FUS1P117103EBI-8118,EBI-7179

Protein-protein interaction databases

BioGridi36186, 69 interactors
DIPiDIP-1462N
IntActiQ12753, 8 interactors
MINTiQ12753
STRINGi4932.YPR008W

Structurei

3D structure databases

ProteinModelPortaliQ12753
SMRiQ12753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000068810
InParanoidiQ12753
OMAiGFADLDN
OrthoDBiEOG092C10Q9

Family and domain databases

Gene3Di3.90.430.10, 1 hit
InterProiView protein in InterPro
IPR001083 Cu_fist_DNA-bd_dom
IPR036395 Cu_fist_DNA-bd_dom_sf
PfamiView protein in Pfam
PF00649 Copper-fist, 1 hit
PRINTSiPR00617 COPPERFIST
SMARTiView protein in SMART
SM01090 Copper-fist, 1 hit
SM00412 Cu_FIST, 1 hit
SUPFAMiSSF57879 SSF57879, 1 hit
PROSITEiView protein in PROSITE
PS01119 COPPER_FIST_1, 1 hit
PS50073 COPPER_FIST_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q12753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLINGIKYA CERCIRGHRV TTCNHTDQPL MMIKPKGRPS TTCDYCKQLR
60 70 80 90 100
KNKNANPEGV CTCGRLEKKK LAQKAKEEAR AKAKEKQRKQ CTCGTDEVCK
110 120 130 140 150
YHAQKRHLRK SPSSSQKKGR SISRSQPMFE RVLSSTSLDS NMLSGHGALS
160 170 180 190 200
DTSSILTSTF LDSEPGVGKI SKDYHHVPSL ASISSLQSSQ SLDQNFSIPQ
210 220 230 240 250
SPPLSSMSFN FLTGNINETN QNHSNHQHSK SGNNWQDSSV SLPAKADSRL
260 270 280 290 300
NMMDKNNSVG LDLLGHSKRI SPISNSRVGE VSVPLEEYIP SDIDGVGRVT
310 320 330 340 350
DKSSLVYDWP FDESIERNFS TTATAATGES KFDINDNCNR INSKSYSKTN
360 370 380 390 400
SMNGNGMNNS NNNNINSNGN DKNNNNSSRQ EHQGNGLFDM FTDSSSISTL
410 420 430 440 450
SRANLLLQEK IGSQENSVKQ ENYSKNPQLR HQLTSRSRSF IHHPANEYLK
460 470 480 490 500
NTFGNSHSND IGKGVEVLSL TPSFMDIPEK ERETERSPSS NYITDRPFTR
510 520 530 540 550
KPRSSSIDVN HRYPPMAPTT VATSPGALNN AVASNLDDQL SLTSLNSQPS
560 570 580 590 600
SIANMMMDPS NLAEQSSIHS VPQSINSPRM PKTGSRQDKN IHTKKEERNP
610 620 630 640 650
LNNIHDLSQL ENVPDEMNQM FSPPLKSMNR PDAIRENSSS SNFIIQGNSM
660 670 680 690
ISTPSGRNDL PDTSPMSSIQ TASPPSQLLT DQGFADLDNF MSSL
Length:694
Mass (Da):76,671
Last modified:November 1, 1996 - v1
Checksum:i0A129F79B4E99CA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31900 Genomic DNA Translation: AAA97587.1
Z71255 Genomic DNA Translation: CAA95048.1
Z48951 Genomic DNA Translation: CAA88786.1
Z49919 Genomic DNA Translation: CAA90152.1
AY692804 Genomic DNA Translation: AAT92823.1
BK006949 Genomic DNA Translation: DAA11435.1
PIRiS59753
RefSeqiNP_015333.1, NM_001184105.1

Genome annotation databases

EnsemblFungiiYPR008W; YPR008W; YPR008W
GeneIDi856117
KEGGisce:YPR008W

Similar proteinsi

Entry informationi

Entry nameiHAA1_YEAST
AccessioniPrimary (citable) accession number: Q12753
Secondary accession number(s): D6W419
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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