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Protein

Transcriptional activator HAA1

Gene

HAA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the transcription of a set of genes, many of which encode membrane proteins. Among the genes regulated are YGR138C and YRO2. Does not seem to be dependent on copper.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11ZincPROSITE-ProRule annotation1
Metal bindingi14ZincPROSITE-ProRule annotation1
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi25ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1 – 40Copper-fistPROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Copper, DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator HAA1
Gene namesi
Name:HAA1
Ordered Locus Names:YPR008W
ORF Names:LPZ8W, YP9531.01, YP9723.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR008W.
SGDiS000006212. HAA1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001949331 – 694Transcriptional activator HAA1Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei291PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12753.
PRIDEiQ12753.

PTM databases

iPTMnetiQ12753.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FUS1P117103EBI-8118,EBI-7179

Protein-protein interaction databases

BioGridi36186. 40 interactors.
DIPiDIP-1462N.
IntActiQ12753. 8 interactors.
MINTiMINT-402478.

Structurei

3D structure databases

ProteinModelPortaliQ12753.
SMRiQ12753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 copper-fist DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000068810.
InParanoidiQ12753.
OMAiKNKNANP.
OrthoDBiEOG092C10Q9.

Family and domain databases

Gene3Di3.90.430.10. 1 hit.
InterProiIPR001083. Cu_fist_DNA-bd_dom.
[Graphical view]
PfamiPF00649. Copper-fist. 1 hit.
[Graphical view]
PRINTSiPR00617. COPPERFIST.
SMARTiSM01090. Copper-fist. 1 hit.
SM00412. Cu_FIST. 1 hit.
[Graphical view]
SUPFAMiSSF57879. SSF57879. 1 hit.
PROSITEiPS01119. COPPER_FIST_1. 1 hit.
PS50073. COPPER_FIST_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLINGIKYA CERCIRGHRV TTCNHTDQPL MMIKPKGRPS TTCDYCKQLR
60 70 80 90 100
KNKNANPEGV CTCGRLEKKK LAQKAKEEAR AKAKEKQRKQ CTCGTDEVCK
110 120 130 140 150
YHAQKRHLRK SPSSSQKKGR SISRSQPMFE RVLSSTSLDS NMLSGHGALS
160 170 180 190 200
DTSSILTSTF LDSEPGVGKI SKDYHHVPSL ASISSLQSSQ SLDQNFSIPQ
210 220 230 240 250
SPPLSSMSFN FLTGNINETN QNHSNHQHSK SGNNWQDSSV SLPAKADSRL
260 270 280 290 300
NMMDKNNSVG LDLLGHSKRI SPISNSRVGE VSVPLEEYIP SDIDGVGRVT
310 320 330 340 350
DKSSLVYDWP FDESIERNFS TTATAATGES KFDINDNCNR INSKSYSKTN
360 370 380 390 400
SMNGNGMNNS NNNNINSNGN DKNNNNSSRQ EHQGNGLFDM FTDSSSISTL
410 420 430 440 450
SRANLLLQEK IGSQENSVKQ ENYSKNPQLR HQLTSRSRSF IHHPANEYLK
460 470 480 490 500
NTFGNSHSND IGKGVEVLSL TPSFMDIPEK ERETERSPSS NYITDRPFTR
510 520 530 540 550
KPRSSSIDVN HRYPPMAPTT VATSPGALNN AVASNLDDQL SLTSLNSQPS
560 570 580 590 600
SIANMMMDPS NLAEQSSIHS VPQSINSPRM PKTGSRQDKN IHTKKEERNP
610 620 630 640 650
LNNIHDLSQL ENVPDEMNQM FSPPLKSMNR PDAIRENSSS SNFIIQGNSM
660 670 680 690
ISTPSGRNDL PDTSPMSSIQ TASPPSQLLT DQGFADLDNF MSSL
Length:694
Mass (Da):76,671
Last modified:November 1, 1996 - v1
Checksum:i0A129F79B4E99CA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31900 Genomic DNA. Translation: AAA97587.1.
Z71255 Genomic DNA. Translation: CAA95048.1.
Z48951 Genomic DNA. Translation: CAA88786.1.
Z49919 Genomic DNA. Translation: CAA90152.1.
AY692804 Genomic DNA. Translation: AAT92823.1.
BK006949 Genomic DNA. Translation: DAA11435.1.
PIRiS59753.
RefSeqiNP_015333.1. NM_001184105.1.

Genome annotation databases

EnsemblFungiiYPR008W; YPR008W; YPR008W.
GeneIDi856117.
KEGGisce:YPR008W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31900 Genomic DNA. Translation: AAA97587.1.
Z71255 Genomic DNA. Translation: CAA95048.1.
Z48951 Genomic DNA. Translation: CAA88786.1.
Z49919 Genomic DNA. Translation: CAA90152.1.
AY692804 Genomic DNA. Translation: AAT92823.1.
BK006949 Genomic DNA. Translation: DAA11435.1.
PIRiS59753.
RefSeqiNP_015333.1. NM_001184105.1.

3D structure databases

ProteinModelPortaliQ12753.
SMRiQ12753.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36186. 40 interactors.
DIPiDIP-1462N.
IntActiQ12753. 8 interactors.
MINTiMINT-402478.

PTM databases

iPTMnetiQ12753.

Proteomic databases

MaxQBiQ12753.
PRIDEiQ12753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR008W; YPR008W; YPR008W.
GeneIDi856117.
KEGGisce:YPR008W.

Organism-specific databases

EuPathDBiFungiDB:YPR008W.
SGDiS000006212. HAA1.

Phylogenomic databases

GeneTreeiENSGT00530000068810.
InParanoidiQ12753.
OMAiKNKNANP.
OrthoDBiEOG092C10Q9.

Enzyme and pathway databases

BioCyciYEAST:G3O-34170-MONOMER.

Miscellaneous databases

PROiQ12753.

Family and domain databases

Gene3Di3.90.430.10. 1 hit.
InterProiIPR001083. Cu_fist_DNA-bd_dom.
[Graphical view]
PfamiPF00649. Copper-fist. 1 hit.
[Graphical view]
PRINTSiPR00617. COPPERFIST.
SMARTiSM01090. Copper-fist. 1 hit.
SM00412. Cu_FIST. 1 hit.
[Graphical view]
SUPFAMiSSF57879. SSF57879. 1 hit.
PROSITEiPS01119. COPPER_FIST_1. 1 hit.
PS50073. COPPER_FIST_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHAA1_YEAST
AccessioniPrimary (citable) accession number: Q12753
Secondary accession number(s): D6W419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.