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Q12753

- HAA1_YEAST

UniProt

Q12753 - HAA1_YEAST

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Protein
Transcriptional activator HAA1
Gene
HAA1, YPR008W, LPZ8W, YP9531.01, YP9723.08
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates the transcription of a set of genes, many of which encode membrane proteins. Among the genes regulated are YGR138C and YRO2. Does not seem to be dependent on copper.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111Zinc By similarity
Metal bindingi14 – 141Zinc By similarity
Metal bindingi23 – 231Zinc By similarity
Metal bindingi25 – 251Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1 – 4040Copper-fist
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. copper ion binding Source: InterPro
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: SGD

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  2. positive regulation of transcription from RNA polymerase II promoter in response to stress Source: SGD
  3. response to acid Source: SGD
  4. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Copper, DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator HAA1
Gene namesi
Name:HAA1
Ordered Locus Names:YPR008W
ORF Names:LPZ8W, YP9531.01, YP9723.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR008w.
SGDiS000006212. HAA1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Transcriptional activator HAA1
PRO_0000194933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei125 – 1251Phosphoserine1 Publication
Modified residuei231 – 2311Phosphoserine1 Publication
Modified residuei241 – 2411Phosphoserine2 Publications
Modified residuei291 – 2911Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12753.
PaxDbiQ12753.

Expressioni

Gene expression databases

GenevestigatoriQ12753.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FUS1P117103EBI-8118,EBI-7179

Protein-protein interaction databases

BioGridi36186. 37 interactions.
DIPiDIP-1462N.
IntActiQ12753. 7 interactions.
MINTiMINT-402478.
STRINGi4932.YPR008W.

Structurei

3D structure databases

ProteinModelPortaliQ12753.
SMRiQ12753. Positions 1-42.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG71500.
GeneTreeiENSGT00530000068810.
OMAiCTCGRLE.
OrthoDBiEOG7J9W29.

Family and domain databases

Gene3Di3.90.430.10. 1 hit.
InterProiIPR001083. Cu_fist_DNA-bd.
[Graphical view]
PfamiPF00649. Copper-fist. 1 hit.
[Graphical view]
PRINTSiPR00617. COPPERFIST.
SMARTiSM00412. Cu_FIST. 1 hit.
[Graphical view]
SUPFAMiSSF57879. SSF57879. 1 hit.
PROSITEiPS01119. COPPER_FIST_1. 1 hit.
PS50073. COPPER_FIST_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12753-1 [UniParc]FASTAAdd to Basket

« Hide

MVLINGIKYA CERCIRGHRV TTCNHTDQPL MMIKPKGRPS TTCDYCKQLR    50
KNKNANPEGV CTCGRLEKKK LAQKAKEEAR AKAKEKQRKQ CTCGTDEVCK 100
YHAQKRHLRK SPSSSQKKGR SISRSQPMFE RVLSSTSLDS NMLSGHGALS 150
DTSSILTSTF LDSEPGVGKI SKDYHHVPSL ASISSLQSSQ SLDQNFSIPQ 200
SPPLSSMSFN FLTGNINETN QNHSNHQHSK SGNNWQDSSV SLPAKADSRL 250
NMMDKNNSVG LDLLGHSKRI SPISNSRVGE VSVPLEEYIP SDIDGVGRVT 300
DKSSLVYDWP FDESIERNFS TTATAATGES KFDINDNCNR INSKSYSKTN 350
SMNGNGMNNS NNNNINSNGN DKNNNNSSRQ EHQGNGLFDM FTDSSSISTL 400
SRANLLLQEK IGSQENSVKQ ENYSKNPQLR HQLTSRSRSF IHHPANEYLK 450
NTFGNSHSND IGKGVEVLSL TPSFMDIPEK ERETERSPSS NYITDRPFTR 500
KPRSSSIDVN HRYPPMAPTT VATSPGALNN AVASNLDDQL SLTSLNSQPS 550
SIANMMMDPS NLAEQSSIHS VPQSINSPRM PKTGSRQDKN IHTKKEERNP 600
LNNIHDLSQL ENVPDEMNQM FSPPLKSMNR PDAIRENSSS SNFIIQGNSM 650
ISTPSGRNDL PDTSPMSSIQ TASPPSQLLT DQGFADLDNF MSSL 694
Length:694
Mass (Da):76,671
Last modified:November 1, 1996 - v1
Checksum:i0A129F79B4E99CA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31900 Genomic DNA. Translation: AAA97587.1.
Z71255 Genomic DNA. Translation: CAA95048.1.
Z48951 Genomic DNA. Translation: CAA88786.1.
Z49919 Genomic DNA. Translation: CAA90152.1.
AY692804 Genomic DNA. Translation: AAT92823.1.
BK006949 Genomic DNA. Translation: DAA11435.1.
PIRiS59753.
RefSeqiNP_015333.1. NM_001184105.1.

Genome annotation databases

EnsemblFungiiYPR008W; YPR008W; YPR008W.
GeneIDi856117.
KEGGisce:YPR008W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31900 Genomic DNA. Translation: AAA97587.1 .
Z71255 Genomic DNA. Translation: CAA95048.1 .
Z48951 Genomic DNA. Translation: CAA88786.1 .
Z49919 Genomic DNA. Translation: CAA90152.1 .
AY692804 Genomic DNA. Translation: AAT92823.1 .
BK006949 Genomic DNA. Translation: DAA11435.1 .
PIRi S59753.
RefSeqi NP_015333.1. NM_001184105.1.

3D structure databases

ProteinModelPortali Q12753.
SMRi Q12753. Positions 1-42.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36186. 37 interactions.
DIPi DIP-1462N.
IntActi Q12753. 7 interactions.
MINTi MINT-402478.
STRINGi 4932.YPR008W.

Proteomic databases

MaxQBi Q12753.
PaxDbi Q12753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR008W ; YPR008W ; YPR008W .
GeneIDi 856117.
KEGGi sce:YPR008W.

Organism-specific databases

CYGDi YPR008w.
SGDi S000006212. HAA1.

Phylogenomic databases

eggNOGi NOG71500.
GeneTreei ENSGT00530000068810.
OMAi CTCGRLE.
OrthoDBi EOG7J9W29.

Enzyme and pathway databases

BioCyci YEAST:G3O-34170-MONOMER.

Miscellaneous databases

NextBioi 981192.

Gene expression databases

Genevestigatori Q12753.

Family and domain databases

Gene3Di 3.90.430.10. 1 hit.
InterProi IPR001083. Cu_fist_DNA-bd.
[Graphical view ]
Pfami PF00649. Copper-fist. 1 hit.
[Graphical view ]
PRINTSi PR00617. COPPERFIST.
SMARTi SM00412. Cu_FIST. 1 hit.
[Graphical view ]
SUPFAMi SSF57879. SSF57879. 1 hit.
PROSITEi PS01119. COPPER_FIST_1. 1 hit.
PS50073. COPPER_FIST_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Haa1, a protein homologous to the copper-regulated transcription factor ace1, is a novel transcriptional activator."
    Keller G., Ray E., Brown P.O., Winge D.R.
    J. Biol. Chem. 276:38697-38702(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-291, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHAA1_YEAST
AccessioniPrimary (citable) accession number: Q12753
Secondary accession number(s): D6W419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

Similar proteinsi