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Protein

Structural maintenance of chromosomes protein 6

Gene

SMC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Probably plays a role in structure.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi109 – 116ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • damaged DNA binding Source: SGD

GO - Biological processi

  • chromosome separation Source: SGD
  • DNA double-strand break attachment to nuclear envelope Source: SGD
  • DNA repair Source: SGD
  • double-strand break repair via homologous recombination Source: SGD
  • protein sumoylation Source: GOC
  • resolution of recombination intermediates Source: SGD
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32449-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 6
Alternative name(s):
DNA repair protein RHC18
Rad18 homolog
Gene namesi
Name:SMC6
Synonyms:RHC18
Ordered Locus Names:YLR383W
ORF Names:L3502.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR383W.
SGDiS000004375. SMC6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
  • site of double-strand break Source: SGD
  • Smc5-Smc6 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190221 – 1114Structural maintenance of chromosomes protein 6Add BLAST1114

Proteomic databases

MaxQBiQ12749.
PRIDEiQ12749.

Interactioni

Subunit structurei

Component of the Smc5-Smc6 complex which consists of KRE29, MMS21, NSE1, NSE3, NSE4, NSE5, SMC5 and SMC6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NSE1Q079134EBI-15099,EBI-30144

Protein-protein interaction databases

BioGridi31642. 91 interactors.
DIPiDIP-6624N.
IntActiQ12749. 5 interactors.
MINTiMINT-675848.

Structurei

3D structure databases

ProteinModelPortaliQ12749.
SMRiQ12749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni530 – 695Flexible hingeAdd BLAST166

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili259 – 529Sequence analysisAdd BLAST271
Coiled coili696 – 969Sequence analysisAdd BLAST274

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 39Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1019 – 1054Ala/Asp-rich (DA-box)Add BLAST36

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC6 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00550000074816.
HOGENOMiHOG000141857.
InParanoidiQ12749.
OMAiQRHRQFI.
OrthoDBiEOG092C08UT.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR033268. Smc5/Smc6.
IPR027132. SMC6.
[Graphical view]
PANTHERiPTHR19306. PTHR19306. 1 hit.
PTHR19306:SF6. PTHR19306:SF6. 1 hit.
SUPFAMiSSF52540. SSF52540. 6 hits.

Sequencei

Sequence statusi: Complete.

Q12749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISTTISGKR PIEQVDDELL SLTAQQENEE QQQQRKRRRH QFAPMTQFNS
60 70 80 90 100
NTLDEDSGFR SSSDVATADQ DNFLEESPSG YIKKVILRNF MCHEHFELEL
110 120 130 140 150
GSRLNFIVGN NGSGKSAILT AITIGLGAKA SETNRGSSLK DLIREGCYSA
160 170 180 190 200
KIILHLDNSK YGAYQQGIFG NEIIVERIIK RDGPASFSLR SENGKEISNK
210 220 230 240 250
KKDIQTVVDY FSVPVSNPMC FLSQDAARSF LTASTSQDKY SHFMKGTLLQ
260 270 280 290 300
EITENLLYAS AIHDSAQENM ALHLENLKSL KAEYEDAKKL LRELNQTSDL
310 320 330 340 350
NERKMLLQAK SLWIDVAHNT DACKNLENEI SGIQQKVDEV TEKIRNRQEK
360 370 380 390 400
IERYTSDGTT IEAQIDAKVI YVNEKDSEHQ NARELLRDVK SRFEKEKSNQ
410 420 430 440 450
AEAQSNIDQG RKKVDALNKT IAHLEEELTK EMGGDKDQMR QELEQLEKAN
460 470 480 490 500
EKLREVNNSL VVSLQDVKNE ERDIQHERES ELRTISRSIQ NKKVELQNIA
510 520 530 540 550
KGNDTFLMNF DRNMDRLLRT IEQRKNEFET PAIGPLGSLV TIRKGFEKWT
560 570 580 590 600
RSIQRAISSS LNAFVVSNPK DNRLFRDIMR SCGIRSNIPI VTYCLSQFDY
610 620 630 640 650
SKGRAHGNYP TIVDALEFSK PEIECLFVDL SRIERIVLIE DKNEARNFLQ
660 670 680 690 700
RNPVNVNMAL SLRDRRSGFQ LSGGYRLDTV TYQDKIRLKV NSSSDNGTQY
710 720 730 740 750
LKDLIEQETK ELQNIRDRYE EKLSEVRSRL KEIDGRLKST KNEMRKTNFR
760 770 780 790 800
MTELKMNVGK VVDTGILNSK INERKNQEQA IASYEAAKEE LGLKIEQIAQ
810 820 830 840 850
EAQPIKEQYD STKLALVEAQ DELQQLKEDI NSRQSKIQKY KDDTIYYEDK
860 870 880 890 900
KKVYLENIKK IEVNVAALKE GIQRQIQNAC AFCSKERIEN VDLPDTQEEI
910 920 930 940 950
KRELDKVSRM IQKAEKSLGL SQEEVIALFE KCRNKYKEGQ KKYMEIDEAL
960 970 980 990 1000
NRLHNSLKAR DQNYKNAEKG TCFDADMDFR ASLKVRKFSG NLSFIKDTKS
1010 1020 1030 1040 1050
LEIYILTTND EKARNVDTLS GGEKSFSQMA LLLATWKPMR SRIIALDEFD
1060 1070 1080 1090 1100
VFMDQVNRKI GTTLIVKKLK DIARTQTIII TPQDIGKIAD IDSSGVSIHR
1110
MRDPERQNNS NFYN
Length:1,114
Mass (Da):128,009
Last modified:November 1, 1996 - v1
Checksum:i55C166C5B72CD957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80930 Genomic DNA. Translation: CAA56902.1.
U19104 Genomic DNA. Translation: AAB67273.1.
X05143 Genomic DNA. Translation: CAA28789.1.
BK006945 Genomic DNA. Translation: DAA09684.1.
PIRiS51470.
RefSeqiNP_013487.1. NM_001182272.1.

Genome annotation databases

EnsemblFungiiYLR383W; YLR383W; YLR383W.
GeneIDi851099.
KEGGisce:YLR383W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80930 Genomic DNA. Translation: CAA56902.1.
U19104 Genomic DNA. Translation: AAB67273.1.
X05143 Genomic DNA. Translation: CAA28789.1.
BK006945 Genomic DNA. Translation: DAA09684.1.
PIRiS51470.
RefSeqiNP_013487.1. NM_001182272.1.

3D structure databases

ProteinModelPortaliQ12749.
SMRiQ12749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31642. 91 interactors.
DIPiDIP-6624N.
IntActiQ12749. 5 interactors.
MINTiMINT-675848.

Proteomic databases

MaxQBiQ12749.
PRIDEiQ12749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR383W; YLR383W; YLR383W.
GeneIDi851099.
KEGGisce:YLR383W.

Organism-specific databases

EuPathDBiFungiDB:YLR383W.
SGDiS000004375. SMC6.

Phylogenomic databases

GeneTreeiENSGT00550000074816.
HOGENOMiHOG000141857.
InParanoidiQ12749.
OMAiQRHRQFI.
OrthoDBiEOG092C08UT.

Enzyme and pathway databases

BioCyciYEAST:G3O-32449-MONOMER.

Miscellaneous databases

PROiQ12749.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR033268. Smc5/Smc6.
IPR027132. SMC6.
[Graphical view]
PANTHERiPTHR19306. PTHR19306. 1 hit.
PTHR19306:SF6. PTHR19306:SF6. 1 hit.
SUPFAMiSSF52540. SSF52540. 6 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSMC6_YEAST
AccessioniPrimary (citable) accession number: Q12749
Secondary accession number(s): D6VZ18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.