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Protein

Protein transport protein SEC39

Gene

SEC39

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex.2 Publications

GO - Biological processi

  • ER-dependent peroxisome organization Source: SGD
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: SGD
  • vesicle-mediated transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32496-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC39
Alternative name(s):
Dependent on SLY1-20 protein 3
Gene namesi
Name:SEC39Imported
Synonyms:DSL3
Ordered Locus Names:YLR440C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR440C.
SGDiS000004432. SEC39.

Subcellular locationi

GO - Cellular componenti

  • Dsl1/NZR complex Source: SGD
  • endoplasmic reticulum Source: SGD
  • endoplasmic reticulum membrane Source: SGD
  • nuclear envelope Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002341091 – 709Protein transport protein SEC39Add BLAST709

Proteomic databases

MaxQBiQ12745.
PRIDEiQ12745.

Interactioni

Subunit structurei

Component of a peripheral membrane protein complex consisting of DSL1, SEC39/DSL3 and TIP20. Bound to a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6 through direct interaction of TIP20 with SEC20. Interacts with TIP20 and DSL1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DSL1P538478EBI-31898,EBI-29249
TIP20P338914EBI-31898,EBI-19396
USE1P531463EBI-31898,EBI-23881

Protein-protein interaction databases

BioGridi31699. 36 interactors.
DIPiDIP-941N.
IntActiQ12745. 16 interactors.
MINTiMINT-487138.

Structurei

Secondary structure

1709
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 42Combined sources10
Helixi49 – 53Combined sources5
Helixi54 – 60Combined sources7
Helixi102 – 104Combined sources3
Helixi105 – 111Combined sources7
Turni112 – 114Combined sources3
Helixi120 – 132Combined sources13
Turni139 – 142Combined sources4
Helixi143 – 147Combined sources5
Helixi156 – 164Combined sources9
Helixi166 – 175Combined sources10
Helixi182 – 187Combined sources6
Helixi190 – 197Combined sources8
Helixi212 – 216Combined sources5
Helixi218 – 225Combined sources8
Helixi228 – 235Combined sources8
Turni238 – 240Combined sources3
Helixi246 – 261Combined sources16
Helixi270 – 289Combined sources20
Helixi294 – 305Combined sources12
Beta strandi310 – 314Combined sources5
Turni315 – 317Combined sources3
Beta strandi318 – 321Combined sources4
Helixi322 – 334Combined sources13
Helixi341 – 348Combined sources8
Helixi352 – 367Combined sources16
Helixi373 – 382Combined sources10
Turni383 – 385Combined sources3
Beta strandi392 – 394Combined sources3
Helixi399 – 412Combined sources14
Helixi416 – 425Combined sources10
Helixi432 – 448Combined sources17
Helixi457 – 477Combined sources21
Helixi479 – 494Combined sources16
Helixi515 – 520Combined sources6
Turni521 – 523Combined sources3
Helixi526 – 535Combined sources10
Helixi539 – 541Combined sources3
Helixi543 – 556Combined sources14
Helixi565 – 582Combined sources18
Helixi586 – 603Combined sources18
Helixi605 – 624Combined sources20
Helixi631 – 633Combined sources3
Helixi637 – 653Combined sources17
Helixi656 – 658Combined sources3
Helixi659 – 673Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K8PX-ray2.60D1-709[»]
ProteinModelPortaliQ12745.
SMRiQ12745.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12745.

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC39 family.Curated

Phylogenomic databases

InParanoidiQ12745.
KOiK20475.
OMAiWPELDDP.
OrthoDBiEOG092C33IA.

Family and domain databases

InterProiIPR013244. Sec39_domain.
[Graphical view]
PfamiPF08314. Sec39. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEEQLYLLA CIFASRADTR NIKKLSTRLG SQSKYLEILC VLWPELDDPK
60 70 80 90 100
NLLFLRELEE EVQSPEGEET TDEDVIVELL ESDSSLIPLI ESDTTTRSNR
110 120 130 140 150
YHELQEFISK KLNNKTLENF EEWLRERILI CNEMIPETPL LYSVLWETAK
160 170 180 190 200
SKVLSTKFIG WVEGVLKPLD HLNKRLHLIF KINEWEKMPD SELFKIIFDG
210 220 230 240 250
VEDMQGYIGI ADVIEDELAP TLSYGKKWET FITEFFNKQQ FSLKSDTNYQ
260 270 280 290 300
LFIKLYYSLE KGVKDNSEAS RKLQSNVVDI LFHNSENLFN LSSLTHKLDE
310 320 330 340 350
LWSILSGFPD EITIEEQKTI TALEMKQFME FFIKCSTKFS FKEIFAITQE
360 370 380 390 400
EESAQLAHFS SLCHEEFNKA NEISSFLQAM YETVLDISKD DKIFTRISMD
410 420 430 440 450
EKLYSILEIL LQMNEFAYIE AIIERFDYSN NTQIYELLVK FFWHFFNNAS
460 470 480 490 500
NGLRKEPEMK KASQTLQIIQ KHMSQRAGTN LTKLEVLLEI SDKLSHYSIN
510 520 530 540 550
LNKSHNGARD TAFKPSNILE YRDCPLDIIS NLLELNPRLY KDLPTTKSLL
560 570 580 590 600
FGIYDSLSIN REGQTGKVEV DLMVLHIDYA LVNLDFGTAY ELGKQVFEIC
610 620 630 640 650
QEAGQHMMKA LGDEHWLTFY QMGKFVDPNW VDNEIPTEII VLQMSILGRL
660 670 680 690 700
LEVCPLEEVE IVTSQWSTLE LELSARDLVK DKYALDGQND NKSKVGGIAR

EIFHNVTNF
Length:709
Mass (Da):82,396
Last modified:November 1, 1996 - v1
Checksum:i8ABD59328A006863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21094 Genomic DNA. Translation: AAB67520.1.
Z30582 Genomic DNA. Translation: CAA83058.1.
BK006945 Genomic DNA. Translation: DAA09741.1.
PIRiS59408.
RefSeqiNP_013545.3. NM_001182328.3.

Genome annotation databases

EnsemblFungiiYLR440C; YLR440C; YLR440C.
GeneIDi851161.
KEGGisce:YLR440C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21094 Genomic DNA. Translation: AAB67520.1.
Z30582 Genomic DNA. Translation: CAA83058.1.
BK006945 Genomic DNA. Translation: DAA09741.1.
PIRiS59408.
RefSeqiNP_013545.3. NM_001182328.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K8PX-ray2.60D1-709[»]
ProteinModelPortaliQ12745.
SMRiQ12745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31699. 36 interactors.
DIPiDIP-941N.
IntActiQ12745. 16 interactors.
MINTiMINT-487138.

Proteomic databases

MaxQBiQ12745.
PRIDEiQ12745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR440C; YLR440C; YLR440C.
GeneIDi851161.
KEGGisce:YLR440C.

Organism-specific databases

EuPathDBiFungiDB:YLR440C.
SGDiS000004432. SEC39.

Phylogenomic databases

InParanoidiQ12745.
KOiK20475.
OMAiWPELDDP.
OrthoDBiEOG092C33IA.

Enzyme and pathway databases

BioCyciYEAST:G3O-32496-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ12745.
PROiQ12745.

Family and domain databases

InterProiIPR013244. Sec39_domain.
[Graphical view]
PfamiPF08314. Sec39. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC39_YEAST
AccessioniPrimary (citable) accession number: Q12745
Secondary accession number(s): D6VZ75, Q7LHI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Cells with a reduced level of SEC39 show a defect in post-translational processing of PRC1/CPY.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.