Q12740 (P5CR_ZALAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:

P5CR

Organism

Zalerion arboricola

Taxonomic identifier

42465 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › mitosporic Ascomycota › Zalerion

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Pyrroline-5-carboxylate reductase		PRO_0000187329

Sequences

	Sequence		Length	Mass (Da)
	Q12740 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 90F0ADC59F0AE7F2	FASTA	320	32,975
	10 20 30 40 50 60 MASTAKEGSE LTLAVIGCGT MGIAILSGIL ASLDEIHAPN SQSSETDETP SKLPTKFIAC 70 80 90 100 110 120 VRSPKGAEKI KKALSPYKTP VKIIQSDNVT ACREADVVLL GCKPYMAEGI LGEEGMVDAL 130 140 150 160 170 180 KGKLLISILA GVPAEQIYGY MYGKTPVNPE KEGLCQVVRA MPNTASGIRE SMTVIATSSP 190 200 210 220 230 240 PLSATTSSLI TWIFKRIGDV VQLPAATMDA STALCGSGPA FFALILEAAI DGAVAMGLPR 250 260 270 280 290 300 AEAQRMAAQT MKGAAGLVLS GEHPALLKDK VTTPGGCTIG GLMVLEEGGV RGTVARAVRE 310 320 ATVVASQLGK GVQGVNGTRF

References

[1]	"Isolation and sequence analysis of the cDNA encoding delta 1-pyrroline-5-carboxylate reductase from Zalerion arboricola." Kelly R., Register E. Gene 172:149-153(1996) [PubMed: 8654976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 20868 / MF5171.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33266 mRNA. Translation: AAC49320.1.
PIR	JC4830.
3D structure databases
ProteinModelPortal	Q12740.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_ZALAR

Accession

Primary (citable) accession number: Q12740

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program