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Protein

Glucan 1,3-beta-glucosidase

Gene

EXG1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei213Proton donorBy similarity1
Active sitei313NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell wall biogenesis/degradation

Protein family/group databases

CAZyiGH5 Glycoside Hydrolase Family 5

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan 1,3-beta-glucosidase (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase
Gene namesi
Name:EXG1
Ordered Locus Names:YALI0F05390g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000000788816 – 421Glucan 1,3-beta-glucosidaseAdd BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi296 ↔ 419By similarity
Disulfide bondi321 ↔ 347By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_505030.1

Structurei

3D structure databases

ProteinModelPortaliQ12725
SMRiQ12725
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000114462
InParanoidiQ12725
KOiK01210
OMAiEGAPGWD
OrthoDBiEOG092C22A6

Family and domain databases

InterProiView protein in InterPro
IPR001547 Glyco_hydro_5
IPR018087 Glyco_hydro_5_CS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00659 GLYCOSYL_HYDROL_F5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTKLVALA GAALASPIQL VPREGSFLGF NYGSEKVHGV NLGGWFVLEP
60 70 80 90 100
FITPSLFEAF GNNDANVPVD EYHYTAWLGK EEAEKRLTDH WNTWITEYDI
110 120 130 140 150
KAIAENYKLN LVRIPIGYWA FSLLPNDPYV QGQEAYLDRA LGWCRKYGVK
160 170 180 190 200
AWVDVHGVPG SQNGFDNSGL RDHWDWPNAD NVQHSINVIN YIAGKYGAPE
210 220 230 240 250
YNDIVVGIEL VNEPLGPAIG MEVIEKYFQE GFWTVRHAGS DTAVVIHDAF
260 270 280 290 300
QEKNYFNNFM TTEQGFWNVV LDHHQYQVFS PGELARNIDQ HIAEVCNVGR
310 320 330 340 350
QASTEYHWRI FGEWSAALTD CTHWLNGVGK GPRLDGSFPG SYYQRSCQGR
360 370 380 390 400
GDIQTWSEQD KQESRRYVEA QLDAWEHGGD GWIYWTYKTE NALEWDFRRL
410 420
VDNGIFPFPY WDRQFPNQCG F
Length:421
Mass (Da):48,275
Last modified:October 11, 2004 - v2
Checksum:i2BB03184758252CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti333R → S in CAA86952 (PubMed:10029988).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46872 Genomic DNA Translation: CAA86952.1
CR382132 Genomic DNA Translation: CAG77837.1
RefSeqiXP_505030.1, XM_505030.1

Genome annotation databases

EnsemblFungiiCAG77837; CAG77837; YALI0_F05390g
GeneIDi2908269
KEGGiyli:YALI0F05390g

Entry informationi

Entry nameiEXG_YARLI
AccessioniPrimary (citable) accession number: Q12725
Secondary accession number(s): Q6C2T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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