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Q12724

- PYRF_YARLI

UniProt

Q12724 - PYRF_YARLI

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351SubstrateBy similarity
Active sitei91 – 911Proton donorPROSITE-ProRule annotation
Binding sitei239 – 2391SubstrateBy similarity
Binding sitei257 – 2571SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
Ordered Locus Names:YALI0E26741g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome E

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Orotidine 5'-phosphate decarboxylasePRO_0000134691Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.Q12724.

Structurei

3D structure databases

ProteinModelPortaliQ12724.
SMRiQ12724. Positions 2-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 593Substrate bindingBy similarity
Regioni89 – 9810Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0284.
InParanoidiQ12724.
OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
TIGRFAMsiTIGR01740. pyrF. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12724-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSYEARANV HKSAFAARVL KLVAAKKTNL CASLDVTTTK ELIELADKVG
60 70 80 90 100
PYVCMIKTHI DIIDDFTYAG TVLPLKELAL KHGFFLFEDR KFADIGNTVK
110 120 130 140 150
HQYKNGVYRI AEWSDITNAH GVPGTGIIAG LRAGAEETVS EQKKEDVSDY
160 170 180 190 200
ENSQYKEFLV PSPNEKLARG LLMLAELSCK GSLATGEYSK QTIELARSDP
210 220 230 240 250
EFVVGFIAQN RPKGDSEDWL ILTPGVGLDD KGDALGQQYR TVEDVMSTGT
260 270 280
DIIIVGRGLY GQNRDPIEEA KRYQKAGWEA YQKINC
Length:286
Mass (Da):31,630
Last modified:November 1, 1997 - v1
Checksum:i7E71BFE84C61F216
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1085KNGVY → RCH in CAC32856. (PubMed:11489863)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ306421 Genomic DNA. Translation: CAC32856.1.
U40564 Genomic DNA. Translation: AAA85392.1.
CR382131 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ306421 Genomic DNA. Translation: CAC32856.1 .
U40564 Genomic DNA. Translation: AAA85392.1 .
CR382131 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q12724.
SMRi Q12724. Positions 2-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q12724.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0284.
InParanoidi Q12724.
OrthoDBi EOG7CVQ76.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
TIGRFAMsi TIGR01740. pyrF. 2 hits.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Insertional mutagenesis in the n-alkane-assimilating yeast Yarrowia lipolytica: generation of tagged mutations in genes involved in hydrophobic substrate utilization."
    Mauersberger S., Wang H., Gaillardin C., Barth G., Nicaud J.-M.
    J. Bacteriol. 183:5102-5109(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
  2. Strick C.A., James L.C., O'Donnell M.M., Elsenboss L.A.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-7 AND 250-284.
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiPYRF_YARLI
AccessioniPrimary (citable) accession number: Q12724
Secondary accession number(s): Q6C4H6, Q9C1U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Strain CLIB 122 / E 150 has a defective URA3 sequence (ura3-302) which is disrupted (positions 8 to 249) by S.cerevisiae SUC2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3