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Reviewed, UniProtKB/Swiss-Prot Q12723 (2NPD_WILMR)

Last modified March 3, 2009. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    2-nitropropane dioxygenase
      Short name=2-NPD
    EC=1.13.11.32
Alternative name(s):
    Nitroalkane oxidase
OrganismWilliopsis mrakii (Yeast) (Hansenula mrakii)
Taxonomic identifier4963 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeWilliopsis

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the oxygenative denitrification of various anionic nitroalkanes.

Catalytic activity

2 2-nitropropane + O2 = 2 acetone + 2 nitrite.

Cofactor

FAD.

Sequence similarities

Belongs to the 2-nitropropane dioxygenase family.

Ontologies

Keywords
   LigandFAD
Flavoprotein
   Molecular functionDioxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function2-nitropropane dioxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3743742-nitropropane dioxygenase
PRO_0000064361

Sequences

Sequence LengthMass (Da)Tools
Q12723-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 63F82BA7453E43F0

FASTA37441,467
        10         20         30         40         50         60 
MRSQIQSFLK TFEVRYPIIQ APMAGASTLE LAATVTRLGG IGSIPMGSLS EKCDAIETQL 

        70         80         90        100        110        120 
ENFDELVGDS GRIVNLNFFA HKEPRSGRAD VNEEWLKKYD KIYGKAGIEF DKKELKLLYP 

       130        140        150        160        170        180 
SFRSIVDPQH PTVRLLKNLK PKIVSFHFGL PHEAVIESLQ ASDIKIFVTV TNLQEFQQAY 

       190        200        210        220        230        240 
ESKLDGVVLQ GWEAGGHRGN FKANDVEDGQ LKTLDLVSTI VDYIDSASIS NPPFIIAAGG 

       250        260        270        280        290        300 
IHDDESIKEL LQFNIAAVQL GTVWLPSSQA TISPEHLKMF QSPKSDTMMT AAISGRNLRT 

       310        320        330        340        350        360 
ISTPFLRDLH QSSPLASIPD YPLPYDSFKS LANDAKQSGK GPQYSAFLAG SNYHKSWKDT 

       370 
RSTEEIFSIL VQDL 

« Hide

References

[1]"Unique primary structure of 2-nitropropane dioxygenase from Hansenula mrakii."
Tchorzewski M., Kurihara T., Esaki N., Soda K.
Eur. J. Biochem. 226:841-846(1994) [PubMed: 7813473] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IFO 0895.

Cross-references

Sequence databases

U13900 Genomic DNA. Translation: AAA64484.1.
PIRS50891.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MON-12527.

Family and domain databases

InterProIPR004136. 2Npropane_dOase.
IPR013785. Aldolase_TIM.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF03060. NPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name2NPD_WILMR
AccessionPrimary (citable) accession number: Q12723
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents