SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q12719

- LAC4_TRAVE

UniProt

Q12719 - LAC4_TRAVE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Laccase-4
Gene
LCC4, LCC1
Organism
Trametes versicolor (White-rot fungus) (Coriolus versicolor)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products Inferred.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Copper 1; type 2 By similarity
Metal bindingi88 – 881Copper 2; type 3 By similarity
Metal bindingi131 – 1311Copper 2; type 3 By similarity
Metal bindingi133 – 1331Copper 3; type 3 By similarity
Metal bindingi418 – 4181Copper 4; type 1 By similarity
Metal bindingi421 – 4211Copper 1; type 2 By similarity
Metal bindingi423 – 4231Copper 3; type 3 By similarity
Metal bindingi473 – 4731Copper 3; type 3 By similarity
Metal bindingi474 – 4741Copper 4; type 1 By similarity
Metal bindingi475 – 4751Copper 2; type 3 By similarity
Metal bindingi479 – 4791Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-4 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 4
Diphenol oxidase 4
Urishiol oxidase 4
Gene namesi
Name:LCC4
Synonyms:LCC1
OrganismiTrametes versicolor (White-rot fungus) (Coriolus versicolor)
Taxonomic identifieri5325 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 520498Laccase-4
PRO_0000002941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi76 – 761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi107 ↔ 509 Inferred
Disulfide bondi139 ↔ 227 Inferred
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi399 – 3991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi497 – 4971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ12719.
SMRiQ12719. Positions 23-519.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 149126Plastocyanin-like 1
Add
BLAST
Domaini161 – 303143Plastocyanin-like 2
Add
BLAST
Domaini370 – 491122Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12719-1 [UniParc]FASTAAdd to Basket

« Hide

MGRFSSLCAL TAVIHSFGRV SAAIGPVTDL TISNADVSPD GFTRAAVLAN    50
GVFPGPLITG NKGDNFQINV IDNLSNETML KSTSIHWHGF FQKGTNWADG 100
AAFVNQCPIA TGNSFLYDFT ATDQAGTFWY HSHLSTQYCD GLRGPMVVYD 150
PSDPHADLYD VDDETTIITL SDWYHTAASL GAAFPIGSDS TLINGLGRFA 200
GGDSTDLAVI TVEQGKRYRM RLLSLSCDPN YVFSIDGHNM TIIEADAVNH 250
EPLTVDSIQI YAGQRYSFVL TADQDIDNYF IRALPSAGTT SFDGGINSAI 300
LRYSGASEVD PTTTETTSVL PLDEANLVPL DSPAAPGDPN IGGVDYALNL 350
DFNFDGTNFF INDVSFVSPT VPVLLQILSG TTSAADLLPS GSLFALPSNS 400
TIEISFPITA TNAPGAPHPF HLHGHTFSIV RTAGSTDTNF VNPVRRDVVN 450
TGTAGDNVTI RFTTDNPGPW FLHCHIDFHL EAGFAIVFSE DTADVSNTTT 500
PSTAWEDLCP TYNALDSSDL 520
Length:520
Mass (Da):55,644
Last modified:November 1, 1996 - v1
Checksum:iFC1032400E9DDFA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84683 Genomic DNA. Translation: CAA59161.1.
PIRiS59533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84683 Genomic DNA. Translation: CAA59161.1 .
PIRi S59533.

3D structure databases

ProteinModelPortali Q12719.
SMRi Q12719. Positions 23-519.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a laccase gene from the white-rot fungus Trametes versicolor and structural features of basidiomycete laccases."
    Joensson L.J., Sjoestroem K., Haeggstroem I., Nyman P.O.
    Biochim. Biophys. Acta 1251:210-215(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PRL 572.

Entry informationi

Entry nameiLAC4_TRAVE
AccessioniPrimary (citable) accession number: Q12719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi