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Q12719

- LAC4_TRAVE

UniProt

Q12719 - LAC4_TRAVE

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Protein

Laccase-4

Gene

LCC4

Organism
Trametes versicolor (White-rot fungus) (Coriolus versicolor)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products.Curated

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Copper 1; type 2By similarity
Metal bindingi88 – 881Copper 2; type 3By similarity
Metal bindingi131 – 1311Copper 2; type 3By similarity
Metal bindingi133 – 1331Copper 3; type 3By similarity
Metal bindingi418 – 4181Copper 4; type 1By similarity
Metal bindingi421 – 4211Copper 1; type 2By similarity
Metal bindingi423 – 4231Copper 3; type 3By similarity
Metal bindingi473 – 4731Copper 3; type 3By similarity
Metal bindingi474 – 4741Copper 4; type 1By similarity
Metal bindingi475 – 4751Copper 2; type 3By similarity
Metal bindingi479 – 4791Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-4 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 4
Diphenol oxidase 4
Urishiol oxidase 4
Gene namesi
Name:LCC4
Synonyms:LCC1
OrganismiTrametes versicolor (White-rot fungus) (Coriolus versicolor)
Taxonomic identifieri5325 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 520498Laccase-4PRO_0000002941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi107 ↔ 509Curated
Disulfide bondi139 ↔ 227Curated
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi399 – 3991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ12719.
SMRiQ12719. Positions 23-519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 149126Plastocyanin-like 1Add
BLAST
Domaini161 – 303143Plastocyanin-like 2Add
BLAST
Domaini370 – 491122Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12719-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRFSSLCAL TAVIHSFGRV SAAIGPVTDL TISNADVSPD GFTRAAVLAN
60 70 80 90 100
GVFPGPLITG NKGDNFQINV IDNLSNETML KSTSIHWHGF FQKGTNWADG
110 120 130 140 150
AAFVNQCPIA TGNSFLYDFT ATDQAGTFWY HSHLSTQYCD GLRGPMVVYD
160 170 180 190 200
PSDPHADLYD VDDETTIITL SDWYHTAASL GAAFPIGSDS TLINGLGRFA
210 220 230 240 250
GGDSTDLAVI TVEQGKRYRM RLLSLSCDPN YVFSIDGHNM TIIEADAVNH
260 270 280 290 300
EPLTVDSIQI YAGQRYSFVL TADQDIDNYF IRALPSAGTT SFDGGINSAI
310 320 330 340 350
LRYSGASEVD PTTTETTSVL PLDEANLVPL DSPAAPGDPN IGGVDYALNL
360 370 380 390 400
DFNFDGTNFF INDVSFVSPT VPVLLQILSG TTSAADLLPS GSLFALPSNS
410 420 430 440 450
TIEISFPITA TNAPGAPHPF HLHGHTFSIV RTAGSTDTNF VNPVRRDVVN
460 470 480 490 500
TGTAGDNVTI RFTTDNPGPW FLHCHIDFHL EAGFAIVFSE DTADVSNTTT
510 520
PSTAWEDLCP TYNALDSSDL
Length:520
Mass (Da):55,644
Last modified:November 1, 1996 - v1
Checksum:iFC1032400E9DDFA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84683 Genomic DNA. Translation: CAA59161.1.
PIRiS59533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84683 Genomic DNA. Translation: CAA59161.1 .
PIRi S59533.

3D structure databases

ProteinModelPortali Q12719.
SMRi Q12719. Positions 23-519.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a laccase gene from the white-rot fungus Trametes versicolor and structural features of basidiomycete laccases."
    Joensson L.J., Sjoestroem K., Haeggstroem I., Nyman P.O.
    Biochim. Biophys. Acta 1251:210-215(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PRL 572.

Entry informationi

Entry nameiLAC4_TRAVE
AccessioniPrimary (citable) accession number: Q12719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3