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Protein

Laccase-4

Gene

LCC4

Organism
Trametes versicolor (White-rot fungus) (Coriolus versicolor)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products.Curated

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86Copper 1; type 2By similarity1
Metal bindingi88Copper 2; type 3By similarity1
Metal bindingi131Copper 2; type 3By similarity1
Metal bindingi133Copper 3; type 3By similarity1
Metal bindingi418Copper 4; type 1By similarity1
Metal bindingi421Copper 1; type 2By similarity1
Metal bindingi423Copper 3; type 3By similarity1
Metal bindingi473Copper 3; type 3By similarity1
Metal bindingi474Copper 4; type 1By similarity1
Metal bindingi475Copper 2; type 3By similarity1
Metal bindingi479Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BRENDAi1.10.3.2. 1626.

Protein family/group databases

CAZyiAA1. Auxiliary Activities 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-4 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 4
Diphenol oxidase 4
Urishiol oxidase 4
Gene namesi
Name:LCC4
Synonyms:LCC1
OrganismiTrametes versicolor (White-rot fungus) (Coriolus versicolor)
Taxonomic identifieri5325 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000294123 – 520Laccase-4Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi107 ↔ 509Curated
Disulfide bondi139 ↔ 227Curated
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Glycosylationi399N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ12719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 149Plastocyanin-like 1Add BLAST126
Domaini161 – 303Plastocyanin-like 2Add BLAST143
Domaini370 – 491Plastocyanin-like 3Add BLAST122

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRFSSLCAL TAVIHSFGRV SAAIGPVTDL TISNADVSPD GFTRAAVLAN
60 70 80 90 100
GVFPGPLITG NKGDNFQINV IDNLSNETML KSTSIHWHGF FQKGTNWADG
110 120 130 140 150
AAFVNQCPIA TGNSFLYDFT ATDQAGTFWY HSHLSTQYCD GLRGPMVVYD
160 170 180 190 200
PSDPHADLYD VDDETTIITL SDWYHTAASL GAAFPIGSDS TLINGLGRFA
210 220 230 240 250
GGDSTDLAVI TVEQGKRYRM RLLSLSCDPN YVFSIDGHNM TIIEADAVNH
260 270 280 290 300
EPLTVDSIQI YAGQRYSFVL TADQDIDNYF IRALPSAGTT SFDGGINSAI
310 320 330 340 350
LRYSGASEVD PTTTETTSVL PLDEANLVPL DSPAAPGDPN IGGVDYALNL
360 370 380 390 400
DFNFDGTNFF INDVSFVSPT VPVLLQILSG TTSAADLLPS GSLFALPSNS
410 420 430 440 450
TIEISFPITA TNAPGAPHPF HLHGHTFSIV RTAGSTDTNF VNPVRRDVVN
460 470 480 490 500
TGTAGDNVTI RFTTDNPGPW FLHCHIDFHL EAGFAIVFSE DTADVSNTTT
510 520
PSTAWEDLCP TYNALDSSDL
Length:520
Mass (Da):55,644
Last modified:November 1, 1996 - v1
Checksum:iFC1032400E9DDFA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84683 Genomic DNA. Translation: CAA59161.1.
PIRiS59533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84683 Genomic DNA. Translation: CAA59161.1.
PIRiS59533.

3D structure databases

ProteinModelPortaliQ12719.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiAA1. Auxiliary Activities 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.10.3.2. 1626.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC4_TRAVE
AccessioniPrimary (citable) accession number: Q12719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.