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Q12717

- LAC5_TRAVE

UniProt

Q12717 - LAC5_TRAVE

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Protein
Laccase-5
Gene
LCC5, LCCIV
Organism
Trametes versicolor (White-rot fungus) (Coriolus versicolor)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products Inferred.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Copper 1; type 2 By similarity
Metal bindingi89 – 891Copper 2; type 3 By similarity
Metal bindingi132 – 1321Copper 2; type 3 By similarity
Metal bindingi134 – 1341Copper 3; type 3 By similarity
Metal bindingi425 – 4251Copper 4; type 1 By similarity
Metal bindingi428 – 4281Copper 1; type 2 By similarity
Metal bindingi430 – 4301Copper 3; type 3 By similarity
Metal bindingi480 – 4801Copper 3; type 3 By similarity
Metal bindingi481 – 4811Copper 4; type 1 By similarity
Metal bindingi482 – 4821Copper 2; type 3 By similarity
Metal bindingi486 – 4861Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-5 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 5
Diphenol oxidase 5
Laccase IV
Urishiol oxidase 5
Gene namesi
Name:LCC5
Synonyms:LCCIV
OrganismiTrametes versicolor (White-rot fungus) (Coriolus versicolor)
Taxonomic identifieri5325 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 527504Laccase-5
PRO_0000002942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi209 – 2091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi233 – 2331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi358 – 3581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi366 – 3661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi393 – 3931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi464 – 4641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ12717.
SMRiQ12717. Positions 24-526.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 150126Plastocyanin-like 1
Add
BLAST
Domaini162 – 306145Plastocyanin-like 2
Add
BLAST
Domaini373 – 498126Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12717-1 [UniParc]FASTAAdd to Basket

« Hide

MGKFHSFVNV VALSLSLSGR VFGAIGPVTD LTISNADVTP DGITRAAVLA    50
GGVFPGPLIT GNKGDEFQIN VIDNLTNETM LKSTTIHWHG IFQAGTNWAD 100
GAAFVNQCPI ATGNSFLYDF TVPDQAGTFW YHSHLSTQYC DGLRGPLVVY 150
DPDDANASLY DVDDDTTVIT LADWYHTAAK LGPAFPAGPD SVLINGLGRF 200
SGDGGGATNL TVITVTQGKR YRFRLVSISC DPNFTFSIDG HNMTIIEVGG 250
VNHEALDVDS IQIFAGQRYS FILNANQSID NYWIRAIPNT GTTDTTGGVN 300
SAILRYDTAE EIEPTTNATT SVIPLTETDL VPLDNPAAPG DPQVGGVDLA 350
MSLDFSFNGS NFFINNETFV PPTVPVLLQI LSGAQDAASL LPNGSVYTLP 400
SNSTIEISFP IITTDGALNA PGAPHPFHLH GHTFSVVRSA GSSTFNYANP 450
VRRDTVSTGN SGDNVTIRFT TDNPGPWFLH CHIDFHLDAG FAIVFAEDTA 500
DTASANPVPT AWSDLCPTYD ALDSSDL 527
Length:527
Mass (Da):56,094
Last modified:November 1, 1996 - v1
Checksum:iD9597491F1F79825
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U44431 mRNA. Translation: AAC49829.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U44431 mRNA. Translation: AAC49829.1 .

3D structure databases

ProteinModelPortali Q12717.
SMRi Q12717. Positions 24-526.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of two laccase complementary DNAs from the ligninolytic basidiomycete Trametes versicolor."
    Ong E., Pollock W.B., Smith M.
    Gene 196:113-119(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 20869 / PAP 52 / 52J.

Entry informationi

Entry nameiLAC5_TRAVE
AccessioniPrimary (citable) accession number: Q12717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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