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Reviewed, UniProtKB/Swiss-Prot Q12717 (LAC5_TRAVE)

Last modified June 16, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Laccase-5
    EC=1.10.3.2
Alternative name(s):
    Benzenediol:oxygen oxidoreductase 5
    Urishiol oxidase 5
    Diphenol oxidase 5
    Laccase IV
Gene names
Name: LCC5
Synonyms: LCCIV
OrganismTrametes versicolor (White-rot fungus) (Coriolus versicolor)
Taxonomic identifier5325 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Aphyllophorales › Trametes

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Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products Probable.

Catalytic activity

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

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Ontologies

Keywords
   Biological processLignin degradation
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncopper ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

laccase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 527504Laccase-5
PRO_0000002942

Regions

Domain25 – 150126Plastocyanin-like 1
Domain162 – 306145Plastocyanin-like 2
Domain373 – 498126Plastocyanin-like 3

Sites

Metal binding871Copper 1; type 2 By similarity
Metal binding891Copper 2; type 3 By similarity
Metal binding1321Copper 2; type 3 By similarity
Metal binding1341Copper 3; type 3 By similarity
Metal binding4251Copper 4; type 1 By similarity
Metal binding4281Copper 1; type 2 By similarity
Metal binding4301Copper 3; type 3 By similarity
Metal binding4801Copper 3; type 3 By similarity
Metal binding4811Copper 4; type 1 By similarity
Metal binding4821Copper 2; type 3 By similarity
Metal binding4861Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation2091N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3581N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation3931N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential
Glycosylation4641N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q12717-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D9597491F1F79825

FASTA52756,094
        10         20         30         40         50         60 
MGKFHSFVNV VALSLSLSGR VFGAIGPVTD LTISNADVTP DGITRAAVLA GGVFPGPLIT 

        70         80         90        100        110        120 
GNKGDEFQIN VIDNLTNETM LKSTTIHWHG IFQAGTNWAD GAAFVNQCPI ATGNSFLYDF 

       130        140        150        160        170        180 
TVPDQAGTFW YHSHLSTQYC DGLRGPLVVY DPDDANASLY DVDDDTTVIT LADWYHTAAK 

       190        200        210        220        230        240 
LGPAFPAGPD SVLINGLGRF SGDGGGATNL TVITVTQGKR YRFRLVSISC DPNFTFSIDG 

       250        260        270        280        290        300 
HNMTIIEVGG VNHEALDVDS IQIFAGQRYS FILNANQSID NYWIRAIPNT GTTDTTGGVN 

       310        320        330        340        350        360 
SAILRYDTAE EIEPTTNATT SVIPLTETDL VPLDNPAAPG DPQVGGVDLA MSLDFSFNGS 

       370        380        390        400        410        420 
NFFINNETFV PPTVPVLLQI LSGAQDAASL LPNGSVYTLP SNSTIEISFP IITTDGALNA 

       430        440        450        460        470        480 
PGAPHPFHLH GHTFSVVRSA GSSTFNYANP VRRDTVSTGN SGDNVTIRFT TDNPGPWFLH 

       490        500        510        520 
CHIDFHLDAG FAIVFAEDTA DTASANPVPT AWSDLCPTYD ALDSSDL

« Hide

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References

[1]"Cloning and sequence analysis of two laccase complementary DNAs from the ligninolytic basidiomycete Trametes versicolor."
Ong E., Pollock W.B., Smith M.
Gene 196:113-119(1997) [PubMed: 9322748] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ATCC 20869 / PAP 52 / 52J.

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Cross-references

Sequence databases

U44431 mRNA. Translation: AAC49829.1.

3D structure databases

HSSPHSSP built from PDB template 1KYA based on UniProtKB Q96UT7.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.10.3.2. 276061.

Family and domain databases

InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
Gene3DG3DSA:2.60.40.420. Cupredoxin. 3 hits.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
PROSITEPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLAC5_TRAVE
AccessionPrimary (citable) accession number: Q12717
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents