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Q12717

- LAC5_TRAVE

UniProt

Q12717 - LAC5_TRAVE

Protein

Laccase-5

Gene

LCC5

Organism
Trametes versicolor (White-rot fungus) (Coriolus versicolor)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.Curated

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Copper 1; type 2By similarity
    Metal bindingi89 – 891Copper 2; type 3By similarity
    Metal bindingi132 – 1321Copper 2; type 3By similarity
    Metal bindingi134 – 1341Copper 3; type 3By similarity
    Metal bindingi425 – 4251Copper 4; type 1By similarity
    Metal bindingi428 – 4281Copper 1; type 2By similarity
    Metal bindingi430 – 4301Copper 3; type 3By similarity
    Metal bindingi480 – 4801Copper 3; type 3By similarity
    Metal bindingi481 – 4811Copper 4; type 1By similarity
    Metal bindingi482 – 4821Copper 2; type 3By similarity
    Metal bindingi486 – 4861Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-5 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 5
    Diphenol oxidase 5
    Laccase IV
    Urishiol oxidase 5
    Gene namesi
    Name:LCC5
    Synonyms:LCCIV
    OrganismiTrametes versicolor (White-rot fungus) (Coriolus versicolor)
    Taxonomic identifieri5325 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 527504Laccase-5PRO_0000002942Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi358 – 3581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ12717.
    SMRiQ12717. Positions 24-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 150126Plastocyanin-like 1Add
    BLAST
    Domaini162 – 306145Plastocyanin-like 2Add
    BLAST
    Domaini373 – 498126Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q12717-1 [UniParc]FASTAAdd to Basket

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    MGKFHSFVNV VALSLSLSGR VFGAIGPVTD LTISNADVTP DGITRAAVLA    50
    GGVFPGPLIT GNKGDEFQIN VIDNLTNETM LKSTTIHWHG IFQAGTNWAD 100
    GAAFVNQCPI ATGNSFLYDF TVPDQAGTFW YHSHLSTQYC DGLRGPLVVY 150
    DPDDANASLY DVDDDTTVIT LADWYHTAAK LGPAFPAGPD SVLINGLGRF 200
    SGDGGGATNL TVITVTQGKR YRFRLVSISC DPNFTFSIDG HNMTIIEVGG 250
    VNHEALDVDS IQIFAGQRYS FILNANQSID NYWIRAIPNT GTTDTTGGVN 300
    SAILRYDTAE EIEPTTNATT SVIPLTETDL VPLDNPAAPG DPQVGGVDLA 350
    MSLDFSFNGS NFFINNETFV PPTVPVLLQI LSGAQDAASL LPNGSVYTLP 400
    SNSTIEISFP IITTDGALNA PGAPHPFHLH GHTFSVVRSA GSSTFNYANP 450
    VRRDTVSTGN SGDNVTIRFT TDNPGPWFLH CHIDFHLDAG FAIVFAEDTA 500
    DTASANPVPT AWSDLCPTYD ALDSSDL 527
    Length:527
    Mass (Da):56,094
    Last modified:November 1, 1996 - v1
    Checksum:iD9597491F1F79825
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44431 mRNA. Translation: AAC49829.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44431 mRNA. Translation: AAC49829.1 .

    3D structure databases

    ProteinModelPortali Q12717.
    SMRi Q12717. Positions 24-526.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of two laccase complementary DNAs from the ligninolytic basidiomycete Trametes versicolor."
      Ong E., Pollock W.B., Smith M.
      Gene 196:113-119(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ATCC 20869 / PAP 52 / 52J.

    Entry informationi

    Entry nameiLAC5_TRAVE
    AccessioniPrimary (citable) accession number: Q12717
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3