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Q12709

- PYRF_HYPAT

UniProt

Q12709 - PYRF_HYPAT

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyr4
Organism
Hypocrea atroviridis (Trichoderma atroviride)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate By similarity
Active sitei101 – 1011Proton donor By similarity
Binding sitei331 – 3311Substrate By similarity
Binding sitei350 – 3501Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:pyr4
OrganismiHypocrea atroviridis (Trichoderma atroviride)
Taxonomic identifieri63577 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Orotidine 5'-phosphate decarboxylase
PRO_0000134687Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ12709.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 663Substrate binding By similarity
Regioni99 – 10810Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12709-1 [UniParc]FASTAAdd to Basket

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MASHPTLKTT FAARSEATTH PLTSYLLRLM DLKASNLCLS ADVPTARELL    50
YLADKIGPSI VVLKTHYDMV SGWDFHPDTG TGAKLASLAR KHGFLIFEDR 100
KFGDIGHTVE LQYTSGSARI IDWAHIVNVN MVPGKASVAS LAQGARRWLE 150
RYPCEVKTSV TVGTPTMDQF DDAEDAKDDE PATVNDNGSN MMEKPIYAGR 200
NGDGRKGSIV SITTVTQQYE SAASPRLGKT IAEGDESLFP GIEEAPLNRG 250
LLILAQMSSE GNFMTGEYTQ ACVEAAREHK DFVMGFISQE ALNTQADDDF 300
IHMTPGCQLP PEDEDQQTNG KVGGDGQGQQ YNTAHKIIGI AGSDIAIVGR 350
GILKASDPVE EAERYRSAAW KAYTERLLR 379
Length:379
Mass (Da):41,259
Last modified:November 1, 1997 - v1
Checksum:i33B6C02043BD1E38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05192 Genomic DNA. Translation: AAA51865.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05192 Genomic DNA. Translation: AAA51865.1 .

3D structure databases

ProteinModelPortali Q12709.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of the pyr4 gene encoding orotidine-5'-phosphate decarboxylase from the biocontrol fungus Trichoderma harzianum."
    Heidenreich E.J., Kubicek C.P.
    Gene 147:151-152(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 36042 / 2440A / CBS 391.92.

Entry informationi

Entry nameiPYRF_HYPAT
AccessioniPrimary (citable) accession number: Q12709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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