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Q12709

- PYRF_HYPAT

UniProt

Q12709 - PYRF_HYPAT

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyr4

Organism
Hypocrea atroviridis (Trichoderma atroviride)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421SubstrateBy similarity
    Active sitei101 – 1011Proton donorPROSITE-ProRule annotation
    Binding sitei331 – 3311SubstrateBy similarity
    Binding sitei350 – 3501SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:pyr4
    OrganismiHypocrea atroviridis (Trichoderma atroviride)
    Taxonomic identifieri63577 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Orotidine 5'-phosphate decarboxylasePRO_0000134687Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ12709.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni64 – 663Substrate bindingBy similarity
    Regioni99 – 10810Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12709-1 [UniParc]FASTAAdd to Basket

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    MASHPTLKTT FAARSEATTH PLTSYLLRLM DLKASNLCLS ADVPTARELL    50
    YLADKIGPSI VVLKTHYDMV SGWDFHPDTG TGAKLASLAR KHGFLIFEDR 100
    KFGDIGHTVE LQYTSGSARI IDWAHIVNVN MVPGKASVAS LAQGARRWLE 150
    RYPCEVKTSV TVGTPTMDQF DDAEDAKDDE PATVNDNGSN MMEKPIYAGR 200
    NGDGRKGSIV SITTVTQQYE SAASPRLGKT IAEGDESLFP GIEEAPLNRG 250
    LLILAQMSSE GNFMTGEYTQ ACVEAAREHK DFVMGFISQE ALNTQADDDF 300
    IHMTPGCQLP PEDEDQQTNG KVGGDGQGQQ YNTAHKIIGI AGSDIAIVGR 350
    GILKASDPVE EAERYRSAAW KAYTERLLR 379
    Length:379
    Mass (Da):41,259
    Last modified:November 1, 1997 - v1
    Checksum:i33B6C02043BD1E38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05192 Genomic DNA. Translation: AAA51865.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U05192 Genomic DNA. Translation: AAA51865.1 .

    3D structure databases

    ProteinModelPortali Q12709.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the pyr4 gene encoding orotidine-5'-phosphate decarboxylase from the biocontrol fungus Trichoderma harzianum."
      Heidenreich E.J., Kubicek C.P.
      Gene 147:151-152(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 36042 / 2440A / CBS 391.92.

    Entry informationi

    Entry nameiPYRF_HYPAT
    AccessioniPrimary (citable) accession number: Q12709
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3