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Q12709 (PYRF_HYPAT) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyr4
OrganismHypocrea atroviridis (Trichoderma atroviride)
Taxonomic identifier63577 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Orotidine 5'-phosphate decarboxylase
PRO_0000134687

Regions

Region64 – 663Substrate binding By similarity
Region99 – 10810Substrate binding By similarity

Sites

Active site1011Proton donor By similarity
Binding site421Substrate By similarity
Binding site3311Substrate By similarity
Binding site3501Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12709 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 33B6C02043BD1E38

FASTA37941,259
        10         20         30         40         50         60 
MASHPTLKTT FAARSEATTH PLTSYLLRLM DLKASNLCLS ADVPTARELL YLADKIGPSI 

        70         80         90        100        110        120 
VVLKTHYDMV SGWDFHPDTG TGAKLASLAR KHGFLIFEDR KFGDIGHTVE LQYTSGSARI 

       130        140        150        160        170        180 
IDWAHIVNVN MVPGKASVAS LAQGARRWLE RYPCEVKTSV TVGTPTMDQF DDAEDAKDDE 

       190        200        210        220        230        240 
PATVNDNGSN MMEKPIYAGR NGDGRKGSIV SITTVTQQYE SAASPRLGKT IAEGDESLFP 

       250        260        270        280        290        300 
GIEEAPLNRG LLILAQMSSE GNFMTGEYTQ ACVEAAREHK DFVMGFISQE ALNTQADDDF 

       310        320        330        340        350        360 
IHMTPGCQLP PEDEDQQTNG KVGGDGQGQQ YNTAHKIIGI AGSDIAIVGR GILKASDPVE 

       370 
EAERYRSAAW KAYTERLLR 

« Hide

References

[1]"Sequence of the pyr4 gene encoding orotidine-5'-phosphate decarboxylase from the biocontrol fungus Trichoderma harzianum."
Heidenreich E.J., Kubicek C.P.
Gene 147:151-152(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 36042 / 2440A / CBS 391.92.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U05192 Genomic DNA. Translation: AAA51865.1.

3D structure databases

ProteinModelPortalQ12709.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 2 hits.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 2 hits.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_HYPAT
AccessionPrimary (citable) accession number: Q12709
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways