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Q12706

- PSK1_SCHPO

UniProt

Q12706 - PSK1_SCHPO

Protein

Serine/threonine-protein kinase psk1

Gene

psk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Phosphorylation at Tyr-102 inactivates the enzyme.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201ATPPROSITE-ProRule annotation
    Active sitei215 – 2151Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi97 – 1059ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_224701. AKT phosphorylates targets in the nucleus.
    REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase psk1 (EC:2.7.11.22)
    Gene namesi
    Name:psk1
    ORF Names:SPCC4G3.08
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC4G3.08.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Serine/threonine-protein kinase psk1PRO_0000086588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021PhosphotyrosineSequence Analysis

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ12706.

    Interactioni

    Protein-protein interaction databases

    BioGridi276057. 19 interactions.
    MINTiMINT-4700049.
    STRINGi4896.SPCC4G3.08-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12706.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 350260Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini351 – 42676AGC-kinase C-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233033.
    KOiK00924.
    OMAiHYEEIEI.
    OrthoDBiEOG7R2BT5.
    PhylomeDBiQ12706.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12706-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVFMFDEHD NLNENYNSHL SSDDEIAEEG YDFEELEASA STITSSSDLK    50
    DGKNAKDEKG TVEFKVAAHG DFISSKGDNY VPSGKMRPAD FQPLTVLGRG 100
    SYGKVLLVKQ KNTGRLFAQK QLKKASIVLR AKGLEQTKNE RQILEEVRHP 150
    FICRLYYAFQ DHDRLYLILQ YAPGGELFSH LAEQRMLPED VVAFYTAELT 200
    LALIHLHKLG IVYRDLKPEN CLLDAEGHIL LTDFGLSKVA ENGADCRSFV 250
    GTEEYCAPEI LLEQPYDHAV DWWSMGILIF DLLTGSPPFT ANNHKRIMEK 300
    ITRAKPNIPF YVTSDARDII NKFLKKNPKQ RLGADGPEKG YDAIKKHRIY 350
    RRIDWNKLEK RMLPPPIVPC ITNPEAAENF SVEFTKLPLS TTPILHEEFG 400
    NLTIGSHSSA FQGFTYVASP NFLNCEFLSN NAVSNH 436
    Length:436
    Mass (Da):49,321
    Last modified:November 1, 1996 - v1
    Checksum:i3498C4BE214530BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45401 Genomic DNA. Translation: BAA08243.1.
    CU329672 Genomic DNA. Translation: CAB09775.1.
    PIRiJC4516.
    RefSeqiNP_587830.1. NM_001022823.2.

    Genome annotation databases

    EnsemblFungiiSPCC4G3.08.1; SPCC4G3.08.1:pep; SPCC4G3.08.
    GeneIDi2539494.
    KEGGispo:SPCC4G3.08.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45401 Genomic DNA. Translation: BAA08243.1 .
    CU329672 Genomic DNA. Translation: CAB09775.1 .
    PIRi JC4516.
    RefSeqi NP_587830.1. NM_001022823.2.

    3D structure databases

    ProteinModelPortali Q12706.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276057. 19 interactions.
    MINTi MINT-4700049.
    STRINGi 4896.SPCC4G3.08-1.

    Proteomic databases

    MaxQBi Q12706.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC4G3.08.1 ; SPCC4G3.08.1:pep ; SPCC4G3.08 .
    GeneIDi 2539494.
    KEGGi spo:SPCC4G3.08.

    Organism-specific databases

    PomBasei SPCC4G3.08.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233033.
    KOi K00924.
    OMAi HYEEIEI.
    OrthoDBi EOG7R2BT5.
    PhylomeDBi Q12706.

    Enzyme and pathway databases

    Reactomei REACT_224701. AKT phosphorylates targets in the nucleus.
    REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

    Miscellaneous databases

    NextBioi 20800656.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of Schizosaccharomyces pombe gene psk1+, encoding a novel putative serine/threonine protein kinase, whose mutation conferred resistance to phenylarsine oxide."
      Mukai H., Miyahara M., Takanaga H., Kitagawa M., Shibata H., Shimakawa M., Ono Y.
      Gene 166:155-159(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPSK1_SCHPO
    AccessioniPrimary (citable) accession number: Q12706
    Secondary accession number(s): O00044
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3