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Q12706 (PSK1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase psk1

EC=2.7.11.22
Gene names
Name:psk1
ORF Names:SPCC4G3.08
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Phosphorylation at Tyr-102 inactivates the enzyme Potential.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Serine/threonine-protein kinase psk1
PRO_0000086588

Regions

Domain91 – 350260Protein kinase
Domain351 – 42676AGC-kinase C-terminal
Nucleotide binding97 – 1059ATP By similarity

Sites

Active site2151Proton acceptor By similarity
Binding site1201ATP By similarity

Amino acid modifications

Modified residue1021Phosphotyrosine Potential

Sequences

Sequence LengthMass (Da)Tools
Q12706 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3498C4BE214530BC

FASTA43649,321
        10         20         30         40         50         60 
MPVFMFDEHD NLNENYNSHL SSDDEIAEEG YDFEELEASA STITSSSDLK DGKNAKDEKG 

        70         80         90        100        110        120 
TVEFKVAAHG DFISSKGDNY VPSGKMRPAD FQPLTVLGRG SYGKVLLVKQ KNTGRLFAQK 

       130        140        150        160        170        180 
QLKKASIVLR AKGLEQTKNE RQILEEVRHP FICRLYYAFQ DHDRLYLILQ YAPGGELFSH 

       190        200        210        220        230        240 
LAEQRMLPED VVAFYTAELT LALIHLHKLG IVYRDLKPEN CLLDAEGHIL LTDFGLSKVA 

       250        260        270        280        290        300 
ENGADCRSFV GTEEYCAPEI LLEQPYDHAV DWWSMGILIF DLLTGSPPFT ANNHKRIMEK 

       310        320        330        340        350        360 
ITRAKPNIPF YVTSDARDII NKFLKKNPKQ RLGADGPEKG YDAIKKHRIY RRIDWNKLEK 

       370        380        390        400        410        420 
RMLPPPIVPC ITNPEAAENF SVEFTKLPLS TTPILHEEFG NLTIGSHSSA FQGFTYVASP 

       430 
NFLNCEFLSN NAVSNH 

« Hide

References

« Hide 'large scale' references
[1]"Identification of Schizosaccharomyces pombe gene psk1+, encoding a novel putative serine/threonine protein kinase, whose mutation conferred resistance to phenylarsine oxide."
Mukai H., Miyahara M., Takanaga H., Kitagawa M., Shibata H., Shimakawa M., Ono Y.
Gene 166:155-159(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D45401 Genomic DNA. Translation: BAA08243.1.
CU329672 Genomic DNA. Translation: CAB09775.1.
PIRJC4516.
RefSeqNP_587830.1. NM_001022823.2.

3D structure databases

ProteinModelPortalQ12706.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276057. 19 interactions.
MINTMINT-4700049.
STRING4896.SPCC4G3.08-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC4G3.08.1; SPCC4G3.08.1:pep; SPCC4G3.08.
GeneID2539494.
KEGGspo:SPCC4G3.08.

Organism-specific databases

PomBaseSPCC4G3.08.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233033.
KOK00924.
OMARSPRRIM.
OrthoDBEOG7R2BT5.
PhylomeDBQ12706.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800656.

Entry information

Entry namePSK1_SCHPO
AccessionPrimary (citable) accession number: Q12706
Secondary accession number(s): O00044
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names