Q12706 (PSK1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase psk1
EC=2.7.11.22

Gene names

Name:	psk1
ORF Names:	SPCC4G3.08

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Phosphorylation at Tyr-102 inactivates the enzyme Potential.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC signal transduction Inferred by curator. Source: PomBase
Cellular_component	cytosol Inferred from direct assay PubMed 16823372. Source: PomBase
Molecular_function	ATP binding Inferred from sequence model. Source: PomBase cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC protein serine/threonine kinase activity Inferred from sequence model. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Serine/threonine-protein kinase psk1		PRO_0000086588
Regions
	Domain	91 – 350	260	Protein kinase
	Domain	351 – 426	76	AGC-kinase C-terminal
	Nucleotide binding	97 – 105	9	ATP By similarity
Sites
	Active site	215	1	Proton acceptor By similarity
	Binding site	120	1	ATP By similarity
Amino acid modifications
	Modified residue	102	1	Phosphotyrosine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q12706 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3498C4BE214530BC	FASTA	436	49,321
	10 20 30 40 50 60 MPVFMFDEHD NLNENYNSHL SSDDEIAEEG YDFEELEASA STITSSSDLK DGKNAKDEKG 70 80 90 100 110 120 TVEFKVAAHG DFISSKGDNY VPSGKMRPAD FQPLTVLGRG SYGKVLLVKQ KNTGRLFAQK 130 140 150 160 170 180 QLKKASIVLR AKGLEQTKNE RQILEEVRHP FICRLYYAFQ DHDRLYLILQ YAPGGELFSH 190 200 210 220 230 240 LAEQRMLPED VVAFYTAELT LALIHLHKLG IVYRDLKPEN CLLDAEGHIL LTDFGLSKVA 250 260 270 280 290 300 ENGADCRSFV GTEEYCAPEI LLEQPYDHAV DWWSMGILIF DLLTGSPPFT ANNHKRIMEK 310 320 330 340 350 360 ITRAKPNIPF YVTSDARDII NKFLKKNPKQ RLGADGPEKG YDAIKKHRIY RRIDWNKLEK 370 380 390 400 410 420 RMLPPPIVPC ITNPEAAENF SVEFTKLPLS TTPILHEEFG NLTIGSHSSA FQGFTYVASP 430 NFLNCEFLSN NAVSNH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of Schizosaccharomyces pombe gene psk1+, encoding a novel putative serine/threonine protein kinase, whose mutation conferred resistance to phenylarsine oxide." Mukai H., Miyahara M., Takanaga H., Kitagawa M., Shibata H., Shimakawa M., Ono Y. Gene 166:155-159(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D45401 Genomic DNA. Translation: BAA08243.1. CU329672 Genomic DNA. Translation: CAB09775.1.
PIR	JC4516.
RefSeq	NP_587830.1. NM_001022823.2.
3D structure databases
ProteinModelPortal	Q12706.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPCC4G3.08-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC4G3.08.1; SPCC4G3.08.1:pep; SPCC4G3.08.
GeneID	2539494.
KEGG	spo:SPCC4G3.08.
Organism-specific databases
PomBase	SPCC4G3.08.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233033.
KO	K00924.
OMA	LTCIANF.
OrthoDB	EOG444PV3.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom. IPR017892. Pkinase_C. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
SMART	SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20800656.

Entry information

Entry name

PSK1_SCHPO

Accession

Primary (citable) accession number: Q12706
Secondary accession number(s): O00044

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program