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Q12706

- PSK1_SCHPO

UniProt

Q12706 - PSK1_SCHPO

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Protein

Serine/threonine-protein kinase psk1

Gene

psk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Tyr-102 inactivates the enzyme.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201ATPPROSITE-ProRule annotation
Active sitei215 – 2151Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1059ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_224701. AKT phosphorylates targets in the nucleus.
REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase psk1 (EC:2.7.11.22)
Gene namesi
Name:psk1
ORF Names:SPCC4G3.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC4G3.08.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Serine/threonine-protein kinase psk1PRO_0000086588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021PhosphotyrosineSequence Analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12706.

Interactioni

Protein-protein interaction databases

BioGridi276057. 19 interactions.
MINTiMINT-4700049.
STRINGi4896.SPCC4G3.08-1.

Structurei

3D structure databases

ProteinModelPortaliQ12706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 350260Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini351 – 42676AGC-kinase C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233033.
InParanoidiQ12706.
KOiK00924.
OMAiHYEEIEI.
OrthoDBiEOG7R2BT5.
PhylomeDBiQ12706.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12706-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVFMFDEHD NLNENYNSHL SSDDEIAEEG YDFEELEASA STITSSSDLK
60 70 80 90 100
DGKNAKDEKG TVEFKVAAHG DFISSKGDNY VPSGKMRPAD FQPLTVLGRG
110 120 130 140 150
SYGKVLLVKQ KNTGRLFAQK QLKKASIVLR AKGLEQTKNE RQILEEVRHP
160 170 180 190 200
FICRLYYAFQ DHDRLYLILQ YAPGGELFSH LAEQRMLPED VVAFYTAELT
210 220 230 240 250
LALIHLHKLG IVYRDLKPEN CLLDAEGHIL LTDFGLSKVA ENGADCRSFV
260 270 280 290 300
GTEEYCAPEI LLEQPYDHAV DWWSMGILIF DLLTGSPPFT ANNHKRIMEK
310 320 330 340 350
ITRAKPNIPF YVTSDARDII NKFLKKNPKQ RLGADGPEKG YDAIKKHRIY
360 370 380 390 400
RRIDWNKLEK RMLPPPIVPC ITNPEAAENF SVEFTKLPLS TTPILHEEFG
410 420 430
NLTIGSHSSA FQGFTYVASP NFLNCEFLSN NAVSNH
Length:436
Mass (Da):49,321
Last modified:November 1, 1996 - v1
Checksum:i3498C4BE214530BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45401 Genomic DNA. Translation: BAA08243.1.
CU329672 Genomic DNA. Translation: CAB09775.1.
PIRiJC4516.
RefSeqiNP_587830.1. NM_001022823.2.

Genome annotation databases

EnsemblFungiiSPCC4G3.08.1; SPCC4G3.08.1:pep; SPCC4G3.08.
GeneIDi2539494.
KEGGispo:SPCC4G3.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45401 Genomic DNA. Translation: BAA08243.1 .
CU329672 Genomic DNA. Translation: CAB09775.1 .
PIRi JC4516.
RefSeqi NP_587830.1. NM_001022823.2.

3D structure databases

ProteinModelPortali Q12706.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276057. 19 interactions.
MINTi MINT-4700049.
STRINGi 4896.SPCC4G3.08-1.

Proteomic databases

MaxQBi Q12706.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC4G3.08.1 ; SPCC4G3.08.1:pep ; SPCC4G3.08 .
GeneIDi 2539494.
KEGGi spo:SPCC4G3.08.

Organism-specific databases

PomBasei SPCC4G3.08.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233033.
InParanoidi Q12706.
KOi K00924.
OMAi HYEEIEI.
OrthoDBi EOG7R2BT5.
PhylomeDBi Q12706.

Enzyme and pathway databases

Reactomei REACT_224701. AKT phosphorylates targets in the nucleus.
REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

Miscellaneous databases

NextBioi 20800656.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Schizosaccharomyces pombe gene psk1+, encoding a novel putative serine/threonine protein kinase, whose mutation conferred resistance to phenylarsine oxide."
    Mukai H., Miyahara M., Takanaga H., Kitagawa M., Shibata H., Shimakawa M., Ono Y.
    Gene 166:155-159(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPSK1_SCHPO
AccessioniPrimary (citable) accession number: Q12706
Secondary accession number(s): O00044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3