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Protein

DNA polymerase gamma

Gene

mip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the replication of mitochondrial DNA.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactori

GO - Molecular functioni

GO - Biological processi

  • mitochondrial DNA replication Source: PomBase
  • mitochondrial genome maintenance Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase gamma (EC:2.7.7.7)
Alternative name(s):
Mitochondrial DNA polymerase catalytic subunit
Gene namesi
Name:mip1
ORF Names:SPCC24B10.22, SPCPB16A4.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC24B10.22.
PomBaseiSPCC24B10.22.

Subcellular locationi

GO - Cellular componenti

  • gamma DNA polymerase complex Source: InterPro
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012771 – 1018DNA polymerase gammaAdd BLAST1018

Proteomic databases

MaxQBiQ12704.
PRIDEiQ12704.

Interactioni

Protein-protein interaction databases

BioGridi275671. 1 interactor.
MINTiMINT-4700012.

Structurei

3D structure databases

ProteinModelPortaliQ12704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

HOGENOMiHOG000176668.
KOiK02332.
OMAiDWSGQEI.
OrthoDBiEOG092C03LT.
PhylomeDBiQ12704.

Family and domain databases

Gene3Di3.30.420.10. 2 hits.
InterProiIPR002297. DNA-dir_DNA_pol_A_mt.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10267. PTHR10267. 1 hit.
PfamiPF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00867. DNAPOLG.
SMARTiSM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.

Sequencei

Sequence statusi: Complete.

Q12704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYKACPSTL TCSKWIHSII KTKKFLYCRH YSSKSFIDNA PLRINPVGVQ
60 70 80 90 100
YLSPALQNQV FPQQNTQISQ LHLDLAKFHL AKHQLLNKET IKLPSFNFRL
110 120 130 140 150
PPLQGKTISE HFYNIGLEFA EPHLSKAIKF SKIDTPVQPK TWKRQPGWTK
160 170 180 190 200
YAKDGSISCV PYPDSDCMVF DVEVLYKVSP FAVVATAVSE DAWYCWLSPW
210 220 230 240 250
LLGKSENDRQ LIPSNPKGAL FVGHNVSFDR QRIREEYNIK SSRNVFLDTM
260 270 280 290 300
SLHVATHGMC SRQKPTWFKA RKAYIRSQST ETSEDDDSSS FDDDYQNYLK
310 320 330 340 350
QEPWLAHSSV NSLKDVAKFH CNITLDKSKR DDFASLEKEP ILQKLNELIT
360 370 380 390 400
YCAHDTYSTH QVFKKVFPQF LEVCPHPATF SAMLSLGSVF LPVNHSWTRY
410 420 430 440 450
INGVEEQYQQ MIQLVDQKLS QYAEKAKDLI NTKDTVLKDP WLRQLDWTPC
460 470 480 490 500
NLYRKLKKAT QEVPVVPKWY KKAYCKTEKR AVITAKSRLA PILLRLKWKK
510 520 530 540 550
HPLAWSDTYG WVFSVERTSK DEIEMLLDQG LVPCSREEDT KLDYNNYIFF
560 570 580 590 600
KVPHKDGPEA RCGSPLSKSY QRYFEEGILQ SDYEVAKKAL EMSASCSYWS
610 620 630 640 650
SARDRIRSQM VVWDKDAELG VPSSVDGFGI ILPCIIPMGT VTRRAVENTW
660 670 680 690 700
LTASNSKKNR LGSELKAMIR APDGYTFVGA DVDSEELWIV ALMGDSQFRL
710 720 730 740 750
HGATALGMMT LEGKKSEGTD LHSKTAAILG VSRDSAKVFN YGRLYGAGLK
760 770 780 790 800
HTTLLLMQMN PTLKTAEAKE LAKKLYASTK GVKSKMSKRL QEMGLPKLTF
810 820 830 840 850
WSQGTESFVF NKLEAMAQLP SPRTPVLDAG ITQALSSKNL SKNSFMTSRV
860 870 880 890 900
NWAIQSSAVD YLHLLLVSMN HLIKKYYLEA RLSLTVHDEV RYLSSDKDKY
910 920 930 940 950
RVAFALQVAN LWTRAFFCQR LGINELPQSV AFFSSVDIDH VLRKDVKMDC
960 970 980 990 1000
VTPSNKVPIP PGEELTIESV LEKLEQSGQS LEPLEQIQCF VDVKATTSAE
1010
ITEEDKKNIA YLKAQAFY
Length:1,018
Mass (Da):116,045
Last modified:March 5, 2002 - v2
Checksum:i9B114BC6FBEE63CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti563G → C in CAA88012 (PubMed:7489897).Curated1
Sequence conflicti571 – 572QR → HA in CAA88012 (PubMed:7489897).Curated2
Sequence conflicti832T → Q in CAA88012 (PubMed:7489897).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47976 Genomic DNA. Translation: CAA88012.1.
CU329672 Genomic DNA. Translation: CAB76231.1.
PIRiJC4375.
T50429.
RefSeqiNP_588025.2. NM_001023016.2.

Genome annotation databases

EnsemblFungiiSPCC24B10.22.1; SPCC24B10.22.1:pep; SPCC24B10.22.
GeneIDi2539099.
KEGGispo:SPCC24B10.22.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47976 Genomic DNA. Translation: CAA88012.1.
CU329672 Genomic DNA. Translation: CAB76231.1.
PIRiJC4375.
T50429.
RefSeqiNP_588025.2. NM_001023016.2.

3D structure databases

ProteinModelPortaliQ12704.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275671. 1 interactor.
MINTiMINT-4700012.

Proteomic databases

MaxQBiQ12704.
PRIDEiQ12704.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC24B10.22.1; SPCC24B10.22.1:pep; SPCC24B10.22.
GeneIDi2539099.
KEGGispo:SPCC24B10.22.

Organism-specific databases

EuPathDBiFungiDB:SPCC24B10.22.
PomBaseiSPCC24B10.22.

Phylogenomic databases

HOGENOMiHOG000176668.
KOiK02332.
OMAiDWSGQEI.
OrthoDBiEOG092C03LT.
PhylomeDBiQ12704.

Miscellaneous databases

PROiQ12704.

Family and domain databases

Gene3Di3.30.420.10. 2 hits.
InterProiIPR002297. DNA-dir_DNA_pol_A_mt.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10267. PTHR10267. 1 hit.
PfamiPF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00867. DNAPOLG.
SMARTiSM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDPOG_SCHPO
AccessioniPrimary (citable) accession number: Q12704
Secondary accession number(s): Q96WV3, Q9P7I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 5, 2002
Last modified: October 5, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.