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Protein

Protein phosphatase PP2A regulatory subunit B

Gene

pab1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.1 Publication

GO - Molecular functioni

GO - Biological processi

  • developmental process Source: GO_Central
  • negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • negative regulation of GTPase activity Source: PomBase
  • negative regulation of septation initiation signaling Source: PomBase
  • peptidyl-serine dephosphorylation Source: GO_Central
  • positive regulation of protein dephosphorylation Source: PomBase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PP2A regulatory subunit B
Alternative name(s):
Protein phosphatase 2A 55 kDa regulatory subunit
Short name:
PR55
Gene namesi
Name:pab1
ORF Names:SPAC227.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC227.07c
PomBaseiSPAC227.07c pab1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714411 – 463Protein phosphatase PP2A regulatory subunit BAdd BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei134Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12702
PaxDbiQ12702
PRIDEiQ12702

PTM databases

iPTMnetiQ12702

Interactioni

Subunit structurei

PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa (PR65) (Subunit A) and a 55 kDa (PR55) (Subunit B) regulatory subunit.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi278020, 21 interactors
DIPiDIP-61472N
IntActiQ12702, 2 interactors
STRINGi4896.SPAC227.07c.1

Structurei

3D structure databases

ProteinModelPortaliQ12702
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 66WD 1Add BLAST40
Repeati87 – 128WD 2Add BLAST42
Repeati174 – 212WD 3Add BLAST39
Repeati223 – 263WD 4Add BLAST41
Repeati282 – 320WD 5Add BLAST39
Repeati337 – 378WD 6Add BLAST42

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000089745
KOiK04354
OMAiMFDRNTR
OrthoDBiEOG092C34FN
PhylomeDBiQ12702

Family and domain databases

InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit
PS00678 WD_REPEATS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q12702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDIEDSLDQ WKFAQCFGDK GDVEDITEAD IISAVEFDHT GDYLATGDKG
60 70 80 90 100
GRVVLFERNH SKKGCEYKFF TEFQSHEPEF DYLKSLEIEE KINKIRWCKR
110 120 130 140 150
TNRAHFLLST NDKTIKLWKL YEKNLKVVAE NNLSDSFHSP MQGPLTTPSQ
160 170 180 190 200
LRLPRLNHHD MIIAAYPRRV YANAHAYHIN SISVNSDAET YISADDLRIN
210 220 230 240 250
LWNLSISDHS FNIVDIKPEN MEELTEVITS AEFHPINCNH LMYSSSKGNI
260 270 280 290 300
KLLDLRQSAL CDNPCKLFED QEDQDSKSFF SEIISSISDV KFSQNGRYIL
310 320 330 340 350
SRDYLTLKIW DVNMEKAPVK TIPLHDVLRS KLCDLYENDC IFDKFECTFS
360 370 380 390 400
GDDKHVLSGS YSNNFGIYPT DSSLPGDRGQ IVLQADKAAF RARKSAANNV
410 420 430 440 450
PKLNAVKNND WRSQPQAAMG SASVGLDPDN LDYNKKILHA SWHPFEDSVA
460
IAATNNLFVF SKL
Length:463
Mass (Da):52,795
Last modified:August 14, 2001 - v2
Checksum:i43B289222A2D8CC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126K → R in BAA09945 (PubMed:9078365).Curated1
Sequence conflicti145L → V in BAA09945 (PubMed:9078365).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63915 Genomic DNA Translation: BAA09945.1
CU329670 Genomic DNA Translation: CAB61456.1
PIRiT50163
RefSeqiNP_592961.1, NM_001018361.2

Genome annotation databases

EnsemblFungiiSPAC227.07c.1; SPAC227.07c.1:pep; SPAC227.07c
GeneIDi2541519
KEGGispo:SPAC227.07c

Similar proteinsi

Entry informationi

Entry namei2ABA_SCHPO
AccessioniPrimary (citable) accession number: Q12702
Secondary accession number(s): Q9UTD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 14, 2001
Last modified: April 25, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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