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Protein

Protein phosphatase PP2A regulatory subunit B

Gene

pab1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of GTPase activity Source: PomBase
  • negative regulation of septation initiation signaling Source: PomBase
  • positive regulation of protein dephosphorylation Source: PomBase
  • regulation of protein phosphatase type 2A activity Source: PomBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PP2A regulatory subunit B
Alternative name(s):
Protein phosphatase 2A 55 kDa regulatory subunit
Short name:
PR55
Gene namesi
Name:pab1
ORF Names:SPAC227.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC227.07c.
PomBaseiSPAC227.07c. pab1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • mitotic spindle Source: PomBase
  • protein phosphatase type 2A complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Protein phosphatase PP2A regulatory subunit BPRO_0000071441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei134 – 1341Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12702.

PTM databases

iPTMnetiQ12702.

Interactioni

Subunit structurei

PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa (PR65) (Subunit A) and a 55 kDa (PR55) (Subunit B) regulatory subunit.1 Publication

Protein-protein interaction databases

BioGridi278020. 20 interactions.
DIPiDIP-61472N.
MINTiMINT-4699996.

Structurei

3D structure databases

ProteinModelPortaliQ12702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 6640WD 1Add
BLAST
Repeati87 – 12842WD 2Add
BLAST
Repeati174 – 21239WD 3Add
BLAST
Repeati223 – 26341WD 4Add
BLAST
Repeati282 – 32039WD 5Add
BLAST
Repeati337 – 37842WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000089745.
KOiK04354.
OMAiMVEGEPN.
OrthoDBiEOG092C34FN.
PhylomeDBiQ12702.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDIEDSLDQ WKFAQCFGDK GDVEDITEAD IISAVEFDHT GDYLATGDKG
60 70 80 90 100
GRVVLFERNH SKKGCEYKFF TEFQSHEPEF DYLKSLEIEE KINKIRWCKR
110 120 130 140 150
TNRAHFLLST NDKTIKLWKL YEKNLKVVAE NNLSDSFHSP MQGPLTTPSQ
160 170 180 190 200
LRLPRLNHHD MIIAAYPRRV YANAHAYHIN SISVNSDAET YISADDLRIN
210 220 230 240 250
LWNLSISDHS FNIVDIKPEN MEELTEVITS AEFHPINCNH LMYSSSKGNI
260 270 280 290 300
KLLDLRQSAL CDNPCKLFED QEDQDSKSFF SEIISSISDV KFSQNGRYIL
310 320 330 340 350
SRDYLTLKIW DVNMEKAPVK TIPLHDVLRS KLCDLYENDC IFDKFECTFS
360 370 380 390 400
GDDKHVLSGS YSNNFGIYPT DSSLPGDRGQ IVLQADKAAF RARKSAANNV
410 420 430 440 450
PKLNAVKNND WRSQPQAAMG SASVGLDPDN LDYNKKILHA SWHPFEDSVA
460
IAATNNLFVF SKL
Length:463
Mass (Da):52,795
Last modified:August 14, 2001 - v2
Checksum:i43B289222A2D8CC3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261K → R in BAA09945 (PubMed:9078365).Curated
Sequence conflicti145 – 1451L → V in BAA09945 (PubMed:9078365).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63915 Genomic DNA. Translation: BAA09945.1.
CU329670 Genomic DNA. Translation: CAB61456.1.
PIRiT50163.
RefSeqiNP_592961.1. NM_001018361.2.

Genome annotation databases

EnsemblFungiiSPAC227.07c.1; SPAC227.07c.1:pep; SPAC227.07c.
GeneIDi2541519.
KEGGispo:SPAC227.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63915 Genomic DNA. Translation: BAA09945.1.
CU329670 Genomic DNA. Translation: CAB61456.1.
PIRiT50163.
RefSeqiNP_592961.1. NM_001018361.2.

3D structure databases

ProteinModelPortaliQ12702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278020. 20 interactions.
DIPiDIP-61472N.
MINTiMINT-4699996.

PTM databases

iPTMnetiQ12702.

Proteomic databases

MaxQBiQ12702.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC227.07c.1; SPAC227.07c.1:pep; SPAC227.07c.
GeneIDi2541519.
KEGGispo:SPAC227.07c.

Organism-specific databases

EuPathDBiFungiDB:SPAC227.07c.
PomBaseiSPAC227.07c. pab1.

Phylogenomic databases

HOGENOMiHOG000089745.
KOiK04354.
OMAiMVEGEPN.
OrthoDBiEOG092C34FN.
PhylomeDBiQ12702.

Miscellaneous databases

PROiQ12702.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei2ABA_SCHPO
AccessioniPrimary (citable) accession number: Q12702
Secondary accession number(s): Q9UTD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 14, 2001
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.