Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase ksg1

Gene

ksg1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the control of sexual development and cell growth under stressed conditions. Phosphorylates AGC kinase gad8 at 'Thr-387', activating gad8 kinase activity and promoting sexual development (PubMed:12805221). Phosphorylates AGC kinase psk1 at 'Ser-248', activating psk1 kinase activity and promoting phosphorylation of ribosomal protein S6 (PubMed:22976295).3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128ATPBy similarity1
Binding sitei184ATPBy similarity1
Active sitei223Proton acceptorPROSITE-ProRule annotation1
Binding sitei227ATP; via carbonyl oxygenBy similarity1
Binding sitei241ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi109 – 111ATPBy similarity3
Nucleotide bindingi178 – 180ATPBy similarity3

GO - Molecular functioni

  • 3-phosphoinositide-dependent protein kinase activity Source: PomBase
  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: PomBase
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 5613
ReactomeiR-SPO-114604 GPVI-mediated activation cascade
R-SPO-1257604 PIP3 activates AKT signaling
R-SPO-165158 Activation of AKT2
R-SPO-202424 Downstream TCR signaling
R-SPO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-SPO-389357 CD28 dependent PI3K/Akt signaling
R-SPO-5218920 VEGFR2 mediated vascular permeability
R-SPO-5625740 RHO GTPases activate PKNs
R-SPO-6804757 Regulation of TP53 Degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ksg11 Publication (EC:2.7.11.12 Publications)
Alternative name(s):
PDK1-like kinase ksg11 Publication
Gene namesi
Name:ksg11 Publication
ORF Names:SPCC576.15cImported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC576.15c
PomBaseiSPCC576.15c ksg1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862261 – 592Serine/threonine-protein kinase ksg1Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Phosphoserine1 Publication1
Modified residuei69Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12701
PaxDbiQ12701
PRIDEiQ12701

PTM databases

iPTMnetiQ12701

Interactioni

Protein-protein interaction databases

BioGridi276079, 13 interactors
STRINGi4896.SPCC576.15c.1

Structurei

3D structure databases

ProteinModelPortaliQ12701
SMRiQ12701
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 366Protein kinasePROSITE-ProRule annotationAdd BLAST268
Domaini461 – 572PHAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 175PIF-pocketBy similarityAdd BLAST46

Domaini

The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233026
InParanoidiQ12701
KOiK06276
OrthoDBiEOG092C0HH3
PhylomeDBiQ12701

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR033931 PDK1-typ_PH
IPR011993 PH-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF14593 PH_3, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q12701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNTHNPNET EASEDAENDT QSESDLSFDH GSSEKLNRAS LPKTQNSAIP
60 70 80 90 100
QSNALNTTPN ESTSQIDSSP KIPSAVPHIS TPNPSSGAST PNIKRVSDFK
110 120 130 140 150
FGEILGEGSY STVLTATENS TKREYAIKVL DKRHIIKEKK EKYVNIEKEA
160 170 180 190 200
LCILSKHPGF IKLFYTFQDA HNLYFVLSLA RNGELLDYIN KLGRFNEICA
210 220 230 240 250
QYYAALIVDS IDYMHGRGVI HRDLKPENIL LDDNMRTKIT DFGSAKILNS
260 270 280 290 300
SHGSHEEDTH HADKPQAHSR SFVGTARYVS PEVLSDKIAG TASDIWAFGC
310 320 330 340 350
ILFQMLAGKP PFVAGNEYLT FQSILHLSYE IPPDISDVAS DLIKKLLVLD
360 370 380 390 400
PKDRLTVDEI HQHPFFNGIK FDNTLWELPP PRLKPFGHTS VLSLSVPNAS
410 420 430 440 450
NKHENGDLTS PLGVPSMVSA STNAAPSPVG TFNRGTLLPC QSNLEEENKE
460 470 480 490 500
WSSILQDDEK ISKIGTLNVY SMSGINGNDA FRFFSSLFRK RKPRTFILTN
510 520 530 540 550
FGRYLCVASD GEGRKTVKEE IPIKSVGMRC RMVKNNEHGW VVETPTKSWS
560 570 580 590
FEDPNGPASA WVELLDKASS ISLPFGNHSV TSFSRSIARS AV
Length:592
Mass (Da):65,662
Last modified:November 1, 1998 - v2
Checksum:iB9A857D1989F2C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99280 Genomic DNA Translation: CAA67672.1
CU329672 Genomic DNA Translation: CAA21194.1
PIRiT43402
RefSeqiNP_588442.1, NM_001023433.2

Genome annotation databases

EnsemblFungiiSPCC576.15c.1; SPCC576.15c.1:pep; SPCC576.15c
GeneIDi2539517
KEGGispo:SPCC576.15c

Similar proteinsi

Entry informationi

Entry nameiKSG1_SCHPO
AccessioniPrimary (citable) accession number: Q12701
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health