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Q126R8

- PUR5_POLSJ

UniProt

Q126R8 - PUR5_POLSJ

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, Bpro_3566
Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPSP296591:GHI4-4286-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Bpro_3566
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
ProteomesiUP000001983: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_0000258379Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi296591.Bpro_3566.

Structurei

3D structure databases

ProteinModelPortaliQ126R8.
SMRiQ126R8. Positions 7-345.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiNPQENDI.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q126R8-1 [UniParc]FASTAAdd to Basket

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MTTSSSSPLS YKDAGVDIDA GDALVERIKP LAKKTMREGV LAGIGGFGAL    50
FEVPKRYKEP VLVSGTDGVG TKLRLAFEWN MHDTVGIDLV AMSVNDVLVQ 100
GAEPLFFLDY FACGKLDVDT AAAVVGGIAK GCELSGCALI GGETAEMPGM 150
YPEGEYDLAG FAVGAVEKSK ILTGKEVQPG DVVLGLASSG VHSNGFSLVR 200
KCIERAGADR PATLDGKPFK QALMEPTRLY VKNVLAALAA HPIKALAHIT 250
GGGLLENIPR VLPEGTAAHL KKGSWPQTEL FAWLQKTAGI DDFEMNRTFN 300
NGIGMVVVVD AANAQATAKT LRDAGEQVYE IGVIAPRGEG AAVIVG 346
Length:346
Mass (Da):36,200
Last modified:August 22, 2006 - v1
Checksum:iAFE7EDCA2D084956
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000316 Genomic DNA. Translation: ABE45474.1.
RefSeqiWP_011484468.1. NC_007948.1.
YP_550372.1. NC_007948.1.

Genome annotation databases

EnsemblBacteriaiABE45474; ABE45474; Bpro_3566.
GeneIDi4013751.
KEGGipol:Bpro_3566.
PATRICi22960366. VBIPolSp102244_3637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000316 Genomic DNA. Translation: ABE45474.1 .
RefSeqi WP_011484468.1. NC_007948.1.
YP_550372.1. NC_007948.1.

3D structure databases

ProteinModelPortali Q126R8.
SMRi Q126R8. Positions 7-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 296591.Bpro_3566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE45474 ; ABE45474 ; Bpro_3566 .
GeneIDi 4013751.
KEGGi pol:Bpro_3566.
PATRICi 22960366. VBIPolSp102244_3637.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi NPQENDI.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci PSP296591:GHI4-4286-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JS666 / ATCC BAA-500.

Entry informationi

Entry nameiPUR5_POLSJ
AccessioniPrimary (citable) accession number: Q126R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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