Q126P9 (KYNB_POLSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	Bpro_3588

Organism

Polaromonas sp. (strain JS666 / ATCC BAA-500) [Complete proteome] [HAMAP]

Taxonomic identifier

296591 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Polaromonas

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Kynurenine formamidase		PRO_0000362127

Sequences

	Sequence		Length	Mass (Da)
	Q126P9 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 2986BBC2329CCDE3	FASTA	221	23,811
	10 20 30 40 50 60 MTARVLPSTT AKPLRLWDIS PPVAPGSPVF PGDTPYQQQW AASIAPGCPV NVSTLTLSPH 70 80 90 100 110 120 IGAHADAPLH YDPQGATIGA VDLTPYIGPC RVIHAIAKGP LIEWEHLAHA VHDLPPRVLV 130 140 150 160 170 180 RTYARMPVER WDPTLAAYAP ETVERLAALG VKLIGIDTAS IDPAGSKTLD SHQVIRQRGL 190 200 210 220 RVLENLVLDE VPEGDYELIA LPLKLMTADA SPVRAVLREL P

References

[1]

"Complete sequence of chromosome of Polaromonas sp. JS666." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JS666 / ATCC BAA-500.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000316 Genomic DNA. Translation: ABE45493.1.
RefSeq	YP_550391.1. NC_007948.1.
3D structure databases
ProteinModelPortal	Q126P9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q126P9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4013734.
GenomeReviews	Gene locus Bpro_3588 in contig CP000316_GR.
KEGG	pol:Bpro_3588.
NMPDR	fig|296591.1.peg.5184.
PATRIC	22960406. VBIPolSp102244_3657.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1878.
HOGENOM	HBG686791.
OMA	HTSKWPL.
ProtClustDB	CLSK953240.
Enzyme and pathway databases
BioCyc	PSP296591:BPRO_3588-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_POLSJ

Accession

Primary (citable) accession number: Q126P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program