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Q12698 (PUR1_LACKL) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase

Short name=ATase
EC=2.4.2.14
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase
Gene names
Name:ADE4
OrganismLachancea kluyveri (Yeast) (Saccharomyces kluyveri)
Taxonomic identifier4934 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.

Cofactor

Binds 1 magnesium ion per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Contains 1 glutamine amidotransferase type-2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 510509Amidophosphoribosyltransferase
PRO_0000139645

Regions

Domain2 – 239238Glutamine amidotransferase type-2

Sites

Active site21For GATase activity By similarity
Metal binding3731Magnesium By similarity
Metal binding3741Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12698 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C3B3580B3F460378

FASTA51057,012
        10         20         30         40         50         60 
MCGILGIALA DQSSVVAPEL FDGSLFLQHR GQDAAGMATC GERGRLYQCK GNGMARDVFT 

        70         80         90        100        110        120 
QHRMSGLVGS MGIAHLRYPT AGSCANSEAQ PFYVNSPYGI CLSHNGTLVN TLSLRSYLDE 

       130        140        150        160        170        180 
VVHRHINTDS DSELLLNVFA AELERHNKYR VNNDDIFHAL EGVYRQCRGG YACVGMLAGY 

       190        200        210        220        230        240 
SLFGFRDPNG IRPLLFGERV NPDGTKDYML ASESVVLKAH NFNKFRDLKP GEAVIIPKDC 

       250        260        270        280        290        300 
NKQEPEFRQV VPTNSYRPDL FEYVYFARPD SVLDGISVYH TRLQMGIKLA ENVKKVVDPD 

       310        320        330        340        350        360 
EIDVVVSVPD TARTCALQCA NHLNKPYREA FVKNRYVGRT FIMPNQKERV SSVRRKLNPM 

       370        380        390        400        410        420 
DFEFKDKRVL IVDDSIVRGT TSKEIINMAK ESGATKVYFA SAAPAIRFNH IYGIDLADTK 

       430        440        450        460        470        480 
QLVAYNRTTD EVAQELGCEK VIYQSLEDLV DCCKTDKIDK FEVGVFTGNY VTGVEDGYLQ 

       490        500        510 
ELERVRALNK AKLTTAKAEV DIGLYNSADY 

« Hide

References

[1]Marsh L., Branda S.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IH404.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U32992 Genomic DNA. Translation: AAA75450.1.

3D structure databases

ProteinModelPortalQ12698.
SMRQ12698. Positions 2-485.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC44.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00074; UER00124.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR000836. PRibTrfase_dom.
[Graphical view]
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. purF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR1_LACKL
AccessionPrimary (citable) accession number: Q12698
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways