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Protein

60S ribosomal protein L13-A

Gene

RPL13A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 133000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL13 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29491-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13-A1 Publication
Alternative name(s):
Large ribosomal subunit protein eL13-A1 Publication
Gene namesi
Name:RPL13A1 Publication
Ordered Locus Names:YDL082W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL082W
SGDiS000002240 RPL13A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929381 – 19960S ribosomal protein L13-AAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei144PhosphothreonineBy similarity1
Modified residuei152PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12690
PaxDbiQ12690
PRIDEiQ12690
TopDownProteomicsiQ12690

PTM databases

iPTMnetiQ12690

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi31979, 316 interactors
IntActiQ12690, 23 interactors
MINTiQ12690
STRINGi4932.YDL082W

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 25Combined sources3
Helixi28 – 45Combined sources18
Beta strandi57 – 59Combined sources3
Turni63 – 67Combined sources5
Beta strandi69 – 71Combined sources3
Helixi77 – 83Combined sources7
Helixi87 – 92Combined sources6
Helixi106 – 122Combined sources17
Beta strandi123 – 125Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10531-199[»]
3J6Yelectron microscopy6.10531-199[»]
3J77electron microscopy6.20631-199[»]
3J78electron microscopy6.30631-199[»]
3JCTelectron microscopy3.08L1-199[»]
4U3MX-ray3.00M3/m32-199[»]
4U3NX-ray3.20M3/m32-199[»]
4U3UX-ray2.90M3/m32-199[»]
4U4NX-ray3.10M3/m32-199[»]
4U4OX-ray3.60M3/m32-199[»]
4U4QX-ray3.00M3/m32-199[»]
4U4RX-ray2.80M3/m32-199[»]
4U4UX-ray3.00M3/m32-199[»]
4U4YX-ray3.20M3/m32-199[»]
4U4ZX-ray3.10M3/m32-199[»]
4U50X-ray3.20M3/m32-199[»]
4U51X-ray3.20M3/m32-199[»]
4U52X-ray3.00M3/m32-199[»]
4U53X-ray3.30M3/m32-199[»]
4U55X-ray3.20M3/m32-199[»]
4U56X-ray3.45M3/m32-199[»]
4U6FX-ray3.10M3/m32-199[»]
4V7Felectron microscopy8.70K1-199[»]
4V88X-ray3.00BL/DL1-199[»]
4V8Telectron microscopy8.10L1-199[»]
4V8Yelectron microscopy4.30BL2-199[»]
4V8Zelectron microscopy6.60BL2-199[»]
5APNelectron microscopy3.91L1-199[»]
5APOelectron microscopy3.41L1-199[»]
5DATX-ray3.15M3/m32-199[»]
5DC3X-ray3.25M3/m32-199[»]
5DGEX-ray3.45M3/m32-199[»]
5DGFX-ray3.30M3/m32-199[»]
5DGVX-ray3.10M3/m32-199[»]
5FCIX-ray3.40M3/m32-199[»]
5FCJX-ray3.10M3/m32-199[»]
5FL8electron microscopy9.50L1-199[»]
5GAKelectron microscopy3.88N1-199[»]
5H4Pelectron microscopy3.07L1-199[»]
5I4LX-ray3.10M3/m32-195[»]
5JCSelectron microscopy9.50L1-199[»]
5JUOelectron microscopy4.00Q1-199[»]
5JUPelectron microscopy3.50Q1-199[»]
5JUSelectron microscopy4.20Q1-199[»]
5JUTelectron microscopy4.00Q1-199[»]
5JUUelectron microscopy4.00Q1-199[»]
5LYBX-ray3.25M3/m32-195[»]
5M1Jelectron microscopy3.30L52-194[»]
5MC6electron microscopy3.80AJ1-199[»]
5MEIX-ray3.50CN/t2-194[»]
5NDGX-ray3.70M3/m32-195[»]
5NDVX-ray3.30M3/m32-195[»]
5NDWX-ray3.70M3/m32-195[»]
5OBMX-ray3.40M3/m32-195[»]
5ON6X-ray3.10CN/t2-194[»]
5T62electron microscopy3.30N1-199[»]
5T6Relectron microscopy4.50N1-199[»]
5TBWX-ray3.00CN/t2-194[»]
5TGAX-ray3.30M3/m32-195[»]
5TGMX-ray3.50M3/m32-195[»]
5Z3Gelectron microscopy3.65P1-199[»]
6C0Felectron microscopy3.70L1-199[»]
6ELZelectron microscopy3.30L1-199[»]
6EM1electron microscopy3.60L1-199[»]
6EM3electron microscopy3.20L1-199[»]
6EM4electron microscopy4.10L1-199[»]
6EM5electron microscopy4.30L1-199[»]
6FT6electron microscopy3.90L1-199[»]
ProteinModelPortaliQ12690
SMRiQ12690
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000007818
HOGENOMiHOG000170452
InParanoidiQ12690
KOiK02873
OMAiNILHNNH
OrthoDBiEOG092C53VP

Family and domain databases

HAMAPiMF_00499 Ribosomal_L13e, 1 hit
InterProiView protein in InterPro
IPR001380 Ribosomal_L13e
IPR018256 Ribosomal_L13e_CS
PANTHERiPTHR11722 PTHR11722, 1 hit
PfamiView protein in Pfam
PF01294 Ribosomal_L13e, 1 hit
PROSITEiView protein in PROSITE
PS01104 RIBOSOMAL_L13E, 1 hit

Sequencei

Sequence statusi: Complete.

Q12690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISKNLPIL KNHFRKHWQE RVKVHFDQAG KKVSRRNARA TRAAKIAPRP
60 70 80 90 100
LDLLRPVVRA PTVKYNRKVR AGRGFTLAEV KAAGLTAAYA RTIGIAVDHR
110 120 130 140 150
RQNRNQEIFD ANVQRLKEYQ SKIIVFPRNG KAPEAEQVLS AAATFPIAQP
160 170 180 190
ATDVEARAVQ DNGESAFRTL RLARSEKKFR GIREKRAREK AEAEAEKKK
Length:199
Mass (Da):22,554
Last modified:November 1, 1996 - v1
Checksum:iEA7CC5F1F3C0335A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74130 Genomic DNA Translation: CAA98648.1
BK006938 Genomic DNA Translation: DAA11777.1
PIRiS67618
RefSeqiNP_010201.1, NM_001180141.1

Genome annotation databases

EnsemblFungiiYDL082W; YDL082W; YDL082W
GeneIDi851477
KEGGisce:YDL082W

Similar proteinsi

Entry informationi

Entry nameiRL13A_YEAST
AccessioniPrimary (citable) accession number: Q12690
Secondary accession number(s): D6VRR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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