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Q12679

- GUNA_ASPKW

UniProt

Q12679 - GUNA_ASPKW

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Protein

Endoglucanase A

Gene

cekA

Organism
Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has carboxylmethylcellulase activity.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH12. Glycoside Hydrolase Family 12.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase A (EC:3.2.1.4)
Alternative name(s):
CMCase-I
Carboxymethylcellulase
Cellulase A
Endo-1,4-beta-glucanase A
Gene namesi
Name:cekA
ORF Names:AKAW_05147
OrganismiAspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi)
Taxonomic identifieri1033177 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006812: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 239223Endoglucanase APRO_0000008019Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ12679.
OrthoDBiEOG72VHHK.

Family and domain databases

Gene3Di2.60.120.180. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR013319. Glyco_hydro_11/12.
IPR002594. Glyco_hydro_12.
[Graphical view]
PfamiPF01670. Glyco_hydro_12. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12679-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSMTLSLF AATAMGQTMC SQYDSASSPP YSVNQNLWGE YQGTGSQCVY
60 70 80 90 100
VDKLSSSGAS WHTKWTWSGG EGTVKSYSNS GLTFDKKLVS DVSSIPTSVT
110 120 130 140 150
WSQDDTNVQA DVSYDLFTAA NADHATSSGD YELMIWLARY GSVQPIGKQI
160 170 180 190 200
ATATVGGKSW EVWYGTSTQA GAEQKTYSFV AGSPINSWSG DIKDFFNYLT
210 220 230
QNQGFPASSQ HLITLQFGTE PFTGGPATFT VDNWTASVN
Length:239
Mass (Da):25,813
Last modified:March 21, 2012 - v2
Checksum:iE3B0304A13827066
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171F → C in BAA02297. (PubMed:7586029)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12901 mRNA. Translation: BAA02297.1.
DF126458 Genomic DNA. Translation: GAA87033.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12901 mRNA. Translation: BAA02297.1 .
DF126458 Genomic DNA. Translation: GAA87033.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH12. Glycoside Hydrolase Family 12.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi Q12679.
OrthoDBi EOG72VHHK.

Family and domain databases

Gene3Di 2.60.120.180. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR013319. Glyco_hydro_11/12.
IPR002594. Glyco_hydro_12.
[Graphical view ]
Pfami PF01670. Glyco_hydro_12. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of cellulase cDNA from Aspergillus kawachii and its expression in Saccharomyces cerevisiae."
    Sakamoto S., Tamura G., Ito K., Ishikawa T., Iwano K., Nishiya N.
    Curr. Genet. 27:435-439(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NBRC 4308.
  2. "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used for brewing the Japanese distilled spirit shochu."
    Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H., Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.
    Eukaryot. Cell 10:1586-1587(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBRC 4308.

Entry informationi

Entry nameiGUNA_ASPKW
AccessioniPrimary (citable) accession number: Q12679
Secondary accession number(s): G7XJV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2012
Last modified: November 26, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3