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Q12679 (GUNA_ASPKW) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoglucanase A

EC=3.2.1.4
Alternative name(s):
CMCase-I
Carboxymethylcellulase
Cellulase A
Endo-1,4-beta-glucanase A
Gene names
Name:cekA
ORF Names:AKAW_05147
OrganismAspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi) [Complete proteome]
Taxonomic identifier1033177 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has carboxylmethylcellulase activity.

Catalytic activity

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sequence similarities

Belongs to the glycosyl hydrolase 12 (cellulase H) family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncellulase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 239223Endoglucanase A
PRO_0000008019

Experimental info

Sequence conflict2171F → C in BAA02297. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q12679 [UniParc].

Last modified March 21, 2012. Version 2.
Checksum: E3B0304A13827066

FASTA23925,813
        10         20         30         40         50         60 
MKLSMTLSLF AATAMGQTMC SQYDSASSPP YSVNQNLWGE YQGTGSQCVY VDKLSSSGAS 

        70         80         90        100        110        120 
WHTKWTWSGG EGTVKSYSNS GLTFDKKLVS DVSSIPTSVT WSQDDTNVQA DVSYDLFTAA 

       130        140        150        160        170        180 
NADHATSSGD YELMIWLARY GSVQPIGKQI ATATVGGKSW EVWYGTSTQA GAEQKTYSFV 

       190        200        210        220        230 
AGSPINSWSG DIKDFFNYLT QNQGFPASSQ HLITLQFGTE PFTGGPATFT VDNWTASVN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of cellulase cDNA from Aspergillus kawachii and its expression in Saccharomyces cerevisiae."
Sakamoto S., Tamura G., Ito K., Ishikawa T., Iwano K., Nishiya N.
Curr. Genet. 27:435-439(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NBRC 4308.
[2]"Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used for brewing the Japanese distilled spirit shochu."
Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H., Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.
Eukaryot. Cell 10:1586-1587(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NBRC 4308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D12901 mRNA. Translation: BAA02297.1.
DF126458 Genomic DNA. Translation: GAA87033.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH12. Glycoside Hydrolase Family 12.
mycoCLAPEGL12A_ASPKA.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG72VHHK.

Family and domain databases

Gene3D2.60.120.180. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013319. Glyco_hydro_11/12.
IPR002594. Glyco_hydro_12.
[Graphical view]
PfamPF01670. Glyco_hydro_12. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGUNA_ASPKW
AccessionPrimary (citable) accession number: Q12679
Secondary accession number(s): G7XJV2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2012
Last modified: November 13, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries