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Q12679

- GUNA_ASPKW

UniProt

Q12679 - GUNA_ASPKW

Protein

Endoglucanase A

Gene

cekA

Organism
Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Has carboxylmethylcellulase activity.

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH12. Glycoside Hydrolase Family 12.
    mycoCLAPiEGL12A_ASPKA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase A (EC:3.2.1.4)
    Alternative name(s):
    CMCase-I
    Carboxymethylcellulase
    Cellulase A
    Endo-1,4-beta-glucanase A
    Gene namesi
    Name:cekA
    ORF Names:AKAW_05147
    OrganismiAspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi)
    Taxonomic identifieri1033177 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006812: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 239223Endoglucanase APRO_0000008019Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG72VHHK.

    Family and domain databases

    Gene3Di2.60.120.180. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013319. Glyco_hydro_11/12.
    IPR002594. Glyco_hydro_12.
    [Graphical view]
    PfamiPF01670. Glyco_hydro_12. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q12679-1 [UniParc]FASTAAdd to Basket

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    MKLSMTLSLF AATAMGQTMC SQYDSASSPP YSVNQNLWGE YQGTGSQCVY    50
    VDKLSSSGAS WHTKWTWSGG EGTVKSYSNS GLTFDKKLVS DVSSIPTSVT 100
    WSQDDTNVQA DVSYDLFTAA NADHATSSGD YELMIWLARY GSVQPIGKQI 150
    ATATVGGKSW EVWYGTSTQA GAEQKTYSFV AGSPINSWSG DIKDFFNYLT 200
    QNQGFPASSQ HLITLQFGTE PFTGGPATFT VDNWTASVN 239
    Length:239
    Mass (Da):25,813
    Last modified:March 21, 2012 - v2
    Checksum:iE3B0304A13827066
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti217 – 2171F → C in BAA02297. (PubMed:7586029)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12901 mRNA. Translation: BAA02297.1.
    DF126458 Genomic DNA. Translation: GAA87033.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12901 mRNA. Translation: BAA02297.1 .
    DF126458 Genomic DNA. Translation: GAA87033.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH12. Glycoside Hydrolase Family 12.
    mycoCLAPi EGL12A_ASPKA.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG72VHHK.

    Family and domain databases

    Gene3Di 2.60.120.180. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013319. Glyco_hydro_11/12.
    IPR002594. Glyco_hydro_12.
    [Graphical view ]
    Pfami PF01670. Glyco_hydro_12. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of cellulase cDNA from Aspergillus kawachii and its expression in Saccharomyces cerevisiae."
      Sakamoto S., Tamura G., Ito K., Ishikawa T., Iwano K., Nishiya N.
      Curr. Genet. 27:435-439(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NBRC 4308.
    2. "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used for brewing the Japanese distilled spirit shochu."
      Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H., Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.
      Eukaryot. Cell 10:1586-1587(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBRC 4308.

    Entry informationi

    Entry nameiGUNA_ASPKW
    AccessioniPrimary (citable) accession number: Q12679
    Secondary accession number(s): G7XJV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3