Reviewed,
UniProtKB/Swiss-Prot Q12676 (FOLD_YEAST)
Last modified
June 16, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Folylpolyglutamate synthase EC=6.3.2.17 Alternative name(s): Folylpoly-gamma-glutamate synthetase Short name=FPGS Tetrahydrofolylpolyglutamate synthase Short name=Tetrahydrofolate synthase | ||||||
| Gene names |
| ||||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 427 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Conversion of folates to polyglutamate derivatives. |
| Catalytic activity | ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). |
| Pathway | Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. |
| Subcellular location | |
| Miscellaneous | Present with 2340 molecules/cell in log phase SD medium. Ref.4 |
| Sequence similarities | Belongs to the folylpolyglutamate synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | folic acid and derivative biosynthetic process Inferred from mutant phenotype. Source: SGD one-carbon compound metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Ref.3 Inferred from direct assay. Source: SGD |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW dihydrofolate synthase activityInferred from mutant phenotype. Source: SGD tetrahydrofolylpolyglutamate synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. Barrell B.G.Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [2] | "Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae." Cherest H., Thomas D., Surdin-Kerjan Y. J. Biol. Chem. 275:14056-14063(2000) [PubMed: 10799479] [Abstract] Cited for: CHARACTERIZATION. |
| [3] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [4] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z49702 Genomic DNA. Translation: CAA89750.1. | |
| PIR | S54574. |
| RefSeq | NP_013831.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FGS based on UniProtKB P15925. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | YMR113W. Saccharomyces cerevisiae. [Contig view] |
| GeneID | 855140. |
| GenomeReviews | Gene locus YMR113W in contig Z71257_GR. |
| KEGG | sce:YMR113W. |
| NMPDR | fig|4932.3.peg.4879. |
Organism-specific databases | |
| CYGD | YMR113w. |
| SGD | S000004719. FOL3. |
| Yeast-GFP | Search... |
Phylogenomic databases | |
| HOGENOM | Q12676. |
| OMA | Q12676. HPYTHAV. |
Enzyme and pathway databases | |
| BRENDA | 6.3.2.17. 250. |
Gene expression databases | |
| ArrayExpress | Q12676. |
| GermOnline | YMR113W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR018109. Folylpolyglutamate_synth_CS. IPR001645. Fpolygl_synthtse. IPR013221. Mur_ligase_cen. [Graphical view] |
| Gene3D | G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. |
| PANTHER | PTHR11136. Fpolygl_synthtse. 1 hit. |
| Pfam | PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01499. folC. 1 hit. |
| PROSITE | PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit. PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 978528. |
Entry information
| Entry name | FOLD_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q12676 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XIII Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names |

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