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Q12669 (KPYK_ASPNG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:pkiA
OrganismAspergillus niger
Taxonomic identifier5061 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Pyruvate kinase
PRO_0000112108

Sites

Metal binding651Potassium By similarity
Metal binding671Potassium By similarity
Metal binding981Potassium By similarity
Metal binding991Potassium; via carbonyl oxygen By similarity
Metal binding2561Magnesium Potential
Metal binding2801Magnesium By similarity
Binding site631Substrate By similarity
Binding site2791Substrate; via amide nitrogen By similarity
Binding site2801Substrate; via amide nitrogen By similarity
Binding site3121Substrate By similarity
Binding site3511ADP Potential
Site2541Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12669 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8B7ED999C46D780C

FASTA52658,134
        10         20         30         40         50         60 
MAASSSLDHL SNRMKLEWHS KLNTEMVPSK NFRRTSIIGT IGPKTNSVEK INSLRTAGLN 

        70         80         90        100        110        120 
VVRMNFSHGS YQYHQSVIDN AREAAKTQVG RPLAIALDTK GPEIRTGNTP DDKDIPIKQG 

       130        140        150        160        170        180 
HELNITTDEQ YATASDDKNM YLDYKNITKV ISPGKLIYVD DGILSFEVLE VVDDKTIRVR 

       190        200        210        220        230        240 
CLNNGNISSR KGVNLPGTDV DLPALSEKDI ADLKFGVRNK VDMVFASFIR RGSDIRHIRE 

       250        260        270        280        290        300 
VLGEEGKEIQ IIAKIENQQG VNNFDEILEE TDGVMVARGD LGIEIPAPKV FIAQKMMIAK 

       310        320        330        340        350        360 
CNIKGKPVIC ATQMLESMTY NPRPTRAEVS DVANAVLDGA DCVMLSGETA KGNYPNEAVK 

       370        380        390        400        410        420 
MMSETCLLAE VAIPHFNVFD ELRNLAPRPT DTVESIAMAA VSASLELNAG AIVVLTTSGK 

       430        440        450        460        470        480 
TARYLSKYRP VCPIVMVTRN PAASRYSHLY RGVWPFLFPE KKPDFNVKVW QEDVDRRLKW 

       490        500        510        520 
GINHALKLGI INKGDNIVCV QGWRGGMGHT NTVRVVPAEE NLGLAE 

« Hide

References

[1]"Isolation and characterization of the Aspergillus niger pyruvate kinase gene."
de Graaff L., van den Broeck H., Visser J.
Curr. Genet. 22:21-27(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 9089 / N402.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S38698 Genomic DNA. Translation: AAB22392.1.
PIRS26869.

3D structure databases

ProteinModelPortalQ12669.
SMRQ12669. Positions 31-515.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ12669.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0469.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_ASPNG
AccessionPrimary (citable) accession number: Q12669
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways