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Q12669

- KPYK_ASPNG

UniProt

Q12669 - KPYK_ASPNG

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Protein

Pyruvate kinase

Gene
pkiA
Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631Substrate By similarity
Metal bindingi65 – 651Potassium By similarity
Metal bindingi67 – 671Potassium By similarity
Metal bindingi98 – 981Potassium By similarity
Metal bindingi99 – 991Potassium; via carbonyl oxygen By similarity
Sitei254 – 2541Transition state stabilizer By similarity
Metal bindingi256 – 2561Magnesium Reviewed prediction
Binding sitei279 – 2791Substrate; via amide nitrogen By similarity
Metal bindingi280 – 2801Magnesium By similarity
Binding sitei280 – 2801Substrate; via amide nitrogen By similarity
Binding sitei312 – 3121Substrate By similarity
Binding sitei351 – 3511ADP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pkiA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Pyruvate kinasePRO_0000112108Add
BLAST

Proteomic databases

PRIDEiQ12669.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ12669.
SMRiQ12669. Positions 31-515.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12669-1 [UniParc]FASTAAdd to Basket

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MAASSSLDHL SNRMKLEWHS KLNTEMVPSK NFRRTSIIGT IGPKTNSVEK    50
INSLRTAGLN VVRMNFSHGS YQYHQSVIDN AREAAKTQVG RPLAIALDTK 100
GPEIRTGNTP DDKDIPIKQG HELNITTDEQ YATASDDKNM YLDYKNITKV 150
ISPGKLIYVD DGILSFEVLE VVDDKTIRVR CLNNGNISSR KGVNLPGTDV 200
DLPALSEKDI ADLKFGVRNK VDMVFASFIR RGSDIRHIRE VLGEEGKEIQ 250
IIAKIENQQG VNNFDEILEE TDGVMVARGD LGIEIPAPKV FIAQKMMIAK 300
CNIKGKPVIC ATQMLESMTY NPRPTRAEVS DVANAVLDGA DCVMLSGETA 350
KGNYPNEAVK MMSETCLLAE VAIPHFNVFD ELRNLAPRPT DTVESIAMAA 400
VSASLELNAG AIVVLTTSGK TARYLSKYRP VCPIVMVTRN PAASRYSHLY 450
RGVWPFLFPE KKPDFNVKVW QEDVDRRLKW GINHALKLGI INKGDNIVCV 500
QGWRGGMGHT NTVRVVPAEE NLGLAE 526
Length:526
Mass (Da):58,134
Last modified:November 1, 1996 - v1
Checksum:i8B7ED999C46D780C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S38698 Genomic DNA. Translation: AAB22392.1.
PIRiS26869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S38698 Genomic DNA. Translation: AAB22392.1 .
PIRi S26869.

3D structure databases

ProteinModelPortali Q12669.
SMRi Q12669. Positions 31-515.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q12669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0469.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the Aspergillus niger pyruvate kinase gene."
    de Graaff L., van den Broeck H., Visser J.
    Curr. Genet. 22:21-27(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9089 / N402.

Entry informationi

Entry nameiKPYK_ASPNG
AccessioniPrimary (citable) accession number: Q12669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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