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Protein

Adenylyl-sulfate kinase

Gene
N/A
Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of activated sulfate.

Catalytic activityi

ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes sulfite from sulfate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase (MET3), Sulfate adenylyltransferase (met3)
  2. Adenylyl-sulfate kinase, Adenylyl-sulfate kinase (EN45_032050)
  3. no protein annotated in this organism
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107Phosphoserine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesis, Methionine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.25. 4606.
UniPathwayiUPA00140; UER00205.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl-sulfate kinase (EC:2.7.1.25)
Alternative name(s):
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase
Short name:
APS kinase
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001059321 – 211Adenylyl-sulfate kinaseAdd BLAST211

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi500485.XP_002559252.1.

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 10Combined sources4
Helixi14 – 21Combined sources8
Beta strandi26 – 31Combined sources6
Helixi34 – 36Combined sources3
Helixi38 – 53Combined sources16
Beta strandi57 – 60Combined sources4
Helixi62 – 65Combined sources4
Turni66 – 72Combined sources7
Helixi77 – 96Combined sources20
Beta strandi100 – 104Combined sources5
Helixi110 – 121Combined sources12
Beta strandi133 – 139Combined sources7
Helixi142 – 146Combined sources5
Helixi153 – 158Combined sources6
Beta strandi161 – 164Combined sources4
Turni166 – 168Combined sources3
Beta strandi179 – 183Combined sources5
Beta strandi185 – 187Combined sources3
Helixi189 – 202Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D6JX-ray2.00A/B1-211[»]
1M7GX-ray1.43A/B/C/D1-211[»]
1M7HX-ray2.00A/B/C/D1-211[»]
3CR7X-ray2.50A/B/C/D23-211[»]
ProteinModelPortaliQ12657.
SMRiQ12657.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12657.

Family & Domainsi

Sequence similaritiesi

Belongs to the APS kinase family.Curated

Phylogenomic databases

eggNOGiKOG0635. Eukaryota.
COG0529. LUCA.

Family and domain databases

CDDicd02027. APSK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNITFHAS ALTRSERTEL RNQRGLTIWL TGLSASGKST LAVELEHQLV
60 70 80 90 100
RDRRVHAYRL DGDNIRFGLN KDLGFSEADR NENIRRIAEV AKLFADSNSI
110 120 130 140 150
AITSFISPYR KDRDTARQLH EVATPGEETG LPFVEVYVDV PVEVAEQRDP
160 170 180 190 200
KGLYKKAREG VIKEFTGISA PYEAPANPEV HVKNYELPVQ DAVKQIIDYL
210
DTKGYLPAKK E
Length:211
Mass (Da):23,770
Last modified:November 1, 1996 - v1
Checksum:i7DDC4BDA867FE7C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39393 Genomic DNA. Translation: AAA81521.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39393 Genomic DNA. Translation: AAA81521.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D6JX-ray2.00A/B1-211[»]
1M7GX-ray1.43A/B/C/D1-211[»]
1M7HX-ray2.00A/B/C/D1-211[»]
3CR7X-ray2.50A/B/C/D23-211[»]
ProteinModelPortaliQ12657.
SMRiQ12657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.XP_002559252.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0635. Eukaryota.
COG0529. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00205.
BRENDAi2.7.1.25. 4606.

Miscellaneous databases

EvolutionaryTraceiQ12657.

Family and domain databases

CDDicd02027. APSK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAPS_PENCH
AccessioniPrimary (citable) accession number: Q12657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.