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Protein

Endoglucanase B

Gene

CELB

Organism
Neocallimastix patriciarum (Rumen fungus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Rate of hydrolysis of cellulo-oligosaccharides increased with increasing chain length from cellotriose to cellopentaose.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei173Proton donorBy similarity1
Active sitei295NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH5 Glycoside Hydrolase Family 5
mycoCLAPiEGL5B_NEOPA

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase B (EC:3.2.1.4)
Alternative name(s):
Cellulase B
Endo-1,4-beta-glucanase B
Gene namesi
Name:CELB
OrganismiNeocallimastix patriciarum (Rumen fungus)
Taxonomic identifieri4758 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisChytridiomycotaNeocallimastigomycetesNeocallimastigalesNeocallimastigaceaeNeocallimastix

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000786418 – 473Endoglucanase BAdd BLAST456

Structurei

3D structure databases

ProteinModelPortaliQ12647
SMRiQ12647
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini391 – 427CBM10 1PROSITE-ProRule annotationAdd BLAST37
Domaini436 – 473CBM10 2PROSITE-ProRule annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 367CatalyticAdd BLAST350
Regioni365 – 387LinkerAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi376 – 381Poly-Thr6

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di3.90.1220.10, 2 hits
InterProiView protein in InterPro
IPR002883 CBM10/Dockerin_dom
IPR009034 Dockerin_dom_fun_sf
IPR001547 Glyco_hydro_5
IPR018087 Glyco_hydro_5_CS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF02013 CBM_10, 2 hits
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF64571 SSF64571, 2 hits
PROSITEiView protein in PROSITE
PS51763 CBM10, 2 hits
PS00659 GLYCOSYL_HYDROL_F5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLNTFSLL SLAIIGSKAM KNISSKELVK DLTIGWSLGN TLDATCFETL
60 70 80 90 100
DYNKNQIASE TCWGNVKTTQ ELYYKLSDLG FNTFRIPTTW SGHFGNAPDY
110 120 130 140 150
KINDQWMKRV HEIVDYAINT GGYAILNIHH ETWNHAFQKN LESAKKILVA
160 170 180 190 200
IWKQIAAEFA DYDEHLIFEG MNEPRKVGDP AEWNGGDYEG WNFVNEMNDL
210 220 230 240 250
FVKTIRATGG NNALRHLMIP TYAACINDGA INNFKFPSGD DKVIVSLHSY
260 270 280 290 300
SPYNFALNNG AGAISNFYDG SEIDWAMNTI NSKFISRGIP VIIGEFGAMN
310 320 330 340 350
RNNEDDRERW AEYYIKKATS IGVPCVIWDN GYFEGEGERF GLINRSTLQV
360 370 380 390 400
VYPKLVNGLI KGLGNSIKTR TTIRRTTTTT TSQSQPTNND SCFSVNLGYS
410 420 430 440 450
CCNGCEVEYT DSDGEWGVEN GNWCGIKSSC SNTSRICWSE KLGYPCCQNT
460 470
SSVVYTDNDG KWGVENGNWC GIY
Length:473
Mass (Da):53,070
Last modified:November 1, 1996 - v1
Checksum:iB11D9F171EA33199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31364 mRNA Translation: CAA83238.1
PIRiS40507

Similar proteinsi

Entry informationi

Entry nameiGUNB_NEOPA
AccessioniPrimary (citable) accession number: Q12647
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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