Reviewed, UniProtKB/Swiss-Prot Q12641 (P5CR_NEUCR)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

Name:	pro-1
ORF Names:	NCU06471

Organism

Neurospora crassa [Complete proteome]

Taxonomic identifier

5141 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.
Sequence caution	The sequence AAA83568.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAA83568.1 differs from that shown. Reason: Frameshift at positions 9, 12 and 16.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Pyrroline-5-carboxylate reductase		PRO_0000187326

Sequences

	Sequence		Length	Mass (Da)
	Q12641-1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 605F1E2FD6FEEB86	FASTA	332	34,215
	10 20 30 40 50 60 MAAPQVKSSS ELTMAVLGCG TMGISILSGI LSSLSSIAQD PSPPPTNPPA LPRHFIATVR 70 80 90 100 110 120 SPSSVAKVES ALSPLVKPSV STLRVLQSTS NVSAAAEADI ILLGCKPYMV SGLLSASGMK 130 140 150 160 170 180 DALTVKHTEG HARSQKIIIS ICAGVTVPDL ERVLREDVGL SADNLPIVVR AMPNTASKIR 190 200 210 220 230 240 ESMTVINTVD PPLPDTVTEL LTWIFERIGE VVYLPPHLMD ACTSLCASGT AFFALMMEAA 250 260 270 280 290 300 ADGGVAMGLP RAEANRMAAQ TMRGAAGLVL EGEHPAILRE KVSTPGGCTI GGLLVLEEGG 310 320 330 VRAAVARAVR EATVVASLLG GGGAKNVNGT RH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of the proline-1 (pro-1) locus of Neurospora crassa, which encodes delta 1-pyrroline-5-carboxylate reductase." Davis C.R., McPeek M.A., McClung C.R. Mol. Gen. Genet. 248:341-350(1995) [PubMed: 7565596] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U30317 Genomic DNA. Translation: AAA83568.1. Sequence problems. AABX02000027 Genomic DNA. Translation: EAA28126.2.
PIR	S57863.
RefSeq	XP_957362.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3873483.
KEGG	ncr:NCU06471.
NMPDR	fig|5141.1.peg.4259.
Enzyme and pathway databases
BioCyc	NCRA-XX3-01:NCRA-XX3-01-001330-MON.
Family and domain databases
InterPro	IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
PANTHER	PTHR11645. P5CR. 2 hits.
Pfam	PF03807. F420_oxidored. 2 hits. [Graphical view]
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_NEUCR

Accession

Primary (citable) accession number: Q12641
Secondary accession number(s): Q7RV72

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	December 4, 2007
Last modified:	November 25, 2008
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)