Q12632 (CHS1_RHIRA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chitin synthase 1
EC=2.4.1.16

Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 1
Class-II chitin synthase 1

Gene names

Name:

CHS1

Organism

Rhizomucor racemosus (Mucor circinelloides f. lusitanicus)

Taxonomic identifier

4841 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Mucoraceae › Mucor

Protein attributes

Sequence length	852 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a major role in cell wall biogenesis.
Catalytic activity	UDP-N-acetyl-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the chitin synthase family. Class II subfamily.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW chitin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chitin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 852	852	Chitin synthase 1		PRO_0000193713
Regions
	Transmembrane	492 – 509	18	Helical; Potential
	Transmembrane	532 – 552	21	Helical; Potential
	Transmembrane	572 – 592	21	Helical; Potential
	Transmembrane	601 – 621	21	Helical; Potential
	Transmembrane	686 – 706	21	Helical; Potential
	Transmembrane	787 – 807	21	Helical; Potential
	Transmembrane	830 – 850	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q12632 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: CB7CC0EB60FF8FA3	FASTA	852	95,851
	10 20 30 40 50 60 MPSIKKQENS NAGGWFSSWF FSNTANEDQD DMLPSTSAAA GETNYARNQQ TLSSLRSQKS 70 80 90 100 110 120 ANKPTTAQNR NSAATLVRTD TESYLDAPKS SRDQANGVLR RKVTRRLQLT NNNLVIDCPI 130 140 150 160 170 180 PDRLLGALTF NDHDEFSQLR YTAATCEPDE FESRGFTLRP KIYNRETELF IVMTMYNEDE 190 200 210 220 230 240 ILFTRTMHGV MKNIAHLCSL KKSTMWGPDG WKKVVVCIVA DGRQVVNKKV LDVLASMGVY 250 260 270 280 290 300 QAGIAKNVVD DKPVKAHIYE YTTQISIDSD MNIKGSDKGI VPVQIMFCLK EKNAKKINSH 310 320 330 340 350 360 RWFFNAFGPI IKPNVCILLD VGTRPGNSSI YQLWKVFDRN PLIGGACGEI RAMLGTACCQ 370 380 390 400 410 420 LLNPLVAAQN FEYKMSNILD KPLESVFGYI SVLPGAFSAY RYAALKNDVN GHGPLEKYFI 430 440 450 460 470 480 GEDLHSNLQG SSQSIKNTGL FEANMYLAED RILCFELVAK KDERWLLQYV GSAFGETDVP 490 500 510 520 530 540 SQLPEFISQR RRWLNGSFFA GVYGLIHFRK IWNSGHGFNR TLLLMIEGIY NVISLVFSWF 550 560 570 580 590 600 SVGNFYIAFY FITKSLSASN VDPFGNGWGS RIFDFCKYAY AFLLFVIFIC SMGNRPQGSK 610 620 630 640 650 660 FLFMACLVGF AIIMCYMLFC SSWLIYKGIQ LAAEKYDWTY DTTTNFQIAM SDPGLRNMVI 670 680 690 700 710 720 SLSSTYGIYL VSSCLHRQPF HMMTSFLPYL LLLPGYINIL NIYAFCNTHD VSWGTKGDNS 730 740 750 760 770 780 VAKDLGVVKV SEKEKGVKTV EIELPADQHD INCQYDEALF ALDEKPSKDT GSGGSLTKDD 790 800 810 820 830 840 YYRSFRTHLV LAWIACNALL VVFITTSDYE SIFNASVGTT YMSIMLWVNC GLGIFRFLGS 850 IMFLLLGIFT SG

References

[1]	Lopez-Matas A. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 1216b / CBS 277.49 / NRRL 3631.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99420 Genomic DNA. Translation: CAA67797.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004834. Chitin_synth. IPR013616. Chitin_synth_N. [Graphical view]
Pfam	PF01644. Chitin_synth_1. 1 hit. PF08407. Chitin_synth_1N. 1 hit. [Graphical view]
ProDom	PD002998. Chitin_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

CHS1_RHIRA

Accession

Primary (citable) accession number: Q12632

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	August 10, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program