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Q12626

- EXG_PICAN

UniProt

Q12626 - EXG_PICAN

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Protein
Glucan 1,3-beta-glucosidase
Gene
N/A
Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei222 – 2221Proton donor By similarity
Active sitei323 – 3231Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.
mycoCLAPiEXG5A_PICAN.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan 1,3-beta-glucosidase (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase
OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifieri870730 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 435405Glucan 1,3-beta-glucosidase
PRO_0000007886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi306 ↔ 432 By similarity
Disulfide bondi331 ↔ 357 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ12626.
SMRiQ12626. Positions 41-435.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

PhylomeDBiQ12626.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12626-1 [UniParc]FASTAAdd to Basket

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MLFPVLHLPK AMKFSSFSLI ASSLLSLVAA APVTLLKRDS RWDYANDKIY    50
GVNIGGWLVL EPFITPSLFE AVSSDVPVDE YHYTEALGKE EAEKRLQEHW 100
STWIKEEDFK GMANAGLNFV RIPIGYWAFQ LAEGDPYVQG QQEYLDKALE 150
WCAKYGLKAW VDLHGAPGSQ NGFDNSGKRG EIGWQNTTGY VDLTVQVLDQ 200
LTSKYGGSNY SDVIIGIELL NEPLGSYLDF DQLVDFYNKG YQLVRNNGNA 250
PVIIHDAYLP DHTFDNVLNT EQDPNVWEVI VDHHHYQVFD EGSLSQSIDE 300
HVSTACGWGQ SENTEYHYSL CGEWTAALTD CAKWLNGAGR GARYDATFGG 350
GNYIGSCDQL YTANYDYFTP EVISNYRRYV EAQMDSFLYG KNAGWVFWCW 400
KTENTIEWDM QRLLGLGIIP QPLDDRQYPN QCGFS 435
Length:435
Mass (Da):49,264
Last modified:November 1, 1996 - v1
Checksum:i840C22F271CC87A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46868 Genomic DNA. Translation: CAA86948.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46868 Genomic DNA. Translation: CAA86948.1 .

3D structure databases

ProteinModelPortali Q12626.
SMRi Q12626. Positions 41-435.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH5. Glycoside Hydrolase Family 5.
mycoCLAPi EXG5A_PICAN.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

PhylomeDBi Q12626.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of 1,3-beta-glucanase-encoding genes from non-conventional yeasts."
    Esteban P.F., Vazquez de Aldana C.R., del Rey F.
    Yeast 15:91-109(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 14754 / CBS 1976 / JCM 3620 / NBRC 0799 / NCYC 495 / NRRL Y-1798 / VKM Y-1397.

Entry informationi

Entry nameiEXG_PICAN
AccessioniPrimary (citable) accession number: Q12626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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