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Protein

Acyl-CoA desaturase

Gene

Ole1

Organism
Histoplasma capsulatum var. capsulatum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Stearyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.UniRule annotation

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Expected to bind 2 Fe2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processElectron transportUniRule annotation, Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport
LigandHemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA desaturaseUniRule annotation (EC:1.14.19.1UniRule annotation)
Gene namesi
Name:Ole1Imported
OrganismiHistoplasma capsulatum var. capsulatumImported
Taxonomic identifieri278162 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Transmembranei82 – 103HelicalSequence analysisAdd BLAST22
Transmembranei199 – 217HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ12619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini349 – 427Cytochrome b5 heme-bindingInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the fatty acid desaturase type 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR009160 Acyl-CoA_deSatase_haem/ster-bd
IPR015876 Acyl-CoA_DS
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR005804 FA_desaturase_dom
IPR001522 FADS-1_CS
PANTHERiPTHR11351 PTHR11351, 1 hit
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF00487 FA_desaturase, 1 hit
PIRSFiPIRSF000345 OLE1, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
PR00075 FACDDSATRASE
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit
PS00476 FATTY_ACID_DESATUR_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q12619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALNEAPTAT PAAETAAGGK AVTTDTARRP NPEPKKVHIT DTPITLANWH
60 70 80 90 100
KHVSWLNVTL IIVIPIYGLV QAYWVPLHLK TALWAVVYYF MTGLGITAGY
110 120 130 140 150
HRLWAHCSYS ATLPLKIYLA AVGGGAVEGS IRWWARGHRA HHRYTDTDKD
160 170 180 190 200
PYSAHKGLLY SHIGWMVMKQ NPKRIGRTDI TDLNEDPVVV WQHRNYLKVV
210 220 230 240 250
IFMGIVFPML VSGLGWGDWL GGFIYAGILR IFFVQQATFC VNSLAHWLGD
260 270 280 290 300
QPFDDRNSPR DHIVTALVTL GEGYHNFHHE FPSDYRNAIE WHQYDPTKWS
310 320 330 340 350
IWIWKQLGLA YDLKQFRANE IEKGRVQQLQ KKIDQRRVKL DWGIPLDQLP
360 370 380 390 400
VIEWDDYVDQ AKNGRGLIAI AGVVHDVTDF IKDHPGGKAM INTGIGKDAT
410 420 430 440 450
AMFNGGVYNH SNAAHNLLST MRVGVIRGGC EVEIWKRAQK EKKEVESVRD
460 470
EYGNRIVRAG AQVTKIPEPI TTADAA
Length:476
Mass (Da):53,707
Last modified:November 1, 1996 - v1
Checksum:i27A0B152AF621D2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85962 Genomic DNA Translation: CAA59938.1
PIRiS52746

Similar proteinsi

Entry informationi

Entry nameiQ12619_AJECA
AccessioniPrimary (citable) accession number: Q12619
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health