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Q12604

- PYRF_DIPMG

UniProt

Q12604 - PYRF_DIPMG

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Dipodascus magnusii (Yeast) (Endomyces magnusii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421SubstrateBy similarity
Active sitei98 – 981Proton donorPROSITE-ProRule annotation
Binding sitei237 – 2371SubstrateBy similarity
Binding sitei255 – 2551SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiDipodascus magnusii (Yeast) (Endomyces magnusii)
Taxonomic identifieri43963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeMagnusiomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Orotidine 5'-phosphate decarboxylasePRO_0000134660Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ12604.
SMRiQ12604. Positions 11-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 663Substrate bindingBy similarity
Regioni96 – 10510Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12604-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTSTQITKP YSTRALTHQS QTARRLLKLM SDKRTNLCAS LDVTTSAELL
60 70 80 90 100
SLADKLGPYI CMVKTHVDII SDFTYDETVV KLVALAKKHG FMIFEDRKFA
110 120 130 140 150
DIGNTVKNQY SKGVYRIVEW ADITNAHSVP GEGIINGLRE AANEYVESEK
160 170 180 190 200
AKGGECENLD RGLIMLAELS SKGSLATGSY TTKTVELAHN NSDFVFGFIA
210 220 230 240 250
QNRMEEVQDS EGNYEDWLIL TPGVGLDDKG DGLGQQYRTV DTVIKNGSDV
260 270 280
IIVGRGLFGK GRDPVVEGKR YRDAGWKAYE ERIN
Length:284
Mass (Da):31,448
Last modified:November 1, 1997 - v1
Checksum:i0E8F8A38FDB8792E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95886 Genomic DNA. Translation: CAA65135.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95886 Genomic DNA. Translation: CAA65135.1 .

3D structure databases

ProteinModelPortali Q12604.
SMRi Q12604. Positions 11-282.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Adamikova L., Nosek J., Tomaska L.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 270.

Entry informationi

Entry nameiPYRF_DIPMG
AccessioniPrimary (citable) accession number: Q12604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3