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Q12604 (PYRF_DIPMG) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismDipodascus magnusii (Yeast) (Endomyces magnusii)
Taxonomic identifier43963 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeMagnusiomyces

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Orotidine 5'-phosphate decarboxylase
PRO_0000134660

Regions

Region64 – 663Substrate binding By similarity
Region96 – 10510Substrate binding By similarity

Sites

Active site981Proton donor By similarity
Binding site421Substrate By similarity
Binding site2371Substrate By similarity
Binding site2551Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q12604 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 0E8F8A38FDB8792E

FASTA28431,448
        10         20         30         40         50         60 
MSTSTQITKP YSTRALTHQS QTARRLLKLM SDKRTNLCAS LDVTTSAELL SLADKLGPYI 

        70         80         90        100        110        120 
CMVKTHVDII SDFTYDETVV KLVALAKKHG FMIFEDRKFA DIGNTVKNQY SKGVYRIVEW 

       130        140        150        160        170        180 
ADITNAHSVP GEGIINGLRE AANEYVESEK AKGGECENLD RGLIMLAELS SKGSLATGSY 

       190        200        210        220        230        240 
TTKTVELAHN NSDFVFGFIA QNRMEEVQDS EGNYEDWLIL TPGVGLDDKG DGLGQQYRTV 

       250        260        270        280 
DTVIKNGSDV IIVGRGLFGK GRDPVVEGKR YRDAGWKAYE ERIN 

« Hide

References

[1]Adamikova L., Nosek J., Tomaska L.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 270.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X95886 Genomic DNA. Translation: CAA65135.1.

3D structure databases

ProteinModelPortalQ12604.
SMRQ12604. Positions 11-282.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_DIPMG
AccessionPrimary (citable) accession number: Q12604
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways