Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q12595

- PYRF_CANPA

UniProt

Q12595 - PYRF_CANPA

Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Candida parapsilosis (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381SubstrateBy similarity
    Active sitei94 – 941Proton donorPROSITE-ProRule annotation
    Binding sitei218 – 2181SubstrateBy similarity
    Binding sitei236 – 2361SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:URA3
    OrganismiCandida parapsilosis (Yeast)
    Taxonomic identifieri5480 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Orotidine 5'-phosphate decarboxylasePRO_0000134652Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ12595.
    SMRiQ12595. Positions 6-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 623Substrate bindingBy similarity
    Regioni92 – 10110Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12595-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTNKSYRER SDTSSSPVTR RLFHLMEQKQ SNLCASVDVR TTKELLSLVD    50
    KLGPYICLVK THIDIIDDFS YEETILPLLE LSKKHKFMIF EDRKFADIGN 100
    TVKHQYTGGV YKIAKWADLT NAHGVTGEGV VKGLKEGAQE TTDEARGLLM 150
    LAELSSKGSL AYGEYSKKTI DIAKTDKDFV MGFIAQNYMG GTDEGFDWVI 200
    MTPGVGLDDK GDNLGQQYRT VDEVISKGTD VIIVGRGLFG KGRDPVVEGK 250
    RYKEAGWNAY LKRVAAGR 268
    Length:268
    Mass (Da):29,807
    Last modified:November 1, 1997 - v1
    Checksum:i6524EA2FCBD9FEFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99635 Genomic DNA. Translation: CAA67955.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99635 Genomic DNA. Translation: CAA67955.1 .

    3D structure databases

    ProteinModelPortali Q12595.
    SMRi Q12595. Positions 6-263.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Nosek J.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SR23 / CBS 7157.

    Entry informationi

    Entry nameiPYRF_CANPA
    AccessioniPrimary (citable) accession number: Q12595
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3