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Protein

Cytochrome P450 52A5

Gene

CYP52A5

Organism
Candida maltosa (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Together with an NADPH cytochrome P450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.

Catalytic activityi

Hydroxylation of N-alkanes at the terminal position.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi473 – 4731Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 52A5 (EC:1.14.14.-)
Alternative name(s):
Alkane-inducible P450-ALK2-A
CYPLIIA5
Gene namesi
Name:CYP52A5
OrganismiCandida maltosa (Yeast)
Taxonomic identifieri5479 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Cytochrome P450 52A5PRO_0000423538Add
BLAST

Expressioni

Inductioni

By N-alkanes.

Structurei

3D structure databases

ProteinModelPortaliQ12581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002974. Cyt_P450_E_CYP52.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01239. EP450IICYP52.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDSTIHEL IQSYITKWYV IVPLAIIIYK VFDYFYVLSL RKRLGAAVPT
60 70 80 90 100
NEETDGYFGF HLPFVLMSKK KDGTIIDFSI ERYPELKHPE TPTFEFPIFT
110 120 130 140 150
VKLISTIDPE NIKAILATQF SDFSLGTRHA HFAPLIGDGI FTLDGAGWKH
160 170 180 190 200
SRAMLRPQFA REQVGHVKLL EPHVQVLFKH IRKNKGREFD LQELFFRFTV
210 220 230 240 250
DSATEFLFGE SVESLRDASI GMTSKSKDVD GIEDFTGAFN YSQNYLASRS
260 270 280 290 300
IMQQFYWILN GKKFRECNAI VHKFADHYVQ KALNLTEADL EKQAGYVFLY
310 320 330 340 350
ELVKQTRDPQ VLRDQLLNIL VAGRDTTAGL LSFVFFELAR NPDVVAKLKD
360 370 380 390 400
EIDTKFGLGE DARIEEITFE SLKQCEYLKA VLNECLRLYP SVPQNFRVAT
410 420 430 440 450
KNTTLPRGGG KDGLSPILVR KGQTVMYSVY ATHRMESVYG KDATTFRPER
460 470 480 490 500
WFEPETRKLG WAFVPFNGGP RICLGQQFAL TEASYVTVRL LQEFSTLTLD
510 520
PNLEYPPKKM SHLTMSLFDG TNVQMY
Length:526
Mass (Da):60,261
Last modified:November 1, 1996 - v1
Checksum:i5D56229D78111BB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55881 Genomic DNA. Translation: CAA39366.1.
PIRiA40576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55881 Genomic DNA. Translation: CAA39366.1.
PIRiA40576.

3D structure databases

ProteinModelPortaliQ12581.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002974. Cyt_P450_E_CYP52.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01239. EP450IICYP52.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "CYP52 (cytochrome P450alk) multigene family in Candida maltosa: molecular cloning and nucleotide sequence of the two tandemly arranged genes."
    Ohkuma M., Tanimoto T., Yano K., Takagi M.
    DNA Cell Biol. 10:271-282(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28140 / CBS 5611 / IAM 12247 / JCM 1504 / NBRC 1977.
  2. "The CYP52 multigene family of Candida maltosa encodes functionally diverse n-alkane-inducible cytochromes P450."
    Zimmer T., Ohkuma M., Ohta A., Takagi M., Schunck W.H.
    Biochem. Biophys. Res. Commun. 224:784-789(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiCP52X_CANMA
AccessioniPrimary (citable) accession number: Q12581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.