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Q12570

- LAC1_BOTFU

UniProt

Q12570 - LAC1_BOTFU

Protein

Laccase-1

Gene

lcc1

Organism
Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 3 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi119 – 1191Copper 1; type 2By similarity
    Metal bindingi121 – 1211Copper 2; type 3By similarity
    Metal bindingi163 – 1631Copper 2; type 3By similarity
    Metal bindingi165 – 1651Copper 3; type 3By similarity
    Metal bindingi445 – 4451Copper 4; type 1By similarity
    Metal bindingi448 – 4481Copper 1; type 2By similarity
    Metal bindingi450 – 4501Copper 3; type 3By similarity
    Metal bindingi504 – 5041Copper 3; type 3By similarity
    Metal bindingi505 – 5051Copper 4; type 1By similarity
    Metal bindingi506 – 5061Copper 2; type 3By similarity
    Metal bindingi510 – 5101Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-1 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 1
    Diphenol oxidase 1
    Urishiol oxidase 1
    Gene namesi
    Name:lcc1
    Synonyms:lac1
    OrganismiBotryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
    Taxonomic identifieri40559 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 561541Laccase-1PRO_0000085584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Inductioni

    Not induced by resveratrol or tannins.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ12570.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 185118Plastocyanin-like 1Add
    BLAST
    Domaini191 – 337147Plastocyanin-like 2Add
    BLAST
    Domaini396 – 525130Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q12570-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNSFFSSLA KFASLSLAFA LPTAEVIPSA LEERQSCANT ATTRSCWGQY    50
    SASTNSYTTV PKTGYWLVVQ NTTLSADGVS RPTLNFNGTI PGPQITADWG 100
    DDVIVHVTNK LTSNGTSIHW HGIRQLNNAQ YDGVPGITQC PIAPGGTLTY 150
    KFHADNYGSS WYHSHFILQY GDGLFGPLVI NGPATANYDV DLGMLFLNDW 200
    NHVPVQSLWD KAKTGAPPTL LTGLMNGTNT YNGAGKKFQT TFTPGLKYRI 250
    RVVNTAVDGH FQFSIDGHSF QVIAMDFVPI VPYNATSILV SIAQRYDIIV 300
    TANAAVGNYW IRAGWQTACS GNTNAANITG ILRYTGSSST ADPTTTSTVT 350
    ASTSCLDEPL ASLVPFVPIN PVASSIMKTT LTTGGGQWLF NGSSLLLNWT 400
    DPTLLTVLNS GNIWPTEYNV IPIESTTANK GWAVLAISGP NGPNHPIHLH 450
    GHDFWTLSQG TGAYTATTAL NLVNPPRRDV MTLPTGGHLV IAFQIDNPGS 500
    WLMHCHIAWH ASEGLALQFV ESESSILPTI GTADVSTFQN TCAAWKAWTP 550
    TEPFPQDDSG I 561
    Length:561
    Mass (Da):60,337
    Last modified:December 12, 2006 - v3
    Checksum:i7F366B289EF73C23
    GO

    Sequence cautioni

    The sequence AAB41823.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence does probably not originate from mRNA or it was not properly spliced.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1182SI → TM in AAB41823. 1 PublicationCurated
    Sequence conflicti372 – 3721V → I in AAB41823. 1 PublicationCurated
    Sequence conflicti429 – 4291N → K in AAB41823. 1 PublicationCurated
    Sequence conflicti481 – 4811M → L in AAB41823. 1 PublicationCurated
    Sequence conflicti484 – 4841P → S in AAB41823. 1 PublicationCurated
    Sequence conflicti511 – 5111A → V in AAB41823. 1 PublicationCurated
    Sequence conflicti547 – 5471A → G in AAB41823. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF243854 Genomic DNA. Translation: AAK77952.1.
    U20192 mRNA. Translation: AAB41823.1. Sequence problems.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF243854 Genomic DNA. Translation: AAK77952.1 .
    U20192 mRNA. Translation: AAB41823.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali Q12570.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Resveratrol acts as a natural profungicide and induces self-intoxication by a specific laccase."
      Schouten A., Wagemakers L., Stefanato F.L., van der Kaaij R.M., van Kan J.A.L.
      Mol. Microbiol. 43:883-894(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
      Strain: SAS56.
    2. "A laccase cDNA from Botrytis cinerea."
      Cantone F.A., Staples R.C.
      Phytopathology 83:1383-1383(1993)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 115-561.
      Strain: SAS56.

    Entry informationi

    Entry nameiLAC1_BOTFU
    AccessioniPrimary (citable) accession number: Q12570
    Secondary accession number(s): Q96WN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 73 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3