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Q12570

- LAC1_BOTFU

UniProt

Q12570 - LAC1_BOTFU

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Protein

Laccase-1

Gene
lcc1, lac1
Organism
Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi119 – 1191Copper 1; type 2 By similarity
Metal bindingi121 – 1211Copper 2; type 3 By similarity
Metal bindingi163 – 1631Copper 2; type 3 By similarity
Metal bindingi165 – 1651Copper 3; type 3 By similarity
Metal bindingi445 – 4451Copper 4; type 1 By similarity
Metal bindingi448 – 4481Copper 1; type 2 By similarity
Metal bindingi450 – 4501Copper 3; type 3 By similarity
Metal bindingi504 – 5041Copper 3; type 3 By similarity
Metal bindingi505 – 5051Copper 4; type 1 By similarity
Metal bindingi506 – 5061Copper 2; type 3 By similarity
Metal bindingi510 – 5101Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene namesi
Name:lcc1
Synonyms:lac1
OrganismiBotryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Taxonomic identifieri40559 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 561541Laccase-1PRO_0000085584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi87 – 871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi226 – 2261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi327 – 3271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi398 – 3981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

Not induced by resveratrol or tannins.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ12570.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 185118Plastocyanin-like 1Add
BLAST
Domaini191 – 337147Plastocyanin-like 2Add
BLAST
Domaini396 – 525130Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12570-1 [UniParc]FASTAAdd to Basket

« Hide

MKNSFFSSLA KFASLSLAFA LPTAEVIPSA LEERQSCANT ATTRSCWGQY    50
SASTNSYTTV PKTGYWLVVQ NTTLSADGVS RPTLNFNGTI PGPQITADWG 100
DDVIVHVTNK LTSNGTSIHW HGIRQLNNAQ YDGVPGITQC PIAPGGTLTY 150
KFHADNYGSS WYHSHFILQY GDGLFGPLVI NGPATANYDV DLGMLFLNDW 200
NHVPVQSLWD KAKTGAPPTL LTGLMNGTNT YNGAGKKFQT TFTPGLKYRI 250
RVVNTAVDGH FQFSIDGHSF QVIAMDFVPI VPYNATSILV SIAQRYDIIV 300
TANAAVGNYW IRAGWQTACS GNTNAANITG ILRYTGSSST ADPTTTSTVT 350
ASTSCLDEPL ASLVPFVPIN PVASSIMKTT LTTGGGQWLF NGSSLLLNWT 400
DPTLLTVLNS GNIWPTEYNV IPIESTTANK GWAVLAISGP NGPNHPIHLH 450
GHDFWTLSQG TGAYTATTAL NLVNPPRRDV MTLPTGGHLV IAFQIDNPGS 500
WLMHCHIAWH ASEGLALQFV ESESSILPTI GTADVSTFQN TCAAWKAWTP 550
TEPFPQDDSG I 561
Length:561
Mass (Da):60,337
Last modified:December 12, 2006 - v3
Checksum:i7F366B289EF73C23
GO

Sequence cautioni

The sequence AAB41823.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence does probably not originate from mRNA or it was not properly spliced.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1182SI → TM in AAB41823. 1 Publication
Sequence conflicti372 – 3721V → I in AAB41823. 1 Publication
Sequence conflicti429 – 4291N → K in AAB41823. 1 Publication
Sequence conflicti481 – 4811M → L in AAB41823. 1 Publication
Sequence conflicti484 – 4841P → S in AAB41823. 1 Publication
Sequence conflicti511 – 5111A → V in AAB41823. 1 Publication
Sequence conflicti547 – 5471A → G in AAB41823. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243854 Genomic DNA. Translation: AAK77952.1.
U20192 mRNA. Translation: AAB41823.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243854 Genomic DNA. Translation: AAK77952.1 .
U20192 mRNA. Translation: AAB41823.1 . Sequence problems.

3D structure databases

ProteinModelPortali Q12570.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Resveratrol acts as a natural profungicide and induces self-intoxication by a specific laccase."
    Schouten A., Wagemakers L., Stefanato F.L., van der Kaaij R.M., van Kan J.A.L.
    Mol. Microbiol. 43:883-894(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: SAS56.
  2. "A laccase cDNA from Botrytis cinerea."
    Cantone F.A., Staples R.C.
    Phytopathology 83:1383-1383(1993)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 115-561.
    Strain: SAS56.

Entry informationi

Entry nameiLAC1_BOTFU
AccessioniPrimary (citable) accession number: Q12570
Secondary accession number(s): Q96WN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 12, 2006
Last modified: July 9, 2014
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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