Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q12570

- LAC1_BOTFU

UniProt

Q12570 - LAC1_BOTFU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Laccase-1

Gene

lcc1

Organism
Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi119 – 1191Copper 1; type 2By similarity
Metal bindingi121 – 1211Copper 2; type 3By similarity
Metal bindingi163 – 1631Copper 2; type 3By similarity
Metal bindingi165 – 1651Copper 3; type 3By similarity
Metal bindingi445 – 4451Copper 4; type 1By similarity
Metal bindingi448 – 4481Copper 1; type 2By similarity
Metal bindingi450 – 4501Copper 3; type 3By similarity
Metal bindingi504 – 5041Copper 3; type 3By similarity
Metal bindingi505 – 5051Copper 4; type 1By similarity
Metal bindingi506 – 5061Copper 2; type 3By similarity
Metal bindingi510 – 5101Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene namesi
Name:lcc1
Synonyms:lac1
OrganismiBotryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Taxonomic identifieri40559 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 561541Laccase-1PRO_0000085584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

Not induced by resveratrol or tannins.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ12570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 185118Plastocyanin-like 1Add
BLAST
Domaini191 – 337147Plastocyanin-like 2Add
BLAST
Domaini396 – 525130Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12570-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNSFFSSLA KFASLSLAFA LPTAEVIPSA LEERQSCANT ATTRSCWGQY
60 70 80 90 100
SASTNSYTTV PKTGYWLVVQ NTTLSADGVS RPTLNFNGTI PGPQITADWG
110 120 130 140 150
DDVIVHVTNK LTSNGTSIHW HGIRQLNNAQ YDGVPGITQC PIAPGGTLTY
160 170 180 190 200
KFHADNYGSS WYHSHFILQY GDGLFGPLVI NGPATANYDV DLGMLFLNDW
210 220 230 240 250
NHVPVQSLWD KAKTGAPPTL LTGLMNGTNT YNGAGKKFQT TFTPGLKYRI
260 270 280 290 300
RVVNTAVDGH FQFSIDGHSF QVIAMDFVPI VPYNATSILV SIAQRYDIIV
310 320 330 340 350
TANAAVGNYW IRAGWQTACS GNTNAANITG ILRYTGSSST ADPTTTSTVT
360 370 380 390 400
ASTSCLDEPL ASLVPFVPIN PVASSIMKTT LTTGGGQWLF NGSSLLLNWT
410 420 430 440 450
DPTLLTVLNS GNIWPTEYNV IPIESTTANK GWAVLAISGP NGPNHPIHLH
460 470 480 490 500
GHDFWTLSQG TGAYTATTAL NLVNPPRRDV MTLPTGGHLV IAFQIDNPGS
510 520 530 540 550
WLMHCHIAWH ASEGLALQFV ESESSILPTI GTADVSTFQN TCAAWKAWTP
560
TEPFPQDDSG I
Length:561
Mass (Da):60,337
Last modified:December 12, 2006 - v3
Checksum:i7F366B289EF73C23
GO

Sequence cautioni

The sequence AAB41823.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence does probably not originate from mRNA or it was not properly spliced.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1182SI → TM in AAB41823. 1 PublicationCurated
Sequence conflicti372 – 3721V → I in AAB41823. 1 PublicationCurated
Sequence conflicti429 – 4291N → K in AAB41823. 1 PublicationCurated
Sequence conflicti481 – 4811M → L in AAB41823. 1 PublicationCurated
Sequence conflicti484 – 4841P → S in AAB41823. 1 PublicationCurated
Sequence conflicti511 – 5111A → V in AAB41823. 1 PublicationCurated
Sequence conflicti547 – 5471A → G in AAB41823. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243854 Genomic DNA. Translation: AAK77952.1.
U20192 mRNA. Translation: AAB41823.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243854 Genomic DNA. Translation: AAK77952.1 .
U20192 mRNA. Translation: AAB41823.1 . Sequence problems.

3D structure databases

ProteinModelPortali Q12570.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Resveratrol acts as a natural profungicide and induces self-intoxication by a specific laccase."
    Schouten A., Wagemakers L., Stefanato F.L., van der Kaaij R.M., van Kan J.A.L.
    Mol. Microbiol. 43:883-894(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: SAS56.
  2. "A laccase cDNA from Botrytis cinerea."
    Cantone F.A., Staples R.C.
    Phytopathology 83:1383-1383(1993)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 115-561.
    Strain: SAS56.

Entry informationi

Entry nameiLAC1_BOTFU
AccessioniPrimary (citable) accession number: Q12570
Secondary accession number(s): Q96WN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3